A profiling platform for the characterization of transglutaminase 2 (TG2) inhibitors

Journal of Biomolecular Screening

Volumn 15, Issue 5, 2010, Pages 478-487

  Schaertl, Sabine ^a   Prime, Michael ^b   Wityak, John ^c   Dominguez, Celia ^c   Munoz Sanjuan, Ignacio ^c   Pacifici, Robert E ^c   Courtney, Stephen ^b   Scheel, Andreas ^a   MacDonald, Douglas ^c  

^a EVOTEC AG   (Germany)

^b EVOTEC UK LTD   (United Kingdom)

^c CHDI MANAGEMENT CHDI FOUNDATION   (United States)

Author keywords

Huntingtons disease; Mechanism of action; TG2; Tissue transglutaminase; Transamidation; Transglutaminase 2 inhibition

Indexed keywords

CYSTAMINE; CYSTEINE; ENZYME INHIBITOR; GUANINE NUCLEOTIDE; GUANOSINE TRIPHOSPHATE; HYDRAZIDE; HYDRAZIDE DERIVATIVE; PROTEIN GLUTAMINE GAMMA GLUTAMYLTRANSFERASE 2; PROTEIN GLUTAMINE GAMMA GLUTAMYLTRANSFERASE 2 INHIBITOR; PUTRESCINE; UNCLASSIFIED DRUG;

ARTICLE; CELL ACTIVITY; CELL ASSAY; HUMAN; HUMAN CELL; HUNTINGTON CHOREA; PRIORITY JOURNAL;

ANIMALS; BIOLOGICAL ASSAY; CELL LINE; ENZYME INHIBITORS; GTP-BINDING PROTEINS; HUMANS; HUNTINGTON DISEASE; MICE; MOLECULAR STRUCTURE; TRANSGLUTAMINASES;

EID: 77953627403     PISSN: 10870571     EISSN: 1552454X     Source Type: Journal    
DOI: 10.1177/1087057110366035     Document Type: Article

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