Transglutaminase-2 interaction with heparin: Identification of a heparin binding site that regulates cell adhesion to fibronectin-transglutaminase-2 matrix

Journal of Biological Chemistry

Volumn 287, Issue 22, 2012, Pages 18005-18017

  Lortat Jacob, Hugues ^a   Burhan, Izhar ^b   Scarpellini, Alessandra ^b   Thomas, Aline ^c   Imberty, Anne ^c   Vivès, Romain R ^a   Johnson, Timothy ^d   Gutierrez, Aldo ^b   Verderio, Elisabetta A M ^b  

^a INSTITUT DE BIOLOGIE STRUCTURALE   (France)

^b NOTTINGHAM TRENT UNIVERSITY   (United Kingdom)

^c CENTRE DE RECHERCHES SUR LES MACROMOLÉCULES VÉGÉTALES CERMAV CNRS   (France)

^d UNIVERSITY OF SHEFFIELD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PARTNERS; BINDING SURFACE; CANCER PROGRESSION; CELL SURFACES; EXTRACELLULAR; HEPARAN SULFATES; HEPARIN BINDING; HEPARIN-BINDING SITE; HIGH AFFINITY; LINEAR SEQUENCE; MOLECULAR BASIS; MULTIFUNCTIONAL PROTEIN; PENTASACCHARIDES; PROTEOGLYCANS; SITE DIRECTED MUTAGENESIS; SPATIAL PROXIMITY; THREE-DIMENSIONAL STRUCTURE; TISSUE REMODELING; WILD TYPES; WOUND HEALING;

AMINO ACIDS; BINDING SITES; CELL ADHESION; CELL MEMBRANES; ENZYME ACTIVITY; HYDRAULIC STRUCTURES; TISSUE;

POLYSACCHARIDES;

ARGININE; ARGINYLGLYCYLASPARTIC ACID; FIBRONECTIN; HEPARIN; PENTASACCHARIDE; PROTEIN GLUTAMINE GAMMA GLUTAMYLTRANSFERASE 2;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; BINDING AFFINITY; CELL ADHESION; CELL MIGRATION; CONTROLLED STUDY; DRUG BINDING SITE; DRUG PROTEIN BINDING; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME STRUCTURE; GENE MUTATION; HUMAN; MOLECULAR INTERACTION; MOLECULAR MODEL; NONHUMAN; PRIORITY JOURNAL; PROTEIN FOLDING; SITE DIRECTED MUTAGENESIS; THREE DIMENSIONAL IMAGING; WILD TYPE;

AMINO ACID SEQUENCE; BINDING SITES; CELL ADHESION; FIBRONECTINS; GTP-BINDING PROTEINS; HEPARIN; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; OLIGOPEPTIDES; PROTEIN BINDING; TRANSGLUTAMINASES;

EID: 84861557321     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.337089     Document Type: Article

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