-
1
-
-
4844225372
-
Drug-induced liver injury; fourteenth updated edition of the bibliographic database of liver injuries and related drugs
-
This article provides an essential database concerning DILI for more than a thousand pharmaceuticals. Importantly, this French database is now available on line (http://server1.dicofm.com/hepatox/index.php) and is regularly updated. Another important database regarding DILI is the FDA’s Liver Toxicity Knowledge Base (LTKB)
-
•• Biour M, Ben Salem C, Chazouillères O, et al (2004) Drug-induced liver injury; fourteenth updated edition of the bibliographic database of liver injuries and related drugs. Gastroenterol Clin Biol 28:720–759. This article provides an essential database concerning DILI for more than a thousand pharmaceuticals. Importantly, this French database is now available on line (http://server1.dicofm.com/hepatox/index.php) and is regularly updated. Another important database regarding DILI is the FDA’s Liver Toxicity Knowledge Base (LTKB) (http://www.fda.gov/ScienceResearch/BioinformaticsTools/LiverToxicityKnowledgeBase).
-
(2004)
Gastroenterol Clin Biol
, vol.28
, pp. 720-759
-
-
Biour, M.1
Ben Salem, C.2
Chazouillères, O.3
-
2
-
-
67649221506
-
Histological patterns in drug-induced liver disease
-
PID: 19474352, COI: 1:STN:280:DC%2BD1MznsVGlsw%3D%3D
-
Ramachandran R, Kakar S (2009) Histological patterns in drug-induced liver disease. J Clin Pathol 62:481–492
-
(2009)
J Clin Pathol
, vol.62
, pp. 481-492
-
-
Ramachandran, R.1
Kakar, S.2
-
3
-
-
0029127584
-
Inhibition of mitochondrial beta-oxidation as a mechanism of hepatotoxicity
-
PID: 7494860, COI: 1:CAS:528:DyaK2MXnvVKrs78%3D
-
Fromenty B, Pessayre D (1995) Inhibition of mitochondrial beta-oxidation as a mechanism of hepatotoxicity. Pharmacol Ther 67:101–154
-
(1995)
Pharmacol Ther
, vol.67
, pp. 101-154
-
-
Fromenty, B.1
Pessayre, D.2
-
4
-
-
55949124005
-
Drug-induced liver injury through mitochondrial dysfunction: mechanisms and detection during preclinical safety studies
-
PID: 18705745, COI: 1:CAS:528:DC%2BD1cXptlaltr0%3D
-
Labbe G, Pessayre D, Fromenty B (2008) Drug-induced liver injury through mitochondrial dysfunction: mechanisms and detection during preclinical safety studies. Fundam Clin Pharmacol 22:335–353
-
(2008)
Fundam Clin Pharmacol
, vol.22
, pp. 335-353
-
-
Labbe, G.1
Pessayre, D.2
Fromenty, B.3
-
5
-
-
79952702137
-
Drug-induced toxicity on mitochondria and lipid metabolism: mechanistic diversity and deleterious consequences for the liver
-
PID: 21145849, COI: 1:CAS:528:DC%2BC3MXjs12hsr8%3D
-
Begriche K, Massart J, Robin MA et al (2011) Drug-induced toxicity on mitochondria and lipid metabolism: mechanistic diversity and deleterious consequences for the liver. J Hepatol 54:773–794
-
(2011)
J Hepatol
, vol.54
, pp. 773-794
-
-
Begriche, K.1
Massart, J.2
Robin, M.A.3
-
6
-
-
77949321706
-
Mitochondrial involvement in drug-induced liver injury
-
PID: 20020267, COI: 1:CAS:528:DC%2BC3cXnvVynu7c%3D
-
Pessayre D, Mansouri A, Berson A et al (2010) Mitochondrial involvement in drug-induced liver injury. Handb Exp Pharmacol 196:311–365
-
(2010)
Handb Exp Pharmacol
, vol.196
, pp. 311-365
-
-
Pessayre, D.1
Mansouri, A.2
Berson, A.3
-
7
-
-
84855872291
-
Central role of mitochondria in drug-induced liver injury
-
PID: 21892896, COI: 1:CAS:528:DC%2BC38XhtVGlurg%3D
-
Pessayre D, Fromenty B, Berson A et al (2012) Central role of mitochondria in drug-induced liver injury. Drug Metab Rev 44:34–87
-
(2012)
Drug Metab Rev
, vol.44
, pp. 34-87
-
-
Pessayre, D.1
Fromenty, B.2
Berson, A.3
-
8
-
-
77949882290
-
Mitochondrial energetics and therapeutics
-
PID: 20078222, COI: 1:CAS:528:DC%2BC3cXivFektL4%3D
-
Wallace DC, Fan W, Procaccio V (2010) Mitochondrial energetics and therapeutics. Annu Rev Pathol 5:297–348
-
(2010)
Annu Rev Pathol
, vol.5
, pp. 297-348
-
-
Wallace, D.C.1
Fan, W.2
Procaccio, V.3
-
9
-
-
84884984539
-
Mitochondrial adaptations and dysfunctions in nonalcoholic fatty liver disease
-
(,),., (, press
-
Begriche K, Massart J, Robin MA et al (2013) Mitochondrial adaptations and dysfunctions in nonalcoholic fatty liver disease. Hepatology (in press)
-
(2013)
Hepatology
-
-
Begriche, K.1
Massart, J.2
Robin, M.A.3
-
10
-
-
17844371476
-
Fetal fatty acid oxidation disorders, their effect on maternal health and neonatal outcome: impact of expanded newborn screening on their diagnosis and management
-
PID: 15817498
-
Shekhawat PS, Matern D, Strauss AW (2005) Fetal fatty acid oxidation disorders, their effect on maternal health and neonatal outcome: impact of expanded newborn screening on their diagnosis and management. Pediatr Res 57:78R–86R
-
(2005)
Pediatr Res
, vol.57
, pp. 78R-86R
-
-
Shekhawat, P.S.1
Matern, D.2
Strauss, A.W.3
-
11
-
-
0025599388
-
Dual effect of amiodarone on mitochondrial respiration. Initial protonophoric uncoupling effect followed by inhibition of the respiratory chain at the levels of complex I and II
-
PID: 1979817, COI: 1:CAS:528:DyaK3MXpsVyksA%3D%3D
-
Fromenty B, Fisch C, Berson A et al (1990) Dual effect of amiodarone on mitochondrial respiration. Initial protonophoric uncoupling effect followed by inhibition of the respiratory chain at the levels of complex I and II. J Pharmacol Exp Ther 255:1377–1384
-
(1990)
J Pharmacol Exp Ther
, vol.255
, pp. 1377-1384
-
-
Fromenty, B.1
Fisch, C.2
Berson, A.3
-
12
-
-
84866596506
-
Prediction of liver injury induced by chemicals in human with a multiparametric assay on isolated mouse liver mitochondria
-
This article reports the effects of more than a hundred drugs on different mitochondrial parameters including oxygen consumption, membrane potential, swelling and cytochrome c release. The data revealed a highly significant relationship between mitochondrial toxicity and the occurrence of drug-induced liver injury in human
-
•• Porceddu M, Buron N, Roussel C, et al (2012) Prediction of liver injury induced by chemicals in human with a multiparametric assay on isolated mouse liver mitochondria. Toxicol Sci. 129:332–345. This article reports the effects of more than a hundred drugs on different mitochondrial parameters including oxygen consumption, membrane potential, swelling and cytochrome c release. The data revealed a highly significant relationship between mitochondrial toxicity and the occurrence of drug-induced liver injury in human.
-
(2012)
Toxicol Sci
, vol.129
, pp. 332-345
-
-
Porceddu, M.1
Buron, N.2
Roussel, C.3
-
13
-
-
0027166095
-
Evaluation of human blood lymphocytes as a model to study the effects of drugs on human mitochondria. Effects of low concentrations of amiodarone on fatty acid oxidation, ATP levels and cell survival
-
PID: 8347165, COI: 1:CAS:528:DyaK3sXmtFKltb4%3D
-
Fromenty B, Letteron P, Fisch C et al (1993) Evaluation of human blood lymphocytes as a model to study the effects of drugs on human mitochondria. Effects of low concentrations of amiodarone on fatty acid oxidation, ATP levels and cell survival. Biochem Pharmacol 46:421–432
-
(1993)
Biochem Pharmacol
, vol.46
, pp. 421-432
-
-
Fromenty, B.1
Letteron, P.2
Fisch, C.3
-
14
-
-
0036257933
-
Progressive reversion of clinical and molecular phenotype in a child with liver mitochondrial DNA depletion
-
PID: 11983456
-
Ducluzeau PH, Lachaux A, Bouvier R et al (2002) Progressive reversion of clinical and molecular phenotype in a child with liver mitochondrial DNA depletion. J Hepatol 36:698–703
-
(2002)
J Hepatol
, vol.36
, pp. 698-703
-
-
Ducluzeau, P.H.1
Lachaux, A.2
Bouvier, R.3
-
15
-
-
33745854202
-
Mitochondrial, metabolic and genotoxic effects of antiretroviral nucleoside reverse-transcriptase inhibitors
-
COI: 1:CAS:528:DC%2BD28XmsVOitbY%3D
-
Igoudjil A, Begriche K, Pessayre D et al (2006) Mitochondrial, metabolic and genotoxic effects of antiretroviral nucleoside reverse-transcriptase inhibitors. Curr Med Chem Anti Infect Agents 5:273–292
-
(2006)
Curr Med Chem Anti Infect Agents
, vol.5
, pp. 273-292
-
-
Igoudjil, A.1
Begriche, K.2
Pessayre, D.3
-
16
-
-
4143050352
-
Mitochondrial oxidative stress in human hepatoma cells exposed to stavudine
-
PID: 15289086, COI: 1:CAS:528:DC%2BD2cXmt1Khtr8%3D
-
Velsor LW, Kovacevic M, Goldstein M et al (2004) Mitochondrial oxidative stress in human hepatoma cells exposed to stavudine. Toxicol Appl Pharmacol 199:10–19
-
(2004)
Toxicol Appl Pharmacol
, vol.199
, pp. 10-19
-
-
Velsor, L.W.1
Kovacevic, M.2
Goldstein, M.3
-
17
-
-
80055050942
-
Screening for active small molecules in mitochondrial complex I deficient patient’s fibroblasts, reveals AICAR as the most beneficial compound
-
PID: 22046392, COI: 1:CAS:528:DC%2BC3MXhsVKlur7E
-
Golubitzky A, Dan P, Weissman S et al (2011) Screening for active small molecules in mitochondrial complex I deficient patient’s fibroblasts, reveals AICAR as the most beneficial compound. PLoS ONE 6:e26883
-
(2011)
PLoS ONE
, vol.6
-
-
Golubitzky, A.1
Dan, P.2
Weissman, S.3
-
18
-
-
84866729278
-
Minimizing the damage: repair pathways keep mitochondrial DNA intact
-
PID: 22992591, COI: 1:CAS:528:DC%2BC38XhtlKrsLzM
-
Kazak L, Reyes A, Holt IJ (2012) Minimizing the damage: repair pathways keep mitochondrial DNA intact. Nat Rev Mol Cell Biol 13:659–671
-
(2012)
Nat Rev Mol Cell Biol
, vol.13
, pp. 659-671
-
-
Kazak, L.1
Reyes, A.2
Holt, I.J.3
-
19
-
-
32444451567
-
Coactivation of Foxa2 through PGC-1β promotes liver fatty acid oxidation and triglyceride/VLDL secretion
-
PID: 16459311, COI: 1:CAS:528:DC%2BD28XhvFyjtL4%3D
-
Wolfrum C, Stoffel M (2006) Coactivation of Foxa2 through PGC-1β promotes liver fatty acid oxidation and triglyceride/VLDL secretion. Cell Metab 3:99–110
-
(2006)
Cell Metab
, vol.3
, pp. 99-110
-
-
Wolfrum, C.1
Stoffel, M.2
-
20
-
-
44249122893
-
Effect of carnitine deprivation on carnitine homeostasis and energy metabolism in mice with systemic carnitine deficiency
-
PID: 18417958, COI: 1:CAS:528:DC%2BD1cXmtVCrurs%3D
-
Knapp AC, Todesco L, Torok M et al (2008) Effect of carnitine deprivation on carnitine homeostasis and energy metabolism in mice with systemic carnitine deficiency. Ann Nutr Metab 52:136–144
-
(2008)
Ann Nutr Metab
, vol.52
, pp. 136-144
-
-
Knapp, A.C.1
Todesco, L.2
Torok, M.3
-
21
-
-
0025677186
-
Amiodarone inhibits the mitochondrial β-oxidation of fatty acids and produces microvesicular steatosis of the liver in mice
-
PID: 2124623, COI: 1:CAS:528:DyaK3MXnsV2mtg%3D%3D
-
Fromenty B, Fisch C, Labbe G et al (1990) Amiodarone inhibits the mitochondrial β-oxidation of fatty acids and produces microvesicular steatosis of the liver in mice. J Pharmacol Exp Ther 255:1371–1376
-
(1990)
J Pharmacol Exp Ther
, vol.255
, pp. 1371-1376
-
-
Fromenty, B.1
Fisch, C.2
Labbe, G.3
-
22
-
-
0028361421
-
Inhibition by nilutamide of the mitochondrial respiratory chain and ATP formation. Possible contribution to the adverse effects of this antiandrogen
-
PID: 8035313, COI: 1:CAS:528:DyaK2cXkvF2htL0%3D
-
Berson A, Schmets L, Fisch C et al (1994) Inhibition by nilutamide of the mitochondrial respiratory chain and ATP formation. Possible contribution to the adverse effects of this antiandrogen. J Pharmacol Exp Ther 270:167–176
-
(1994)
J Pharmacol Exp Ther
, vol.270
, pp. 167-176
-
-
Berson, A.1
Schmets, L.2
Fisch, C.3
-
23
-
-
56049086590
-
Biguanide-induced mitochondrial dysfunction yields increased lactate production and cytotoxicity of aerobically-poised HepG2 cells and human hepatocytes in vitro
-
PID: 18817800, COI: 1:CAS:528:DC%2BD1cXhsVWrsrvE
-
Dykens JA, Jamieson J, Marroquin L et al (2008) Biguanide-induced mitochondrial dysfunction yields increased lactate production and cytotoxicity of aerobically-poised HepG2 cells and human hepatocytes in vitro. Toxicol Appl Pharmacol 233:203–210
-
(2008)
Toxicol Appl Pharmacol
, vol.233
, pp. 203-210
-
-
Dykens, J.A.1
Jamieson, J.2
Marroquin, L.3
-
24
-
-
0024433707
-
Tianeptine, a new tricyclic antidepressant metabolized by beta-oxidation of its heptanoic side chain, inhibits the mitochondrial oxidation of medium and short chain fatty acids in mice
-
PID: 2597170, COI: 1:CAS:528:DyaK3cXkvVKgsw%3D%3D
-
Fromenty B, Fréneaux E, Labbe G et al (1989) Tianeptine, a new tricyclic antidepressant metabolized by beta-oxidation of its heptanoic side chain, inhibits the mitochondrial oxidation of medium and short chain fatty acids in mice. Biochem Pharmacol 38:3743–3751
-
(1989)
Biochem Pharmacol
, vol.38
, pp. 3743-3751
-
-
Fromenty, B.1
Fréneaux, E.2
Labbe, G.3
-
25
-
-
0025250709
-
Stereoselective and nonstereoselective effects of ibuprofen enantiomers on mitochondrial beta-oxidation of fatty acids
-
PID: 2123005
-
Fréneaux E, Fromenty B, Berson A et al (1990) Stereoselective and nonstereoselective effects of ibuprofen enantiomers on mitochondrial beta-oxidation of fatty acids. J Pharmacol Exp Ther 255:529–535
-
(1990)
J Pharmacol Exp Ther
, vol.255
, pp. 529-535
-
-
Fréneaux, E.1
Fromenty, B.2
Berson, A.3
-
26
-
-
0028302917
-
Inhibition by perhexiline of oxidative phosphorylation and the β-oxidation of fatty acids: possible role in pseudoalcoholic liver lesions
-
PID: 8138270, COI: 1:CAS:528:DyaK2cXkvF2gtbo%3D
-
Deschamps D, DeBeco V, Fisch C et al (1994) Inhibition by perhexiline of oxidative phosphorylation and the β-oxidation of fatty acids: possible role in pseudoalcoholic liver lesions. Hepatology 19:948–961
-
(1994)
Hepatology
, vol.19
, pp. 948-961
-
-
Deschamps, D.1
DeBeco, V.2
Fisch, C.3
-
27
-
-
0032410542
-
Binding of nonsteroidal antiinflammatory drugs to the α-subunit of the trifunctional protein of long chain fatty acid oxidation
-
PID: 9694975, COI: 1:CAS:528:DyaK1cXlsVWhtr8%3D
-
Baldwin GS, Murphy VJ, Yang Z et al (1998) Binding of nonsteroidal antiinflammatory drugs to the α-subunit of the trifunctional protein of long chain fatty acid oxidation. J Pharmacol Exp Ther 286:1110–1114
-
(1998)
J Pharmacol Exp Ther
, vol.286
, pp. 1110-1114
-
-
Baldwin, G.S.1
Murphy, V.J.2
Yang, Z.3
-
28
-
-
34247203727
-
Tamoxifen inhibits topoisomerases, depletes mitochondrial DNA, and triggers steatosis in mouse liver
-
PID: 17277197, COI: 1:CAS:528:DC%2BD2sXltFehtb4%3D
-
Larosche I, Lettéron P, Fromenty B et al (2007) Tamoxifen inhibits topoisomerases, depletes mitochondrial DNA, and triggers steatosis in mouse liver. J Pharmacol Exp Ther 321:526–535
-
(2007)
J Pharmacol Exp Ther
, vol.321
, pp. 526-535
-
-
Larosche, I.1
Lettéron, P.2
Fromenty, B.3
-
29
-
-
72149113307
-
Inhibition of hepatic carnitine palmitoyl-transferase I (CPT IA) by valproyl-CoA as a possible mechanism of valproate-induced steatosis
-
This article showed that valproyl-CoA is inhibiting CPT1, a key enzyme involved the mitochondrial β-oxidation of LCFAs. Many other investigations from this group deciphered the mitochondrial toxicity of this antiepileptic drug
-
• Aires CC, Ijlst L, Stet F, Prip-Buus C, et al (2010) Inhibition of hepatic carnitine palmitoyl-transferase I (CPT IA) by valproyl-CoA as a possible mechanism of valproate-induced steatosis. Biochem Pharmacol. 79:792–799. This article showed that valproyl-CoA is inhibiting CPT1, a key enzyme involved in the mitochondrial β-oxidation of LCFAs. Many other investigations from this group deciphered the mitochondrial toxicity of this antiepileptic drug (see for instance references 30 and 40).
-
(2010)
Biochem Pharmacol.
, vol.79
, pp. 792-799
-
-
Aires, C.C.1
Ijlst, L.2
Stet, F.3
Prip-Buus, C.4
-
30
-
-
0035964970
-
Differential effect of valproate and its Delta2- and Delta4-unsaturated metabolites, on the beta-oxidation rate of long-chain and medium-chain fatty acids
-
PID: 11566289, COI: 1:CAS:528:DC%2BD3MXmvVygu7s%3D
-
Silva MF, Ruiter JP, Ijlst L et al (2001) Differential effect of valproate and its Delta2- and Delta4-unsaturated metabolites, on the beta-oxidation rate of long-chain and medium-chain fatty acids. Chem Biol Interact 137:203–212
-
(2001)
Chem Biol Interact
, vol.137
, pp. 203-212
-
-
Silva, M.F.1
Ruiter, J.P.2
Ijlst, L.3
-
31
-
-
66049157560
-
Serum metabolomics reveals irreversible inhibition of fatty acid β-oxidation through the suppression of PPARα activation as a contributing mechanism of acetaminophen-induced hepatotoxicity
-
PID: 19256530
-
Chen C, Krausz KW, Shah YM et al (2009) Serum metabolomics reveals irreversible inhibition of fatty acid β-oxidation through the suppression of PPARα activation as a contributing mechanism of acetaminophen-induced hepatotoxicity. Chem Res Toxicol 22:699–707
-
(2009)
Chem Res Toxicol
, vol.22
, pp. 699-707
-
-
Chen, C.1
Krausz, K.W.2
Shah, Y.M.3
-
32
-
-
0025774993
-
Acetaminophen toxicity results in site-specific mitochondrial damage in isolated mouse hepatocytes
-
PID: 2002047, COI: 1:CAS:528:DyaK3MXhvF2hu7g%3D
-
Burcham PC, Harman AW (1991) Acetaminophen toxicity results in site-specific mitochondrial damage in isolated mouse hepatocytes. J Biol Chem 266:5049–5054
-
(1991)
J Biol Chem
, vol.266
, pp. 5049-5054
-
-
Burcham, P.C.1
Harman, A.W.2
-
33
-
-
79151471077
-
Mitochondrial CYP2E1 is sufficient to mediate oxidative stress and cytotoxicity induced by ethanol and acetaminophen
-
PID: 21130154, COI: 1:CAS:528:DC%2BC3MXhtlegt7g%3D
-
Knockaert L, Descatoire V, Vadrot N et al (2011) Mitochondrial CYP2E1 is sufficient to mediate oxidative stress and cytotoxicity induced by ethanol and acetaminophen. Toxicol In Vitro 25:475–484
-
(2011)
Toxicol In Vitro
, vol.25
, pp. 475-484
-
-
Knockaert, L.1
Descatoire, V.2
Vadrot, N.3
-
34
-
-
2142639373
-
Gene expression profiling reveals multiple toxicity endpoints induced by hepatotoxicants
-
PID: 15120968, COI: 1:CAS:528:DC%2BD2cXjs1aqu78%3D
-
Huang Q, Jin X, Gaillard ET et al (2004) Gene expression profiling reveals multiple toxicity endpoints induced by hepatotoxicants. Mutat Res 549:147–167
-
(2004)
Mutat Res
, vol.549
, pp. 147-167
-
-
Huang, Q.1
Jin, X.2
Gaillard, E.T.3
-
35
-
-
33646874825
-
Involvement of Toll-like receptor 4 in acetaminophen hepatotoxicity
-
PID: 16439473, COI: 1:CAS:528:DC%2BD28XlvVeisb0%3D
-
Yohe HC, O’Hara KA, Hunt JA et al (2006) Involvement of Toll-like receptor 4 in acetaminophen hepatotoxicity. Am J Physiol Gastrointest Liver Physiol 290:G1269–G1279
-
(2006)
Am J Physiol Gastrointest Liver Physiol
, vol.290
, pp. G1269-G1279
-
-
Yohe, H.C.1
O’Hara, K.A.2
Hunt, J.A.3
-
36
-
-
84865159199
-
Differences in early acetaminophen hepatotoxicity between obese ob/ob and db/db mice
-
PID: 22647274, COI: 1:CAS:528:DC%2BC38XhtlShu7nJ
-
Aubert J, Begriche K, Delannoy M et al (2012) Differences in early acetaminophen hepatotoxicity between obese ob/ob and db/db mice. J Pharmacol Exp Ther 342:676–687
-
(2012)
J Pharmacol Exp Ther
, vol.342
, pp. 676-687
-
-
Aubert, J.1
Begriche, K.2
Delannoy, M.3
-
37
-
-
0030602865
-
Inhibition of carnitine palmitoyltransferase-1 in rat heart and liver by perhexiline and amiodarone
-
PID: 8694852, COI: 1:CAS:528:DyaK28Xkt1Krsbk%3D
-
Kennedy JA, Unger SA, Horowitz JD (1996) Inhibition of carnitine palmitoyltransferase-1 in rat heart and liver by perhexiline and amiodarone. Biochem Pharmacol 52:273–280
-
(1996)
Biochem Pharmacol
, vol.52
, pp. 273-280
-
-
Kennedy, J.A.1
Unger, S.A.2
Horowitz, J.D.3
-
38
-
-
0029859494
-
Troglitazone inhibits fatty acid oxidation and esterification, and gluconeogenesis in isolated hepatocytes from starved rats
-
PID: 8866561, COI: 1:CAS:528:DyaK28XmsVyqsr4%3D
-
Fulgencio JP, Kohl C, Girard J et al (1996) Troglitazone inhibits fatty acid oxidation and esterification, and gluconeogenesis in isolated hepatocytes from starved rats. Diabetes 45:1556–1562
-
(1996)
Diabetes
, vol.45
, pp. 1556-1562
-
-
Fulgencio, J.P.1
Kohl, C.2
Girard, J.3
-
39
-
-
0026341780
-
Inhibition by salicylic acid of the activation and thus oxidation of long chain fatty acids. Possible role in the development of Reye’s syndrome
-
PID: 1941634, COI: 1:CAS:528:DyaK38XktFc%3D
-
Deschamps D, Fisch C, Fromenty B et al (1991) Inhibition by salicylic acid of the activation and thus oxidation of long chain fatty acids. Possible role in the development of Reye’s syndrome. J Pharmacol Exp Ther 259:894–904
-
(1991)
J Pharmacol Exp Ther
, vol.259
, pp. 894-904
-
-
Deschamps, D.1
Fisch, C.2
Fromenty, B.3
-
40
-
-
80255136274
-
Valproic acid utilizes the isoleucine breakdown pathway for its complete β-oxidation
-
PID: 21843514
-
Luís PB, Ruiter JP, Ofman R et al (2011) Valproic acid utilizes the isoleucine breakdown pathway for its complete β-oxidation. Biochem Pharmacol 82:1740–1746
-
(2011)
Biochem Pharmacol
, vol.82
, pp. 1740-1746
-
-
Luís, P.B.1
Ruiter, J.P.2
Ofman, R.3
-
41
-
-
0035110961
-
Mechanisms for experimental buprenorphine hepatotoxicity: major role of mitochondrial dysfunction versus metabolic activation
-
PID: 11281555, COI: 1:CAS:528:DC%2BD3MXislCksLY%3D
-
Berson A, Fau D, Fornacciari R et al (2001) Mechanisms for experimental buprenorphine hepatotoxicity: major role of mitochondrial dysfunction versus metabolic activation. J Hepatol 34:261–269
-
(2001)
J Hepatol
, vol.34
, pp. 261-269
-
-
Berson, A.1
Fau, D.2
Fornacciari, R.3
-
42
-
-
0023706706
-
Inhibition of the mitochondrial oxidation of fatty acids by tetracycline in mice and in man: possible role in microvesicular steatosis induced by this antibiotic
-
PID: 3417225
-
Fréneaux E, Labbe G, Letteron P et al (1988) Inhibition of the mitochondrial oxidation of fatty acids by tetracycline in mice and in man: possible role in microvesicular steatosis induced by this antibiotic. Hepatology 8:1056–1062
-
(1988)
Hepatology
, vol.8
, pp. 1056-1062
-
-
Fréneaux, E.1
Labbe, G.2
Letteron, P.3
-
43
-
-
0026074809
-
Effects of various tetracycline derivatives on in vitro and in vivo beta-oxidation of fatty acids, egress of triglycerides from the liver, accumulation of hepatic triglycerides, and mortality in mice
-
PID: 1997011, COI: 1:CAS:528:DyaK3MXhtlGlsLk%3D
-
Labbe G, Fromenty B, Freneaux E et al (1991) Effects of various tetracycline derivatives on in vitro and in vivo beta-oxidation of fatty acids, egress of triglycerides from the liver, accumulation of hepatic triglycerides, and mortality in mice. Biochem Pharmacol 41:638–641
-
(1991)
Biochem Pharmacol
, vol.41
, pp. 638-641
-
-
Labbe, G.1
Fromenty, B.2
Freneaux, E.3
-
44
-
-
67349139961
-
Protective effect of bicyclol on tetracycline-induced fatty liver in mice
-
PID: 19427351, COI: 1:CAS:528:DC%2BD1MXnsFamtrc%3D
-
Yu HY, Wang BL, Zhao J et al (2009) Protective effect of bicyclol on tetracycline-induced fatty liver in mice. Toxicology 261:112–118
-
(2009)
Toxicology
, vol.261
, pp. 112-118
-
-
Yu, H.Y.1
Wang, B.L.2
Zhao, J.3
-
45
-
-
84855986971
-
Minocycline exerts uncoupling and inhibiting effects on mitochondrial respiration through adenine nucleotide translocase inhibition
-
PID: 21884796, COI: 1:CAS:528:DC%2BC38Xht1Ont7o%3D
-
Cuenca-Lopez MD, Karachitos A, Massarotto L et al (2012) Minocycline exerts uncoupling and inhibiting effects on mitochondrial respiration through adenine nucleotide translocase inhibition. Pharmacol Res 65:120–128
-
(2012)
Pharmacol Res
, vol.65
, pp. 120-128
-
-
Cuenca-Lopez, M.D.1
Karachitos, A.2
Massarotto, L.3
-
46
-
-
78751634054
-
The effects of antidepressants on mitochondrial function in a model cell system and isolated mitochondria
-
PID: 21120605, COI: 1:CAS:528:DC%2BC3cXhsV2nsL%2FF
-
Abdel-Razaq W, Kendall DA, Bates TE (2011) The effects of antidepressants on mitochondrial function in a model cell system and isolated mitochondria. Neurochem Res 36:327–338
-
(2011)
Neurochem Res
, vol.36
, pp. 327-338
-
-
Abdel-Razaq, W.1
Kendall, D.A.2
Bates, T.E.3
-
47
-
-
84865281542
-
In vitro inhibition of mitochondrial respiratory rate by antidepressants
-
PID: 22842584
-
Hroudová J, Fišar Z (2012) In vitro inhibition of mitochondrial respiratory rate by antidepressants. Toxicol Lett 213:345–352
-
(2012)
Toxicol Lett
, vol.213
, pp. 345-352
-
-
Hroudová, J.1
Fišar, Z.2
-
48
-
-
84863091436
-
Inhibition of mitochondrial complex I by various non-steroidal anti-inflammatory drugs and its protection by quercetin via a coenzyme Q-like action
-
PID: 22652335
-
Sandoval-Acuña C, Lopez-Alarcón C, Aliaga ME et al (2012) Inhibition of mitochondrial complex I by various non-steroidal anti-inflammatory drugs and its protection by quercetin via a coenzyme Q-like action. Chem Biol Interact 199:18–28
-
(2012)
Chem Biol Interact
, vol.199
, pp. 18-28
-
-
Sandoval-Acuña, C.1
Lopez-Alarcón, C.2
Aliaga, M.E.3
-
49
-
-
77957888842
-
2+ on oxidative phosphorylation in liver, brain, and heart mitochondria using state 3 oxidation rate assays
-
PID: 20800605, COI: 1:CAS:528:DC%2BC3cXhtlSjt7jN
-
2+ on oxidative phosphorylation in liver, brain, and heart mitochondria using state 3 oxidation rate assays. Toxicol Appl Pharmacol 249:65–75
-
(2010)
Toxicol Appl Pharmacol
, vol.249
, pp. 65-75
-
-
Gunter, T.E.1
Gerstner, B.2
Lester, T.3
-
50
-
-
0029978235
-
Fialuridine and its metabolites inhibit DNA polymerase γ at sites of multiple adjacent analog incorporation, decrease mtDNA abundance, and cause mitochondrial structural defects in cultured hepatoblasts
-
PID: 8622980, COI: 1:CAS:528:DyaK28XisVWitbk%3D
-
Lewis W, Levine ES, Griniuviene B et al (1996) Fialuridine and its metabolites inhibit DNA polymerase γ at sites of multiple adjacent analog incorporation, decrease mtDNA abundance, and cause mitochondrial structural defects in cultured hepatoblasts. Proc Natl Acad Sci USA 93:3592–3597
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 3592-3597
-
-
Lewis, W.1
Levine, E.S.2
Griniuviene, B.3
-
51
-
-
24044489629
-
Uridine in the prevention and treatment of NRTI-related mitochondrial toxicity
-
PID: 16152713, COI: 1:CAS:528:DC%2BD2MXhtVOlsb3M
-
Walker UA, Venhoff N (2005) Uridine in the prevention and treatment of NRTI-related mitochondrial toxicity. Antivir Ther 10(Suppl 2):M117–M123
-
(2005)
Antivir Ther
, vol.10
, pp. M117-M123
-
-
Walker, U.A.1
Venhoff, N.2
-
52
-
-
0041822082
-
Tacrine inhibits topoisomerases and DNA synthesis to cause mitochondrial DNA depletion and apoptosis in mouse liver
-
PID: 12939598, COI: 1:CAS:528:DC%2BD3sXnvVKjtLk%3D
-
Mansouri A, Haouzi D, Descatoire V et al (2003) Tacrine inhibits topoisomerases and DNA synthesis to cause mitochondrial DNA depletion and apoptosis in mouse liver. Hepatology 38:715–725
-
(2003)
Hepatology
, vol.38
, pp. 715-725
-
-
Mansouri, A.1
Haouzi, D.2
Descatoire, V.3
-
53
-
-
27144508153
-
Peroxynitrite-induced mitochondrial and endonuclease-mediated nuclear DNA damage in acetaminophen hepatotoxicity
-
PID: 16081675, COI: 1:CAS:528:DC%2BD2MXhtFyhtrzL
-
Cover C, Mansouri A, Knight TR et al (2005) Peroxynitrite-induced mitochondrial and endonuclease-mediated nuclear DNA damage in acetaminophen hepatotoxicity. J Pharmacol Exp Ther 315:879–887
-
(2005)
J Pharmacol Exp Ther
, vol.315
, pp. 879-887
-
-
Cover, C.1
Mansouri, A.2
Knight, T.R.3
-
54
-
-
70349779185
-
Troglitazone, but not rosiglitazone, damages mitochondrial DNA and induces mitochondrial dysfunction and cell death in human hepatocytes
-
PID: 19632256, COI: 1:CAS:528:DC%2BD1MXht1GmtbzP
-
Rachek LI, Yuzefovych LV, Ledoux SP et al (2009) Troglitazone, but not rosiglitazone, damages mitochondrial DNA and induces mitochondrial dysfunction and cell death in human hepatocytes. Toxicol Appl Pharmacol 240:348–354
-
(2009)
Toxicol Appl Pharmacol
, vol.240
, pp. 348-354
-
-
Rachek, L.I.1
Yuzefovych, L.V.2
Ledoux, S.P.3
-
55
-
-
0036788329
-
Impaired adaptive resynthesis and prolonged depletion of hepatic mitochondrial DNA after repeated alcohol binges in mice
-
PID: 12360488, COI: 1:CAS:528:DC%2BD38Xotl2nsLo%3D
-
Demeilliers C, Maisonneuve C, Grodet A et al (2002) Impaired adaptive resynthesis and prolonged depletion of hepatic mitochondrial DNA after repeated alcohol binges in mice. Gastroenterology 123:1278–1290
-
(2002)
Gastroenterology
, vol.123
, pp. 1278-1290
-
-
Demeilliers, C.1
Maisonneuve, C.2
Grodet, A.3
-
56
-
-
84869005234
-
Involvement of fatty acid metabolism in the hepatotoxicity induced by divalproex sodium
-
PID: 22531971, COI: 1:STN:280:DC%2BC38rnvVOgsA%3D%3D
-
Wang W, Lin R, Zhang J et al (2012) Involvement of fatty acid metabolism in the hepatotoxicity induced by divalproex sodium. Hum Exp Toxicol 31:1092–1101
-
(2012)
Hum Exp Toxicol
, vol.31
, pp. 1092-1101
-
-
Wang, W.1
Lin, R.2
Zhang, J.3
-
57
-
-
10044264310
-
Disruption of hepatic lipid homeostasis in mice after amiodarone treatment is associated with peroxisome proliferator-activated receptor-α target gene activation
-
PID: 15265979, COI: 1:CAS:528:DC%2BD2cXhtVKmt7fL
-
McCarthy TC, Pollak PT, Hanniman EA et al (2004) Disruption of hepatic lipid homeostasis in mice after amiodarone treatment is associated with peroxisome proliferator-activated receptor-α target gene activation. J Pharmacol Exp Ther 311:864–873
-
(2004)
J Pharmacol Exp Ther
, vol.311
, pp. 864-873
-
-
McCarthy, T.C.1
Pollak, P.T.2
Hanniman, E.A.3
-
58
-
-
36549009674
-
Gene expression profiling in livers of mice after acute inhibition of beta-oxidation
-
PID: 17933490
-
van der Leij FR, Bloks VW, Grefhorst A et al (2007) Gene expression profiling in livers of mice after acute inhibition of beta-oxidation. Genomics 90:680–689
-
(2007)
Genomics
, vol.90
, pp. 680-689
-
-
van der Leij, F.R.1
Bloks, V.W.2
Grefhorst, A.3
-
59
-
-
84880945769
-
Drug-induced liver injury in obesity
-
PID: 23298629
-
Fromenty B (2013) Drug-induced liver injury in obesity. J Hepatol 58:824–826
-
(2013)
J Hepatol
, vol.58
, pp. 824-826
-
-
Fromenty, B.1
-
60
-
-
0038643426
-
Inhibition of microsomal triglyceride transfer protein: another mechanism for drug-induced steatosis in mice
-
PID: 12829995
-
Lettéron P, Sutton A, Mansouri A et al (2003) Inhibition of microsomal triglyceride transfer protein: another mechanism for drug-induced steatosis in mice. Hepatology 38:133–140
-
(2003)
Hepatology
, vol.38
, pp. 133-140
-
-
Lettéron, P.1
Sutton, A.2
Mansouri, A.3
-
61
-
-
79957474305
-
Induction of vesicular steatosis by amiodarone and tetracycline is associated with up-regulation of lipogenic genes in HepaRG cells
-
This article was the first report demonstrating that amiodarone and tetracycline was able to induce vesicular steatosis the well-differentiated human hepatoma HepaRG cells. This study confirmed that both drugs can inhibit mitochondrial β-oxidation as previously described [21, 37, 42-44, 74–76], but also revealed that amiodarone could also increase de novo lipogenesis
-
• Anthérieu S, Rogue A, Fromenty B, et al (2011) Induction of vesicular steatosis by amiodarone and tetracycline is associated with up-regulation of lipogenic genes in HepaRG cells. Hepatology 53:1895–1905. This article was the first report demonstrating that amiodarone and tetracycline was able to induce vesicular steatosis in the well-differentiated human hepatoma HepaRG cells. This study confirmed that both drugs can inhibit mitochondrial β-oxidation as previously described [21, 37, 42-44, 74–76], but also revealed that amiodarone could also increase de novo lipogenesis.
-
(2011)
Hepatology
, vol.53
, pp. 1895-1905
-
-
Anthérieu, S.1
Rogue, A.2
Fromenty, B.3
-
62
-
-
0023231725
-
Inhibition of mitochondrial β-oxidation of fatty acids by pirprofen. Role in microvesicular steatosis due to this nonsteroidal anti-inflammatory drug
-
PID: 3116197
-
Genève J, Hayat-Bonan B, Labbe G et al (1987) Inhibition of mitochondrial β-oxidation of fatty acids by pirprofen. Role in microvesicular steatosis due to this nonsteroidal anti-inflammatory drug. J Pharmacol Exp Ther 242:1133–1137
-
(1987)
J Pharmacol Exp Ther
, vol.242
, pp. 1133-1137
-
-
Genève, J.1
Hayat-Bonan, B.2
Labbe, G.3
-
63
-
-
66349128492
-
PAT proteins, an ancient family of lipid droplet proteins that regulate cellular lipid stores
-
PID: 19375517, COI: 1:CAS:528:DC%2BD1MXntVKlsrc%3D
-
Bickel PE, Tansey JT, Welte MA (2009) PAT proteins, an ancient family of lipid droplet proteins that regulate cellular lipid stores. Biochem Biophys Acta 1791:419–440
-
(2009)
Biochem Biophys Acta
, vol.1791
, pp. 419-440
-
-
Bickel, P.E.1
Tansey, J.T.2
Welte, M.A.3
-
64
-
-
84860241971
-
Toxicity of octanoate and decanoate in rat peripheral tissues: evidence of bioenergetic dysfunction and oxidative damage induction in liver and skeletal muscle
-
PID: 22015654, COI: 1:CAS:528:DC%2BC3MXhs1OqsrrL
-
Scaini G, Simon KR, Tonin AM et al (2012) Toxicity of octanoate and decanoate in rat peripheral tissues: evidence of bioenergetic dysfunction and oxidative damage induction in liver and skeletal muscle. Mol Cell Biochem 361:329–335
-
(2012)
Mol Cell Biochem
, vol.361
, pp. 329-335
-
-
Scaini, G.1
Simon, K.R.2
Tonin, A.M.3
-
65
-
-
0030997076
-
Histopathologic changes associated with fialuridine hepatotoxicity
-
PID: 9071726, COI: 1:STN:280:DyaK2s3isFemsQ%3D%3D
-
Kleiner DE, Gaffey MJ, Sallie R et al (1997) Histopathologic changes associated with fialuridine hepatotoxicity. Mod Pathol 10:192–199
-
(1997)
Mod Pathol
, vol.10
, pp. 192-199
-
-
Kleiner, D.E.1
Gaffey, M.J.2
Sallie, R.3
-
66
-
-
0035080157
-
Myositis, microvesicular hepatitis, and progression to cirrhosis from troglitazone added to simvastatin
-
PID: 11281188, COI: 1:STN:280:DC%2BD3M3gvVCqtg%3D%3D
-
Caldwell SH, Hespenheide EE, von Borstel RW (2001) Myositis, microvesicular hepatitis, and progression to cirrhosis from troglitazone added to simvastatin. Dig Dis Sci 46:376–378
-
(2001)
Dig Dis Sci
, vol.46
, pp. 376-378
-
-
Caldwell, S.H.1
Hespenheide, E.E.2
von Borstel, R.W.3
-
67
-
-
0033983457
-
Subacute hepatic failure associated with a new antidiabetic agent, troglitazone: a case report with autopsy examination
-
PID: 10685643, COI: 1:STN:280:DC%2BD3c7kvVSkuw%3D%3D
-
Fukano M, Amano S, Sato J et al (2000) Subacute hepatic failure associated with a new antidiabetic agent, troglitazone: a case report with autopsy examination. Hum Pathol 31:250–253
-
(2000)
Hum Pathol
, vol.31
, pp. 250-253
-
-
Fukano, M.1
Amano, S.2
Sato, J.3
-
68
-
-
0033988825
-
Hepatotoxicity due to troglitazone: report of two cases and review of adverse events reported to the United States Food and Drug Administration
-
PID: 10638596, COI: 1:STN:280:DC%2BD3c7gt1Wgtg%3D%3D
-
Kohlroser J, Mathai J, Reichheld J et al (2000) Hepatotoxicity due to troglitazone: report of two cases and review of adverse events reported to the United States Food and Drug Administration. Am J Gastroenterol 95:272–276
-
(2000)
Am J Gastroenterol
, vol.95
, pp. 272-276
-
-
Kohlroser, J.1
Mathai, J.2
Reichheld, J.3
-
69
-
-
40949165722
-
Inhibition of mitochondrial fatty acid oxidation in vivo only slightly suppresses gluconeogenesis but enhances clearance of glucose in mice
-
PID: 18302288, COI: 1:CAS:528:DC%2BD1cXktVOhsb0%3D
-
Derks TG, van Dijk TH, Grefhorst A et al (2008) Inhibition of mitochondrial fatty acid oxidation in vivo only slightly suppresses gluconeogenesis but enhances clearance of glucose in mice. Hepatology 47:1032–1042
-
(2008)
Hepatology
, vol.47
, pp. 1032-1042
-
-
Derks, T.G.1
van Dijk, T.H.2
Grefhorst, A.3
-
70
-
-
0023815483
-
Amineptine, a tricyclic antidepressant, inhibits the mitochondrial oxidation of fatty acids and produces microvesicular steatosis of the liver in mice
-
PID: 3183967
-
Le Dinh T, Freneaux E, Labbe G et al (1988) Amineptine, a tricyclic antidepressant, inhibits the mitochondrial oxidation of fatty acids and produces microvesicular steatosis of the liver in mice. J Pharmacol Exp Ther 247:745–750
-
(1988)
J Pharmacol Exp Ther
, vol.247
, pp. 745-750
-
-
Le Dinh, T.1
Freneaux, E.2
Labbe, G.3
-
71
-
-
84867356237
-
Lipidomic profiling reveals protective function of fatty acid oxidation in cocaine-induced hepatotoxicity
-
This study epitomizes the fact that non-pharmaceutical compounds are able to inhibit mitochondrial β-oxidation and cause microvesicular steatosis. In this study, cocaine-induced inhibition of hepatic β-oxidation was associated with the accumulation of palmitoyl-carnitine in serum and liver. Interestingly, accretion of acyl-carnitine derivatives can be also observed with valproic acid
-
• Shi X, Yao D, Gosnell BA, et al (2012) Lipidomic profiling reveals protective function of fatty acid oxidation in cocaine-induced hepatotoxicity. J Lipid Res. 53:2318–2330. This study epitomizes the fact that non-pharmaceutical compounds are able to inhibit mitochondrial β-oxidation and cause microvesicular steatosis. In this study, cocaine-induced inhibition of hepatic β-oxidation was associated with the accumulation of palmitoyl-carnitine in serum and liver. Interestingly, accretion of acyl-carnitine derivatives can be also observed with valproic acid.
-
(2012)
J Lipid Res
, vol.53
, pp. 2318-2330
-
-
Shi, X.1
Yao, D.2
Gosnell, B.A.3
-
72
-
-
80054908941
-
Inhibition of mitochondrial respiratory chain is involved in triptolide-induced liver injury
-
PID: 21907767, COI: 1:CAS:528:DC%2BC3MXhtlOksrbI
-
Fu Q, Huang X, Shu B et al (2011) Inhibition of mitochondrial respiratory chain is involved in triptolide-induced liver injury. Fitoterapia 82:1241–1248
-
(2011)
Fitoterapia
, vol.82
, pp. 1241-1248
-
-
Fu, Q.1
Huang, X.2
Shu, B.3
-
73
-
-
84860821984
-
PFOS-induced hepatic steatosis, the mechanistic actions on β-oxidation and lipid transport
-
PID: 22484034, COI: 1:CAS:528:DC%2BC38XnslSms7w%3D
-
Wan HT, Zhao YG, Wei X et al (2012) PFOS-induced hepatic steatosis, the mechanistic actions on β-oxidation and lipid transport. Biochim Biophys Acta 1820:1092–1101
-
(2012)
Biochim Biophys Acta
, vol.1820
, pp. 1092-1101
-
-
Wan, H.T.1
Zhao, Y.G.2
Wei, X.3
-
74
-
-
0035161962
-
Toxicity of amiodarone and amiodarone analogues on isolated rat liver mitochondria
-
PID: 11690709, COI: 1:CAS:528:DC%2BD38XktFWg
-
Spaniol M, Bracher R, Ha HR et al (2001) Toxicity of amiodarone and amiodarone analogues on isolated rat liver mitochondria. J Hepatol 35:628–636
-
(2001)
J Hepatol
, vol.35
, pp. 628-636
-
-
Spaniol, M.1
Bracher, R.2
Ha, H.R.3
-
75
-
-
16244412284
-
Mechanisms of benzarone and benzbromarone-induced hepatic toxicity
-
PID: 15799034, COI: 1:CAS:528:DC%2BD2MXjsV2msbk%3D
-
Kaufmann P, Török M, Hänni A et al (2005) Mechanisms of benzarone and benzbromarone-induced hepatic toxicity. Hepatology 41:925–935
-
(2005)
Hepatology
, vol.41
, pp. 925-935
-
-
Kaufmann, P.1
Török, M.2
Hänni, A.3
-
76
-
-
84873821138
-
Mechanisms of hepatocellular toxicity associated with dronedarone
-
This article showed for the first time that the new antiarrhythmic drug dronedarone is able to impair mitochondrial function in a similar way that amiodarone, its structural analogue. Moreover, this article and others (see for instance [74] and [75]) confirmed our original data published in 1990 showing that amiodarone can have a dual effect on OXPHOS (i.e. uncoupling and inhibition) and inhibit mitochondrial fatty acid β-oxidation [11, 21]
-
• Felser A, Blum K, Lindinger PW, et al (2013) Mechanisms of hepatocellular toxicity associated with dronedarone. A comparison to amiodarone. Toxicol Sci. 131:480–490. This article showed for the first time that the new antiarrhythmic drug dronedarone is able to impair mitochondrial function in a similar way that amiodarone, its structural analogue. Moreover, this article and others (see for instance [74] and [75]) confirmed our original data published in 1990 showing that amiodarone can have a dual effect on OXPHOS (i.e. uncoupling and inhibition) and inhibit mitochondrial fatty acid β-oxidation [11, 21].
-
(2013)
A Comparison to Amiodarone. Toxicol Sci
, vol.131
, pp. 480-490
-
-
Felser, A.1
Blum, K.2
Lindinger, P.W.3
-
77
-
-
84867850890
-
Assessment of the role of in situ generated (E)-2,4-diene-valproic acid in the toxicity of valproic acid and (E)-2-ene-valproic acid in sandwich-cultured rat hepatocytes
-
PID: 22940460, COI: 1:CAS:528:DC%2BC38XhtlKrtrbN
-
Surendradoss J, Chang TK, Abbott FS (2012) Assessment of the role of in situ generated (E)-2,4-diene-valproic acid in the toxicity of valproic acid and (E)-2-ene-valproic acid in sandwich-cultured rat hepatocytes. Toxicol Appl Pharmacol 264:413–422
-
(2012)
Toxicol Appl Pharmacol
, vol.264
, pp. 413-422
-
-
Surendradoss, J.1
Chang, T.K.2
Abbott, F.S.3
-
78
-
-
10744222741
-
Depletion of mitochondrial DNA in liver under antiretroviral therapy with didanosine, stavudine, or zalcitabine
-
PID: 14767983, COI: 1:CAS:528:DC%2BD2cXjtlait7g%3D
-
Walker UA, Bäuerle J, Laguno M et al (2004) Depletion of mitochondrial DNA in liver under antiretroviral therapy with didanosine, stavudine, or zalcitabine. Hepatology 39:311–317
-
(2004)
Hepatology
, vol.39
, pp. 311-317
-
-
Walker, U.A.1
Bäuerle, J.2
Laguno, M.3
-
79
-
-
0035577787
-
Hyperlactatemia and antiretroviral therapy: the Swiss HIV Cohort Study
-
PID: 11692306, COI: 1:CAS:528:DC%2BD3MXpt1KjtL8%3D
-
Boubaker K, Flepp M, Sudre P et al (2001) Hyperlactatemia and antiretroviral therapy: the Swiss HIV Cohort Study. Clin Infect Dis 33:1931–1937
-
(2001)
Clin Infect Dis
, vol.33
, pp. 1931-1937
-
-
Boubaker, K.1
Flepp, M.2
Sudre, P.3
-
80
-
-
77949878549
-
Drugs interfering with mitochondrial disorders
-
PID: 19839725, COI: 1:CAS:528:DC%2BC3cXjslegsb0%3D
-
Finsterer J, Segall L (2010) Drugs interfering with mitochondrial disorders. Drug Chem Toxicol 33:138–151
-
(2010)
Drug Chem Toxicol
, vol.33
, pp. 138-151
-
-
Finsterer, J.1
Segall, L.2
-
81
-
-
67049145568
-
R964C mutation of DNA polymerase γ imparts increased stavudine toxicity by decreasing nucleoside analog discrimination and impairing polymerase activity
-
PID: 19364868, COI: 1:CAS:528:DC%2BD1MXntFGks7g%3D
-
Bailey CM, Kasiviswanathan R, Copeland WC et al (2009) R964C mutation of DNA polymerase γ imparts increased stavudine toxicity by decreasing nucleoside analog discrimination and impairing polymerase activity. Antimicrob Agents Chemother 53:2610–2612
-
(2009)
Antimicrob Agents Chemother
, vol.53
, pp. 2610-2612
-
-
Bailey, C.M.1
Kasiviswanathan, R.2
Copeland, W.C.3
-
82
-
-
78049516212
-
Polymerase γ gene POLG determines the risk of sodium valproate-induced liver toxicity
-
This article showed for the first time that a particular genetic variation in the POLG gene was strongly associated with valproate-induced liver toxicity. This gene is encoding the DNA polymerase γ, which is the only DNA polymerase involved in mtDNA replication. However, it is still unclear how mutations in the POLG gene could favor VPA-induced liver injury, contrary to antiretroviral nucleoside analogue-induced toxicity [81]
-
• Stewart JD, Horvath R, Baruffini E, et al (2010) Polymerase γ gene POLG determines the risk of sodium valproate-induced liver toxicity. Hepatology. 52:1791–1796. This article showed for the first time that a particular genetic variation in the POLG gene was strongly associated with valproate-induced liver toxicity. This gene is encoding the DNA polymerase γ, which is the only DNA polymerase involved in mtDNA replication. However, it is still unclear how mutations in the POLG gene could favor VPA-induced liver injury, contrary to antiretroviral nucleoside analogue-induced toxicity [81].
-
(2010)
Hepatology
, vol.52
, pp. 1791-1796
-
-
Stewart, J.D.1
Horvath, R.2
Baruffini, E.3
-
83
-
-
0035045720
-
Homozygosity for alanine in the mitochondrial targeting sequence of superoxide dismutase and risk for severe alcoholic liver disease
-
PID: 11313317, COI: 1:CAS:528:DC%2BD3MXjs1SrtL4%3D
-
Degoul F, Sutton A, Mansouri A et al (2001) Homozygosity for alanine in the mitochondrial targeting sequence of superoxide dismutase and risk for severe alcoholic liver disease. Gastroenterology 120:1468–1474
-
(2001)
Gastroenterology
, vol.120
, pp. 1468-1474
-
-
Degoul, F.1
Sutton, A.2
Mansouri, A.3
-
84
-
-
54049115421
-
+/− mouse: modeling the mitochondrial role in drug toxicity
-
PID: 18762273, COI: 1:CAS:528:DC%2BD1cXht12rs7zI
-
+/− mouse: modeling the mitochondrial role in drug toxicity. Drug Discov Today 13:982–988
-
(2008)
Drug Discov Today
, vol.13
, pp. 982-988
-
-
Boelsterli, U.A.1
Hsiao, C.J.2
-
85
-
-
45549103125
-
Partial leptin deficiency favors diet-induced obesity and related metabolic disorders in mice
-
PID: 18349116, COI: 1:CAS:528:DC%2BD1cXlvFCju7c%3D
-
Begriche K, Lettéron P, Abbey-Toby A et al (2008) Partial leptin deficiency favors diet-induced obesity and related metabolic disorders in mice. Am J Physiol Endocrinol Metab 294:E939–E951
-
(2008)
Am J Physiol Endocrinol Metab
, vol.294
, pp. E939-E951
-
-
Begriche, K.1
Lettéron, P.2
Abbey-Toby, A.3
-
86
-
-
0036247430
-
Drugs and steatohepatitis
-
PID: 12016549, COI: 1:CAS:528:DC%2BD38XktlSjtrg%3D
-
Farrell GC (2002) Drugs and steatohepatitis. Semin Liver Dis 22:185–194
-
(2002)
Semin Liver Dis
, vol.22
, pp. 185-194
-
-
Farrell, G.C.1
-
87
-
-
0034884143
-
Liver biopsy in psoriatic arthritis to detect methotrexate hepatotoxicity
-
PID: 17039139, COI: 1:STN:280:DC%2BD28ngs1Cjtg%3D%3D
-
Grismer LE, Gill SA, Harris MD (2001) Liver biopsy in psoriatic arthritis to detect methotrexate hepatotoxicity. J Clin Rheumatol 7:224–227
-
(2001)
J Clin Rheumatol
, vol.7
, pp. 224-227
-
-
Grismer, L.E.1
Gill, S.A.2
Harris, M.D.3
-
88
-
-
33947267189
-
Chemotherapy-associated hepatotoxicity and surgery for colorectal liver metastases
-
PID: 17315288, COI: 1:CAS:528:DC%2BD2sXkt12nt7s%3D
-
Zorzi D, Laurent A, Pawlik TM et al (2007) Chemotherapy-associated hepatotoxicity and surgery for colorectal liver metastases. Br J Surg 94:274–286
-
(2007)
Br J Surg
, vol.94
, pp. 274-286
-
-
Zorzi, D.1
Laurent, A.2
Pawlik, T.M.3
-
89
-
-
0031921972
-
Steatohepatitis-inducing drugs cause mitochondrial dysfunction and lipid peroxidation in rat hepatocytes
-
PID: 9516397, COI: 1:CAS:528:DyaK1cXisVWms7g%3D
-
Berson A, De Beco V, Lettéron P et al (1998) Steatohepatitis-inducing drugs cause mitochondrial dysfunction and lipid peroxidation in rat hepatocytes. Gastroenterology 114:764–774
-
(1998)
Gastroenterology
, vol.114
, pp. 764-774
-
-
Berson, A.1
De Beco, V.2
Lettéron, P.3
-
90
-
-
79551595838
-
Overexpression of Bcl-2 in hepatocytes protects against injury but does not attenuate fibrosis in a mouse model of chronic cholestatic liver disease
-
PID: 20856227, COI: 1:CAS:528:DC%2BC3MXhtlarur4%3D
-
Mitchell C, Mahrouf-Yorgov M, Mayeuf A et al (2011) Overexpression of Bcl-2 in hepatocytes protects against injury but does not attenuate fibrosis in a mouse model of chronic cholestatic liver disease. Lab Invest 91:273–282
-
(2011)
Lab Invest
, vol.91
, pp. 273-282
-
-
Mitchell, C.1
Mahrouf-Yorgov, M.2
Mayeuf, A.3
-
91
-
-
0022007068
-
Elevated hepatic mitochondrial and peroxisomal oxidative capacities in fed and starved adult obese (ob/ob) mice
-
PID: 4062906, COI: 1:CAS:528:DyaL2MXlsFymtb4%3D
-
Brady LJ, Brady PS, Romsos DR et al (1985) Elevated hepatic mitochondrial and peroxisomal oxidative capacities in fed and starved adult obese (ob/ob) mice. Biochem J 231:439–444
-
(1985)
Biochem J
, vol.231
, pp. 439-444
-
-
Brady, L.J.1
Brady, P.S.2
Romsos, D.R.3
-
92
-
-
34249663150
-
Selective estrogen receptor modulator raloxifene-associated aggravation of nonalcoholic steatohepatitis
-
PID: 17473493
-
Takamura T, Shimizu A, Komura T et al (2007) Selective estrogen receptor modulator raloxifene-associated aggravation of nonalcoholic steatohepatitis. Intern Med 46:579–581
-
(2007)
Intern Med
, vol.46
, pp. 579-581
-
-
Takamura, T.1
Shimizu, A.2
Komura, T.3
-
93
-
-
41949102373
-
High concentrations of stavudine impair fatty acid oxidation without depleting mitochondrial DNA in cultured rat hepatocytes
-
PID: 18299183, COI: 1:CAS:528:DC%2BD1cXkvFWgtr0%3D
-
Igoudjil A, Massart J, Begriche K et al (2008) High concentrations of stavudine impair fatty acid oxidation without depleting mitochondrial DNA in cultured rat hepatocytes. Toxicol In Vitro 22:887–898
-
(2008)
Toxicol In Vitro
, vol.22
, pp. 887-898
-
-
Igoudjil, A.1
Massart, J.2
Begriche, K.3
-
94
-
-
84872168020
-
Raloxifene affects fatty acid oxidation in livers from ovariectomized rats by acting as a pro-oxidant agent
-
PID: 23201442, COI: 1:CAS:528:DC%2BC3sXnvFCgtg%3D%3D
-
Martins-Maciel ER, Campos LB, Salgueiro-Pagadigorria CL et al (2013) Raloxifene affects fatty acid oxidation in livers from ovariectomized rats by acting as a pro-oxidant agent. Toxicol Lett 217:82–89
-
(2013)
Toxicol Lett
, vol.217
, pp. 82-89
-
-
Martins-Maciel, E.R.1
Campos, L.B.2
Salgueiro-Pagadigorria, C.L.3
-
95
-
-
33847078905
-
Tamoxifen induces oxidative stress and mitochondrial apoptosis via stimulating mitochondrial nitric oxide synthase
-
PID: 17283165, COI: 1:CAS:528:DC%2BD2sXht1yntr0%3D
-
Nazarewicz RR, Zenebe WJ, Parihar A et al (2007) Tamoxifen induces oxidative stress and mitochondrial apoptosis via stimulating mitochondrial nitric oxide synthase. Cancer Res 67:1282–1290
-
(2007)
Cancer Res
, vol.67
, pp. 1282-1290
-
-
Nazarewicz, R.R.1
Zenebe, W.J.2
Parihar, A.3
-
96
-
-
84878001036
-
An in vitro study of the ameliorative role of α-tocopherol on methotrexate-induced oxidative stress in rat heart mitochondria
-
PID: 23072846
-
Singh K, Malviya A, Bhori M et al (2012) An in vitro study of the ameliorative role of α-tocopherol on methotrexate-induced oxidative stress in rat heart mitochondria. J Basic Clin Physiol Pharmacol 23:163–168
-
(2012)
J Basic Clin Physiol Pharmacol
, vol.23
, pp. 163-168
-
-
Singh, K.1
Malviya, A.2
Bhori, M.3
-
97
-
-
77957961658
-
Tamoxifen induces triacylglycerol accumulation in the mouse liver by activation of fatty acid synthesis
-
PID: 20658461, COI: 1:CAS:528:DC%2BC3cXhtlejsrjM
-
Cole LK, Jacobs RL, Vance DE (2010) Tamoxifen induces triacylglycerol accumulation in the mouse liver by activation of fatty acid synthesis. Hepatology 52:1258–1265
-
(2010)
Hepatology
, vol.52
, pp. 1258-1265
-
-
Cole, L.K.1
Jacobs, R.L.2
Vance, D.E.3
-
98
-
-
82355183884
-
High-throughput analysis of mitochondrial oxygen consumption
-
® . This methodology can allow the high-throughput assessment of drug-induced alteration of mitochondrial function such as MRC activity and mtFAO ([12] and Table 2)
-
® . This methodology can allow the high-throughput assessment of drug-induced alteration of mitochondrial function such as MRC activity and mtFAO ([12] and Table 2).
-
(2012)
Methods Mol Biol
, vol.810
, pp. 59-72
-
-
Hynes, J.1
Swiss, R.L.2
Will, Y.3
-
99
-
-
84876484196
-
Chemotherapy-associated liver injury in patients with colorectal liver metastases: a systematic review and meta-analysis
-
PID: 22766981
-
Robinson SM, Wilson CH, Burt AD et al (2012) Chemotherapy-associated liver injury in patients with colorectal liver metastases: a systematic review and meta-analysis. Ann Surg Oncol 19:4287–4299
-
(2012)
Ann Surg Oncol
, vol.19
, pp. 4287-4299
-
-
Robinson, S.M.1
Wilson, C.H.2
Burt, A.D.3
-
100
-
-
84875202553
-
A unifying ontology to integrate histological and clinical observations for drug-induced liver injury
-
PID: 23395088, COI: 1:CAS:528:DC%2BC3sXksFaksL8%3D
-
Wang Y, Lin Z, Liu Z et al (2013) A unifying ontology to integrate histological and clinical observations for drug-induced liver injury. Am J Pathol 182:1180–1187
-
(2013)
Am J Pathol
, vol.182
, pp. 1180-1187
-
-
Wang, Y.1
Lin, Z.2
Liu, Z.3
|