Valproic acid utilizes the isoleucine breakdown pathway for its complete β-oxidation

Biochemical Pharmacology

Volumn 82, Issue 11, 2011, Pages 1740-1746

  Luís, Paula B M ^a,b   Ruiter, Jos P ^b   Ofman, Rob ^b   Ijlst, Lodewijk ^b   Moedas, Marco ^a   Diogo, Luísa ^c   Garcia, Paula ^c   De Almeida, Isabel Tavares ^a   Duran, Marinus ^b   Wanders, Ronald J ^b   Silva, Margarida F B ^a  

^a UNIVERSITY OF LISBON   (Portugal)

^b ACADEMIC MEDICAL CENTER   (Netherlands)

^c CENTRO HOSPITALAR E UNIVERSITÁRIO DE COIMBRA   (Portugal)

Author keywords

2 Methyl 3 hydroxybutyryl CoA dehydrogenase; Crotonase; Drug metabolism; Isoleucine; Mitochondrial dysfunction; Valproic acid

Indexed keywords

2 METHYL 3 HYDROXYBUTYRYL COA DEHYDROGENASE; 3 HYDROXYACYL COENZYME A DEHYDROGENASE; 3 HYDROXYVALPROYL COA; CARBOXYLIC ACID; CROTONYL COENZYME A; ENOYL COENZYME A HYDRATASE; HYDROLYASE; ISOLEUCINE; UNCLASSIFIED DRUG; VALPROIC ACID;

2 METHYL 3 HYDROXYBUTYRYL COA DEHYDROGENASE DEFICIENCY; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; ENZYME ACTIVITY; ENZYME DEFICIENCY; ENZYMOLOGY; FATTY ACID OXIDATION; FIBROBLAST; GAS CHROMATOGRAPHY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOPRECIPITATION; KIDNEY HOMOGENATE; MASS SPECTROMETRY; PRIORITY JOURNAL; URINE;

ACYL COENZYME A; ALCOHOL OXIDOREDUCTASES; CELL LINE; ENOYL-COA HYDRATASE; FIBROBLASTS; HUMANS; HYDROXYBUTYRATES; ISOLEUCINE; OXIDATION-REDUCTION; SUBSTRATE SPECIFICITY; VALPROIC ACID;

EID: 80255136274     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2011.07.103     Document Type: Article

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