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Volumn 53, Issue 6, 2011, Pages 1895-1905

Induction of vesicular steatosis by amiodarone and tetracycline is associated with up-regulation of lipogenic genes in heparg cells

Author keywords

[No Author keywords available]

Indexed keywords

ACYL COENZYME A DESATURASE 1; AMIODARONE; CHOLESTEROL; CHOLESTEROL ESTER; DYE; FAT DROPLET; FATTY ACID SYNTHASE; MESSENGER RNA; OLEIC ACID; PHOSPHATIDYLCHOLINE; PHOSPHATIDYLETHANOLAMINE; PROTEIN; TETRACYCLINE; THYROID HORMONE INDUCIBLE HEPATIC PROTEIN; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

EID: 79957474305     PISSN: 02709139     EISSN: 15273350     Source Type: Journal    
DOI: 10.1002/hep.24290     Document Type: Article
Times cited : (139)

References (46)
  • 1
    • 33644547706 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease: from steatosis to cirrhosis
    • Farrell GC, Larter CZ. Nonalcoholic fatty liver disease: from steatosis to cirrhosis. Hepatology 2006; 43( Suppl.): S99-S112.
    • (2006) Hepatology , vol.43 , Issue.SUPPL.
    • Farrell, G.C.1    Larter, C.Z.2
  • 2
    • 33645828659 scopus 로고    scopus 로고
    • Lipid metabolism and liver inflammation. II. Fatty liver disease and fatty acid oxidation
    • Reddy JK, Rao MS. Lipid metabolism and liver inflammation. II. Fatty liver disease and fatty acid oxidation. Am J Physiol Gastrointest Liver Physiol 2006; 290: G852-G858.
    • (2006) Am J Physiol Gastrointest Liver Physiol , vol.290
    • Reddy, J.K.1    Rao, M.S.2
  • 3
    • 7444229195 scopus 로고    scopus 로고
    • Applications of cytotoxicity assays and pre-lethal mechanistic assays for assessment of human hepatotoxicity potential
    • Xu JJ, Diaz D, O'Brien PJ. Applications of cytotoxicity assays and pre-lethal mechanistic assays for assessment of human hepatotoxicity potential. Chem Biol Interact 2004; 150: 115-128.
    • (2004) Chem Biol Interact , vol.150 , pp. 115-128
    • Xu, J.J.1    Diaz, D.2    O'Brien, P.J.3
  • 5
    • 0031057309 scopus 로고    scopus 로고
    • Cationic amphiphilic drug-induced phospholipidosis
    • Halliwell WH. Cationic amphiphilic drug-induced phospholipidosis. Toxicol Pathol 1997; 25: 53-60.
    • (1997) Toxicol Pathol , vol.25 , pp. 53-60
    • Halliwell, W.H.1
  • 7
    • 77949916811 scopus 로고    scopus 로고
    • Enhanced steatosis by nuclear receptor ligands: a study in cultured human hepatocytes and hepatoma cells with a characterized nuclear receptor expression profile
    • Moya M, Gomez-Lechon MJ, Castell JV, Jover R. Enhanced steatosis by nuclear receptor ligands: a study in cultured human hepatocytes and hepatoma cells with a characterized nuclear receptor expression profile. Chem Biol Interact 2010; 184: 376-387.
    • (2010) Chem Biol Interact , vol.184 , pp. 376-387
    • Moya, M.1    Gomez-Lechon, M.J.2    Castell, J.V.3    Jover, R.4
  • 8
    • 55049126741 scopus 로고    scopus 로고
    • Evolving concepts in liver tissue modeling and implications for in vitro toxicology
    • Guillouzo A, Guguen-Guillouzo C. Evolving concepts in liver tissue modeling and implications for in vitro toxicology. Expert Opin Drug Metab Toxicol 2008; 4: 1279-1294.
    • (2008) Expert Opin Drug Metab Toxicol , vol.4 , pp. 1279-1294
    • Guillouzo, A.1    Guguen-Guillouzo, C.2
  • 9
    • 29944444269 scopus 로고    scopus 로고
    • Expression of cytochromes P450, conjugating enzymes and nuclear receptors in human hepatoma HepaRG cells
    • Aninat C, Piton A, Glaise D, Le Charpentier T, Langouet S, Morel F, et al. Expression of cytochromes P450, conjugating enzymes and nuclear receptors in human hepatoma HepaRG cells. Drug Metab Dispos 2006; 34: 75-83.
    • (2006) Drug Metab Dispos , vol.34 , pp. 75-83
    • Aninat, C.1    Piton, A.2    Glaise, D.3    Le Charpentier, T.4    Langouet, S.5    Morel, F.6
  • 10
    • 76749107104 scopus 로고    scopus 로고
    • Stable expression, activity, and inducibility of cytochromes P450 in differentiated HepaRG cells
    • Antherieu S, Chesne C, Li R, Camus S, Lahoz A, Picazo L, et al. Stable expression, activity, and inducibility of cytochromes P450 in differentiated HepaRG cells. Drug Metab Dispos 2010; 38: 516-525.
    • (2010) Drug Metab Dispos , vol.38 , pp. 516-525
    • Antherieu, S.1    Chesne, C.2    Li, R.3    Camus, S.4    Lahoz, A.5    Picazo, L.6
  • 11
    • 0023706706 scopus 로고
    • Inhibition of the mitochondrial oxidation of fatty acids by tetracycline in mice and in man: possible role in microvesicular steatosis induced by this antibiotic
    • Freneaux E, Labbe G, Letteron P, The Le D, Degott C, Geneve J, et al. Inhibition of the mitochondrial oxidation of fatty acids by tetracycline in mice and in man: possible role in microvesicular steatosis induced by this antibiotic. Hepatology 1988; 8: 1056-1062.
    • (1988) Hepatology , vol.8 , pp. 1056-1062
    • Freneaux, E.1    Labbe, G.2    Letteron, P.3    The Le, D.4    Degott, C.5    Geneve, J.6
  • 13
    • 0029127584 scopus 로고
    • Inhibition of mitochondrial beta-oxidation as a mechanism of hepatotoxicity
    • Fromenty B, Pessayre D. Inhibition of mitochondrial beta-oxidation as a mechanism of hepatotoxicity. Pharmacol Ther 1995; 67: 101-154.
    • (1995) Pharmacol Ther , vol.67 , pp. 101-154
    • Fromenty, B.1    Pessayre, D.2
  • 15
    • 34247351508 scopus 로고    scopus 로고
    • Transdifferentiation of hepatocyte-like cells from the human hepatoma HepaRG cell line through bipotent progenitor
    • Cerec V, Glaise D, Garnier D, Morosan S, Turlin B, Drenou B, et al. Transdifferentiation of hepatocyte-like cells from the human hepatoma HepaRG cell line through bipotent progenitor. Hepatology 2007; 45: 957-967.
    • (2007) Hepatology , vol.45 , pp. 957-967
    • Cerec, V.1    Glaise, D.2    Garnier, D.3    Morosan, S.4    Turlin, B.5    Drenou, B.6
  • 16
    • 0028310839 scopus 로고
    • Hepatic lipase induces the formation of pre-beta 1 high density lipoprotein (HDL) from triacylglycerol-rich HDL2. A study comparing liver perfusion to in vitro incubation with lipases
    • Barrans A, Collet X, Barbaras R, Jaspard B, Manent J, Vieu C, et al. Hepatic lipase induces the formation of pre-beta 1 high density lipoprotein (HDL) from triacylglycerol-rich HDL2. A study comparing liver perfusion to in vitro incubation with lipases. J Biol Chem 1994; 269: 11572-11577.
    • (1994) J Biol Chem , vol.269 , pp. 11572-11577
    • Barrans, A.1    Collet, X.2    Barbaras, R.3    Jaspard, B.4    Manent, J.5    Vieu, C.6
  • 17
    • 0030048923 scopus 로고    scopus 로고
    • Cell-generated nitric oxide inactivates rat hepatocyte mitochondria in vitro but reacts with hemoglobin in vivo
    • Fisch C, Robin MA, Letteron P, Fromenty B, Berson A, Renault S, et al. Cell-generated nitric oxide inactivates rat hepatocyte mitochondria in vitro but reacts with hemoglobin in vivo. Gastroenterology 1996; 110: 210-220.
    • (1996) Gastroenterology , vol.110 , pp. 210-220
    • Fisch, C.1    Robin, M.A.2    Letteron, P.3    Fromenty, B.4    Berson, A.5    Renault, S.6
  • 18
    • 58949088436 scopus 로고    scopus 로고
    • Dose- and time-dependent effects of phenobarbital on gene expression profiling in human hepatoma HepaRG cells
    • Lambert CB, Spire C, Claude N, Guillouzo A. Dose- and time-dependent effects of phenobarbital on gene expression profiling in human hepatoma HepaRG cells. Toxicol Appl Pharmacol 2009; 234: 345-360.
    • (2009) Toxicol Appl Pharmacol , vol.234 , pp. 345-360
    • Lambert, C.B.1    Spire, C.2    Claude, N.3    Guillouzo, A.4
  • 20
    • 65949090538 scopus 로고    scopus 로고
    • Differential effect of oleic and palmitic acid on lipid accumulation and apoptosis in cultured hepatocytes
    • Ricchi M, Odoardi MR, Carulli L, Anzivino C, Ballestri S, Pinetti A, et al. Differential effect of oleic and palmitic acid on lipid accumulation and apoptosis in cultured hepatocytes. J Gastroenterol Hepatol 2009; 24: 830-840.
    • (2009) J Gastroenterol Hepatol , vol.24 , pp. 830-840
    • Ricchi, M.1    Odoardi, M.R.2    Carulli, L.3    Anzivino, C.4    Ballestri, S.5    Pinetti, A.6
  • 21
    • 0025677186 scopus 로고
    • Amiodarone inhibits the mitochondrial beta-oxidation of fatty acids and produces microvesicular steatosis of the liver in mice
    • Fromenty B, Fisch C, Labbe G, Degott C, Deschamps D, Berson A, et al. Amiodarone inhibits the mitochondrial beta-oxidation of fatty acids and produces microvesicular steatosis of the liver in mice. J Pharmacol Exp Ther 1990; 255: 1371-1376.
    • (1990) J Pharmacol Exp Ther , vol.255 , pp. 1371-1376
    • Fromenty, B.1    Fisch, C.2    Labbe, G.3    Degott, C.4    Deschamps, D.5    Berson, A.6
  • 24
    • 50649125425 scopus 로고
    • Tetracycline toxicity in pregnancy. Liver and pancreatic dysfunction
    • Whalley PJ, Adams RH, Combes B. Tetracycline toxicity in pregnancy. Liver and pancreatic dysfunction. JAMA 1964; 189: 357-362.
    • (1964) JAMA , vol.189 , pp. 357-362
    • Whalley, P.J.1    Adams, R.H.2    Combes, B.3
  • 26
    • 68949116060 scopus 로고    scopus 로고
    • A novel pregnane X receptor and S14-mediated lipogenic pathway in human hepatocyte
    • Moreau A, Teruel C, Beylot M, Albalea V, Tamasi V, Umbdenstock T, et al. A novel pregnane X receptor and S14-mediated lipogenic pathway in human hepatocyte. Hepatology 2009; 49: 2068-2079.
    • (2009) Hepatology , vol.49 , pp. 2068-2079
    • Moreau, A.1    Teruel, C.2    Beylot, M.3    Albalea, V.4    Tamasi, V.5    Umbdenstock, T.6
  • 27
    • 65649112138 scopus 로고    scopus 로고
    • In vitro assay for drug-induced hepatosteatosis using rat primary hepatocytes, a fluorescent lipid analog and gene expression analysis
    • Fujimura H, Murakami N, Kurabe M, Toriumi W. In vitro assay for drug-induced hepatosteatosis using rat primary hepatocytes, a fluorescent lipid analog and gene expression analysis. J Appl Toxicol 2009; 29: 356-363.
    • (2009) J Appl Toxicol , vol.29 , pp. 356-363
    • Fujimura, H.1    Murakami, N.2    Kurabe, M.3    Toriumi, W.4
  • 28
    • 33845978765 scopus 로고    scopus 로고
    • Genomic cluster and network analysis for predictive screening for hepatotoxicity
    • Fukushima T, Kikkawa R, Hamada Y, Horii I. Genomic cluster and network analysis for predictive screening for hepatotoxicity. J Toxicol Sci 2006; 31: 419-432.
    • (2006) J Toxicol Sci , vol.31 , pp. 419-432
    • Fukushima, T.1    Kikkawa, R.2    Hamada, Y.3    Horii, I.4
  • 29
    • 34547914464 scopus 로고    scopus 로고
    • Acute hepatotoxicity: a predictive model based on focused illumina microarrays
    • Zidek N, Hellmann J, Kramer PJ, Hewitt PG. Acute hepatotoxicity: a predictive model based on focused illumina microarrays. Toxicol Sci 2007; 99: 289-302.
    • (2007) Toxicol Sci , vol.99 , pp. 289-302
    • Zidek, N.1    Hellmann, J.2    Kramer, P.J.3    Hewitt, P.G.4
  • 31
    • 30544452121 scopus 로고    scopus 로고
    • Up-regulation of ADRP in fatty liver in human and liver steatosis in mice fed with high fat diet
    • Motomura W, Inoue M, Ohtake T, Takahashi N, Nagamine M, Tanno S, et al. Up-regulation of ADRP in fatty liver in human and liver steatosis in mice fed with high fat diet. Biochem Biophys Res Commun 2006; 340: 1111-1118.
    • (2006) Biochem Biophys Res Commun , vol.340 , pp. 1111-1118
    • Motomura, W.1    Inoue, M.2    Ohtake, T.3    Takahashi, N.4    Nagamine, M.5    Tanno, S.6
  • 32
    • 0030724392 scopus 로고    scopus 로고
    • Adipose differentiation-related protein is an ubiquitously expressed lipid storage droplet-associated protein
    • Brasaemle DL, Barber T, Wolins NE, Serrero G, Blanchette-Mackie EJ, Londos C. Adipose differentiation-related protein is an ubiquitously expressed lipid storage droplet-associated protein. J Lipid Res 1997; 38: 2249-2263.
    • (1997) J Lipid Res , vol.38 , pp. 2249-2263
    • Brasaemle, D.L.1    Barber, T.2    Wolins, N.E.3    Serrero, G.4    Blanchette-Mackie, E.J.5    Londos, C.6
  • 33
    • 77950462731 scopus 로고    scopus 로고
    • Increased lipolysis in adipose tissues is associated with elevation of systemic free fatty acids and insulin resistance in perilipin null mice
    • Zhai W, Xu C, Ling Y, Liu S, Deng J, Qi Y, et al. Increased lipolysis in adipose tissues is associated with elevation of systemic free fatty acids and insulin resistance in perilipin null mice. Horm Metab Res; 42: 247-253.
    • Horm Metab Res , vol.42 , pp. 247-253
    • Zhai, W.1    Xu, C.2    Ling, Y.3    Liu, S.4    Deng, J.5    Qi, Y.6
  • 34
    • 0035912744 scopus 로고    scopus 로고
    • Tissue-specific overexpression of lipoprotein lipase causes tissue-specific insulin resistance
    • Kim JK, Fillmore JJ, Chen Y, Yu C, Moore IK, Pypaert M, et al. Tissue-specific overexpression of lipoprotein lipase causes tissue-specific insulin resistance. Proc Natl Acad Sci U S A 2001; 98: 7522-7527.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 7522-7527
    • Kim, J.K.1    Fillmore, J.J.2    Chen, Y.3    Yu, C.4    Moore, I.K.5    Pypaert, M.6
  • 35
    • 35748972366 scopus 로고    scopus 로고
    • Genes involved in fatty acid partitioning and binding, lipolysis, monocyte/macrophage recruitment, and inflammation are overexpressed in the human fatty liver of insulin-resistant subjects
    • Westerbacka J, Kolak M, Kiviluoto T, Arkkila P, Siren J, Hamsten A, et al. Genes involved in fatty acid partitioning and binding, lipolysis, monocyte/macrophage recruitment, and inflammation are overexpressed in the human fatty liver of insulin-resistant subjects. Diabetes 2007; 56: 2759-2765.
    • (2007) Diabetes , vol.56 , pp. 2759-2765
    • Westerbacka, J.1    Kolak, M.2    Kiviluoto, T.3    Arkkila, P.4    Siren, J.5    Hamsten, A.6
  • 36
    • 13644258653 scopus 로고    scopus 로고
    • A toxicogenomic approach to drug-induced phospholipidosis: analysis of its induction mechanism and establishment of a novel in vitro screening system
    • Sawada H, Takami K, Asahi S. A toxicogenomic approach to drug-induced phospholipidosis: analysis of its induction mechanism and establishment of a novel in vitro screening system. Toxicol Sci 2005; 83: 282-292.
    • (2005) Toxicol Sci , vol.83 , pp. 282-292
    • Sawada, H.1    Takami, K.2    Asahi, S.3
  • 38
    • 0025945759 scopus 로고
    • Non-alcoholic steatohepatitis: impaired antipyrine metabolism and hypertriglyceridaemia may be clues to its pathogenesis
    • Fiatarone JR, Coverdale SA, Batey RG, Farrell GC. Non-alcoholic steatohepatitis: impaired antipyrine metabolism and hypertriglyceridaemia may be clues to its pathogenesis. J Gastroenterol Hepatol 1991; 6: 585-590.
    • (1991) J Gastroenterol Hepatol , vol.6 , pp. 585-590
    • Fiatarone, J.R.1    Coverdale, S.A.2    Batey, R.G.3    Farrell, G.C.4
  • 39
    • 30744476746 scopus 로고    scopus 로고
    • Relationship between in vivo chlorzoxazone hydroxylation, hepatic cytochrome P450 2E1 content and liver injury in obese non-alcoholic fatty liver disease patients
    • Orellana M, Rodrigo R, Varela N, Araya J, Poniachik J, Csendes A, et al. Relationship between in vivo chlorzoxazone hydroxylation, hepatic cytochrome P450 2E1 content and liver injury in obese non-alcoholic fatty liver disease patients. Hepatol Res 2006; 34: 57-63.
    • (2006) Hepatol Res , vol.34 , pp. 57-63
    • Orellana, M.1    Rodrigo, R.2    Varela, N.3    Araya, J.4    Poniachik, J.5    Csendes, A.6
  • 40
    • 0032030819 scopus 로고    scopus 로고
    • Reduction in hepatic cytochrome P-450 is correlated to the degree of liver fat content in animal models of steatosis in the absence of inflammation
    • Leclercq I, Horsmans Y, Desager JP, Delzenne N, Geubel AP. Reduction in hepatic cytochrome P-450 is correlated to the degree of liver fat content in animal models of steatosis in the absence of inflammation. J Hepatol 1998; 28: 410-416.
    • (1998) J Hepatol , vol.28 , pp. 410-416
    • Leclercq, I.1    Horsmans, Y.2    Desager, J.P.3    Delzenne, N.4    Geubel, A.P.5
  • 41
    • 0027379673 scopus 로고
    • Evidence for CYP3A-mediated N-deethylation of amiodarone in human liver microsomal fractions
    • Fabre G, Julian B, Saint-Aubert B, Joyeux H, Berger Y. Evidence for CYP3A-mediated N-deethylation of amiodarone in human liver microsomal fractions. Drug Metab Dispos 1993; 21: 978-985.
    • (1993) Drug Metab Dispos , vol.21 , pp. 978-985
    • Fabre, G.1    Julian, B.2    Saint-Aubert, B.3    Joyeux, H.4    Berger, Y.5
  • 42
    • 0034015751 scopus 로고    scopus 로고
    • Inhibitory effects of amiodarone and its N-deethylated metabolite on human cytochrome P450 activities: prediction of in vivo drug interactions
    • Ohyama K, Nakajima M, Suzuki M, Shimada N, Yamazaki H, Yokoi T. Inhibitory effects of amiodarone and its N-deethylated metabolite on human cytochrome P450 activities: prediction of in vivo drug interactions. Br J Clin Pharmacol 2000; 49: 244-253.
    • (2000) Br J Clin Pharmacol , vol.49 , pp. 244-253
    • Ohyama, K.1    Nakajima, M.2    Suzuki, M.3    Shimada, N.4    Yamazaki, H.5    Yokoi, T.6
  • 43
    • 0021253216 scopus 로고
    • Amiodarone-associated phospholipidosis and fibrosis of the liver. Light, immunohistochemical, and electron microscopic studies
    • Poucell S, Ireton J, Valencia-Mayoral P, Downar E, Larratt L, Patterson J, et al. Amiodarone-associated phospholipidosis and fibrosis of the liver. Light, immunohistochemical, and electron microscopic studies. Gastroenterology 1984; 86: 926-936.
    • (1984) Gastroenterology , vol.86 , pp. 926-936
    • Poucell, S.1    Ireton, J.2    Valencia-Mayoral, P.3    Downar, E.4    Larratt, L.5    Patterson, J.6
  • 44
    • 0016572270 scopus 로고
    • Drug-induced phospholipidosis II. Tissue distribution of the amphiphilic drug chlorphentermine
    • Lullmann H, Lullmann-Rauch R, Wassermann O. Drug-induced phospholipidosis II. Tissue distribution of the amphiphilic drug chlorphentermine. CRC Crit Rev Toxicol 1975; 4: 185-218.
    • (1975) CRC Crit Rev Toxicol , vol.4 , pp. 185-218
    • Lullmann, H.1    Lullmann-Rauch, R.2    Wassermann, O.3
  • 45
    • 33751216445 scopus 로고    scopus 로고
    • Roles of phosphatidate phosphatase enzymes in lipid metabolism
    • Carman GM, Han GS. Roles of phosphatidate phosphatase enzymes in lipid metabolism. Trends Biochem Sci 2006; 31: 694-699.
    • (2006) Trends Biochem Sci , vol.31 , pp. 694-699
    • Carman, G.M.1    Han, G.S.2
  • 46
    • 33847259816 scopus 로고    scopus 로고
    • Determination of phospholipidosis potential based on gene expression analysis in HepG2 cells
    • Atienzar F, Gerets H, Dufrane S, Tilmant K, Cornet M, Dhalluin S, et al. Determination of phospholipidosis potential based on gene expression analysis in HepG2 cells. Toxicol Sci 2007; 96: 101-114.
    • (2007) Toxicol Sci , vol.96 , pp. 101-114
    • Atienzar, F.1    Gerets, H.2    Dufrane, S.3    Tilmant, K.4    Cornet, M.5    Dhalluin, S.6


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