Serum metabolomics reveals irreversible inhibition of fatty acid β-oxidation through the suppression of PPARα activation as a contributing mechanism of acetaminophen-induced hepatotoxicity

Chemical Research in Toxicology

Volumn 22, Issue 4, 2009, Pages 699-707

  Chen, Chi ^a,c   Krausz, Kristopher W ^a   Shah, Yatrik M ^a   Idle, Jeffrey R ^b   Gonzalez, Frank J ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b CHARLES UNIVERSITY   (Czech Republic)

^c UNIVERSITY OF MINNESOTA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACYLCARNITINE; AMINOTRANSFERASE; CYTOCHROME P450 2E1; FATTY ACID; GLUTATHIONE; PARACETAMOL; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; TRIACYLGLYCEROL;

AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DISEASE MARKER; ENZYME ACTIVITY; FATTY ACID OXIDATION; FEMALE; LIQUID CHROMATOGRAPHY; LIVER TOXICITY; MALE; MASS SPECTROMETRY; METABOLOME; METABOLOMICS; MOUSE; NONHUMAN; PROTEIN FUNCTION; UPREGULATION; WILD TYPE;

ACETAMINOPHEN; ANIMALS; CARNITINE; CHROMATOGRAPHY, LIQUID; CYTOCHROME P-450 CYP2E1; FATTY ACIDS; GLUTATHIONE; LIVER DISEASES; MASS SPECTROMETRY; METABOLOMICS; MICE; MICE, KNOCKOUT; PPAR ALPHA; TIME FACTORS;

MUS;

EID: 66049157560     PISSN: 0893228X     EISSN: 15205010     Source Type: Journal    
DOI: 10.1021/tx800464q     Document Type: Article

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