Differential effect of valproate and its Δ2- and Δ4-unsaturated metabolites, on the β-oxidation rate of long-chain and medium-chain fatty acids

Chemico-Biological Interactions

Volumn 137, Issue 3, 2001, Pages 203-212

  Silva, Margarida F B ^a,b   Ruiter, Jos P N ^a   IJlst, Lodewijk ^a   Jakobs, Cornelis ^c   Duran, Marinus ^a   De Almeida, Isabel Tavares ^b   Wanders, Ronald J A ^a  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

^b RESEARCH INSTITUTE FOR MEDICINES IMED ULISBOA   (Portugal)

^c VU UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

2 Valproate; 4 Valproate; Fatty acid oxidation; Inhibition; Mitochondrial oxidation; Valproate

Indexed keywords

2 PROPYL 2 PENTENOIC ACID; 2 PROPYL 4 PENTENOIC ACID; ACYL COENZYME A; HYDROCINNAMIC ACID; LONG CHAIN FATTY ACID; MEDIUM CHAIN FATTY ACID; MYRISTIC ACID; OLEIC ACID; PALMITIC ACID; PHENYLPROPIONIC ACID DERIVATIVE; UNSATURATED FATTY ACID; VALPROIC ACID; VALPROIC ACID DERIVATIVE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENZYME INHIBITION; FATTY ACID METABOLISM; FATTY ACID OXIDATION; LIVER CELL; MALE; METABOLIC INHIBITION; MITOCHONDRION; NONHUMAN; RAT;

ANIMALS; ANTICONVULSANTS; CELL SURVIVAL; FATTY ACIDS, MONOUNSATURATED; HEPATOCYTES; MALE; MYRISTIC ACID; OLEIC ACID; OXIDATION-REDUCTION; PALMITIC ACID; PHENYLPROPIONATES; RATS; RATS, WISTAR; TRITIUM; VALPROIC ACID;

EID: 0035964970     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0009-2797(01)00234-4     Document Type: Article

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