Gomisin A inhibits lipopolysaccharide-induced inflammatory responses in N9 microglia via blocking the NF-κB/MAPKs pathway

Food and Chemical Toxicology

Volumn 63, Issue , 2014, Pages 119-127

  Wang, Xiaoxiao ^a   Hu, Di ^a   Zhang, Lijia ^a   Lian, Guoning ^a   Zhao, Siqi ^a,b   Wang, Chunming ^a   Yin, Jun ^a   Wu, Chunfu ^a   Yang, Jingyu ^a  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^b INSTITUTE OF BIOPHYSICS   (China)

Author keywords

Gomisin A; LPS; MAPKs; Microglia; NF B; ROS

Indexed keywords

CYCLOOXYGENASE 2; GOMISIN A; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; NITRIC OXIDE; PROSTAGLANDIN E2; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 2; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; BRAIN CORTEX; CELL ACTIVATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CULTURE MEDIUM; CYTOKINE PRODUCTION; DOWN REGULATION; DRUG CYTOTOXICITY; EMBRYO; ENZYME ACTIVATION; ENZYME INHIBITION; GENE EXPRESSION; HIPPOCAMPUS; MICROGLIA; NERVE CELL NECROSIS; NERVE CELL STIMULATION; NERVOUS SYSTEM INFLAMMATION; NEUROBLASTOMA; NEUROPROTECTION; NONHUMAN; PROSTAGLANDIN SYNTHESIS INHIBITION; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; TUMOR CELL LINE;

RATTUS; SCHISANDRA CHINENSIS;

GOMISIN A; LPS; MAPKS; MICROGLIA; NF-ΚB; ROS;

ANIMALS; BASE SEQUENCE; BLOTTING, WESTERN; CELLS, CULTURED; CYCLOOCTANES; CYTOKINES; DINOPROSTONE; DIOXOLES; DNA PRIMERS; ENZYME ACTIVATION; LIGNANS; LIPOPOLYSACCHARIDES; MAP KINASE SIGNALING SYSTEM; MICROGLIA; NADPH OXIDASE; NF-KAPPA B; NITRIC OXIDE; RATS; RATS, WISTAR; REACTIVE OXYGEN SPECIES; RNA, MESSENGER;

EID: 84888405076     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2013.10.048     Document Type: Article

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