Reversal of P-glycoprotein-mediated multidrug resistance of cancer cells by five schizandrins isolated from the Chinese herb Fructus Schizandrae

Cancer Chemotherapy and Pharmacology

Volumn 62, Issue 6, 2008, Pages 1015-1026

  Huang, Min ^b   Jin, Jing ^c   Sun, Hua ^a   Liu, Geng Tao ^a  

^a INSTITUTE OF MATERIA MEDICA   (China)

^b STANFORD UNIVERSITY   (United States)

^c CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

Fructus Schizandrae; Multidrug resistance; Pgp; Schizandrins

Indexed keywords

DOXORUBICIN; GLYCOPROTEIN P; LIGNAN DERIVATIVE; MESSENGER RNA; PACLITAXEL; PLANT EXTRACT; PROTEIN KINASE C; SCHIZANDRIN; SCHIZANDRIN A; UNCLASSIFIED DRUG; VINCRISTINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CANCER CELL; CANCER CELL CULTURE; CANCER RESISTANCE; CELL ASSAY; CELL LEVEL; CHINESE HERB; CONCENTRATION RESPONSE; CONTROLLED STUDY; CROSS RESISTANCE; DOWN REGULATION; DRUG ACCUMULATION; DRUG EFFECT; DRUG MECHANISM; DRUG POTENCY; DRUG POTENTIATION; DRUG SENSITIVITY; DRUG STRUCTURE; FRUCTUS SCHIZANDRAE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LIVER CELL CARCINOMA; MOUSE; MULTIDRUG RESISTANCE; NONHUMAN; NUDE MOUSE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; TUMOR GROWTH; TUMOR XENOGRAFT;

ANIMALS; APOPTOSIS; CELL LINE, TUMOR; CYCLOOCTANES; DIOXOLES; DOXORUBICIN; DRUG EVALUATION, PRECLINICAL; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; DRUGS, CHINESE HERBAL; FRUIT; GENES, MDR; HUMANS; LIGNANS; MICE; MICE, NUDE; NEOPLASM PROTEINS; P-GLYCOPROTEIN; PHYTOTHERAPY; PLANT PREPARATIONS; POLYCYCLIC COMPOUNDS; PROTEIN KINASE C; SCHISANDRA; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 51849149141     PISSN: 03445704     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00280-008-0691-0     Document Type: Article

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