The lignan-rich fractions of Fructus Schisandrae improve insulin sensitivity via the PPAR-γ pathways in in vitro and in vivo studies

Journal of Ethnopharmacology

Volumn 135, Issue 2, 2011, Pages 455-462

  Kwon, Dae Young ^a   Kim, Da Sol ^b   Yang, Hye Jeong ^a   Park, Sunmin ^b  

^a Korea Food Research Institute   (South Korea)

^b Hoseo University   (South Korea)

Author keywords

Fructus Schisandrae; Insulin sensitivity; Insulin signaling; Lignan; PPAR agonist

Indexed keywords

ANGELOYLGOMISIN H; DEOXYSCHIZANDRIN; GAMMA SCHIZANDRIN; GLUCOSE; GOMISIN; GOMISIN A; INSULIN; LIGNAN DERIVATIVE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; ROSIGLITAZONE; SCHISANDRA CHINENSIS EXTRACT; SCHIZANDRIN; UNCLASSIFIED DRUG;

ADIPOCYTE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG ISOLATION; DRUG RECEPTOR BINDING; FRACTIONATION; FRUIT; GLUCOSE HOMEOSTASIS; GLUCOSE TRANSPORT; HUMAN; HUMAN CELL; HYPERGLYCEMIA; HYPERINSULINEMIA; IN VITRO STUDY; IN VIVO STUDY; INSULIN RELEASE; INSULIN SENSITIVITY; MALE; MEDICINAL PLANT; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; ORAL GLUCOSE TOLERANCE TEST; RAT; SCHISANDRA CHINENSIS;

3T3-L1 CELLS; ANIMALS; BLOOD GLUCOSE; DIABETES MELLITUS, EXPERIMENTAL; GLUCOSE TOLERANCE TEST; INSULIN; INSULIN RESISTANCE; LIGNANS; MICE; PLANT EXTRACTS; PPAR GAMMA; RATS; SCHISANDRA; TRIGLYCERIDES;

ANIMALIA; RATTUS; SCHISANDRA CHINENSIS;

EID: 79955682914     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jep.2011.03.037     Document Type: Article

References (30)

1. American Institute of Nutrition AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet Journal of Nutrition 123 1993 1939 1951
2. M. Bajaj, S. Suraamornkul, P. Piper, L.J. Hardies, L. Glass, E. Cersosimo, T. Pratipanawatr, Y. Miyazaki, and R.A. DeFronzo Decreased plasma adiponectin concentrations are closely related to hepatic fat content and hepatic insulin resistance in pioglitazone-treated type 2 diabetic patients Journal of Clinical Endocrinology Metabolism 89 2004 200 206 (Pubitemid 38183882)
3. J.C. Chan, V. Malik, W. Jia, T. Kadowaki, C.S. Yajnik, K.H. Yoon, and F.B. Hu Diabetes in Asia: epidemiology, risk factors and pathophysiology JAMA 301 2009 2129 2140
4. 4-induced hepatic oxidative stress in rats Phytotherpy Research 23 2009 251 256
5. M.S. Chang, M.S. Oh, D.R. Kim, K.J. Jung, S. Park, S.B. Choi, B.S. Ko, and S.K. Park Effects of okchun-san, a herbal formulation, on blood glucose levels and body weight in a model of type 2 diabetes Journal of Ethnopharmacology 103 2006 491 495 (Pubitemid 43143389)
6. S.B. Choi, J.S. Jang, and S. Park Estrogen and exercise may enhance beta-cell function and mass via insulin receptor substrate 2 induction in ovariectomized diabetic rats Endocrinology 146 2005 4786 4794 (Pubitemid 41446616)
7. R.A. DeFronzo, R.C. Bonadonna, and E. Ferrannini Pathogenesis of NIDDM: a balanced overview Diabetes Care 15 1992 318 353
8. M.T. Flowers, M. Miyazaki, X. Liu, and J.M. Ntambi Probing the role of stearoyl-CoA desaturase-1 in hepatic insulin resistance Journal of Clinical Investigation 116 2006 1478 1481
9. S. Frontoni, S.B. Choi, D. Banduch, and L. Rossetti In vivo insulin resistance induced by amylin primarily through inhibition of insulin-stimulated glycogen synthesis in skeletal muscle Diabetes 40 1991 568 573
10. L.G. Fryer, A. Parbu-Patel, and D. Carling The antidiabetic drugs rosiglitazone and metformin stimulate AMP-activated protein kinase through distinct signaling pathways Journal of Biological Chemistry 277 2002 25226 25232 (Pubitemid 34951829)
11. 2-induced apoptotic cell death in intestinal epithelial cells through nuclear factor-kappaB International Journal of Molecular Medicine 26 2010 401 406
12. Y.A. Hosokawa, H. Hosokawa, C. Chen, and J.L. Leahy Mechanism of impaired glucose-potentiated insulin secretion in diabetic 90% pancreatectomy rats. Study using glucagons like peptide-1 (7-37) Journal of Clinical Investigation 97 1996 180 186 (Pubitemid 26022593)
13. F. Huang, Y. Xiong, L. Xu, S. Ma, and C. Dou Sedative and hypnotic activities of the ethanol fraction from Fructus Schisandrae in mice and rats Journal of Ethnopharmacology 110 2007 471 475 (Pubitemid 46386359)
14. B.S. Ko, S.K. Park, S.B. Choi, D.W. Jun, M.K. Choi, and S. Park A study on hypoglycemic effects of crude extracts of Schizandrae Fructus Journal of Korean Applied Biological Chemistry 47 2004 258 264
15. C.H. Lau, C.M. Chan, Y.W. Chan, K.M. Lau, T.W. Lau, F.C. Lam, C.T. Che, P.C. Leung, K.P. Fung, Y.Y. Ho, and C.B. Lau In vitro antidiabetic activities of five medicinal herbs used in Chinese medicinal formulae Phytotherpy Research 22 2008 1384 1388
16. L.A. Leiter Can thiazolidinediones delay disease progression in type 2 diabetes? Current Medical Research and Opinion 22 2006 1193 1201 (Pubitemid 44000739)
17. Y. Lu, and D.F. Chen Analysis of Schisandra chinensis and Schisandra sphenanthera Journal of Chromatography A 1216 2009 1980 1990
18. L. Martinez, M. Berenguer, M.C. Bruce, Y. Le Marchand-Brustel, and R. Govers Rosiglitazone increases cell surface GLUT4 levels in 3T3-L1 adipocytes through an enhancement of endosomal recycling Biochemical Pharmacology 79 2010 1300 1309
19. S.Y. Oh, Y.H. Kim, D.S. Bae, B.H. Um, C.H. Pan, C.Y. Kim, H.J. Lee, and J.K. Lee Anti-inflammatory effects of gomisin N, gomisin J, and schisandrin C isolated from the fruit of Schisandra chinensis Bioscience Biotechnology Biochemistry 74 2010 285 291
20. S.Y. Pan, H. Dong, X.Y. Zhao, C.J. Xiang, H.Y. Fang, W.F. Fong, Z.L. Yu, and K.M. Ko Schisandrin B from Schisandra chinensis reduces hepatic lipid contents in hypercholesterolaemic mice Journal of Pharmacy and Pharmacology 60 2008 399 403 (Pubitemid 351269829)
21. S. Park, I.S. Ahn, D.Y. Kwon, B.S. Ko, and W.K. Jun Ginsenoside Rb1 and Rg1 suppress triacylglycerol accumulation in 3T3-L1 adipocytes and enhance β-cell insulin secretion and viability in Min6 cells via PKA dependent pathways Bioscience Biotechnology Biochemistry 72 2008 2815 2823
22. S. Park, S.M. Hong, I.S. Ahn, Y.J. Kim, and J.B. Lee Huang-Lian-Jie-Du- Tang supplemented with Schisandra chinensis Baill. and Polygonatum odoratum Druce improved glucose tolerance by potentiating insulinotropic actions in islets in 90% pancreatectomized diabetic rats Bioscience Biotechnology Biochemistry 73 2009 2384 2392
23. S.A. Polyzos, J. Kountouras, and C. Zavos Nonalcoholic fatty liver disease: the pathogenetic roles of insulin resistance and adipocytokines Current Molecular Medicine 9 2009 299 314
24. L. Rossetti, G.I. Shulman, W. Zawalich, and R.A. DeFronzo Effect of chronic hyperglycemia on in vivo insulin secretion in partially pancreatectomized rats Journal of Clinical Investigation 80 1987 1037 1044 (Pubitemid 18075639)
25. E. Sebokova, I. Klimes, R. Moss, P. Stolba, M.M. Wiersma, and A. Mitková Muscle GLUT4 protein levels and impaired triglyceride metabolism in streptozotocin diabetic rats. Effect of a high sucrose diet and fish oil supplementation Annual New York Academy Science 683 1993 218 227 (Pubitemid 23236671)
26. A. Shimaya, K.S. Kovacina, and R.A. Roth On the mechanism for neomycin reversal of wortmannin inhibition of insulin stimulation of glucose uptake Journal of Biological Chemistry 279 2004 55277 55282 (Pubitemid 40068849)
27. A. Stacchiotti, G. Li Volti, A. Lavazza, R. Rezzani, and L.F. Rodella Schisandrin B stimulates a cytoprotective response in rat liver exposed to mercuric chloride Food and Chemical Toxicology 47 2009 2834 2840
28. S.I. Taylor Deconstructing type 2 diabetes Cell 97 1999 9 12 (Pubitemid 29165884)
29. K.H. Yoon, J.H. Lee, J.W. Kim, J.H. Cho, Y.H. Choi, S.H. Ko, P. Zimmet, and H.Y. Son Epidemic obesity and type 2 diabetes in Asia Lancet 368 2006 1681 1688 (Pubitemid 46048556)
30. J. Zhang, L.L. Shi, and Y.N. Zheng Dibenzocyclooctadiene lignans from Fructus Schisandrae Chinensis improve glucose uptake in vitro Natural Product Communications 5 2010 231 234