Anti-inflammatory effects of schisandrin isolated from the fruit of Schisandra chinensis Baill

European Journal of Pharmacology

Volumn 591, Issue 1-3, 2008, Pages 293-299

  Guo, Lian Yu ^a   Hung, Tran Manh ^b   Bae, Ki Hwan ^b   Shin, Eun Myoung ^a   Zhou, Hong Yu ^a   Hong, Yoo Na ^a   Kang, Sam Sik ^a   Kim, Hyun Pyo ^c   Kim, Yeong Shik ^a  

^a Seoul National University   (South Korea)

^b Chungnam National University   (South Korea)

^c Kangwon National University   (South Korea)

Author keywords

c Jun N terminal kinase; Cyclooxygenase 2; Inducible nitric oxide synthase; Nuclear factor kappaB; P38 mitogen activated protein kinase; Paw edema; Schisandrin; Septic shock; Vascular permeability

Indexed keywords

ACETIC ACID; CARRAGEENAN; CYCLOOXYGENASE 2; DEXAMETHASONE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE P38; NITRIC OXIDE; NITRITE; PROSTAGLANDIN E2; SCHISANDRA CHINENSIS EXTRACT; SCHIZANDRIN; STRESS ACTIVATED PROTEIN KINASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BLOOD VESSEL PERMEABILITY; CONTROLLED STUDY; DRUG DOSE COMPARISON; DRUG EFFECT; DRUG ISOLATION; ENZYME ACTIVITY; FRUIT; IN VITRO STUDY; MOUSE; NONHUMAN; PAW EDEMA; PRIORITY JOURNAL; SCHISANDRA CHINENSIS; SCHISANDRACEAE; SEPSIS;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CAPILLARY PERMEABILITY; CELL LINE; CYCLOOCTANES; CYCLOOXYGENASE 2; DINOPROSTONE; FRUIT; GENE EXPRESSION REGULATION; INFLAMMATION; LIGNANS; LIPOPOLYSACCHARIDES; MACROPHAGES; MALE; MICE; MICE, INBRED ICR; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; NITRITES; POLYCYCLIC COMPOUNDS; SCHISANDRA; SEPSIS;

EID: 48749095664     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2008.06.074     Document Type: Article

References (23)

1. Aga M., Watters J.J., Pfeiffer Z.A., Wiepz G.J., Sommer J.A., and Bertics P.J. Evidence for nucleotide receptor modulation of cross talk between MAP kinase and NF-kappa B signaling pathways in murine RAW 264.7 macrophages. Am. J. Physiol. Cell Physiol. 286 (2004) C923-930
2. Ando Y., Inoue M., Araki S., and Morino Y. Inhibition of carrageenin-induced paw edema by a superoxide dismutase derivative that circulates bound to albumin. Biochim. Biophys. Acta. 1073 (1991) 374-379
3. Boughton-Smith N.K., Evans S.M., Hawkey C.J., Cole A.T., Balsitis M., Whittle B.J., and Moncada S. Nitric oxide synthase activity in ulcerative colitis and Crohn's disease. Lancet 342 (1993) 338-340
4. Chan E.D., and Riches D.W. IFN-gamma + LPS induction of iNOS is modulated by ERK, JNK/SAPK, and p38(mapk) in a mouse macrophage cell line. Am. J. Physiol. Cell Physiol. 280 (2001) C441-450
5. Chen Z., Hagler J., Palombella V.J., Melandri F., Scherer D., Ballard D., and Maniatis T. Signal-induced site-specific phosphorylation targets I kappa B alpha to the ubiquitin-proteasome pathway. Genes Dev. 9 (1995) 1586-1597
6. DeFranco A.L., Hambleton J., McMahon M., and Weinstein S.L. Examination of the role of MAP kinase in the response of macrophages to lipopolysaccharide. Prog. Clin. Biol. Res. 392 (1995) 407-420
7. Gilliam M.B., Sherman M.P., Griscavage J.M., and Ignarro L.J. A spectrophotometric assay for nitrate using NADPH oxidation by Aspergillus nitrate reductase. Anal. Biochem. 212 (1993) 359-365
8. Kenzel S., Mancuso G., Malley R., Teti G., Golenbock D.T., and Henneke P. c-Jun kinase is a critical signaling molecule in a neonatal model of group B streptococcal sepsis. J. Immunol. 176 (2006) 3181-3188
9. Klintman D., Li X., Santen S., Schramm R., Jeppsson B., and Thorlacius H. p38 mitogen-activated protein kinase-dependent chemokine production, leukocyte recruitment, and hepatocellular apoptosis in endotoxemic liver injury. Ann. Surg. 242 (2005) 830-838 discussion 838-839
10. Knoferl M.W., Diodato M.D., Schwacha M.G., Cioffi W.G., Bland K.I., and Chaudry I.H. Cyclooxygenase-2-mediated regulation of Kupffer cell interleukin-6 production following trauma-hemorrhage and subsequent sepsis. Shock 16 (2001) 479-483
11. Ko K.M., Ip S.P., Poon M.K., Wu S.S., Che C.T., Ng K.H., and Kong Y.C. Effect of a lignan-enriched fructus schisandrae extract on hepatic glutathione status in rats: protection against carbon tetrachloride toxicity. Planta Med. 61 (1995) 134-137
12. Liu G.T. Pharmacological actions and clinical use of fructus schizandrae. Chin. Med. J. (Engl.) 102 (1989) 740-749
13. Mestre J.R., Mackrell P.J., Rivadeneira D.E., Stapleton P.P., Tanabe T., and Daly J.M. Redundancy in the signaling pathways and promoter elements regulating cyclooxygenase-2 gene expression in endotoxin-treated macrophage/monocytic cells. J. Biol. Chem. 276 (2001) 3977-3982
14. Moon K.Y., Hahn B.S., Lee J., and Kim Y.S. A cell-based assay system for monitoring NF-kappaB activity in human HaCat transfectant cells. Anal. Biochem. 292 (2001) 17-21
15. Peng T., Lu X., Lei M., Moe G.W., and Feng Q. Inhibition of p38 MAPK decreases myocardial TNF-alpha expression and improves myocardial function and survival in endotoxemia. Cardiovasc. Res. 59 (2003) 893-900
16. Peng J., Fan G., Qu L., Zhou X., and Wu Y. Application of preparative high-speed counter-current chromatography for isolation and separation of schizandrin and gomisin A from Schisandra chinensis. J. Chromatogr. A 1082 (2005) 203-207
17. Salvemini D., Wang Z.Q., Wyatt P.S., Bourdon D.M., Marino M.H., Manning P.T., and Currie M.G. Nitric oxide: a key mediator in the early and late phase of carrageenan-induced rat paw inflammation. Br. J. Pharmacol. 118 (1996) 829-838
18. Seibert K., Zhang Y., Leahy K., Hauser S., Masferrer J., Perkins W., Lee L., and Isakson P. Pharmacological and biochemical demonstration of the role of cyclooxygenase 2 in inflammation and pain. Proc. Natl. Acad. Sci. U. S. A. 91 (1994) 12013-12017
19. Song G.Y., Chung C.S., Chaudry I.H., and Ayala A. Immune suppression in polymicrobial sepsis: differential regulation of Th1 and Th2 responses by p38 MAPK. J. Surg. Res. 91 (2000) 141-146
20. Tsao L.T., Tsai P.S., Lin R.H., Huang L.J., Kuo S.C., and Wang J.P. Inhibition of lipopolysaccharide-induced expression of inducible nitric oxide synthase by phenolic (3E)-4-(2-hydroxyphenyl)but-3-en-2-one in RAW 264.7 macrophages. Biochem. Pharmacol. 70 (2005) 618-626
21. Wei W., Li X.H., Zhang H.Q., and Wu S.G. Anti-inflammatory and Immunopharmacology. 1st ed (2004), Renmin weisheng chubanshe, Bei Jing 10-27
22. Whittle B.A. The use of changes in capillary permeability in mice to distinguish between narcotic and nonnarcotic alalgesicsanalgesics. Br. J. Pharmacol. Chemother. 22 (1964) 246-253
23. Zhou H.Y., Shin E.M., Guo L.Y., Zou L.B., Xu G.H., Lee S.H., Ze K.R., Kim E.K., Kang S.S., and Kim Y.S. Anti-inflammatory activity of 21(alpha, beta)-methylmelianodiols, novel compounds from Poncirus trifoliata Rafinesque. Eur. J. Pharmacol. 572 2-3 (2007) 239-248