Schisandrin B exerts anti-neuroinflammatory activity by inhibiting the Toll-like receptor 4-dependent MyD88/IKK/NF-κB signaling pathway in lipopolysaccharide-induced microglia

European Journal of Pharmacology

Volumn 692, Issue 1-3, 2012, Pages 29-37

  Zeng, Ke Wu ^a   Zhang, Tai ^a   Fu, Hong ^a   Liu, Geng Xin ^a   Wang, Xue Mei ^a  

^a PEKING UNIVERSITY   (China)

Author keywords

Microglia; Neuroinflammation; Neuroprotection; Schisandrin B

Indexed keywords

I KAPPA B KINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MYELOID DIFFERENTIATION FACTOR 88; NITRIC OXIDE; PROSTAGLANDIN E2; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SCHIZANDRIN B; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL FUNCTION; CONTROLLED STUDY; DRUG DETERMINATION; DRUG EFFICACY; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME REGULATION; FETUS; MALE; MICROGLIA; MOUSE; NERVOUS SYSTEM INFLAMMATION; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; RAT; SCHISANDRA CHINENSIS; SIGNAL TRANSDUCTION; TREATMENT RESPONSE;

ANIMALS; ANTI-INFLAMMATORY AGENTS; BRAIN; CELL DEATH; COCULTURE TECHNIQUES; CYCLOOCTANES; DINOPROSTONE; DOWN-REGULATION; ENZYME ACTIVATION; I-KAPPA B KINASE; INTERLEUKIN-1BETA; INTERLEUKIN-6; LIGNANS; LIPOPOLYSACCHARIDES; MALE; MICE; MICROGLIA; MYELOID DIFFERENTIATION FACTOR 88; NADPH OXIDASE; NEURONS; NEUROPROTECTIVE AGENTS; NF-KAPPA B; NITRIC OXIDE; POLYCYCLIC COMPOUNDS; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84865861915     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2012.05.030     Document Type: Article

References (29)

1. P. Agostinho, R.A. Cunha, and C. Oliveira Neuroinflammation, oxidative stress and the pathogenesis of Alzheimer's disease Curr. Pharm. Des. 16 2010 2766 2778
2. M. Avila, and C. Gonzalez-Espinosa Signaling through Tolllike receptor 4 and mast celldependent innate immunity responses IUBMB Life 63 2011 873 880
3. E. Blasi, A. Ardizzoni, B. Colombari, R. Neglia, C. Baschieri, S. Peppoloni, and M. Cinco NF-kB activation and p38 phosphorylation in microglial cells infected with Leptospira or exposed to partially purified leptospiral lipoproteins Microb. Pathog. 42 2007 80 87
4. E. Carrasco, D. Casper, and P. Werner PGE(2) receptor EP1 renders dopaminergic neurons selectively vulnerable to low-level oxidative stress and direct PGE(2) neurotoxicity J. Neurosci. Res. 85 2007 3109 3117
5. P.Y. Chiu, H.Y. Leung, M.K.T. Poon, and K.M. Ko Chronic schisandrin B treatment improves mitochondrial antioxidant status and tissue heat shock protein production in various tissues of young adult and middle-aged rats Biogerontology 7 2006 199 210
6. C.K. Combs Inflammation and microglia actions in Alzheimer's disease J. Neuroimmune Pharmacol. 4 2009 380 388
7. P. Eikelenboom, E. van Exel, J.J.M. Hoozemans, R. Veerhuis, A.J.M. Rozemuller, and W.A. van Gool Neuroinflammation - an early event in both the history and pathogenesis of Alzheimer's disease Neurodegener. Dis. 7 2010 38 41
8. V.V. Giridharan, R.A. Thandavarayan, S. Sato, K.M. Ko, and T. Konishi Prevention of scopolamine-induced memory deficits by schisandrin B, an antioxidant lignan from Schisandra chinensis in mice Free Radic. Res. 45 2011 950 958
9. V.V. Giridharan, R.A. Thandavarayan, H.N. Bhilwade, K.M. Ko, K. Watanabe, and T. Konishi Schisandrin B attenuates cisplatin-induced oxidative stress, genotoxicity and neurotoxicity through modulating NF-κB pathway in mice Free Radic. Res. 46 2012 50 60
10. F. González-Scarano, and G. Baltuch Microglia as mediators of inflammatory and degenerative diseases Annu. Rev. Neurosci. 22 1999 219 240
11. M.B. Graeber, W. Li, and M.L. Rodriguez Role of microglia in CNS inflammation FEBS Lett. 585 2011 3798 3805
12. L.Y. Guo, T.M. Hung, K.H. Bae, E.M. Shin, H.Y. Zhou, Y.N. Hong, S.S. Kang, H.P. Kim, and Y.S. Kim Anti-inflammatory effect of schisandrin isolated from the fruit of Schisandra chinensis Baill Eur. J. Pharmacol. 591 2008 293 299
13. K. Hemmer, L. Fransen, H. Vanderstichele, E. Vanmechelen, and P. Heuschling An in vitro model for the study of microglia-induced neurodegeneration: involvement of nitric oxide and tumor necrosis factor-alpha Neurochem. Int. 38 2001 557 565
14. E.C. Hirsch, S. Vyas, and S. Hunot Neuroinflammation in Parkinson's disease Parkinsonism Relat. Disord. 18 2012 210 212
15. M. Higuchi, B. Ji, J. Maeda, M. Maruyama, M. Ono, M. Sawada, and T. Suhara Alzheimer's disease and microglia Clin. Neurol 51 2011 1031
16. S.P. Ip, and K.M. Ko The crucial antioxidant action of schisandrin B in protecting against carbon tetrachloride hepatotoxicity in mice: a comparative study with butylated hydroxytoluene Biochem. Pharmacol. 52 1996 1687 1693
17. J.H. Jara, B.B. Singh, A.M. Floden, and C.K. Combs Tumor necrosis factor alpha stimulates NMDA receptor activity in mouse cortical neurons resulting in ERK-dependent death J. Neurochem. 100 2007 1407 1420
18. D.H. Kim, T.M. Hung, K.H. Bae, J.W. Jung, S. Lee, B.H. Yoon, J.H. Cheong, K.H. Ko, and J.H. Ryu Gomisin A improves scopolamine-induced memory impairment in mice Eur. J. Pharmacol. 542 2006 129 135
19. S.M. Krance, P.C. Keng, J. Palis, and N. Ballatori Transient glutathione depletion determines terminal differentiation in HL-60 cells Oxid. Med. Cell. Longev. 3 2010 53 60
20. Y. Li, X. Hu, Y. Liu, Y. Bao, and L. An Nimodipine protects dopaminergic neurons against inflammation-mediated degeneration through inhibition of microglial activation Neuropharmacology 56 2009 580 589
21. S.L. Liu, and T. Kielian Microglial activation by Citrobacter koseri is mediated by TLR4-and MyD88-dependent pathways J. Immunol. 183 2009 5537 5547
22. Y.J. Moon, J.Y. Lee, M.S. Oh, Y.K. Pak, K.S. Park, T.H. Oh, and T.Y. Yune Inhibition of inflammation and oxidative stress by Angelica dahuricae radix extract decreases apoptotic cell death and improves functional recovery after spinal cord injury J. Neurosci. Res. 90 2012 243 256
23. E. Polazzi, and B. Monti Microglia and neuroprotection: from in vitro studies to therapeutic applications Prog. Neurobiol. 92 2010 293 315
24. W.W. Sheng, Y.J. Zong, A. Mohammad, D. Ajit, J.K. Cui, D.D. Han, J.L. Hamilton, A. Simonyi, A.Y. Sun, Z.Z. Gu, J.S. Hong, G.A. Weisman, A. Gary, and G.Y. Sun Pro-inflammatory cytokines and lipopolysaccharide induce changes in cell morphology, and upregulation of ERK1/2, iNOS and sPLA(2)-IIA expression in astrocytes and microglia J. Neuroinflammation 8 2011 121
25. B. Wang, and X.M. Wang Schisandrin B protects rat cortical neurons against Abeta1-42-induced neurotoxicity Pharmazie 64 2009 450 454
26. J.Y. Wang, and J.Y. Wang Hypoxia/reoxygenation induce's nitric oxide and TNF-alpha release from cultured microglia but not astrocytes of the rat Chin. J. Physiol. 50 2007 127 134
27. K.W. Zeng, H. Fu, G.X. Liu, and X.M. Wang Icariin attenuates lipopolysaccharide-induced microglial activation and resultant death of neurons by inhibiting TAK1/IKK/NF-kappaB and JNK/p38 MAPK pathways Int. Immunopharmacol. 10 2010 668 678
28. W. Zhang, K. Phillips, A.R. Wielgus, J. Liu, A. Albertini, F.A. Zucca, R. Faust, S.Y. Qian, D.S. Miller, C.F. Chignell, B. Wilson, V. Jackson-Lewis, S. Przedborski, D. Joset, J. Loike, J.S. Hong, D. Sulzer, and L. Zecca Neuromelanin activates microglia and induces degeneration of dopaminergic neurons: implications for progression of Parkinson's disease Neurotox. Res. 19 2011 63 72
29. L.H. Zhu, W. Bi, R.B. Qi, H.D. Wang, and D.X. Lu Luteolin inhibits microglial inflammation and improves neuron survival against inflammation Int. J. Neurosci. 121 2011 329 336