Anti-apoptotic and hepatoprotective effects of gomisin A on fulminant hepatic failure induced by D-galactosamine and lipopolysaccharide in mice

Journal of Pharmacological Sciences

Volumn 106, Issue 2, 2008, Pages 225-233

  Kim, Sung Hwa ^a   Yeong, Shik Kim ^b   Sam, Sik Kang ^b   Bae, KiHwan ^c   Tran, Manh Hung ^c   Lee, Sun Mee ^a  

^a Sungkyunkwan University   (South Korea)

^b Seoul National University   (South Korea)

^c Chungnam National University   (South Korea)

Author keywords

Apoptosis; D galactosamine (GalN); Gomisin A; Lipopolysaccharide (LPS); Oxidative stress; Tumor necrosis factor (TNF)

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CASPASE 3; GALACTOSAMINE; GLUTATHIONE; GOMISIN A; LIPOPOLYSACCHARIDE; TUMOR NECROSIS FACTOR ALPHA;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANALYTIC METHOD; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CHEMICAL ANALYSIS; COMPARATIVE STUDY; CONTROLLED STUDY; DNA FRAGMENTATION; DOSE RESPONSE; HISTOLOGY; LIPID PEROXIDATION; LIVER FAILURE; LIVER INJURY; LIVER PROTECTION; MALE; MITOCHONDRION; MOUSE; NICK END LABELING; NONHUMAN; OXIDATIVE STRESS; SURVIVAL RATE;

EID: 40549098089     PISSN: 13478613     EISSN: 13478648     Source Type: Journal    
DOI: 10.1254/jphs.FP0071738     Document Type: Article

References (35)

1. Nakama T Hirono S Moriuchi A Hasuike S Nagata K Hori T Etoposide prevents apoptosis in mouse liver with D-galactosamine/lipopolysaccharide-induced fulminant hepatic failure resulting in reduction of lethality Hepatology. 33 2001 1441 1450
2. Xiong Q Hase K Tezuka Y Namba T Kadota S Acteoside inhibits apoptosis in D-galactosamine and lipopolysaccharide-induced liver injury Life Sci. 65 1999 421 430
3. Ou M China-English manual of common-used prescriptions in Traditional Chinese medicine 1992 Guangdong Science and Technology Press Guangzhou, China 69 70
4. Jung GT Ju IO Choi JS Hong JS The antioxidative, antimicrobial and nitrite scavenging effects of Schisandra chinensis RUPRECHT (Omija) seed Korean J Food Sci Technol. 32 2000 928 935
5. Kim BH Lee YS Kang KS The mechanism of retinol-induced irritation and its application to anti-irritant development Toxicol Lett. 146 2003 65 73
6. Heo JH Park JG Cheon HJ Kim YS Kang SS Hung TM Hepatoprotective activities of gomisin A and gomisin N Kor J Pharmacogn. 37 2006 294 301
7. Kim SH Cheon HJ Park JG Kim YS Kang SS Xu GH Hepatoprotective activities of glycyrrhizin and baicalin in primary cultured rat hepatocytes J Pharm Soc Korea. 50 2006 358 366
8. Maeda S Takeda S Miyamoto Y Aburada M Harada M Effects of gomisin A on liver functions in hepatotoxic chemicals-treated rats Jpn J Pharmacol. 38 1985 347 353
9. Mizoguchi Y Shin T Kobayashi K Morisawa S Effect of gomisin A in an immunologically-induced acute hepatic failure model Planta Med. 57 1991 11 14
10. Kubo S Ohkura Y Mizoguchi Y Matsui-Yuasa I Otani S Morisawa S Effect of Gomisin A (TJN-101) on liver regeneration Planta Med. 58 1992 489 492
11. Buege JA Aust SD Microsomal lipid peroxidation Methods Enzymol. 52 1978 302 310
12. Tietze F Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: applications to mammalian blood and other tissues Anal Biochem. 27 1969 502 522
13. Griffith OW Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine Anal Biochem. 106 1980 207 212
14. Johnson D Lardy HA Isolation of liver and kidney mitochondria Methods Enzymol. 10 1967 456 470
15. Bradford MM A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding Anal Biochem. 72 1976 248 254
16. Elimadi A Sapena R Settaf A Le Louet H Tillement J Morin D Attenuation of liver normothermic ischemia-reperfusion injury by preservation of mitochondrial functions with S-15176, a potent trimetazidine derivative Biochem Pharmacol. 62 2001 509 516
17. Morin D Pires F Plin C Tillement JP Role of the permeability transition pore in cytochrome C release from mitochondria during ischemia-reperfusion in rat liver Biochem Pharmacol. 68 2004 2065 2073
18. Shiokawa D Ohyama H Yamada T Takahashi K Tanuma S Identification of an endonuclease responsible for apoptosis in rat thymocytes Eur J Biochem. 226 1994 23 30
19. Ikeya Y Taguchi H Yosioka I Kobayashi H The constituents of Schizandra chinensis Baill. I. Isolation and structure determination of five new lignans, gomisin A, B, C, F and G, and the absolute structure of schizandrin Chem Pharm Bull. 27 1979 1383 1394
20. Kiso Y Tohkin M Hikino H Ikeya Y Taguchi H Mechanism of antihepatotoxic activity of wuweizisu C and gomisin A1 Planta Med. 51 1985 331 334
21. Wendel A Tiegs G Werner C Evidence for the involvement of a reperfusion injury in galactosamine/endotoxin-induced hepatitis in mice Biochem Pharmacol. 36 1987 2637 2639
22. Leist M Gantner F Bohlinger I Tiegs G Germann PG Wendel A Tumor necrosis factor-induced hepatocyte apoptosis precedes liver failure in experimental murine shock models Am J Pathol. 146 1995 1220 1234
23. Zamzami N Hirsch T Dallaporta B Petit PX Kroemer G Mitochondrial implication in accidental and programmed cell death: apoptosis and necrosis J Bioenerg Biomembr. 29 1997 185 193
24. Paradies G Petrosillo G Pistolese M Di Venosa N Serena D Ruggiero FM Lipid peroxidation and alterations to oxidative metabolism in mitochondria isolated from rat heart subjected to ischemia and reperfusion Free Radic Biol Med. 27 1999 42 50
25. Crompton M The mitochondrial permeability transition pore and its role in cell death Biochem J. 341 1999 233 249
26. Bernardi P Petronilli V Di Lisa F Forte M A mitochondrial perspective on cell death Trends Biochem Sci. 26 2001 112 117
27. Soriano ME Nicolosi L Bernardi P Desensitization of the permeability transition pore by cyclosporin a prevents activation of the mitochondrial apoptotic pathway and liver damage by tumor necrosis factor-alpha J Biol Chem. 279 2004 36803 36808
28. McClain CJ Tumor necrosis and alcoholic hepatitis Hepatology. 14 1991 394 396
29. Larrea E Garcia N Qian C Civeira MP Prieto J Tumor necrosis factor alpha gene expression and the response to interferon in chronic hepatitis C Hepatology. 23 1996 210 217
30. Morikawa A Sugiyama T Kato Y Koide N Jiang GZ Takahashi K Apoptotic cell death in the response of D-galactosamine-sensitized mice to lipopolysaccharide as an experimental endotoxic shock model Infect Immun. 64 1996 734 738
31. Bohlinger I Leist M Gantner F Angermuller S Tiegs G Wendel A DNA fragmentation in mouse organs during endotoxic shock Am J Pathol. 149 1996 1381 1393
32. Brouckaert P Fiers W Tumor necrosis factor and the systemic inflammatory response syndrome Curr Top Microbiol Immunol. 216 1996 167 187
33. Bruccoleri A Gallucci R Germolec DR Blackshear P Simeonova P Thurman RG Induction of early-immediate genes by tumor necrosis factor alpha contribute to liver repair following chemical-induced hepatotoxicity Hepatology. 25 1997 133 141
34. Mignon A Rouquet N Fabre M Martin S Pages JC Dhainaut JF LPS challenge in D-galactosamine-sensitized mice accounts for caspase-dependent fulminant hepatitis, not for septic shock Am J Respir Crit Care Med. 159 1999 1308 1315
35. Wang Y Singh R Lefkowitch JH Rigoli RM Czaja MJ Tumor necrosis factor-induced toxic liver injury results from JNK2-dependent activation of caspase-8 and the mitochondrial death pathway J Biol Chem. 281 2006 15258 15267