메뉴 건너뛰기




Volumn 88, Issue 3, 2013, Pages 706-715

Nrf2 is a potential therapeutic target in radioresistance in human cancer

Author keywords

Antioxidant; Nrf2; Radioresistance; ROS; Targeted therapy

Indexed keywords

HEME OXYGENASE 1; HYPOXIA INDUCIBLE FACTOR 1; PEROXIREDOXIN; PROTEIN MDM2; RADIOPROTECTIVE AGENT; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); SMALL INTERFERING RNA; TRANSCRIPTION FACTOR NRF2;

EID: 84888300793     PISSN: 10408428     EISSN: 18790461     Source Type: Journal    
DOI: 10.1016/j.critrevonc.2013.09.001     Document Type: Review
Times cited : (94)

References (138)
  • 1
    • 0035984912 scopus 로고    scopus 로고
    • ROS, stress-activated kinases and stress signaling in cancer
    • Benhar M., Engelberg D., Levitzki A. ROS, stress-activated kinases and stress signaling in cancer. EMBO Rep 2002, 3:420-425.
    • (2002) EMBO Rep , vol.3 , pp. 420-425
    • Benhar, M.1    Engelberg, D.2    Levitzki, A.3
  • 2
    • 2942593991 scopus 로고    scopus 로고
    • ROS stress in cancer cells and therapeutic implications
    • Pelicano H., Carney D., Huang P. ROS stress in cancer cells and therapeutic implications. Drug Resist Updat 2004, 7:97-110.
    • (2004) Drug Resist Updat , vol.7 , pp. 97-110
    • Pelicano, H.1    Carney, D.2    Huang, P.3
  • 3
    • 71549168293 scopus 로고    scopus 로고
    • Peroxiredoxins, a novel target in cancer radiotherapy
    • Zhang B., Wang Y., Su Y. Peroxiredoxins, a novel target in cancer radiotherapy. Cancer Lett 2009, 286:154-160.
    • (2009) Cancer Lett , vol.286 , pp. 154-160
    • Zhang, B.1    Wang, Y.2    Su, Y.3
  • 4
    • 44949179401 scopus 로고    scopus 로고
    • Should supplemental antioxidant administration be avoided during chemotherapy and radiation therapy
    • Lawenda B.D., Kelly K.M., Ladas E.J., Sagar S.M., Vickers A., Blumberg J.B. Should supplemental antioxidant administration be avoided during chemotherapy and radiation therapy. J Natl Cancer Inst 2008, 100:773-783.
    • (2008) J Natl Cancer Inst , vol.100 , pp. 773-783
    • Lawenda, B.D.1    Kelly, K.M.2    Ladas, E.J.3    Sagar, S.M.4    Vickers, A.5    Blumberg, J.B.6
  • 5
    • 84888298338 scopus 로고    scopus 로고
    • Antioxidants reduce consequences of radiation exposure
    • 8
    • Okunieff P., Swarts S., Keng P., et al. Antioxidants reduce consequences of radiation exposure. Adv Exp Med Biol 2008, 16:5-7. 8.
    • (2008) Adv Exp Med Biol , vol.16 , pp. 5-7
    • Okunieff, P.1    Swarts, S.2    Keng, P.3
  • 6
    • 0037317521 scopus 로고    scopus 로고
    • The role of p53 in determining sensitivity to radiotherapy
    • Gudkov A.V., Komarova E.A. The role of p53 in determining sensitivity to radiotherapy. Nat Rev Cancer 2003, 3:117-129.
    • (2003) Nat Rev Cancer , vol.3 , pp. 117-129
    • Gudkov, A.V.1    Komarova, E.A.2
  • 7
    • 7944223434 scopus 로고    scopus 로고
    • Increased expression of antioxidant enzymes in radioresistant variant from U251 human glioblastoma cell line
    • Lee H.C., Kim D.W., Jung K.Y., et al. Increased expression of antioxidant enzymes in radioresistant variant from U251 human glioblastoma cell line. Int J Mol Med 2004, 13:883-887.
    • (2004) Int J Mol Med , vol.13 , pp. 883-887
    • Lee, H.C.1    Kim, D.W.2    Jung, K.Y.3
  • 8
    • 64749093574 scopus 로고    scopus 로고
    • Association of reactive oxygen species levels and radioresistance in cancer stem cells
    • Diehn M., Cho R.W., Lobo N.A., et al. Association of reactive oxygen species levels and radioresistance in cancer stem cells. Nature 2009, 458:780-783.
    • (2009) Nature , vol.458 , pp. 780-783
    • Diehn, M.1    Cho, R.W.2    Lobo, N.A.3
  • 9
    • 76649089973 scopus 로고    scopus 로고
    • Loss of Keap1 function in prostate cancer cells causes chemo-and radio-resistance and promotes tumor growth
    • Zhang P., Singh A., Yegnasubramanian S., et al. Loss of Keap1 function in prostate cancer cells causes chemo-and radio-resistance and promotes tumor growth. Mol Cancer Ther 2010, 9:336-346.
    • (2010) Mol Cancer Ther , vol.9 , pp. 336-346
    • Zhang, P.1    Singh, A.2    Yegnasubramanian, S.3
  • 10
    • 84864405467 scopus 로고    scopus 로고
    • An effective strategy for increasing the radiosensitivity of human lung cancer cells by blocking Nrf2-dependent antioxidant responses
    • Lee S., Lim M.J., Kim M.H., et al. An effective strategy for increasing the radiosensitivity of human lung cancer cells by blocking Nrf2-dependent antioxidant responses. Free Radic Biol Med 2012, 53:807-816.
    • (2012) Free Radic Biol Med , vol.53 , pp. 807-816
    • Lee, S.1    Lim, M.J.2    Kim, M.H.3
  • 11
    • 0037044791 scopus 로고    scopus 로고
    • Phosphorylation of Nrf2 at Ser-40 by protein kinase C regulates antioxidant response element-mediated transcription
    • Huang H.C., Nguyen T., Pickett C.B. Phosphorylation of Nrf2 at Ser-40 by protein kinase C regulates antioxidant response element-mediated transcription. J Biol Chem 2002, 277:42769-42774.
    • (2002) J Biol Chem , vol.277 , pp. 42769-42774
    • Huang, H.C.1    Nguyen, T.2    Pickett, C.B.3
  • 13
    • 0027954494 scopus 로고
    • Free radicals in biology: oxidative stress and the effects of ionizing radiation
    • Riley P. Free radicals in biology: oxidative stress and the effects of ionizing radiation. Int J Radiat Biol 1994, 65:27-33.
    • (1994) Int J Radiat Biol , vol.65 , pp. 27-33
    • Riley, P.1
  • 14
    • 0027976408 scopus 로고
    • Initial events in the cellular effects of ionizing radiations: clustered damage in DNA
    • Goodhead D. Initial events in the cellular effects of ionizing radiations: clustered damage in DNA. Int J Radiat Biol 1994, 65:7-17.
    • (1994) Int J Radiat Biol , vol.65 , pp. 7-17
    • Goodhead, D.1
  • 15
    • 60649100252 scopus 로고    scopus 로고
    • Cancer stem cells and tumor response to therapy: current problems and future prospects
    • Milas L., Hittelman W.N. Cancer stem cells and tumor response to therapy: current problems and future prospects. Semin Radiat Oncol 2009, 19:96-105.
    • (2009) Semin Radiat Oncol , vol.19 , pp. 96-105
    • Milas, L.1    Hittelman, W.N.2
  • 16
    • 77950972011 scopus 로고    scopus 로고
    • Radiation resistance of cancer stem cells: the 4 R's of radiobiology revisited
    • Pajonk F., Vlashi E., McBride W.H. Radiation resistance of cancer stem cells: the 4 R's of radiobiology revisited. Stem Cells 2010, 28:639-648.
    • (2010) Stem Cells , vol.28 , pp. 639-648
    • Pajonk, F.1    Vlashi, E.2    McBride, W.H.3
  • 17
    • 0025029088 scopus 로고
    • DNA damage and repair following treatment with ionizing radiation
    • Powell S., McMillan T.J. DNA damage and repair following treatment with ionizing radiation. Radiother Oncol 1990, 19:95-108.
    • (1990) Radiother Oncol , vol.19 , pp. 95-108
    • Powell, S.1    McMillan, T.J.2
  • 18
    • 7944237254 scopus 로고    scopus 로고
    • Antioxidants and radiation therapy
    • 3207S-9S
    • Borek C. Antioxidants and radiation therapy. J Nutr 2004, 134. 3207S-9S.
    • (2004) J Nutr , vol.134
    • Borek, C.1
  • 19
    • 0034490213 scopus 로고    scopus 로고
    • Antisense of human peroxiredoxin II enhances radiation-induced cell death
    • Park S.H., Chung Y.M., Lee Y.S., et al. Antisense of human peroxiredoxin II enhances radiation-induced cell death. Clin Cancer Res 2000, 6:4915-4920.
    • (2000) Clin Cancer Res , vol.6 , pp. 4915-4920
    • Park, S.H.1    Chung, Y.M.2    Lee, Y.S.3
  • 20
    • 10344234178 scopus 로고    scopus 로고
    • Redox modulation of human prostate carcinoma cells by selenite increases radiation-induced cell killing
    • Husbeck B., Peehl D.M., Knox S.J. Redox modulation of human prostate carcinoma cells by selenite increases radiation-induced cell killing. Free Radic Biol Med 2005, 38:50-57.
    • (2005) Free Radic Biol Med , vol.38 , pp. 50-57
    • Husbeck, B.1    Peehl, D.M.2    Knox, S.J.3
  • 21
    • 28644438156 scopus 로고    scopus 로고
    • The role of peroxiredoxin II in radiation-resistant MCF-7 breast cancer cells
    • Wang T., Tamae D., LeBon T., Shively J.E., Yen Y., Li J.J. The role of peroxiredoxin II in radiation-resistant MCF-7 breast cancer cells. Cancer Res 2005, 65:10338-10346.
    • (2005) Cancer Res , vol.65 , pp. 10338-10346
    • Wang, T.1    Tamae, D.2    LeBon, T.3    Shively, J.E.4    Yen, Y.5    Li, J.J.6
  • 22
    • 34548134503 scopus 로고    scopus 로고
    • Do antioxidants interfere with radiation therapy for cancer
    • Moss R.W. Do antioxidants interfere with radiation therapy for cancer. Integr Cancer Ther 2007, 6:281-292.
    • (2007) Integr Cancer Ther , vol.6 , pp. 281-292
    • Moss, R.W.1
  • 23
    • 9244241576 scopus 로고    scopus 로고
    • Identification of human brain tumour initiating cells
    • Singh S.K., Hawkins C., Clarke I.D., et al. Identification of human brain tumour initiating cells. Nature 2004, 432:396-401.
    • (2004) Nature , vol.432 , pp. 396-401
    • Singh, S.K.1    Hawkins, C.2    Clarke, I.D.3
  • 24
    • 28244472369 scopus 로고    scopus 로고
    • Prospective identification of tumorigenic prostate cancer stem cells
    • Collins A.T., Berry P.A., Hyde C., Stower M.J., Maitland N.J. Prospective identification of tumorigenic prostate cancer stem cells. Cancer Res 2005, 65:10946-10951.
    • (2005) Cancer Res , vol.65 , pp. 10946-10951
    • Collins, A.T.1    Berry, P.A.2    Hyde, C.3    Stower, M.J.4    Maitland, N.J.5
  • 25
    • 33846512398 scopus 로고    scopus 로고
    • Identification of a subpopulation of cells with cancer stem cell properties in head and neck squamous cell carcinoma
    • Prince M., Sivanandan R., Kaczorowski A., et al. Identification of a subpopulation of cells with cancer stem cell properties in head and neck squamous cell carcinoma. Proc Natl Acad Sci U S A 2007, 973-978.
    • (2007) Proc Natl Acad Sci U S A , pp. 973-978
    • Prince, M.1    Sivanandan, R.2    Kaczorowski, A.3
  • 26
    • 34547193404 scopus 로고    scopus 로고
    • Phenotypic characterization of human colorectal cancer stem cells
    • Dalerba P., Dylla S.J., Park I.K., et al. Phenotypic characterization of human colorectal cancer stem cells. Proc Natl Acad Sci U S A 2007, 104:10158-10163.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 10158-10163
    • Dalerba, P.1    Dylla, S.J.2    Park, I.K.3
  • 27
    • 69549114870 scopus 로고    scopus 로고
    • Identification, molecular characterization, clinical prognosis, and therapeutic targeting of human bladder tumor-initiating cells
    • Chan K.S., Espinosa I., Chao M., et al. Identification, molecular characterization, clinical prognosis, and therapeutic targeting of human bladder tumor-initiating cells. Proc Natl Acad Sci U S A 2009, 106:14016-14021.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 14016-14021
    • Chan, K.S.1    Espinosa, I.2    Chao, M.3
  • 28
    • 84861701350 scopus 로고    scopus 로고
    • Targeting a cornerstone of radiation resistance: cancer stem cell
    • Moncharmont C., Levy A., Gilormini M., et al. Targeting a cornerstone of radiation resistance: cancer stem cell. Cancer Lett 2012, 322:139-147.
    • (2012) Cancer Lett , vol.322 , pp. 139-147
    • Moncharmont, C.1    Levy, A.2    Gilormini, M.3
  • 29
    • 0031577292 scopus 로고    scopus 로고
    • An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements
    • Itoh K., Chiba T., Takahashi S., et al. An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements. Biochem Biophys Res Commun 1997, 236:313-322.
    • (1997) Biochem Biophys Res Commun , vol.236 , pp. 313-322
    • Itoh, K.1    Chiba, T.2    Takahashi, S.3
  • 30
    • 51649130168 scopus 로고    scopus 로고
    • Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy
    • Shibata T., Ohta T., Tong K.I., et al. Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy. Proc Natl Acad Sci U S A 2008, 105:13568-13573.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 13568-13573
    • Shibata, T.1    Ohta, T.2    Tong, K.I.3
  • 31
    • 3543008924 scopus 로고    scopus 로고
    • Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2
    • Kobayashi A., Kang M.I., Okawa H., et al. Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2. Mol Cell Biol 2004, 24:7130-7139.
    • (2004) Mol Cell Biol , vol.24 , pp. 7130-7139
    • Kobayashi, A.1    Kang, M.I.2    Okawa, H.3
  • 32
    • 33748052967 scopus 로고    scopus 로고
    • Nrf2-Keap1 regulation of cellular defense mechanisms against electrophiles and reactive oxygen species
    • Kobayashi M., Yamamoto M. Nrf2-Keap1 regulation of cellular defense mechanisms against electrophiles and reactive oxygen species. Adv Enzyme Regul 2006, 46:113-140.
    • (2006) Adv Enzyme Regul , vol.46 , pp. 113-140
    • Kobayashi, M.1    Yamamoto, M.2
  • 33
    • 84888291491 scopus 로고    scopus 로고
    • Overview of enzymes of drug metabolism
    • 9
    • Meyer U.A. Overview of enzymes of drug metabolism. J Pharmacokinet Biopharm 1996, 44:5-9. 9.
    • (1996) J Pharmacokinet Biopharm , vol.44 , pp. 5-9
    • Meyer, U.A.1
  • 34
    • 21744445077 scopus 로고    scopus 로고
    • Nrf2, a multi-organ protector
    • Lee J.M., Li J., Johnson D.A., et al. Nrf2, a multi-organ protector. FASEB J 2005, 19:1061-1066.
    • (2005) FASEB J , vol.19 , pp. 1061-1066
    • Lee, J.M.1    Li, J.2    Johnson, D.A.3
  • 35
    • 33750885385 scopus 로고    scopus 로고
    • Dysfunctional KEAP1-NRF2 interaction in non-small-cell lung cancer
    • Singh A., Misra V., Thimmulappa R.K., et al. Dysfunctional KEAP1-NRF2 interaction in non-small-cell lung cancer. PLoS Med 2006, 3:e420.
    • (2006) PLoS Med , vol.3
    • Singh, A.1    Misra, V.2    Thimmulappa, R.K.3
  • 36
    • 40449107193 scopus 로고    scopus 로고
    • Loss of Keap1 function activates Nrf2 and provides advantages for lung cancer cell growth
    • Ohta T., Iijima K., Miyamoto M., et al. Loss of Keap1 function activates Nrf2 and provides advantages for lung cancer cell growth. Cancer Res 2008, 68:1303-1309.
    • (2008) Cancer Res , vol.68 , pp. 1303-1309
    • Ohta, T.1    Iijima, K.2    Miyamoto, M.3
  • 37
    • 66149168685 scopus 로고    scopus 로고
    • Nrf2 enhances cell proliferation and resistance to anticancer drugs in human lung cancer
    • Homma S., Ishii Y., Morishima Y., et al. Nrf2 enhances cell proliferation and resistance to anticancer drugs in human lung cancer. Clin Cancer Res 2009, 15:3423-3432.
    • (2009) Clin Cancer Res , vol.15 , pp. 3423-3432
    • Homma, S.1    Ishii, Y.2    Morishima, Y.3
  • 38
    • 33344456501 scopus 로고    scopus 로고
    • Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancer
    • Padmanabhan B., Tong K.I., Ohta T., et al. Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancer. Mol Cell 2006, 21:689-700.
    • (2006) Mol Cell , vol.21 , pp. 689-700
    • Padmanabhan, B.1    Tong, K.I.2    Ohta, T.3
  • 39
    • 79958702879 scopus 로고    scopus 로고
    • Frequent epigenetics inactivation of KEAP1 gene in non-small cell lung cancer
    • Muscarella L.A., Parrella P., D'Alessandro V., et al. Frequent epigenetics inactivation of KEAP1 gene in non-small cell lung cancer. Epigenetics 2011, 6:710-719.
    • (2011) Epigenetics , vol.6 , pp. 710-719
    • Muscarella, L.A.1    Parrella, P.2    D'Alessandro, V.3
  • 40
    • 33749993417 scopus 로고    scopus 로고
    • The consensus coding sequences of human breast and colorectal cancers
    • Sjöblom T., Jones S., Wood L.D., et al. The consensus coding sequences of human breast and colorectal cancers. Science 2006, 314:268-274.
    • (2006) Science , vol.314 , pp. 268-274
    • Sjöblom, T.1    Jones, S.2    Wood, L.D.3
  • 41
    • 34548577395 scopus 로고    scopus 로고
    • A mutation of Keap1 found in breast cancer impairs its ability to repress Nrf2 activity
    • Nioi P., Nguyen T. A mutation of Keap1 found in breast cancer impairs its ability to repress Nrf2 activity. Biochem Biophys Res Commun 2007, 362:816-821.
    • (2007) Biochem Biophys Res Commun , vol.362 , pp. 816-821
    • Nioi, P.1    Nguyen, T.2
  • 42
    • 53049105119 scopus 로고    scopus 로고
    • Genetic alteration of Keap1 confers constitutive Nrf2 activation and resistance to chemotherapy in gallbladder cancer
    • e1354
    • Shibata T., Kokubu A., Gotoh M., et al. Genetic alteration of Keap1 confers constitutive Nrf2 activation and resistance to chemotherapy in gallbladder cancer. Gastroenterology 2008, 135:1358-1368. e1354.
    • (2008) Gastroenterology , vol.135 , pp. 1358-1368
    • Shibata, T.1    Kokubu, A.2    Gotoh, M.3
  • 43
    • 79960958309 scopus 로고    scopus 로고
    • Keap1 mutations and Nrf2 pathway activation in epithelial ovarian cancer
    • Konstantinopoulos P.A., Spentzos D., Fountzilas E., et al. Keap1 mutations and Nrf2 pathway activation in epithelial ovarian cancer. Cancer Res 2011, 71:5081-5089.
    • (2011) Cancer Res , vol.71 , pp. 5081-5089
    • Konstantinopoulos, P.A.1    Spentzos, D.2    Fountzilas, E.3
  • 44
    • 84857997256 scopus 로고    scopus 로고
    • Methylation of the KEAP1 gene promoter region in human colorectal cancer
    • Hanada N., Takahata T., Zhou Q., et al. Methylation of the KEAP1 gene promoter region in human colorectal cancer. BMC Cancer 2012, 12:66.
    • (2012) BMC Cancer , vol.12 , pp. 66
    • Hanada, N.1    Takahata, T.2    Zhou, Q.3
  • 45
    • 76749106638 scopus 로고    scopus 로고
    • Oncogenic NRF2 mutations in squamous cell carcinomas of oesophagus and skin
    • Kim Y.R., Oh J.E., Kim M.S., et al. Oncogenic NRF2 mutations in squamous cell carcinomas of oesophagus and skin. J Pathol 2010, 220:446-451.
    • (2010) J Pathol , vol.220 , pp. 446-451
    • Kim, Y.R.1    Oh, J.E.2    Kim, M.S.3
  • 46
    • 78549273400 scopus 로고    scopus 로고
    • Global downstream pathway analysis reveals a dependence of oncogenic NF-E2-related factor 2 mutation on the mTOR growth signaling pathway
    • Shibata T., Saito S., Kokubu A., Suzuki T., Yamamoto M., Hirohashi S. Global downstream pathway analysis reveals a dependence of oncogenic NF-E2-related factor 2 mutation on the mTOR growth signaling pathway. Cancer Res 2010, 70:9095-9105.
    • (2010) Cancer Res , vol.70 , pp. 9095-9105
    • Shibata, T.1    Saito, S.2    Kokubu, A.3    Suzuki, T.4    Yamamoto, M.5    Hirohashi, S.6
  • 47
    • 0026556492 scopus 로고
    • Endogenous glutathione levels modulate both constitutive and UVA radiation/hydrogen peroxide inducible expression of the human heme oxygenase gene
    • Lautier D., Luscher P., Tyrrell R.M. Endogenous glutathione levels modulate both constitutive and UVA radiation/hydrogen peroxide inducible expression of the human heme oxygenase gene. Carcinogenesis 1992, 13:227-232.
    • (1992) Carcinogenesis , vol.13 , pp. 227-232
    • Lautier, D.1    Luscher, P.2    Tyrrell, R.M.3
  • 48
    • 0032571164 scopus 로고    scopus 로고
    • Heme oxygenase induction by UVA radiation A response to oxidative stress in rat liver
    • Ossola J.O., Tomaro M.L. Heme oxygenase induction by UVA radiation A response to oxidative stress in rat liver. Int J Biochem Cell Biol 1998, 30:285-292.
    • (1998) Int J Biochem Cell Biol , vol.30 , pp. 285-292
    • Ossola, J.O.1    Tomaro, M.L.2
  • 49
    • 0037464355 scopus 로고    scopus 로고
    • Antiapoptotic effect of haem oxygenase-1 induced by nitric oxide in experimental solid tumour
    • Tanaka S., Akaike T., Fang J., et al. Antiapoptotic effect of haem oxygenase-1 induced by nitric oxide in experimental solid tumour. Br J Cancer 2003, 88:902-909.
    • (2003) Br J Cancer , vol.88 , pp. 902-909
    • Tanaka, S.1    Akaike, T.2    Fang, J.3
  • 52
    • 0033543566 scopus 로고    scopus 로고
    • Nrf2, a Cap'n'Collar transcription factor, regulates induction of the heme oxygenase-1 gene
    • Alam J., Stewart D., Touchard C., Boinapally S., Choi A.M., Cook J.L. Nrf2, a Cap'n'Collar transcription factor, regulates induction of the heme oxygenase-1 gene. J Biol Chem 1999, 274:26071-26078.
    • (1999) J Biol Chem , vol.274 , pp. 26071-26078
    • Alam, J.1    Stewart, D.2    Touchard, C.3    Boinapally, S.4    Choi, A.M.5    Cook, J.L.6
  • 54
    • 34250193619 scopus 로고    scopus 로고
    • Colonic expression of heme oxygenase-1 is associated with a better long-term survival in patients with colorectal cancer
    • Becker J.C., Fukui H., Imai Y., et al. Colonic expression of heme oxygenase-1 is associated with a better long-term survival in patients with colorectal cancer. Scand J Gastroenterol 2007, 42:852-858.
    • (2007) Scand J Gastroenterol , vol.42 , pp. 852-858
    • Becker, J.C.1    Fukui, H.2    Imai, Y.3
  • 55
    • 21044452445 scopus 로고    scopus 로고
    • Inhibition of heme oxygenase-1 increases responsiveness of pancreatic cancer cells to anticancer treatment
    • Berberat P.O., Dambrauskas Z., Gulbinas A., et al. Inhibition of heme oxygenase-1 increases responsiveness of pancreatic cancer cells to anticancer treatment. Clin Cancer Res 2005, 11:3790-3798.
    • (2005) Clin Cancer Res , vol.11 , pp. 3790-3798
    • Berberat, P.O.1    Dambrauskas, Z.2    Gulbinas, A.3
  • 57
    • 78049460778 scopus 로고    scopus 로고
    • Clinical significance of heme oxygenase-1 expression in non-muscle-invasive bladder cancer
    • Miyake M., Fujimoto K., Anai S., et al. Clinical significance of heme oxygenase-1 expression in non-muscle-invasive bladder cancer. Urol Int 2010, 85:355-363.
    • (2010) Urol Int , vol.85 , pp. 355-363
    • Miyake, M.1    Fujimoto, K.2    Anai, S.3
  • 58
    • 84861730556 scopus 로고    scopus 로고
    • Expression of heme oxygenase-1 in non-small cell lung cancer (NSCLC) and its correlation with clinical data
    • Degese M.S., Mendizabal J.E., Gandini N.A., et al. Expression of heme oxygenase-1 in non-small cell lung cancer (NSCLC) and its correlation with clinical data. Lung Cancer 2012, 77:168-175.
    • (2012) Lung Cancer , vol.77 , pp. 168-175
    • Degese, M.S.1    Mendizabal, J.E.2    Gandini, N.A.3
  • 59
    • 41149177653 scopus 로고    scopus 로고
    • Suppression of Nrf2-driven heme oxygenase-1 enhances the chemosensitivity of lung cancer A549 cells toward cisplatin
    • Kim H.R., Kim S., Kim E.J., et al. Suppression of Nrf2-driven heme oxygenase-1 enhances the chemosensitivity of lung cancer A549 cells toward cisplatin. Lung Cancer 2008, 60:47-56.
    • (2008) Lung Cancer , vol.60 , pp. 47-56
    • Kim, H.R.1    Kim, S.2    Kim, E.J.3
  • 60
    • 79953889329 scopus 로고    scopus 로고
    • Nrf2 is overexpressed in pancreatic cancer: implications for cell proliferation and therapy
    • Lister A., Nedjadi T., Kitteringham N.R., et al. Nrf2 is overexpressed in pancreatic cancer: implications for cell proliferation and therapy. Mol Cancer 2011, 10:37.
    • (2011) Mol Cancer , vol.10 , pp. 37
    • Lister, A.1    Nedjadi, T.2    Kitteringham, N.R.3
  • 61
    • 27544484871 scopus 로고    scopus 로고
    • Expression of heme oxygenase-1 protects endothelial cells from irradiation-induced apoptosis
    • Ewing P., Wilke A., Eissner G., Holler E., Andreesen R., Gerbitz A. Expression of heme oxygenase-1 protects endothelial cells from irradiation-induced apoptosis. Endothelium 2005, 12:113-119.
    • (2005) Endothelium , vol.12 , pp. 113-119
    • Ewing, P.1    Wilke, A.2    Eissner, G.3    Holler, E.4    Andreesen, R.5    Gerbitz, A.6
  • 62
    • 0035290737 scopus 로고    scopus 로고
    • Prediction of radiosensitivity in human esophageal squamous cell carcinomas with heme oxygenase-1: a clinicopathological and immunohistochemical study
    • Yokoyama S., Mita S., Okabe A., Abe M., Ogawa M. Prediction of radiosensitivity in human esophageal squamous cell carcinomas with heme oxygenase-1: a clinicopathological and immunohistochemical study. Oncol Rep 2001, 8:355-358.
    • (2001) Oncol Rep , vol.8 , pp. 355-358
    • Yokoyama, S.1    Mita, S.2    Okabe, A.3    Abe, M.4    Ogawa, M.5
  • 63
    • 80053439769 scopus 로고    scopus 로고
    • NRF2 mutation confers malignant potential and resistance to chemoradiation therapy in advanced esophageal squamous cancer
    • Shibata T., Kokubu A., Saito S., et al. NRF2 mutation confers malignant potential and resistance to chemoradiation therapy in advanced esophageal squamous cancer. Neoplasia 2011, 13:864-873.
    • (2011) Neoplasia , vol.13 , pp. 864-873
    • Shibata, T.1    Kokubu, A.2    Saito, S.3
  • 64
    • 70350064471 scopus 로고    scopus 로고
    • Et alFunctional expression of heme oxygenase-1 in human differentiated epidermis and its regulation by cytokines
    • Numata I., Okuyama R., Memezawa A., Ito Y., Takeda K., Furuyama K. et alFunctional expression of heme oxygenase-1 in human differentiated epidermis and its regulation by cytokines. J Invest Dermatol 2009, 129:2594-2603.
    • (2009) J Invest Dermatol , vol.129 , pp. 2594-2603
    • Numata, I.1    Okuyama, R.2    Memezawa, A.3    Ito, Y.4    Takeda, K.5    Furuyama, K.6
  • 65
    • 84864775335 scopus 로고    scopus 로고
    • Nrf2-dependent and Nrf2-independent induction of phase 2 detoxifying and antioxidant enzymes during keratinocyte differentiation
    • Piao M.S., Park J.J., Choi J.Y., et al. Nrf2-dependent and Nrf2-independent induction of phase 2 detoxifying and antioxidant enzymes during keratinocyte differentiation. Arch Dermatol Res 2012, 304:387-395.
    • (2012) Arch Dermatol Res , vol.304 , pp. 387-395
    • Piao, M.S.1    Park, J.J.2    Choi, J.Y.3
  • 66
    • 0033643459 scopus 로고    scopus 로고
    • Antioxidant regulation of genes encoding enzymes that detoxify xenobiotics and carcinogens
    • Dhakshinamoorthy S., Long D.J., Jaiswal A.K. Antioxidant regulation of genes encoding enzymes that detoxify xenobiotics and carcinogens. Curr Top Cell Regul 2001, 36:201-216.
    • (2001) Curr Top Cell Regul , vol.36 , pp. 201-216
    • Dhakshinamoorthy, S.1    Long, D.J.2    Jaiswal, A.K.3
  • 67
    • 0033805326 scopus 로고    scopus 로고
    • Persuasive evidence that quinone reductase type 1 (DT diaphorase) protects cells against the toxicity of electrophiles and reactive forms of oxygen
    • Dinkova-Kostova A.T., Talalay P. Persuasive evidence that quinone reductase type 1 (DT diaphorase) protects cells against the toxicity of electrophiles and reactive forms of oxygen. Free Radic Biol Med 2000, 29:231-240.
    • (2000) Free Radic Biol Med , vol.29 , pp. 231-240
    • Dinkova-Kostova, A.T.1    Talalay, P.2
  • 68
    • 77955125402 scopus 로고    scopus 로고
    • Relationship between radiosensitivity and Nrf2 target gene expression in human hematopoietic stem cells
    • Kato K., Takahashi K., Monzen S., et al. Relationship between radiosensitivity and Nrf2 target gene expression in human hematopoietic stem cells. Radiat Res 2010, 174:177-184.
    • (2010) Radiat Res , vol.174 , pp. 177-184
    • Kato, K.1    Takahashi, K.2    Monzen, S.3
  • 70
    • 33846703755 scopus 로고    scopus 로고
    • Human prx1 gene is a target of Nrf2 and is up-regulated by hypoxia/reoxygenation: implication to tumor biology
    • Kim Y.J., Ahn J.Y., Liang P., Ip C., Zhang Y., Park Y.M. Human prx1 gene is a target of Nrf2 and is up-regulated by hypoxia/reoxygenation: implication to tumor biology. Cancer Res 2007, 67:546-554.
    • (2007) Cancer Res , vol.67 , pp. 546-554
    • Kim, Y.J.1    Ahn, J.Y.2    Liang, P.3    Ip, C.4    Zhang, Y.5    Park, Y.M.6
  • 71
    • 30544431972 scopus 로고    scopus 로고
    • Inhibition of lung tumor growth and augmentation of radiosensitivity by decreasing peroxiredoxin I expression
    • Chen M.F., Keng P.C., Shau H., et al. Inhibition of lung tumor growth and augmentation of radiosensitivity by decreasing peroxiredoxin I expression. Int J Radiat Oncol Biol Phys 2006, 64:581-591.
    • (2006) Int J Radiat Oncol Biol Phys , vol.64 , pp. 581-591
    • Chen, M.F.1    Keng, P.C.2    Shau, H.3
  • 72
    • 84862489824 scopus 로고    scopus 로고
    • Downregulation of peroxiredoxin I by a novel fully human phage display recombinant antibody induces apoptosis and enhances radiation sensitization in A549 lung carcinoma cells
    • Guo Q., Huang X., Zhang J., Luo Y., Peng Z., Li S. Downregulation of peroxiredoxin I by a novel fully human phage display recombinant antibody induces apoptosis and enhances radiation sensitization in A549 lung carcinoma cells. Cancer Biother Radiopharm 2012, 27:307-316.
    • (2012) Cancer Biother Radiopharm , vol.27 , pp. 307-316
    • Guo, Q.1    Huang, X.2    Zhang, J.3    Luo, Y.4    Peng, Z.5    Li, S.6
  • 73
    • 37849032288 scopus 로고    scopus 로고
    • Adenovirus-mediated transfer of siRNA against peroxiredoxin I enhances the radiosensitivity of human intestinal cancer
    • Zhang B., Wang Y., Liu K., et al. Adenovirus-mediated transfer of siRNA against peroxiredoxin I enhances the radiosensitivity of human intestinal cancer. Biochem Pharmacol 2008, 75:660-667.
    • (2008) Biochem Pharmacol , vol.75 , pp. 660-667
    • Zhang, B.1    Wang, Y.2    Liu, K.3
  • 74
    • 79951956638 scopus 로고    scopus 로고
    • Transcription factor Nrf2 maintains the basal expression of Mdm2: an implication of the regulation of p53 signaling by Nrf2
    • You A., Nam C.W., Wakabayashi N., Yamamoto M., Kensler T.W., Kwak M.K. Transcription factor Nrf2 maintains the basal expression of Mdm2: an implication of the regulation of p53 signaling by Nrf2. Arch Biochem Biophys 2011, 507:356-364.
    • (2011) Arch Biochem Biophys , vol.507 , pp. 356-364
    • You, A.1    Nam, C.W.2    Wakabayashi, N.3    Yamamoto, M.4    Kensler, T.W.5    Kwak, M.K.6
  • 75
    • 84878856689 scopus 로고    scopus 로고
    • Radiosensitization of wildtype p53 cancer cells by the MDM2-inhibitor PXN727 is associated with altered heat shock protein 70 (Hsp70) levels
    • Schilling D., Düwel M., Molls M., Multhoff G. Radiosensitization of wildtype p53 cancer cells by the MDM2-inhibitor PXN727 is associated with altered heat shock protein 70 (Hsp70) levels. Cell Stress Chaperones 2013, 18:183-191.
    • (2013) Cell Stress Chaperones , vol.18 , pp. 183-191
    • Schilling, D.1    Düwel, M.2    Molls, M.3    Multhoff, G.4
  • 76
    • 35948985191 scopus 로고    scopus 로고
    • The radiation response of hormone-resistant prostate cancer induced by long-term hormone therapy
    • Wu C.T., Chen W.C., Liao S.K., Hsu C.L., Lee K.D., Chen M.F. The radiation response of hormone-resistant prostate cancer induced by long-term hormone therapy. Endocr Relat Cancer 2007, 14:633-643.
    • (2007) Endocr Relat Cancer , vol.14 , pp. 633-643
    • Wu, C.T.1    Chen, W.C.2    Liao, S.K.3    Hsu, C.L.4    Lee, K.D.5    Chen, M.F.6
  • 77
    • 67349268492 scopus 로고    scopus 로고
    • Increase in thiol oxidative stress via glutathione reductase inhibition as a novel approach to enhance cancer sensitivity to X-ray irradiation
    • Zhao Y., Seefeldt T., Chen W., et al. Increase in thiol oxidative stress via glutathione reductase inhibition as a novel approach to enhance cancer sensitivity to X-ray irradiation. Free Radic Biol Med 2009, 47:176-183.
    • (2009) Free Radic Biol Med , vol.47 , pp. 176-183
    • Zhao, Y.1    Seefeldt, T.2    Chen, W.3
  • 78
    • 11444250615 scopus 로고    scopus 로고
    • Recent developments in the regulation of the angiogenic switch by cellular stress factors in tumors
    • North S., Moenner M., Bikfalvi A. Recent developments in the regulation of the angiogenic switch by cellular stress factors in tumors. Cancer Lett 2005, 218:1-14.
    • (2005) Cancer Lett , vol.218 , pp. 1-14
    • North, S.1    Moenner, M.2    Bikfalvi, A.3
  • 79
    • 0034021690 scopus 로고    scopus 로고
    • Hypoxia, clonal selection, and the role of HIF-1 in tumor progression
    • Semenza G.L. Hypoxia, clonal selection, and the role of HIF-1 in tumor progression. Crit Rev Biochem Mol Biol 2000, 35:71-103.
    • (2000) Crit Rev Biochem Mol Biol , vol.35 , pp. 71-103
    • Semenza, G.L.1
  • 80
    • 24144493814 scopus 로고    scopus 로고
    • Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing
    • Guzy R.D., Hoyos B., Robin E., et al. Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing. Cell Metab 2005, 1:401-408.
    • (2005) Cell Metab , vol.1 , pp. 401-408
    • Guzy, R.D.1    Hoyos, B.2    Robin, E.3
  • 81
    • 84960987950 scopus 로고
    • The concentration of oxygen dissolved in tissues at the time of irradiation as a factor in radiotherapy
    • Gray L.H., Conger A.D., Ebert M., Hornsey S., Scott O.C. The concentration of oxygen dissolved in tissues at the time of irradiation as a factor in radiotherapy. Br J Radiol 1953, 26:638-648.
    • (1953) Br J Radiol , vol.26 , pp. 638-648
    • Gray, L.H.1    Conger, A.D.2    Ebert, M.3    Hornsey, S.4    Scott, O.C.5
  • 82
    • 80053355093 scopus 로고    scopus 로고
    • How can we overcome tumor hypoxia in radiation therapy
    • Harada H. How can we overcome tumor hypoxia in radiation therapy. J Radiat Res 2011, 52:545-556.
    • (2011) J Radiat Res , vol.52 , pp. 545-556
    • Harada, H.1
  • 83
    • 0142166332 scopus 로고    scopus 로고
    • Targeting HIF-1 for cancer therapy
    • Semenza G.L. Targeting HIF-1 for cancer therapy. Nat Rev Cancer 2003, 3:721-732.
    • (2003) Nat Rev Cancer , vol.3 , pp. 721-732
    • Semenza, G.L.1
  • 84
    • 0038626211 scopus 로고    scopus 로고
    • Tumor response to radiotherapy regulated by endothelial cell apoptosis
    • Garcia-Barros M., Paris F., Cordon-Cardo C., et al. Tumor response to radiotherapy regulated by endothelial cell apoptosis. Science 2003, 300:1155-1159.
    • (2003) Science , vol.300 , pp. 1155-1159
    • Garcia-Barros, M.1    Paris, F.2    Cordon-Cardo, C.3
  • 85
    • 0029753008 scopus 로고    scopus 로고
    • Activation of hypoxia-inducible transcription factor depends primarily upon redox-sensitive stabilization of its α subunit
    • Huang L.E., Arany Z., Livingston D.M., Bunn H.F. Activation of hypoxia-inducible transcription factor depends primarily upon redox-sensitive stabilization of its α subunit. J Biol Chem 1996, 271:32253-32259.
    • (1996) J Biol Chem , vol.271 , pp. 32253-32259
    • Huang, L.E.1    Arany, Z.2    Livingston, D.M.3    Bunn, H.F.4
  • 86
    • 0037500967 scopus 로고    scopus 로고
    • Overexpression of hypoxia-inducible factor 1alpha indicates diminished response to radiotherapy and unfavorable prognosis in patients receiving radical radiotherapy for cervical cancer
    • Bachtiary B., Schindl M., Pötter R., et al. Overexpression of hypoxia-inducible factor 1alpha indicates diminished response to radiotherapy and unfavorable prognosis in patients receiving radical radiotherapy for cervical cancer. Clin Cancer Res 2003, 9:2234-2240.
    • (2003) Clin Cancer Res , vol.9 , pp. 2234-2240
    • Bachtiary, B.1    Schindl, M.2    Pötter, R.3
  • 87
    • 78649396776 scopus 로고    scopus 로고
    • Cycling hypoxia increases U87 glioma cell radioresistance via ROS induced higher and long-term HIF-1 signal transduction activity
    • Hsieh C.H., Lee C.H., Liang J.A., Yu C.Y., Shyu W.C. Cycling hypoxia increases U87 glioma cell radioresistance via ROS induced higher and long-term HIF-1 signal transduction activity. Oncol Rep 2010, 24:1629-1636.
    • (2010) Oncol Rep , vol.24 , pp. 1629-1636
    • Hsieh, C.H.1    Lee, C.H.2    Liang, J.A.3    Yu, C.Y.4    Shyu, W.C.5
  • 88
    • 2342611976 scopus 로고    scopus 로고
    • Radiation activates HIF-1 to regulate vascular radiosensitivity in tumors: role of reoxygenation, free radicals, and stress granules
    • Moeller B.J., Cao Y., Li C.Y., Dewhirst M.W. Radiation activates HIF-1 to regulate vascular radiosensitivity in tumors: role of reoxygenation, free radicals, and stress granules. Cancer Cell 2004, 5:429-441.
    • (2004) Cancer Cell , vol.5 , pp. 429-441
    • Moeller, B.J.1    Cao, Y.2    Li, C.Y.3    Dewhirst, M.W.4
  • 89
    • 84865626729 scopus 로고    scopus 로고
    • The effects of nrf2 on tumor angiogenesis: a review of the possible mechanisms of action
    • Zhou S., Ye W., Zhang M., Liang J. The effects of nrf2 on tumor angiogenesis: a review of the possible mechanisms of action. Crit Rev Eukaryot Gene Expr 2012, 22:149-160.
    • (2012) Crit Rev Eukaryot Gene Expr , vol.22 , pp. 149-160
    • Zhou, S.1    Ye, W.2    Zhang, M.3    Liang, J.4
  • 90
    • 79952749190 scopus 로고    scopus 로고
    • NRF2 blockade suppresses colon tumor angiogenesis by inhibiting hypoxia-induced activation of HIF-1α
    • Kim T.H., Hur E.G., Kang S.J., et al. NRF2 blockade suppresses colon tumor angiogenesis by inhibiting hypoxia-induced activation of HIF-1α. Cancer Res 2011, 71:2260-2275.
    • (2011) Cancer Res , vol.71 , pp. 2260-2275
    • Kim, T.H.1    Hur, E.G.2    Kang, S.J.3
  • 91
    • 77649341172 scopus 로고    scopus 로고
    • Targeting transcription factor NF-κB to overcome chemoresistance and radioresistance in cancer therapy
    • Li F., Sethi G. Targeting transcription factor NF-κB to overcome chemoresistance and radioresistance in cancer therapy. Biochim Biophys Acta 2010, 1805:167-180.
    • (2010) Biochim Biophys Acta , vol.1805 , pp. 167-180
    • Li, F.1    Sethi, G.2
  • 92
    • 0036174013 scopus 로고    scopus 로고
    • Activation of nuclear factor κB in radioresistance of TP53-inactive human keratinocytes
    • Chen X., Shen B., Xia L., et al. Activation of nuclear factor κB in radioresistance of TP53-inactive human keratinocytes. Cancer Res 2002, 62:1213-1221.
    • (2002) Cancer Res , vol.62 , pp. 1213-1221
    • Chen, X.1    Shen, B.2    Xia, L.3
  • 93
    • 33846327627 scopus 로고    scopus 로고
    • Nuclear factor-κB p65 inhibits mitogen-activated protein kinase signaling pathway in radioresistant breast cancer cells
    • Ahmed K.M., Dong S., Fan M., Li J.J. Nuclear factor-κB p65 inhibits mitogen-activated protein kinase signaling pathway in radioresistant breast cancer cells. Mol Cancer Res 2006, 4:945-955.
    • (2006) Mol Cancer Res , vol.4 , pp. 945-955
    • Ahmed, K.M.1    Dong, S.2    Fan, M.3    Li, J.J.4
  • 94
    • 33846006906 scopus 로고    scopus 로고
    • HER-2 and NF-κB as the targets for therapy-resistant breast cancer
    • Ahmed K.M., Cao N., Li J.J. HER-2 and NF-κB as the targets for therapy-resistant breast cancer. Anticancer Res 2006, 26:4235-4243.
    • (2006) Anticancer Res , vol.26 , pp. 4235-4243
    • Ahmed, K.M.1    Cao, N.2    Li, J.J.3
  • 95
    • 60149100173 scopus 로고    scopus 로고
    • Ionizing radiation-induced NF-κB activation requires PARP-1 function to confer radioresistance
    • Veuger S.J., Hunter J.E., Durkacz B.W. Ionizing radiation-induced NF-κB activation requires PARP-1 function to confer radioresistance. Oncogene 2008, 28:832-842.
    • (2008) Oncogene , vol.28 , pp. 832-842
    • Veuger, S.J.1    Hunter, J.E.2    Durkacz, B.W.3
  • 96
    • 58349107292 scopus 로고    scopus 로고
    • NF-κB-mediated HER2 overexpression in radiation-adaptive resistance
    • Cao N., Li S., Wang Z., et al. NF-κB-mediated HER2 overexpression in radiation-adaptive resistance. Radiat Res 2009, 171:9-21.
    • (2009) Radiat Res , vol.171 , pp. 9-21
    • Cao, N.1    Li, S.2    Wang, Z.3
  • 97
    • 38849168275 scopus 로고    scopus 로고
    • Parthenolide sensitizes cells to X-ray-induced cell killing through inhibition of NF-κB and split-dose repair
    • Mendonca M.S., Chin-Sinex H., Gomez-Millan J., et al. Parthenolide sensitizes cells to X-ray-induced cell killing through inhibition of NF-κB and split-dose repair. Radiat Res 2007, 168:689-697.
    • (2007) Radiat Res , vol.168 , pp. 689-697
    • Mendonca, M.S.1    Chin-Sinex, H.2    Gomez-Millan, J.3
  • 98
    • 35848957914 scopus 로고    scopus 로고
    • Cepharanthin-enhanced radiosensitivity through the inhibition of radiation-induced nuclear factor-kappaB activity in human oral squamous cell carcinoma cells
    • Tamatani T., Azuma M., Motegi K., Takamaru N., Kawashima Y., Bando T. Cepharanthin-enhanced radiosensitivity through the inhibition of radiation-induced nuclear factor-kappaB activity in human oral squamous cell carcinoma cells. Int J Oncol 2007, 31:761-768.
    • (2007) Int J Oncol , vol.31 , pp. 761-768
    • Tamatani, T.1    Azuma, M.2    Motegi, K.3    Takamaru, N.4    Kawashima, Y.5    Bando, T.6
  • 99
    • 53149108942 scopus 로고    scopus 로고
    • Docosahexaenoic acid sensitizes Ramos cells to Gamma-irradiation-induced apoptosis through involvement of PPAR-γ activation and NF-κB suppression
    • Zand H., Rahimipour A., Salimi S., Shafiee S.M. Docosahexaenoic acid sensitizes Ramos cells to Gamma-irradiation-induced apoptosis through involvement of PPAR-γ activation and NF-κB suppression. Mol Cell Biochem 2008, 317:113-120.
    • (2008) Mol Cell Biochem , vol.317 , pp. 113-120
    • Zand, H.1    Rahimipour, A.2    Salimi, S.3    Shafiee, S.M.4
  • 100
    • 63849257538 scopus 로고    scopus 로고
    • Induction of autophagic cell death and radiosensitization by the pharmacological inhibition of nuclear factor-kappa B activation in human glioma cell lines
    • Tsuboi Y., Kurimoto M., Nagai S., et al. Induction of autophagic cell death and radiosensitization by the pharmacological inhibition of nuclear factor-kappa B activation in human glioma cell lines. J Neurosurg 2009, 110:594-604.
    • (2009) J Neurosurg , vol.110 , pp. 594-604
    • Tsuboi, Y.1    Kurimoto, M.2    Nagai, S.3
  • 101
    • 80051547982 scopus 로고    scopus 로고
    • Selenium-containing thioredoxin reductase inhibitor ethaselen sensitizes non-small cell lung cancer to radiotherapy
    • Wang L., Fu J.N., Wang J.Y., et al. Selenium-containing thioredoxin reductase inhibitor ethaselen sensitizes non-small cell lung cancer to radiotherapy. Anticancer Drugs 2011, 22:732-740.
    • (2011) Anticancer Drugs , vol.22 , pp. 732-740
    • Wang, L.1    Fu, J.N.2    Wang, J.Y.3
  • 102
    • 84875221247 scopus 로고    scopus 로고
    • Radiation, inflammation, and immune responses in cancer
    • Multhoff G., Radons J. Radiation, inflammation, and immune responses in cancer. Front Oncol 2012, 2:58.
    • (2012) Front Oncol , vol.2 , pp. 58
    • Multhoff, G.1    Radons, J.2
  • 103
    • 80052014052 scopus 로고    scopus 로고
    • Inflammation meets cancer, with NF-[kappa] B as the matchmaker
    • Ben-Neriah Y., Karin M. Inflammation meets cancer, with NF-[kappa] B as the matchmaker. Nat Immunol 2011, 12:715-723.
    • (2011) Nat Immunol , vol.12 , pp. 715-723
    • Ben-Neriah, Y.1    Karin, M.2
  • 104
    • 57449111441 scopus 로고    scopus 로고
    • Regulatory potential for concerted modulation of Nrf2-and Nfkb1-mediated gene expression in inflammation and carcinogenesis
    • Nair S., Doh S.T., Chan J.Y., Kong A.N., Cai L. Regulatory potential for concerted modulation of Nrf2-and Nfkb1-mediated gene expression in inflammation and carcinogenesis. Br J Cancer 2008, 99:2070-2082.
    • (2008) Br J Cancer , vol.99 , pp. 2070-2082
    • Nair, S.1    Doh, S.T.2    Chan, J.Y.3    Kong, A.N.4    Cai, L.5
  • 105
    • 0029658030 scopus 로고    scopus 로고
    • The absence of p21Cip1/WAF1 alters keratinocyte growth and differentiation and promotes ras-tumor progression
    • Missero C., Di Cunto F., Kiyokawa H., Koff A., Dotto G.P. The absence of p21Cip1/WAF1 alters keratinocyte growth and differentiation and promotes ras-tumor progression. Genes Dev 1996, 10:3065-3075.
    • (1996) Genes Dev , vol.10 , pp. 3065-3075
    • Missero, C.1    Di Cunto, F.2    Kiyokawa, H.3    Koff, A.4    Dotto, G.P.5
  • 106
    • 0034932440 scopus 로고    scopus 로고
    • Biologic factors and response to radiotherapy in carcinoma of the cervix
    • Mukherjee G., Freeman A., Moore R., et al. Biologic factors and response to radiotherapy in carcinoma of the cervix. Int J Gynecol Cancer 2001, 11:187-193.
    • (2001) Int J Gynecol Cancer , vol.11 , pp. 187-193
    • Mukherjee, G.1    Freeman, A.2    Moore, R.3
  • 107
    • 84888291518 scopus 로고    scopus 로고
    • The clinical characteristics and expression of P21 in recurrent early glottic cancer after radiation therapy
    • Lee J.C., Kim H., Lee S.W., et al. The clinical characteristics and expression of P21 in recurrent early glottic cancer after radiation therapy. Korean J Otolaryngol-Head Neck Surg 2005, 48:630-635.
    • (2005) Korean J Otolaryngol-Head Neck Surg , vol.48 , pp. 630-635
    • Lee, J.C.1    Kim, H.2    Lee, S.W.3
  • 108
    • 78751498295 scopus 로고    scopus 로고
    • Co-overexpression of p21 and Ki-67 in head and neck squamous cell carcinoma relative to a significantly poor prognosis
    • Fischer C.A., Jung M., Zlobec I., et al. Co-overexpression of p21 and Ki-67 in head and neck squamous cell carcinoma relative to a significantly poor prognosis. Head Neck 2011, 33:267-273.
    • (2011) Head Neck , vol.33 , pp. 267-273
    • Fischer, C.A.1    Jung, M.2    Zlobec, I.3
  • 109
    • 0032587148 scopus 로고    scopus 로고
    • Relationship between expression of p21WAF1/CIP1 and radio resistance in human gliomas
    • Kokunai T., Tamaki N. Relationship between expression of p21WAF1/CIP1 and radio resistance in human gliomas. Cancer Sci 1999, 90:638-646.
    • (1999) Cancer Sci , vol.90 , pp. 638-646
    • Kokunai, T.1    Tamaki, N.2
  • 110
    • 0037304898 scopus 로고    scopus 로고
    • New roles for p21 and p27 cell-cycle inhibitors: a function for each cell compartment
    • Coqueret O. New roles for p21 and p27 cell-cycle inhibitors: a function for each cell compartment. Trends Cell Biol 2003, 13:65-70.
    • (2003) Trends Cell Biol , vol.13 , pp. 65-70
    • Coqueret, O.1
  • 111
    • 62349118232 scopus 로고    scopus 로고
    • Inflammation and chronic oxidative stress in radiation-induced late normal tissue injury: therapeutic implications
    • Zhao W., Robbins M.E.C. Inflammation and chronic oxidative stress in radiation-induced late normal tissue injury: therapeutic implications. Curr Med Chem 2009, 16:130-143.
    • (2009) Curr Med Chem , vol.16 , pp. 130-143
    • Zhao, W.1    Robbins, M.E.C.2
  • 112
    • 0034977952 scopus 로고    scopus 로고
    • The cyclin-dependent kinase inhibitor p21 protects the lung from oxidative stress
    • O'Reilly M.A., Staversky R.J., Watkins R.H., et al. The cyclin-dependent kinase inhibitor p21 protects the lung from oxidative stress. Am J Respir Cell Mol Biol 2001, 24:703.
    • (2001) Am J Respir Cell Mol Biol , vol.24 , pp. 703
    • O'Reilly, M.A.1    Staversky, R.J.2    Watkins, R.H.3
  • 113
    • 0036594890 scopus 로고    scopus 로고
    • The role of the cyclin-dependent kinase inhibitor p21 in apoptosis
    • Gartel A.L., Tyner A.L. The role of the cyclin-dependent kinase inhibitor p21 in apoptosis. Mol Cancer Ther 2002, 1:639-649.
    • (2002) Mol Cancer Ther , vol.1 , pp. 639-649
    • Gartel, A.L.1    Tyner, A.L.2
  • 114
    • 67449128222 scopus 로고    scopus 로고
    • Direct interaction between Nrf2 and p21 Cip1/WAF1 upregulates the Nrf2-mediated antioxidant response
    • Chen W., Sun Z., Wang X.J., et al. Direct interaction between Nrf2 and p21 Cip1/WAF1 upregulates the Nrf2-mediated antioxidant response. Mol Cell 2009, 34:663-673.
    • (2009) Mol Cell , vol.34 , pp. 663-673
    • Chen, W.1    Sun, Z.2    Wang, X.J.3
  • 115
    • 0035281565 scopus 로고    scopus 로고
    • Ataxia telangiectasia mutated is essential during adult neurogenesis
    • Allen D.M., van Praag H., Ray J., et al. Ataxia telangiectasia mutated is essential during adult neurogenesis. Genes Dev 2001, 15:554-566.
    • (2001) Genes Dev , vol.15 , pp. 554-566
    • Allen, D.M.1    van Praag, H.2    Ray, J.3
  • 116
    • 0035370172 scopus 로고    scopus 로고
    • ATM protein expression correlates with radioresistance in primary glioblastoma cells in culture
    • Tribius S., Pidel A., Casper D. ATM protein expression correlates with radioresistance in primary glioblastoma cells in culture. Int J Radiat Oncol Biol Phys 2001, 50:511-523.
    • (2001) Int J Radiat Oncol Biol Phys , vol.50 , pp. 511-523
    • Tribius, S.1    Pidel, A.2    Casper, D.3
  • 117
    • 0032535715 scopus 로고    scopus 로고
    • Loss of atm radiosensitizes multiple p53 null tissues
    • Westphal C.H., Hoyes K.P., Canman C.E., et al. Loss of atm radiosensitizes multiple p53 null tissues. Cancer Res 1998, 58:5637-5639.
    • (1998) Cancer Res , vol.58 , pp. 5637-5639
    • Westphal, C.H.1    Hoyes, K.P.2    Canman, C.E.3
  • 118
    • 34249815846 scopus 로고    scopus 로고
    • ATM-NF-kB connection as a target for tumor radiosensitization
    • Ahmed K.M., Li J.J. ATM-NF-kB connection as a target for tumor radiosensitization. Curr Cancer Drug Targets 2007, 7:335-342.
    • (2007) Curr Cancer Drug Targets , vol.7 , pp. 335-342
    • Ahmed, K.M.1    Li, J.J.2
  • 119
    • 3543084994 scopus 로고    scopus 로고
    • Distinct roles of c-Abl and Atm in oxidative stress response are mediated by protein kinase C δ
    • Li B., Wang X., Rasheed N., et al. Distinct roles of c-Abl and Atm in oxidative stress response are mediated by protein kinase C δ. Genes Dev 2004, 18:1824-1837.
    • (2004) Genes Dev , vol.18 , pp. 1824-1837
    • Li, B.1    Wang, X.2    Rasheed, N.3
  • 120
    • 66749098316 scopus 로고    scopus 로고
    • Molecular signatures of prostate stem cells reveal novel signaling pathways and provide insights into prostate cancer
    • Blum R., Gupta R., Burger P.E., et al. Molecular signatures of prostate stem cells reveal novel signaling pathways and provide insights into prostate cancer. PLoS ONE 2009, 4:e5722.
    • (2009) PLoS ONE , vol.4
    • Blum, R.1    Gupta, R.2    Burger, P.E.3
  • 121
  • 122
    • 52549087785 scopus 로고    scopus 로고
    • Cancer stem cells in solid tumours: accumulating evidence and unresolved questions
    • Visvader J.E., Lindeman G.J. Cancer stem cells in solid tumours: accumulating evidence and unresolved questions. Nat Rev Cancer 2008, 8:755-768.
    • (2008) Nat Rev Cancer , vol.8 , pp. 755-768
    • Visvader, J.E.1    Lindeman, G.J.2
  • 123
    • 64549108961 scopus 로고    scopus 로고
    • Redox regulation and its emerging roles in stem cells and stem-like cancer cells
    • Ogasawara M.A., Zhang H. Redox regulation and its emerging roles in stem cells and stem-like cancer cells. Antioxid Redox Signal 2009, 11:1107-1122.
    • (2009) Antioxid Redox Signal , vol.11 , pp. 1107-1122
    • Ogasawara, M.A.1    Zhang, H.2
  • 124
    • 51349120502 scopus 로고    scopus 로고
    • Regulation of reactive oxygen species and genomic stability in hematopoietic stem cells
    • Naka K., Muraguchi T., Hoshii T., Hirao A. Regulation of reactive oxygen species and genomic stability in hematopoietic stem cells. Antioxid Redox Signal 2008, 10:1883-1894.
    • (2008) Antioxid Redox Signal , vol.10 , pp. 1883-1894
    • Naka, K.1    Muraguchi, T.2    Hoshii, T.3    Hirao, A.4
  • 125
    • 82155171284 scopus 로고    scopus 로고
    • Regulation of reactive oxygen species in stem cells and cancer stem cells
    • Kobayashi C.I., Suda T. Regulation of reactive oxygen species in stem cells and cancer stem cells. J Cell Physiol 2012, 227:421-430.
    • (2012) J Cell Physiol , vol.227 , pp. 421-430
    • Kobayashi, C.I.1    Suda, T.2
  • 126
    • 33845904383 scopus 로고    scopus 로고
    • The response of CD24-/lowCD44+ breast cancer-initiating cells to radiation
    • Phillips T.M., McBride W.H., Pajonk F. The response of CD24-/lowCD44+ breast cancer-initiating cells to radiation. J Natl Cancer Inst 2006, 98:1777-1785.
    • (2006) J Natl Cancer Inst , vol.98 , pp. 1777-1785
    • Phillips, T.M.1    McBride, W.H.2    Pajonk, F.3
  • 127
    • 21944452087 scopus 로고    scopus 로고
    • Nrf1 and Nrf2 regulate rat glutamate-cysteine ligase catalytic subunit transcription indirectly via NF-kappaB and AP-1
    • Yang H., Magilnick N., Lee C., et al. Nrf1 and Nrf2 regulate rat glutamate-cysteine ligase catalytic subunit transcription indirectly via NF-kappaB and AP-1. Mol Cell Biol 2005, 25:5933-5946.
    • (2005) Mol Cell Biol , vol.25 , pp. 5933-5946
    • Yang, H.1    Magilnick, N.2    Lee, C.3
  • 128
    • 79957963355 scopus 로고    scopus 로고
    • Pro-oxidants ameliorate radiation-induced apoptosis through activation of the calcium-ERK1/2-Nrf2 pathway
    • Khan N.M., Sandur S.K., Checker R., Sharma D., Poduval T.B., Sainis K.B. Pro-oxidants ameliorate radiation-induced apoptosis through activation of the calcium-ERK1/2-Nrf2 pathway. Free Radic Biol Med 2011, 51:115-128.
    • (2011) Free Radic Biol Med , vol.51 , pp. 115-128
    • Khan, N.M.1    Sandur, S.K.2    Checker, R.3    Sharma, D.4    Poduval, T.B.5    Sainis, K.B.6
  • 129
    • 78449270816 scopus 로고    scopus 로고
    • Ionizing radiation activates the Nrf2 antioxidant response
    • McDonald J.T., Kim K., Norris A.J., et al. Ionizing radiation activates the Nrf2 antioxidant response. Cancer Res 2010, 70:8886-8895.
    • (2010) Cancer Res , vol.70 , pp. 8886-8895
    • McDonald, J.T.1    Kim, K.2    Norris, A.J.3
  • 130
    • 77958129306 scopus 로고    scopus 로고
    • Gain of Nrf2 function in non-small-cell lung cancer cells confers radioresistance
    • Singh A., Bodas M., Wakabayashi N., Bunz F., Biswal S. Gain of Nrf2 function in non-small-cell lung cancer cells confers radioresistance. Antioxid Redox Signal 2010, 13:1627-1637.
    • (2010) Antioxid Redox Signal , vol.13 , pp. 1627-1637
    • Singh, A.1    Bodas, M.2    Wakabayashi, N.3    Bunz, F.4    Biswal, S.5
  • 131
    • 84868328577 scopus 로고    scopus 로고
    • 2-Deoxy-d-glucose and 6-aminonicotinamide-mediated Nrf2 down regulation leads to radiosensitization of malignant cells via abrogation of GSH mediated defense
    • Sharma P.K., Varshney R. 2-Deoxy-d-glucose and 6-aminonicotinamide-mediated Nrf2 down regulation leads to radiosensitization of malignant cells via abrogation of GSH mediated defense. Free Radic Res 2012, 46:1446-1457.
    • (2012) Free Radic Res , vol.46 , pp. 1446-1457
    • Sharma, P.K.1    Varshney, R.2
  • 132
    • 79955612814 scopus 로고    scopus 로고
    • Luteolin inhibits Nrf2 leading to negative regulation of the Nrf2/ARE pathway and sensitization of human lung carcinoma A549 cells to therapeutic drugs
    • Tang X., Wang H., Fan L., et al. Luteolin inhibits Nrf2 leading to negative regulation of the Nrf2/ARE pathway and sensitization of human lung carcinoma A549 cells to therapeutic drugs. Free Radic Biol Med 2011, 50:1599-1609.
    • (2011) Free Radic Biol Med , vol.50 , pp. 1599-1609
    • Tang, X.1    Wang, H.2    Fan, L.3
  • 133
    • 84884815897 scopus 로고    scopus 로고
    • Drug resistance associates with activation of Nrf2 in MCF-7/DOX cells, and wogonin reverses it by down-regulating Nrf2-mediated cellular defense response
    • Zhong Y., Zhang F., Sun Z., et al. Drug resistance associates with activation of Nrf2 in MCF-7/DOX cells, and wogonin reverses it by down-regulating Nrf2-mediated cellular defense response. Mol Carcinog 2013, 52:824-834.
    • (2013) Mol Carcinog , vol.52 , pp. 824-834
    • Zhong, Y.1    Zhang, F.2    Sun, Z.3
  • 134
    • 79952122321 scopus 로고    scopus 로고
    • Brusatol enhances the efficacy of chemotherapy by inhibiting the Nrf2-mediated defense mechanism
    • Ren D., Villeneuve N.F., Jiang T., et al. Brusatol enhances the efficacy of chemotherapy by inhibiting the Nrf2-mediated defense mechanism. Proc Natl Acad Sci U S A 2011, 108:1433-1438.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 1433-1438
    • Ren, D.1    Villeneuve, N.F.2    Jiang, T.3
  • 135
    • 33744950387 scopus 로고    scopus 로고
    • Glycogen synthase kinase-3β inhibits the xenobiotic and antioxidant cell response by direct phosphorylation and nuclear exclusion of the transcription factor Nrf2
    • Salazar M., Rojo A.I., Velasco D., de Sagarra R.M., Cuadrado A. Glycogen synthase kinase-3β inhibits the xenobiotic and antioxidant cell response by direct phosphorylation and nuclear exclusion of the transcription factor Nrf2. J Biol Chem 2006, 281:14841-14851.
    • (2006) J Biol Chem , vol.281 , pp. 14841-14851
    • Salazar, M.1    Rojo, A.I.2    Velasco, D.3    de Sagarra, R.M.4    Cuadrado, A.5
  • 136
    • 84861389705 scopus 로고    scopus 로고
    • E-cadherin inhibits nuclear accumulation of Nrf2: implications for chemoresistance of cancer cells
    • Kim W.D., Kim Y.W., Cho I.J., Lee C.H., Kim S.G. E-cadherin inhibits nuclear accumulation of Nrf2: implications for chemoresistance of cancer cells. J Cell Sci 2012, 125:1284-1295.
    • (2012) J Cell Sci , vol.125 , pp. 1284-1295
    • Kim, W.D.1    Kim, Y.W.2    Cho, I.J.3    Lee, C.H.4    Kim, S.G.5
  • 137
    • 84862280943 scopus 로고    scopus 로고
    • Caveolin-1 inhibits expression of antioxidant enzymes through direct interaction with nuclear erythroid 2 p45-related factor-2 (Nrf2)
    • Li W., Liu H., Zhou J.S., et al. Caveolin-1 inhibits expression of antioxidant enzymes through direct interaction with nuclear erythroid 2 p45-related factor-2 (Nrf2). J Biol Chem 2012, 287:20922-20930.
    • (2012) J Biol Chem , vol.287 , pp. 20922-20930
    • Li, W.1    Liu, H.2    Zhou, J.S.3
  • 138
    • 68849092533 scopus 로고    scopus 로고
    • Cul3 overexpression depletes Nrf2 in breast cancer and is associated with sensitivity to carcinogens, to oxidative stress, and to chemotherapy
    • Loignon M., Miao W., Hu L., et al. Cul3 overexpression depletes Nrf2 in breast cancer and is associated with sensitivity to carcinogens, to oxidative stress, and to chemotherapy. Mol Cancer Ther 2009, 8:2432-2440.
    • (2009) Mol Cancer Ther , vol.8 , pp. 2432-2440
    • Loignon, M.1    Miao, W.2    Hu, L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.