Inflammation and chronic oxidative stress in radiation-induced late normal tissue injury: Therapeutic implications

Current Medicinal Chemistry

Volumn 16, Issue 2, 2009, Pages 130-143

  Zhao, Weiling ^a   Robbins, Mike E C ^a  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

Author keywords

Anti oxidants; Chronic oxidative stress; Inflammation; Ionizing radiation; Late normal tissue injury; Peroxisomal proliferator activated receptors; Reactive oxygen species; Renin angiotensin system

Indexed keywords

2 ETHYL 5,7 DIMETHYL 3 [4 [2 (2H TETRAZOL 5 YL)PHENYL]BENZYL]IMIDAZO[4,5 B]PYRIDINE; ALDOSTERONE; ALPHA TOCOPHEROL; ANGIOTENSIN 1 RECEPTOR ANTAGONIST; ANGIOTENSIN[1-7]; CATALASE; CLOFIBRATE; CYTOKINE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; GLUTATHIONE PEROXIDASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MALONALDEHYDE; MESALAZINE; PENTOXIFYLLINE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR AGONIST; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA AGONIST; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA AGONIST; PIOGLITAZONE; PIRINIXIC ACID; PRAVASTATIN; PROTEIN TYROSINE KINASE; RAMIPRIL; REACTIVE NITROGEN SPECIES; REACTIVE OXYGEN METABOLITE; SUPEROXIDE DISMUTASE; TUMOR NECROSIS FACTOR ALPHA; XANTHINE OXIDASE; ANTIOXIDANT; FREE RADICAL;

BRAIN INJURY; CELL SURVIVAL; COGNITIVE DEFECT; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DNA DAMAGE; DRUG EFFICACY; DRUG MECHANISM; ENTEROPATHY; FIBROSIS; HEART VENTRICLE HYPERTROPHY; HOMEOSTASIS; HUMAN; HYPERLIPIDEMIA; HYPERTENSION; INFLAMMATION; INTESTINAL FIBROSIS; IONIZING RADIATION; KIDNEY DISEASE; LIPID PEROXIDATION; LONG TERM CARE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OXIDATIVE STRESS; PATHOGENESIS; QUALITY OF LIFE; RADIATION INDUCED LATE NORMAL TISSUE INJURY; RADIATION INJURY; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; REVIEW; RISK REDUCTION; SIGNAL TRANSDUCTION; SKIN FIBROSIS; SURVIVAL RATE; CENTRAL NERVOUS SYSTEM DISEASE; CHRONIC DISEASE; METABOLISM; NEOPLASM; PHYSIOLOGY; RADIATION EXPOSURE;

ANTIOXIDANTS; CENTRAL NERVOUS SYSTEM DISEASES; CHRONIC DISEASE; FREE RADICALS; HUMANS; INFLAMMATION; NEOPLASMS; OXIDATIVE STRESS; RADIATION INJURIES; RADIATION, IONIZING; REACTIVE NITROGEN SPECIES; REACTIVE OXYGEN SPECIES; RENIN-ANGIOTENSIN SYSTEM;

EID: 62349118232     PISSN: 09298673     EISSN: None     Source Type: Journal    
DOI: 10.2174/092986709787002790     Document Type: Review

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