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Volumn 10, Issue 23, 1996, Pages 3065-3075

The absence of p21(Cip1/WAF1) alters keratinocyte growth and differentiation and promotes ras-tumor progression

Author keywords

CDK inhibitors; Cell cycle; ras oncogene; tumor suppression

Indexed keywords

CYCLIN DEPENDENT KINASE; PROTEIN KINASE INHIBITOR; PROTEIN P21; PROTEIN P27; CALCIUM; CDKN1A PROTEIN, MOUSE; CYCLIN DEPENDENT KINASE INHIBITOR 1A; CYCLINE; TRANSFORMING GROWTH FACTOR BETA;

EID: 0029658030     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.10.23.3065     Document Type: Article
Times cited : (289)

References (57)
  • 1
    • 0029147796 scopus 로고
    • Transforming growth factor β 1 inhibits mouse keratinocytes late in G1 independent of effects on gene transcription
    • Alexandrow, M.G. and H.L. Moses. 1995. Transforming growth factor β 1 inhibits mouse keratinocytes late in G1 independent of effects on gene transcription. Cancer Res. 55: 3928-3932.
    • (1995) Cancer Res. , vol.55 , pp. 3928-3932
    • Alexandrow, M.G.1    Moses, H.L.2
  • 2
    • 0027406396 scopus 로고
    • Different levels of v-Ha-Ras-p21 expression in primary keratinocytes transformed with Harvey sarcoma virus correlate with benign versus malignant behavior
    • Brissette, J., C. Missero, S.H. Yuspa, and G.P. Dotto . 1992. Different levels of v-Ha-Ras-p21 expression in primary keratinocytes transformed with Harvey sarcoma virus correlate with benign versus malignant behavior. Mol Carcinogenesis 7: 21-25.
    • (1992) Mol Carcinogenesis , vol.7 , pp. 21-25
    • Brissette, J.1    Missero, C.2    Yuspa, S.H.3    Dotto, G.P.4
  • 4
    • 0029079944 scopus 로고
    • Fyn tyrosine kinase is involved in keratinocyte differentiation control
    • Calautti, E., C. Missero, P.L. Stein, R.M. Ezzell, and G.P. Dotto. 1995. Fyn tyrosine kinase is involved in keratinocyte differentiation control. Genes & Dev. 9: 2279-2291.
    • (1995) Genes & Dev. , vol.9 , pp. 2279-2291
    • Calautti, E.1    Missero, C.2    Stein, P.L.3    Ezzell, R.M.4    Dotto, G.P.5
  • 5
    • 0028899480 scopus 로고
    • Separate domains of p21 involved in the inhibition of Cdk kinase and PCNA
    • Chen, I., P. Jackson, M. Kirschner, and A. Dutta. 1995. Separate domains of p21 involved in the inhibition of Cdk kinase and PCNA. Nature 374: 386-388.
    • (1995) Nature , vol.374 , pp. 386-388
    • Chen, I.1    Jackson, P.2    Kirschner, M.3    Dutta, A.4
  • 6
    • 0029315510 scopus 로고
    • Tumor suppressors, kinases and clamps: How p53 regulates the cell cycle in response to DNA damage
    • Cox, L.S. and D.P. Lane. 1995. Tumor suppressors, kinases and clamps: How p53 regulates the cell cycle in response to DNA damage. BioEssays 17: 501-508.
    • (1995) BioEssays , vol.17 , pp. 501-508
    • Cox, L.S.1    Lane, D.P.2
  • 7
    • 0028978183 scopus 로고
    • CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control
    • CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control. Cell 82: 675-684.
    • (1995) Cell , vol.82 , pp. 675-684
    • Deng, C.1    Zhang, P.2    Harper, J.3    Elledge, S.4    Leder, P.5
  • 8
    • 0027514311 scopus 로고
    • Coordinate changes in gene expression which mark the spinous to granular cell transition in epidermis are regulated by protein kinase C
    • Dlugosz, A.A. and S.H. Yuspa. 1993. Coordinate changes in gene expression which mark the spinous to granular cell transition in epidermis are regulated by protein kinase C. J. Cell Biol. 120: 217-225.
    • (1993) J. Cell Biol. , vol.120 , pp. 217-225
    • Dlugosz, A.A.1    Yuspa, S.H.2
  • 10
    • 0022368305 scopus 로고
    • Specific growth response of ras-transformed embryo fibroblasts to tumor promoters
    • Dotto, G.P., L.F. Parada, and R.A. Weinberg. 1985. Specific growth response of ras-transformed embryo fibroblasts to tumor promoters. Nature 318: 472-475.
    • (1985) Nature , vol.318 , pp. 472-475
    • Dotto, G.P.1    Parada, L.F.2    Weinberg, R.A.3
  • 11
    • 0009745229 scopus 로고
    • Malignant transformation of mouse primary keratinocytes by HaSV and its modulation by surrounding normal cells
    • Dotto, G.P., R.A. Weinberg, and A. Ariza. 1988. Malignant transformation of mouse primary keratinocytes by HaSV and its modulation by surrounding normal cells. Proc. Natl. Acad. Sci. 85: 6389-6393.
    • (1988) Proc. Natl. Acad. Sci. , vol.85 , pp. 6389-6393
    • Dotto, G.P.1    Weinberg, R.A.2    Ariza, A.3
  • 12
    • 0026698263 scopus 로고
    • Association of human cyclin E with a periodic G1-S phase protein kinase
    • Dulic, V., E. Lees, and S.I. Reed. 1992. Association of human cyclin E with a periodic G1-S phase protein kinase. Science 257: 1958-1961.
    • (1992) Science , vol.257 , pp. 1958-1961
    • Dulic, V.1    Lees, E.2    Reed, S.I.3
  • 15
    • 0027731971 scopus 로고
    • Inhibition of CDK2 activity in vivo by an associated 20KD regulatory subunit
    • Gu, Y., C.W. Turek, and D.O. Morgan. 1993. Inhibition of CDK2 activity in vivo by an associated 20KD regulatory subunit. Nature 366: 707-710.
    • (1993) Nature , vol.366 , pp. 707-710
    • Gu, Y.1    Turek, C.W.2    Morgan, D.O.3
  • 16
    • 0028941483 scopus 로고
    • Correlation of terminal cell cycle arrest of skeletal muscle with induction of p21 by MyoD
    • Halevy, O., B. Novitch, D. Spicer, S. Skapek, J. Rhee, G. Hannon, D. Beach, and A. Lassar. 1995. Correlation of terminal cell cycle arrest of skeletal muscle with induction of p21 by MyoD. Science 267: 1018-1021.
    • (1995) Science , vol.267 , pp. 1018-1021
    • Halevy, O.1    Novitch, B.2    Spicer, D.3    Skapek, S.4    Rhee, J.5    Hannon, G.6    Beach, D.7    Lassar, A.8
  • 17
    • 0027496935 scopus 로고
    • The p21 cdk-interacting protein Cip1 is a potent inhibitor of Gl cyclin-dependent kinases
    • Harper, J.W., G.R. Adami, N. Wei, K. Keyomarsi, and S.J. Elledge. 1993. The p21 cdk-interacting protein Cip1 is a potent inhibitor of Gl cyclin-dependent kinases. Cell 75: 805-816.
    • (1993) Cell , vol.75 , pp. 805-816
    • Harper, J.W.1    Adami, G.R.2    Wei, N.3    Keyomarsi, K.4    Elledge, S.J.5
  • 18
    • 0018865014 scopus 로고
    • Calcium regulation of growth and differentiation of mouse epidermal cells in culture
    • Hennings, H., D. Michael, C. Cheng, P. Steinert, K. Holbrook, and S.H. Yuspa. 1980. Calcium regulation of growth and differentiation of mouse epidermal cells in culture. Cell 19: 245-254.
    • (1980) Cell , vol.19 , pp. 245-254
    • Hennings, H.1    Michael, D.2    Cheng, C.3    Steinert, P.4    Holbrook, K.5    Yuspa, S.H.6
  • 21
    • 0027987170 scopus 로고
    • Induction of differentiation in human promyelocytic HL-60 leukemia cells activates p21, WAF1/C1P1, expression in the absence of p53
    • Jiang, H., J. Lin, S. Zao-zhong, F. Collart, E. Huberman, and P. Fisher. 1994. Induction of differentiation in human promyelocytic HL-60 leukemia cells activates p21, WAF1/C1P1, expression in the absence of p53. Oncogens 9: 3397-3406.
    • (1994) Oncogens , vol.9 , pp. 3397-3406
    • Jiang, H.1    Lin, J.2    Zao-zhong, S.3    Collart, F.4    Huberman, E.5    Fisher, P.6
  • 22
    • 0029031949 scopus 로고
    • The melanoma differentiation-associated gene mda-6, which encodes the cyclin-dependent kinase inhibitor p21, is differentially expressed during growth, differentiation and progression in human melanoma cells
    • Jiang, H., J. Lin, S. Zao-zhong, M. Herlyn, R. Kerbel, B. Weiss- man, D. Welch, and P. Fisher. 1995. The melanoma differentiation-associated gene mda-6, which encodes the cyclin-dependent kinase inhibitor p21, is differentially expressed during growth, differentiation and progression in human melanoma cells. Oncogene 11: 1855-1864.
    • (1995) Oncogene , vol.11 , pp. 1855-1864
    • Jiang, H.1    Lin, J.2    Zao-zhong, S.3    Herlyn, M.4    Kerbel, R.5    Man, B.6    Welch, D.7    Fisher, P.8
  • 24
    • 0027203921 scopus 로고
    • Reduction of p53 gene dosage does not increase initiation or promotion but enhances malignant progression of chemically induced skin tumors
    • Kemp, C.J., L.A. Donehower, A. Bradley, and A. Balmain. 1993. Reduction of p53 gene dosage does not increase initiation or promotion but enhances malignant progression of chemically induced skin tumors. Cell 74: 813-822.
    • (1993) Cell , vol.74 , pp. 813-822
    • Kemp, C.J.1    Donehower, L.A.2    Bradley, A.3    Balmain, A.4
  • 26
    • 0029133503 scopus 로고
    • Inhibition of cyclin-dependent kinase activity triggers neuronal differentiation of mouse neuroblastoma cells
    • Kranenburg, O., V. Scharnhorst, A. Van der Eb, and A. Zantema. 1995. Inhibition of cyclin-dependent kinase activity triggers neuronal differentiation of mouse neuroblastoma cells. J. Cell Biol. 131: 227-234.
    • (1995) J. Cell Biol. , vol.131 , pp. 227-234
    • Kranenburg, O.1    Scharnhorst, V.2    Van der Eb, A.3    Zantema, A.4
  • 27
  • 28
    • 0028074603 scopus 로고
    • Differential effects by the p21 CDK inhibitor on PCNA dependent DNA replication and repair
    • Li, R., S. Waga, G.J. Hannon, D. Beach, and B. Stillman. 1994. Differential effects by the p21 CDK inhibitor on PCNA dependent DNA replication and repair. Nature 371: 534-537.
    • (1994) Nature , vol.371 , pp. 534-537
    • Li, R.1    Waga, S.2    Hannon, G.J.3    Beach, D.4    Stillman, B.5
  • 31
    • 0025222517 scopus 로고
    • The transforming growth factor-β family
    • Massaguè, J. 1990. The transforming growth factor-β family. Annu. Rev. Cell Biol. 6: 597-641.
    • (1990) Annu. Rev. Cell Biol. , vol.6 , pp. 597-641
    • Massaguè, J.1
  • 32
    • 0028176483 scopus 로고
    • Cloning of p27 KIP1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals
    • Massaguè, J., K. Polyak, M.H. Lee, H. Erdjument-Bromage, A. Koff, J.M. Roberts, and P. Tempst. 1994. Cloning of p27 KIP1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals. Cell 78: 59-66.
    • (1994) Cell , vol.78 , pp. 59-66
    • Massaguè, J.1    Polyak, K.2    Lee, M.H.3    Erdjument-Bromage, H.4    Koff, A.5    Roberts, J.M.6    Tempst, P.7
  • 33
    • 0344727060 scopus 로고    scopus 로고
    • WAF1/Cip1 and terminal differentiation control of normal epithelia
    • WAF1/Cip1 and terminal differentiation control of normal epithelia. Mol. Cell. Diff. 4: 1-16.
    • (1996) Mol. Cell. Diff. , vol.4 , pp. 1-16
    • Missero, C.1    Dotto, G.P.2
  • 34
    • 0026004630 scopus 로고
    • Escape from TGF-β control and oncogene cooperation in skin tumor development
    • Missero, C., S. Ramon y Cajal, and G.P. Dotto. 1991. Escape from TGF-β control and oncogene cooperation in skin tumor development. Proc. Natl. Acad. Sci. 88: 9613-9617.
    • (1991) Proc. Natl. Acad. Sci. , vol.88 , pp. 9613-9617
    • Missero, C.1    Ramon Y Cajal, S.2    Dotto, G.P.3
  • 35
    • 0029020945 scopus 로고
    • Involvement of the cell cycle inhibitor Cip1 /WAF1 and the EIa-associated p300 protein in terminal differentiation
    • Missero,C., E. Calautti, R. Eckner, J. Chin, L.-H. Tsai, D.M. Livingston, and G.P. Dotto. 1995. Involvement of the cell cycle inhibitor Cip1 /WAF1 and the EIa-associated p300 protein in terminal differentiation. Proc. Natl. Acad. Sci. 92: 5451-5455.
    • (1995) Proc. Natl. Acad. Sci. , vol.92 , pp. 5451-5455
    • Missero, C.1    Calautti, E.2    Eckner, R.3    Chin, J.4    Tsai, L.-H.5    Livingston, D.M.6    Dotto, G.P.7
  • 37
    • 0028342664 scopus 로고
    • Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen
    • Noda, A., Y. Ning, S.F. Venable, O.M. Pereira-Smith, and J.R. Smith. 1994. Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen. Exp. Cell Res. 211: 90-98.
    • (1994) Exp. Cell Res. , vol.211 , pp. 90-98
    • Noda, A.1    Ning, Y.2    Venable, S.F.3    Pereira-Smith, O.M.4    Smith, J.R.5
  • 39
    • 0023101785 scopus 로고
    • Efficient retrovirus-mediated transfer and expression of a human adenosine deaminase gene in diploid skin fibroblasts from an adenosine deaminase-deficient human
    • Palmer, T.D., R.A. Hock, R.A. Osborne, and A.D. Miller. 1987. Efficient retrovirus-mediated transfer and expression of a human adenosine deaminase gene in diploid skin fibroblasts from an adenosine deaminase-deficient human. Proc. Natl. Acad. Sci. 84: 1055-1059.
    • (1987) Proc. Natl. Acad. Sci. , vol.84 , pp. 1055-1059
    • Palmer, T.D.1    Hock, R.A.2    Osborne, R.A.3    Miller, A.D.4
  • 40
    • 0024473604 scopus 로고
    • G1 events and regulation of cell proliferation
    • Pardee, A.B. 1989. G1 events and regulation of cell proliferation. Science 246: 603-608.
    • (1989) Science , vol.246 , pp. 603-608
    • Pardee, A.B.1
  • 43
    • 85046112695 scopus 로고
    • Kip/Cip and INK4 CDK inhibitors cooperate to induce cell cycle arrest in response to TGF-β
    • Reynisdottir, R., K. Polyak, A. Lavarone, and J. Massaguè. 1995. Kip/Cip and INK4 CDK inhibitors cooperate to induce cell cycle arrest in response to TGF-β. Genes & Dev. 9: 1149-1163.
    • (1995) Genes & Dev. , vol.9 , pp. 1149-1163
    • Reynisdottir, R.1    Polyak, K.2    Lavarone, A.3    Massaguè, J.4
  • 46
    • 0028171292 scopus 로고
    • G1 phase progression: Cycling on Cue
    • Sherr, C.J. 1994. G1 phase progression: Cycling on Cue. Cell 79:551-555.
    • (1994) Cell , vol.79 , pp. 551-555
    • Sherr, C.J.1
  • 48
    • 0029957019 scopus 로고    scopus 로고
    • A nonenzymatic p21 protein inhibitor of stress-activated protein kinases
    • Shim, J., H. Lee, J. Park, H. Kim, and E.-J. Choi. 1996. A nonenzymatic p21 protein inhibitor of stress-activated protein kinases. Nature 381: 804-807.
    • (1996) Nature , vol.381 , pp. 804-807
    • Shim, J.1    Lee, H.2    Park, J.3    Kim, H.4    Choi, E.-J.5
  • 49
    • 0028675510 scopus 로고
    • Cip1 inhibits DNA replication but not PCNA-dependent nucleotide excision-repair
    • Shivji, M.K.K., S.J. Grey, U.P. Strausfeld, R.D. Wood, and J.J. Blow. 1994. Cip1 inhibits DNA replication but not PCNA-dependent nucleotide excision-repair. Curr. Biol. 4: 1062-1068.
    • (1994) Curr. Biol. , vol.4 , pp. 1062-1068
    • Shivji, M.K.K.1    Grey, S.J.2    Strausfeld, U.P.3    Wood, R.D.4    Blow, J.J.5
  • 51
    • 0028352434 scopus 로고
    • The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA
    • Waga, S., G.J. Hannon, D. Beach, and B. Stillman. 1994. The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA. Nature 369: 574-578.
    • (1994) Nature , vol.369 , pp. 574-578
    • Waga, S.1    Hannon, G.J.2    Beach, D.3    Stillman, B.4
  • 52
    • 0027968207 scopus 로고
    • Extensive contribution of Rb-deficient cells to adult chimeric mice with limited histopathological consequences
    • Weinberg, R.A. and T. Jacks. 1994. Extensive contribution of Rb-deficient cells to adult chimeric mice with limited histopathological consequences. EMBO J. 13: 4251-4259.
    • (1994) EMBO J. , vol.13 , pp. 4251-4259
    • Weinberg, R.A.1    Jacks, T.2
  • 54
    • 0027968207 scopus 로고
    • Extensive contribution of Rb-deficient cells to adult chimeric mice with limited histopathological consequences
    • Williams, B.O., E.M. Schmitt, L. Remington, R.T. Bronson, D.M. Albert, R.A. Weinberg, and T. Jacks. 1994. Extensive contribution of Rb-deficient cells to adult chimeric mice with limited histopathological consequences. EMBO J. 13: 4251-4259.
    • (1994) EMBO J. , vol.13 , pp. 4251-4259
    • Williams, B.O.1    Schmitt, E.M.2    Remington, L.3    Bronson, R.T.4    Albert, D.M.5    Weinberg, R.A.6    Jacks, T.7
  • 56
    • 0028820762 scopus 로고
    • The p21 cyclin-dependent kinase inhibitor suppresses tumorigencity in vivo
    • Yang, Z.Y., N.D. Perkins, T. Ohno, E.G. Nabel, and G.J. Nabel. 1995. The p21 cyclin-dependent kinase inhibitor suppresses tumorigencity in vivo. Nature Med. 1: 1052-1056.
    • (1995) Nature Med. , vol.1 , pp. 1052-1056
    • Yang, Z.Y.1    Perkins, N.D.2    Ohno, T.3    Nabel, E.G.4    Nabel, G.J.5
  • 57
    • 0028983384 scopus 로고
    • CIP1-related domain to bind cyclin/cdk2 and regulate interactions with E2F
    • CIP1-related domain to bind cyclin/cdk2 and regulate interactions with E2F. Genes &. Dev. 9: 1740-1752.
    • (1995) Genes &. Dev. , vol.9 , pp. 1740-1752
    • Zhu, L.1    Harlow, E.2    Dynlacht, B.D.3


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