Biologic factors and response to radiotherapy in carcinoma of the cervix

International Journal of Gynecological Cancer

Volumn 11, Issue 3, 2001, Pages 187-193

  Mukherjee, Geetashree ^a   Freeman, A ^c   Moore, R ^b   Kumaraswamy, ^a   Devi, K Uma ^a   Morris, L S ^c   Coleman, N ^c   Dilworth, S ^d   Prabhakaran, P S ^a   Stanley, M A ^b  

^a KIDWAI MEMORIAL INSTITUTE OF ONCOLOGY   (India)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c ADDENBROOKE S HOSPITAL   (United Kingdom)

^d HAMMERSMITH HOSPITAL   (United Kingdom)

Author keywords

Bax protein; Bcl 2 protein; Immunohistochemistry; p53; Uterine cervix

Indexed keywords

BIOLOGICAL FACTOR; MINICHROMOSOME MAINTENANCE PROTEIN 2; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P21; PROTEIN P53; TUMOR MARKER; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CANCER RADIOTHERAPY; CANCER STAGING; CANCER SURGERY; CELL CYCLE; CONTROLLED STUDY; DNA DAMAGE; DNA REPAIR; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IONIZING RADIATION; MAJOR CLINICAL STUDY; MINICHROMOSOME; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; RADIATION DOSE; RADIATION RESPONSE; RADIOSENSITIVITY; TREATMENT OUTCOME; TUMOR CELL; TUMOR GROWTH; UTERINE CERVIX CARCINOMA;

BCL-2-ASSOCIATED X PROTEIN; CARCINOMA, SQUAMOUS CELL; CARRIER PROTEINS; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; MEDICAL RECORDS; NUCLEAR PROTEINS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; RETROSPECTIVE STUDIES; RHO GTP-BINDING PROTEINS; TUMOR MARKERS, BIOLOGICAL; TUMOR SUPPRESSOR PROTEIN P53; UTERINE CERVICAL NEOPLASMS;

EID: 0034932440     PISSN: 1048891X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1525-1438.2001.01014.x     Document Type: Article

References (44)

1. Strategies for global control of cervical cancer
2. Radiation therapy of cervical cancer: New developments
3. Radiosensitivity and the cell cycle
4. Modulation of the apoptotic response: Potential for improving the outcome in clinical radiotherapy
5. Demonstration of DNA damage / repair in individual cells using in situ end labelling: Association of p53 with sites of DNA damage
6. Molecular controls of growth arrest and apoptosis: p53 - Dependent and independent pathways
7. WAFI, a potential mediator of p53 tumor suppression
8. The p21 cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases
9. WAFI/CIPI is induced in p53-mediated GI arrest and apoptosis
10. The p21 inhibitor of cyclin-dependent kinase controls DNA replication by interaction with PCNA
11. Radiation - Mediated gene expression in the pathogenesis of the clinical radiation response
12. Programmed cell death: Apoptosis and oncogenesis
13. Molecular regulation of apoptosis: Genetic controls on cell death
14. Initiation of DNA replication in eukaryotic cells
15. Properties of the nuclear P1 protein, a mammalian homologue of the yeast Mcm 3 replication protein
16. MCM proteins: Evolution, properties and role in DNA replication
17. Mechanisms restricting DNA replication to once per cell cycle: The role of Cdc 6 and ORC
18. Putting it all together: Building a prereplicative complex
19. XMcm 7, a novel member of the Xenopus Mcm family, interacts with XMcm 3 and co-localises with it throughout replication
20. Bcl-2 and p53 oncoprotein expression during colorectal tumorigenesis
21. P-glycoprotein is not expressed in a majority of colorectal carcinomas and is not regulated by mutant p53 in vivo
22. Immunohistochemical analysis of in vivo patterns of Bcl-X expression
23. Differential expression of bcl-2 in intestinal epithelia. Correlation with attenuation of apoptosis in colonic crypts and the incidence of colonic neoplasia
24. Apoptosis and expression of Bax, Bcl-x, and Bcl-2 apoptotic regulatory proteins in colorectal carcinomas, and associations with p53 genotype/phenotype
25. Bax and bcl-2 expressions predict response to radiotheraphy in human cervical cancer
26. Bax protein expression correlate with radiation-induced apoptosis in radiation therapy for cervical carcinoma
27. Potential molecular targets for manipulating the radiation response
28. Prognostic significance of the bcl-2 apoptotic family of proteins in primary and recurrent cervical cancer
29. Apoptosis: Its significance in cancer and cancer therapy
30. Apoptosis as a predictor of response to radiotherapy in cervical carcinoma
31. Improved cervical smear assessment using antibodies against proteins that regulate DNA replication
32. Cdc6 protein causes premature entry into S phase in a mammalian cell-free system
33. Apoptosis as a therapeutic target
34. Expression of bcl-2 in invasive and in situ carcinoma of the uterine cervix
35. Relationship between p21/WAF-1/CIP-1 and apoptosis in cervical cancer durning radiation therapy
36. Molecular biology of the cell cycle: Potential for therapeutic applications in radiation oncology
37. Tumor proliferation, p53 expression, and apoptosis in laryngeal carcinoma: Relation to the results of radiotherapy
38. The p53 pathway
39. Overexpression of p53 protein and its relation to HPV in squamous intraepithelial lesion and cervical carcinoma
40. p53 gene status in endometrial carcinomas showing diffuse positivity for p53 protein by immunohistochemical analysis
41. Interference of proteins involved in the cytoplasmic sequestration of p53 with human papillomavirus E6-mediated degradation
42. Changes in the physical state and expression of human papillomavirus type 16 in the progression of cervical intraepithelial neoplasia lesions analysed by PCR
43. P53 in tumor pathology: Can we trust immunohistochemistry? - Revisited!
44. p53 polymorphism and risk of cervical cancer