-
1
-
-
78449269612
-
Molecular motors in neurons: transport mechanisms and roles in brain function, development, and disease
-
Hirokawa N., et al. Molecular motors in neurons: transport mechanisms and roles in brain function, development, and disease. Neuron 2010, 68:610-638.
-
(2010)
Neuron
, vol.68
, pp. 610-638
-
-
Hirokawa, N.1
-
2
-
-
84875443717
-
Axonal transport deficits and neurodegenerative diseases
-
Millecamps S., Julien J-P. Axonal transport deficits and neurodegenerative diseases. Nat. Rev. Neurosci. 2013, 14:161-176.
-
(2013)
Nat. Rev. Neurosci.
, vol.14
, pp. 161-176
-
-
Millecamps, S.1
Julien, J.-P.2
-
3
-
-
0035369084
-
Charcot-Marie-Tooth disease type 2A caused by mutation in a microtubule motor KIF1Bbeta
-
Zhao C., et al. Charcot-Marie-Tooth disease type 2A caused by mutation in a microtubule motor KIF1Bbeta. Cell 2001, 105:587-597.
-
(2001)
Cell
, vol.105
, pp. 587-597
-
-
Zhao, C.1
-
4
-
-
18644365196
-
A kinesin heavy chain (KIF5A) mutation in hereditary spastic paraplegia (SPG10)
-
Reid E., et al. A kinesin heavy chain (KIF5A) mutation in hereditary spastic paraplegia (SPG10). Am. J. Hum. Genet. 2002, 71:1189-1194.
-
(2002)
Am. J. Hum. Genet.
, vol.71
, pp. 1189-1194
-
-
Reid, E.1
-
5
-
-
42449095555
-
Effect of spastic paraplegia mutations in KIF5A kinesin on transport activity
-
Ebbing B., et al. Effect of spastic paraplegia mutations in KIF5A kinesin on transport activity. Hum. Mol. Genet. 2008, 17:1245-1252.
-
(2008)
Hum. Mol. Genet.
, vol.17
, pp. 1245-1252
-
-
Ebbing, B.1
-
6
-
-
73549083820
-
Delivery of GABAARs to synapses is mediated by HAP1-KIF5 and disrupted by mutant huntingtin
-
Twelvetrees A.E., et al. Delivery of GABAARs to synapses is mediated by HAP1-KIF5 and disrupted by mutant huntingtin. Neuron 2010, 65:53-65.
-
(2010)
Neuron
, vol.65
, pp. 53-65
-
-
Twelvetrees, A.E.1
-
7
-
-
84861183934
-
KIF1A missense mutations in SPG30, an autosomal recessive spastic paraplegia: distinct phenotypes according to the nature of the mutations
-
Klebe S., et al. KIF1A missense mutations in SPG30, an autosomal recessive spastic paraplegia: distinct phenotypes according to the nature of the mutations. Eur. J. Hum. Genet. 2012, 20:645-649.
-
(2012)
Eur. J. Hum. Genet.
, vol.20
, pp. 645-649
-
-
Klebe, S.1
-
8
-
-
79955556527
-
Exome sequencing and disease-network analysis of a single family implicate a mutation in KIF1A in hereditary spastic paraparesis
-
Erlich Y., et al. Exome sequencing and disease-network analysis of a single family implicate a mutation in KIF1A in hereditary spastic paraparesis. Genome Res. 2011, 21:658-664.
-
(2011)
Genome Res.
, vol.21
, pp. 658-664
-
-
Erlich, Y.1
-
9
-
-
84861542834
-
Mutations in the tail domain of DYNC1H1 cause dominant spinal muscular atrophy
-
Harms M.B., et al. Mutations in the tail domain of DYNC1H1 cause dominant spinal muscular atrophy. Neurology 2012, 78:1714-1720.
-
(2012)
Neurology
, vol.78
, pp. 1714-1720
-
-
Harms, M.B.1
-
10
-
-
80051671416
-
Exome sequencing identifies a DYNC1H1 mutation in a large pedigree with dominant axonal Charcot-Marie-Tooth disease
-
Weedon M.N., et al. Exome sequencing identifies a DYNC1H1 mutation in a large pedigree with dominant axonal Charcot-Marie-Tooth disease. Am. J. Hum. Genet. 2011, 89:308-312.
-
(2011)
Am. J. Hum. Genet.
, vol.89
, pp. 308-312
-
-
Weedon, M.N.1
-
11
-
-
0037382240
-
Mutant dynactin in motor neuron disease
-
Puls I., et al. Mutant dynactin in motor neuron disease. Nat. Genet. 2003, 33:455-456.
-
(2003)
Nat. Genet.
, vol.33
, pp. 455-456
-
-
Puls, I.1
-
12
-
-
59149097039
-
DCTN1 mutations in Perry syndrome
-
Farrer M.J., et al. DCTN1 mutations in Perry syndrome. Nat. Genet. 2009, 41:163-165.
-
(2009)
Nat. Genet.
, vol.41
, pp. 163-165
-
-
Farrer, M.J.1
-
13
-
-
84860303904
-
The p150(Glued) CAP-Gly domain regulates initiation of retrograde transport at synaptic termini
-
Lloyd T.E., et al. The p150(Glued) CAP-Gly domain regulates initiation of retrograde transport at synaptic termini. Neuron 2012, 74:344-360.
-
(2012)
Neuron
, vol.74
, pp. 344-360
-
-
Lloyd, T.E.1
-
14
-
-
84860272533
-
Dynactin is required for transport initiation from the distal axon
-
Moughamian A.J., Holzbaur E.L.F. Dynactin is required for transport initiation from the distal axon. Neuron 2012, 74:331-343.
-
(2012)
Neuron
, vol.74
, pp. 331-343
-
-
Moughamian, A.J.1
Holzbaur, E.L.F.2
-
15
-
-
3142636768
-
Huntingtin controls neurotrophic support and survival of neurons by enhancing BDNF vesicular transport along microtubules
-
Gauthier L.R., et al. Huntingtin controls neurotrophic support and survival of neurons by enhancing BDNF vesicular transport along microtubules. Cell 2004, 118:127-138.
-
(2004)
Cell
, vol.118
, pp. 127-138
-
-
Gauthier, L.R.1
-
16
-
-
34547193908
-
Huntingtin facilitates dynein/dynactin-mediated vesicle transport
-
Caviston J.P., et al. Huntingtin facilitates dynein/dynactin-mediated vesicle transport. Proc. Natl. Acad. Sci. U.S.A. 2007, 104:10045-10050.
-
(2007)
Proc. Natl. Acad. Sci. U.S.A.
, vol.104
, pp. 10045-10050
-
-
Caviston, J.P.1
-
17
-
-
49149112606
-
Huntingtin phosphorylation acts as a molecular switch for anterograde/retrograde transport in neurons
-
Colin E., et al. Huntingtin phosphorylation acts as a molecular switch for anterograde/retrograde transport in neurons. EMBO J. 2008, 27:1-11.
-
(2008)
EMBO J.
, vol.27
, pp. 1-11
-
-
Colin, E.1
-
18
-
-
57049184027
-
Phosphorylation of mutant huntingtin at S421 restores anterograde and retrograde transport in neurons
-
Zala D., et al. Phosphorylation of mutant huntingtin at S421 restores anterograde and retrograde transport in neurons. Hum. Mol. Genet. 2008, 17:3837-3846.
-
(2008)
Hum. Mol. Genet.
, vol.17
, pp. 3837-3846
-
-
Zala, D.1
-
19
-
-
0141750470
-
Disruption of axonal transport by loss of huntingtin or expression of pathogenic polyQ proteins in Drosophila
-
Gunawardena S., et al. Disruption of axonal transport by loss of huntingtin or expression of pathogenic polyQ proteins in Drosophila. Neuron 2003, 40:25-40.
-
(2003)
Neuron
, vol.40
, pp. 25-40
-
-
Gunawardena, S.1
-
20
-
-
0032519646
-
Interaction of huntingtin-associated protein with dynactin P150Glued
-
Li S.H., et al. Interaction of huntingtin-associated protein with dynactin P150Glued. J. Neurosci. 1998, 18:1261-1269.
-
(1998)
J. Neurosci.
, vol.18
, pp. 1261-1269
-
-
Li, S.H.1
-
21
-
-
33645642673
-
Interaction of huntingtin-associated protein-1 with kinesin light chain: implications in intracellular trafficking in neurons
-
McGuire J.R., et al. Interaction of huntingtin-associated protein-1 with kinesin light chain: implications in intracellular trafficking in neurons. J. Biol. Chem. 2006, 150:3552-3559.
-
(2006)
J. Biol. Chem.
, vol.150
, pp. 3552-3559
-
-
McGuire, J.R.1
-
22
-
-
84855816126
-
Modification of Mecp2 dosage alters axonal transport through the huntingtin/Hap1 pathway
-
Roux J-C., et al. Modification of Mecp2 dosage alters axonal transport through the huntingtin/Hap1 pathway. Neurobiol. Dis. 2011, 45:786-795.
-
(2011)
Neurobiol. Dis.
, vol.45
, pp. 786-795
-
-
Roux, J.-C.1
-
23
-
-
77955436243
-
Huntingtin is required for mitotic spindle orientation and mammalian neurogenesis
-
Godin J.D., et al. Huntingtin is required for mitotic spindle orientation and mammalian neurogenesis. Neuron 2010, 67:392-406.
-
(2010)
Neuron
, vol.67
, pp. 392-406
-
-
Godin, J.D.1
-
24
-
-
80555136825
-
Ciliogenesis is regulated by a huntingtin-HAP1-PCM1 pathway and is altered in Huntington disease
-
Keryer G., et al. Ciliogenesis is regulated by a huntingtin-HAP1-PCM1 pathway and is altered in Huntington disease. J. Clin. Invest. 2011, 121:4372-4382.
-
(2011)
J. Clin. Invest.
, vol.121
, pp. 4372-4382
-
-
Keryer, G.1
-
25
-
-
53949113331
-
Action in the axon: generation and transport of signaling endosomes
-
Cosker K.E., et al. Action in the axon: generation and transport of signaling endosomes. Curr. Opin. Neurobiol. 2008, 18:270-275.
-
(2008)
Curr. Opin. Neurobiol.
, vol.18
, pp. 270-275
-
-
Cosker, K.E.1
-
26
-
-
0036083379
-
The IGF-1/Akt pathway is neuroprotective in Huntington's disease and involves Huntingtin phosphorylation by Akt
-
Humbert S., et al. The IGF-1/Akt pathway is neuroprotective in Huntington's disease and involves Huntingtin phosphorylation by Akt. Dev. Cell 2002, 2:831-837.
-
(2002)
Dev. Cell
, vol.2
, pp. 831-837
-
-
Humbert, S.1
-
27
-
-
84885478810
-
Genetic and pharmacological inhibition of calcineurin corrects the BDNF transport defect in Huntington's disease
-
Pineda J.R., et al. Genetic and pharmacological inhibition of calcineurin corrects the BDNF transport defect in Huntington's disease. Mol. Brain 2009, 11:1-11.
-
(2009)
Mol. Brain
, vol.11
, pp. 1-11
-
-
Pineda, J.R.1
-
28
-
-
33749620373
-
Rab5 and Rab7 control endocytic sorting along the axonal retrograde transport pathway
-
Deinhardt K., et al. Rab5 and Rab7 control endocytic sorting along the axonal retrograde transport pathway. Neuron 2006, 52:293-305.
-
(2006)
Neuron
, vol.52
, pp. 293-305
-
-
Deinhardt, K.1
-
29
-
-
0037371509
-
Mutations in the small GTPase late endosomal protein RAB7 cause Charcot-Marie-Tooth type 2B neuropathy
-
Verhoeven K., et al. Mutations in the small GTPase late endosomal protein RAB7 cause Charcot-Marie-Tooth type 2B neuropathy. Am. J. Hum. Genet. 2003, 72:722-727.
-
(2003)
Am. J. Hum. Genet.
, vol.72
, pp. 722-727
-
-
Verhoeven, K.1
-
30
-
-
84876555190
-
Defective axonal transport of Rab7 GTPase results in dysregulated trophic signaling
-
Zhang K., et al. Defective axonal transport of Rab7 GTPase results in dysregulated trophic signaling. J. Neurosci. 2013, 33:7451-7462.
-
(2013)
J. Neurosci.
, vol.33
, pp. 7451-7462
-
-
Zhang, K.1
-
31
-
-
77955272733
-
Tubulin post-translational modifications: encoding functions on the neuronal microtubule cytoskeleton
-
Janke C., Kneussel M. Tubulin post-translational modifications: encoding functions on the neuronal microtubule cytoskeleton. Trends Neurosci. 2010, 33:362-372.
-
(2010)
Trends Neurosci.
, vol.33
, pp. 362-372
-
-
Janke, C.1
Kneussel, M.2
-
32
-
-
39749165656
-
Differential regulation of dynein and kinesin motor proteins by tau
-
Dixit R., et al. Differential regulation of dynein and kinesin motor proteins by tau. Science 2008, 319:1086-1089.
-
(2008)
Science
, vol.319
, pp. 1086-1089
-
-
Dixit, R.1
-
33
-
-
7344220963
-
Segregation of a missense mutation in the microtubule-associated protein tau gene with familial frontotemporal dementia and parkinsonism
-
Dumanchin C., et al. Segregation of a missense mutation in the microtubule-associated protein tau gene with familial frontotemporal dementia and parkinsonism. Hum. Mol. Genet. 1998, 7:1825-1829.
-
(1998)
Hum. Mol. Genet.
, vol.7
, pp. 1825-1829
-
-
Dumanchin, C.1
-
34
-
-
2442642836
-
Retarded axonal transport of R406W mutant tau in transgenic mice with a neurodegenerative tauopathy
-
Zhang B., et al. Retarded axonal transport of R406W mutant tau in transgenic mice with a neurodegenerative tauopathy. J. Neurosci. 2004, 24:4657-4667.
-
(2004)
J. Neurosci.
, vol.24
, pp. 4657-4667
-
-
Zhang, B.1
-
35
-
-
0029998294
-
Cellular phosphorylation of tau by GSK-3 beta influences tau binding to microtubules and microtubule organisation
-
Wagner U., et al. Cellular phosphorylation of tau by GSK-3 beta influences tau binding to microtubules and microtubule organisation. J. Cell Sci. 1996, 109:1537-1543.
-
(1996)
J. Cell Sci.
, vol.109
, pp. 1537-1543
-
-
Wagner, U.1
-
36
-
-
84859348885
-
Reduced axonal transport and increased excitotoxic retinal ganglion cell degeneration in mice transgenic for human mutant P301S tau
-
Bull N.D., et al. Reduced axonal transport and increased excitotoxic retinal ganglion cell degeneration in mice transgenic for human mutant P301S tau. PLoS ONE 2012, 7:e34724.
-
(2012)
PLoS ONE
, vol.7
-
-
Bull, N.D.1
-
37
-
-
84857073309
-
Regulation of mitochondrial transport and inter-microtubule spacing by tau phosphorylation at the sites hyperphosphorylated in Alzheimer's disease
-
Shahpasand K., et al. Regulation of mitochondrial transport and inter-microtubule spacing by tau phosphorylation at the sites hyperphosphorylated in Alzheimer's disease. J. Neurosci. 2012, 32:2430-2441.
-
(2012)
J. Neurosci.
, vol.32
, pp. 2430-2441
-
-
Shahpasand, K.1
-
38
-
-
0032721512
-
Spastin, a new AAA protein, is altered in the most frequent form of autosomal dominant spastic paraplegia
-
Hazan J., et al. Spastin, a new AAA protein, is altered in the most frequent form of autosomal dominant spastic paraplegia. Nat. Genet. 1999, 23:296-303.
-
(1999)
Nat. Genet.
, vol.23
, pp. 296-303
-
-
Hazan, J.1
-
39
-
-
78650415043
-
Hereditary spastic paraplegias: membrane traffic and the motor pathway
-
Blackstone C., et al. Hereditary spastic paraplegias: membrane traffic and the motor pathway. Nat. Rev. Neurosci. 2011, 12:31-42.
-
(2011)
Nat. Rev. Neurosci.
, vol.12
, pp. 31-42
-
-
Blackstone, C.1
-
40
-
-
84875679362
-
Mitochondria targeted therapeutic approaches in Parkinson's and Huntington's diseases
-
Chaturvedi R.K., Beal M.F. Mitochondria targeted therapeutic approaches in Parkinson's and Huntington's diseases. Mol. Cell. Neurosci. 2013, 55:101-114.
-
(2013)
Mol. Cell. Neurosci.
, vol.55
, pp. 101-114
-
-
Chaturvedi, R.K.1
Beal, M.F.2
-
41
-
-
84873323723
-
Vesicular glycolysis provides on-board energy for fast axonal transport
-
Zala D., et al. Vesicular glycolysis provides on-board energy for fast axonal transport. Cell 2013, 152:479-491.
-
(2013)
Cell
, vol.152
, pp. 479-491
-
-
Zala, D.1
-
42
-
-
84875267467
-
A new locus for X-linked dominant Charcot-Marie-Tooth disease (CMTX6) is caused by mutations in the pyruvate dehydrogenase kinase isoenzyme 3 (PDK3) gene
-
Kennerson M.L., et al. A new locus for X-linked dominant Charcot-Marie-Tooth disease (CMTX6) is caused by mutations in the pyruvate dehydrogenase kinase isoenzyme 3 (PDK3) gene. Hum. Mol. Genet. 2013, 22:1404-1416.
-
(2013)
Hum. Mol. Genet.
, vol.22
, pp. 1404-1416
-
-
Kennerson, M.L.1
-
43
-
-
84870888232
-
A nonsense mutation in DHTKD1 causes Charcot-Marie-Tooth disease type 2 in a large Chinese pedigree
-
Xu W-Y., et al. A nonsense mutation in DHTKD1 causes Charcot-Marie-Tooth disease type 2 in a large Chinese pedigree. Am. J. Hum. Genet. 2012, 91:1088-1094.
-
(2012)
Am. J. Hum. Genet.
, vol.91
, pp. 1088-1094
-
-
Xu, W.-Y.1
-
44
-
-
0036469290
-
Glycogen synthase kinase 3 phosphorylates kinesin light chains and negatively regulates kinesin-based motility
-
Morfini G., et al. Glycogen synthase kinase 3 phosphorylates kinesin light chains and negatively regulates kinesin-based motility. EMBO J. 2002, 21:281-293.
-
(2002)
EMBO J.
, vol.21
, pp. 281-293
-
-
Morfini, G.1
-
45
-
-
84859205994
-
Casein kinase 2 reverses tail-independent inactivation of kinesin-1
-
Xu J., et al. Casein kinase 2 reverses tail-independent inactivation of kinesin-1. Nat. Commun. 2012, 3:754.
-
(2012)
Nat. Commun.
, vol.3
, pp. 754
-
-
Xu, J.1
-
46
-
-
84859604514
-
Phosphorylation-regulated axonal dependent transport of syntaxin 1 is mediated by a kinesin-1 adapter
-
Chua J.J.E., et al. Phosphorylation-regulated axonal dependent transport of syntaxin 1 is mediated by a kinesin-1 adapter. Proc. Natl. Acad. Sci. U.S.A. 2012, 109:5862-5867.
-
(2012)
Proc. Natl. Acad. Sci. U.S.A.
, vol.109
, pp. 5862-5867
-
-
Chua, J.J.E.1
-
47
-
-
84859607330
-
Lemur tyrosine kinase-2 signalling regulates kinesin-1 light chain-2 phosphorylation and binding of Smad2 cargo
-
Manser C., et al. Lemur tyrosine kinase-2 signalling regulates kinesin-1 light chain-2 phosphorylation and binding of Smad2 cargo. Oncogene 2012, 31:2773-2782.
-
(2012)
Oncogene
, vol.31
, pp. 2773-2782
-
-
Manser, C.1
-
48
-
-
79953141458
-
Phosphorylation of kinesin light chain 1 at serine 460 modulates binding and trafficking of calsyntenin-1
-
Vagnoni A., et al. Phosphorylation of kinesin light chain 1 at serine 460 modulates binding and trafficking of calsyntenin-1. J. Cell Sci. 2011, 124:1032-1042.
-
(2011)
J. Cell Sci.
, vol.124
, pp. 1032-1042
-
-
Vagnoni, A.1
-
49
-
-
37749000849
-
Disruption of KIF17-Mint1 interaction by CaMKII-dependent phosphorylation: a molecular model of kinesin-cargo release
-
Guillaud L., et al. Disruption of KIF17-Mint1 interaction by CaMKII-dependent phosphorylation: a molecular model of kinesin-cargo release. Nat. Cell Biol. 2008, 10:19-29.
-
(2008)
Nat. Cell Biol.
, vol.10
, pp. 19-29
-
-
Guillaud, L.1
-
50
-
-
34547473554
-
Control of a kinesin-cargo linkage mechanism by JNK pathway kinases
-
Horiuchi D., et al. Control of a kinesin-cargo linkage mechanism by JNK pathway kinases. Curr. Biol. 2007, 17:1313-1317.
-
(2007)
Curr. Biol.
, vol.17
, pp. 1313-1317
-
-
Horiuchi, D.1
-
51
-
-
67649826155
-
Pathogenic huntingtin inhibits fast axonal transport by activating JNK3 and phosphorylating kinesin
-
Morfini G.A., et al. Pathogenic huntingtin inhibits fast axonal transport by activating JNK3 and phosphorylating kinesin. Nat. Neurosci. 2009, 12:864-871.
-
(2009)
Nat. Neurosci.
, vol.12
, pp. 864-871
-
-
Morfini, G.A.1
-
52
-
-
84874789461
-
JNK-interacting protein 3 mediates the retrograde transport of activated c-Jun N-terminal kinase and lysosomes
-
Drerup C.M., Nechiporuk A.V. JNK-interacting protein 3 mediates the retrograde transport of activated c-Jun N-terminal kinase and lysosomes. PLoS Genet. 2013, 9:e1003303.
-
(2013)
PLoS Genet.
, vol.9
-
-
Drerup, C.M.1
Nechiporuk, A.V.2
-
53
-
-
79955856733
-
JNK: a stress-activated protein kinase therapeutic strategies and involvement in Alzheimer's and various neurodegenerative abnormalities
-
Mehan S., et al. JNK: a stress-activated protein kinase therapeutic strategies and involvement in Alzheimer's and various neurodegenerative abnormalities. J. Mol. Neurosci. 2011, 43:376-390.
-
(2011)
J. Mol. Neurosci.
, vol.43
, pp. 376-390
-
-
Mehan, S.1
-
54
-
-
32544432052
-
Inhibition of calcineurin by FK506 protects against polyglutamine-huntingtin toxicity through an increase of huntingtin phosphorylation at S421
-
Pardo R., et al. Inhibition of calcineurin by FK506 protects against polyglutamine-huntingtin toxicity through an increase of huntingtin phosphorylation at S421. J. Neurosci. 2006, 26:1635-1645.
-
(2006)
J. Neurosci.
, vol.26
, pp. 1635-1645
-
-
Pardo, R.1
-
55
-
-
78049342155
-
Phosphorylation of huntingtin at Ser421 in YAC128 neurons is associated with protection of YAC128 neurons from NMDA-mediated excitotoxicity and is modulated by PP1 and PP2A
-
Metzler M., et al. Phosphorylation of huntingtin at Ser421 in YAC128 neurons is associated with protection of YAC128 neurons from NMDA-mediated excitotoxicity and is modulated by PP1 and PP2A. J. Neurosci. 2010, 30:14318-14329.
-
(2010)
J. Neurosci.
, vol.30
, pp. 14318-14329
-
-
Metzler, M.1
-
56
-
-
84877740982
-
Huntingtin mediates anxiety/depression-related behaviors and hippocampal neurogenesis
-
Ben M'barek K., et al. Huntingtin mediates anxiety/depression-related behaviors and hippocampal neurogenesis. J. Neurosci. 2013, 33:8608-8620.
-
(2013)
J. Neurosci.
, vol.33
, pp. 8608-8620
-
-
Ben M'barek, K.1
-
57
-
-
84860915669
-
HDAC6 at the intersection of neuroprotection and neurodegeneration
-
d'Ydewalle C., et al. HDAC6 at the intersection of neuroprotection and neurodegeneration. Traffic 2012, 13:771-779.
-
(2012)
Traffic
, vol.13
, pp. 771-779
-
-
d'Ydewalle, C.1
-
58
-
-
33750618516
-
Microtubule acetylation promotes kinesin-1 binding and transport
-
Reed N.A., et al. Microtubule acetylation promotes kinesin-1 binding and transport. Curr. Biol. 2006, 16:2166-2172.
-
(2006)
Curr. Biol.
, vol.16
, pp. 2166-2172
-
-
Reed, N.A.1
-
59
-
-
34047175919
-
Histone deacetylase 6 inhibition compensates for the transport deficit in Huntington's disease by increasing tubulin acetylation
-
Dompierre J.P., et al. Histone deacetylase 6 inhibition compensates for the transport deficit in Huntington's disease by increasing tubulin acetylation. J. Neurosci. 2007, 27:3571-3583.
-
(2007)
J. Neurosci.
, vol.27
, pp. 3571-3583
-
-
Dompierre, J.P.1
-
60
-
-
77956525855
-
HDAC6 regulates mitochondrial transport in hippocampal neurons
-
Chen S., et al. HDAC6 regulates mitochondrial transport in hippocampal neurons. PLoS ONE 2010, 5:e10848.
-
(2010)
PLoS ONE
, vol.5
-
-
Chen, S.1
-
61
-
-
0030240325
-
Reduction of acetylated alpha-tubulin immunoreactivity in neurofibrillary tangle-bearing neurons in Alzheimer's disease
-
Hempen B., Brion J.P. Reduction of acetylated alpha-tubulin immunoreactivity in neurofibrillary tangle-bearing neurons in Alzheimer's disease. J. Neuropathol. Exp. Neurol. 1996, 55:964-972.
-
(1996)
J. Neuropathol. Exp. Neurol.
, vol.55
, pp. 964-972
-
-
Hempen, B.1
Brion, J.P.2
-
62
-
-
79958064073
-
Hdac6 knock-out increases tubulin acetylation but does not modify disease progression in the R6/2 mouse model of Huntington's disease
-
Bobrowska A., et al. Hdac6 knock-out increases tubulin acetylation but does not modify disease progression in the R6/2 mouse model of Huntington's disease. PLoS ONE 2011, 6:e20696.
-
(2011)
PLoS ONE
, vol.6
-
-
Bobrowska, A.1
-
63
-
-
84875948762
-
Hdac6 deletion delays disease progression in the SOD1G93A mouse model of ALS
-
Taes I., et al. Hdac6 deletion delays disease progression in the SOD1G93A mouse model of ALS. Hum. Mol. Genet. 2013, 22:1783-1790.
-
(2013)
Hum. Mol. Genet.
, vol.22
, pp. 1783-1790
-
-
Taes, I.1
-
64
-
-
84865179881
-
HDAC6 inhibitor blocks amyloid beta-induced impairment of mitochondrial transport in hippocampal neurons
-
Kim C., et al. HDAC6 inhibitor blocks amyloid beta-induced impairment of mitochondrial transport in hippocampal neurons. PLoS ONE 2012, 7:e42983.
-
(2012)
PLoS ONE
, vol.7
-
-
Kim, C.1
-
65
-
-
84871946821
-
Reducing HDAC6 ameliorates cognitive deficits in a mouse model for Alzheimer's disease
-
Govindarajan N., et al. Reducing HDAC6 ameliorates cognitive deficits in a mouse model for Alzheimer's disease. EMBO Mol. Med. 2013, 5:52-63.
-
(2013)
EMBO Mol. Med.
, vol.5
, pp. 52-63
-
-
Govindarajan, N.1
-
66
-
-
84875241051
-
HDAC6 mutations rescue human tau-induced microtubule defects in Drosophila
-
Xiong Y., et al. HDAC6 mutations rescue human tau-induced microtubule defects in Drosophila. Proc. Natl. Acad. Sci. U.S.A. 2013, 110:4604-4609.
-
(2013)
Proc. Natl. Acad. Sci. U.S.A.
, vol.110
, pp. 4604-4609
-
-
Xiong, Y.1
-
67
-
-
84872982286
-
HDAC6 as a target for neurodegenerative diseases: what makes it different from the other HDACs?
-
Simões-Pires C., et al. HDAC6 as a target for neurodegenerative diseases: what makes it different from the other HDACs?. Mol. Neurodegener. 2013, 8:7.
-
(2013)
Mol. Neurodegener.
, vol.8
, pp. 7
-
-
Simões-Pires, C.1
-
68
-
-
84863230105
-
The microtubule-stabilizing agent, epothilone D, reduces axonal dysfunction, neurotoxicity, cognitive deficits, and Alzheimer-like pathology in an interventional study with aged tau transgenic mice
-
Zhang B., et al. The microtubule-stabilizing agent, epothilone D, reduces axonal dysfunction, neurotoxicity, cognitive deficits, and Alzheimer-like pathology in an interventional study with aged tau transgenic mice. J. Neurosci. 2012, 32:3601-3611.
-
(2012)
J. Neurosci.
, vol.32
, pp. 3601-3611
-
-
Zhang, B.1
-
69
-
-
84861313192
-
Hyperdynamic microtubules, cognitive deficits, and pathology are improved in tau transgenic mice with low doses of the microtubule-stabilizing agent BMS-241027
-
Barten D.M., et al. Hyperdynamic microtubules, cognitive deficits, and pathology are improved in tau transgenic mice with low doses of the microtubule-stabilizing agent BMS-241027. J. Neurosci. 2012, 32:7137-7145.
-
(2012)
J. Neurosci.
, vol.32
, pp. 7137-7145
-
-
Barten, D.M.1
-
70
-
-
84871821848
-
The meaning of mitochondrial movement to a neuron's life
-
Lovas J.R., Wang X. The meaning of mitochondrial movement to a neuron's life. Biochim. Biophys. Acta 2013, 1833:184-194.
-
(2013)
Biochim. Biophys. Acta
, vol.1833
, pp. 184-194
-
-
Lovas, J.R.1
Wang, X.2
-
71
-
-
84867773087
-
Mitophagy: mechanisms, pathophysiological roles, and analysis
-
Ding W-X., Yin X-M. Mitophagy: mechanisms, pathophysiological roles, and analysis. Biol. Chem. 2012, 393:547-564.
-
(2012)
Biol. Chem.
, vol.393
, pp. 547-564
-
-
Ding, W.-X.1
Yin, X.-M.2
-
72
-
-
37549068958
-
Proprioceptive sensory neuropathy in mice with a mutation in the cytoplasmic dynein heavy chain 1 gene
-
Chen X-J., et al. Proprioceptive sensory neuropathy in mice with a mutation in the cytoplasmic dynein heavy chain 1 gene. J. Neurosci. 2007, 27:14515-14524.
-
(2007)
J. Neurosci.
, vol.27
, pp. 14515-14524
-
-
Chen, X.-J.1
-
73
-
-
0037734370
-
Mutations in dynein link motor neuron degeneration to defects in retrograde transport
-
Hafezparast M., et al. Mutations in dynein link motor neuron degeneration to defects in retrograde transport. Science 2003, 300:808-812.
-
(2003)
Science
, vol.300
, pp. 808-812
-
-
Hafezparast, M.1
-
74
-
-
21344472483
-
A mutation in dynein rescues axonal transport defects and extends the life span of ALS mice
-
Kieran D., et al. A mutation in dynein rescues axonal transport defects and extends the life span of ALS mice. J. Cell Biol. 2005, 169:561-567.
-
(2005)
J. Cell Biol.
, vol.169
, pp. 561-567
-
-
Kieran, D.1
-
75
-
-
50849110466
-
A novel mouse model with impaired dynein/dynactin function develops amyotrophic lateral sclerosis (ALS)-like features in motor neurons and improves lifespan in SOD1-ALS mice
-
Teuling E., et al. A novel mouse model with impaired dynein/dynactin function develops amyotrophic lateral sclerosis (ALS)-like features in motor neurons and improves lifespan in SOD1-ALS mice. Hum. Mol. Genet. 2008, 17:2849-2862.
-
(2008)
Hum. Mol. Genet.
, vol.17
, pp. 2849-2862
-
-
Teuling, E.1
-
76
-
-
68549121208
-
A switch in retrograde signaling from survival to stress in rapid-onset neurodegeneration
-
Perlson E., et al. A switch in retrograde signaling from survival to stress in rapid-onset neurodegeneration. J. Neurosci. 2009, 29:9903-9917.
-
(2009)
J. Neurosci.
, vol.29
, pp. 9903-9917
-
-
Perlson, E.1
-
77
-
-
80052510244
-
Cytoplasmic dynein
-
Allan V.J. Cytoplasmic dynein. Biochem. Soc. Trans. 2011, 39:1169-1178.
-
(2011)
Biochem. Soc. Trans.
, vol.39
, pp. 1169-1178
-
-
Allan, V.J.1
-
78
-
-
33645778345
-
Genetic analysis of the cytoplasmic dynein subunit families
-
Pfister K.K., et al. Genetic analysis of the cytoplasmic dynein subunit families. PLoS Genet. 2006, 2:e1.
-
(2006)
PLoS Genet.
, vol.2
-
-
Pfister, K.K.1
-
79
-
-
0027480960
-
A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. The Huntington's Disease Collaborative Research Group
-
The Huntington's Disease Collaborative Research Group
-
A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. The Huntington's Disease Collaborative Research Group. Cell 1993, 72:971-983. The Huntington's Disease Collaborative Research Group.
-
(1993)
Cell
, vol.72
, pp. 971-983
-
-
-
80
-
-
77951641282
-
MFN2 point mutations occur in 3.4% of Charcot-Marie-Tooth families. An investigation of 232 Norwegian CMT families
-
Braathen G.J., et al. MFN2 point mutations occur in 3.4% of Charcot-Marie-Tooth families. An investigation of 232 Norwegian CMT families. BMC Med. Genet. 2010, 11:48.
-
(2010)
BMC Med. Genet.
, vol.11
, pp. 48
-
-
Braathen, G.J.1
-
81
-
-
84879478992
-
Axonal transport defects in a mitofusin 2 loss of function model of Charcot-Marie-Tooth disease in zebrafish
-
Chapman A.L., et al. Axonal transport defects in a mitofusin 2 loss of function model of Charcot-Marie-Tooth disease in zebrafish. PLoS ONE 2013, 8:e67276.
-
(2013)
PLoS ONE
, vol.8
-
-
Chapman, A.L.1
-
82
-
-
34347353311
-
Impairments in fast axonal transport and motor neuron deficits in transgenic mice expressing familial Alzheimer's disease-linked mutant presenilin 1
-
Lazarov O., et al. Impairments in fast axonal transport and motor neuron deficits in transgenic mice expressing familial Alzheimer's disease-linked mutant presenilin 1. J. Neurosci. 2007, 27:7011-7020.
-
(2007)
J. Neurosci.
, vol.27
, pp. 7011-7020
-
-
Lazarov, O.1
-
83
-
-
84886752586
-
Presenilin controls kinesin-1 and dynein function during APP-vesicle transport in vivo
-
Gunawardena S., et al. Presenilin controls kinesin-1 and dynein function during APP-vesicle transport in vivo. Hum. Mol. Genet. 2013, 22:3828-3843.
-
(2013)
Hum. Mol. Genet.
, vol.22
, pp. 3828-3843
-
-
Gunawardena, S.1
-
84
-
-
81055140895
-
PINK1 and Parkin target miro for phosphorylation and degradation to arrest mitochondrial motility
-
Wang X., et al. PINK1 and Parkin target miro for phosphorylation and degradation to arrest mitochondrial motility. Cell 2011, 147:893-906.
-
(2011)
Cell
, vol.147
, pp. 893-906
-
-
Wang, X.1
-
85
-
-
0036849511
-
Charcot-Marie-Tooth disease neurofilament mutations disrupt neurofilament assembly and axonal transport
-
Brownlees J., et al. Charcot-Marie-Tooth disease neurofilament mutations disrupt neurofilament assembly and axonal transport. Hum. Mol. Genet. 2002, 11:2837-2844.
-
(2002)
Hum. Mol. Genet.
, vol.11
, pp. 2837-2844
-
-
Brownlees, J.1
-
86
-
-
18844446126
-
Mutations in the neurofilament light gene linked to Charcot-Marie-Tooth disease cause defects in transport
-
Pérez-Ollé R., et al. Mutations in the neurofilament light gene linked to Charcot-Marie-Tooth disease cause defects in transport. J. Neurochem. 2005, 93:861-874.
-
(2005)
J. Neurochem.
, vol.93
, pp. 861-874
-
-
Pérez-Ollé, R.1
-
87
-
-
0037198698
-
Disruption of dynein/dynactin inhibits axonal transport in motor neurons causing late-onset progressive degeneration
-
LaMonte B.H., et al. Disruption of dynein/dynactin inhibits axonal transport in motor neurons causing late-onset progressive degeneration. Neuron 2002, 34:715-727.
-
(2002)
Neuron
, vol.34
, pp. 715-727
-
-
LaMonte, B.H.1
-
88
-
-
0041353535
-
Huntingtin interacts with REST/NRSF to modulate the transcription of NRSE-controlled neuronal genes
-
Zuccato C., et al. Huntingtin interacts with REST/NRSF to modulate the transcription of NRSE-controlled neuronal genes. Nat. Genet. 2003, 35:76-83.
-
(2003)
Nat. Genet.
, vol.35
, pp. 76-83
-
-
Zuccato, C.1
-
89
-
-
84876932695
-
Imbalance of p75(NTR)/TrkB protein expression in Huntington's disease: implication for neuroprotective therapies
-
Brito V., et al. Imbalance of p75(NTR)/TrkB protein expression in Huntington's disease: implication for neuroprotective therapies. Cell Death Dis. 2013, 4:e595.
-
(2013)
Cell Death Dis.
, vol.4
-
-
Brito, V.1
-
90
-
-
77954362528
-
Impaired TrkB-mediated ERK1/2 activation in Huntington disease knock-in striatal cells involves reduced p52/p46 Shc expression
-
Ginés S., et al. Impaired TrkB-mediated ERK1/2 activation in Huntington disease knock-in striatal cells involves reduced p52/p46 Shc expression. J. Biol. Chem. 2010, 285:21537-21548.
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 21537-21548
-
-
Ginés, S.1
-
91
-
-
84875509193
-
Mutant huntingtin alters retrograde transport of TrkB receptors in striatal dendrites
-
Liot G., et al. Mutant huntingtin alters retrograde transport of TrkB receptors in striatal dendrites. J. Neurosci. 2013, 33:6298-6309.
-
(2013)
J. Neurosci.
, vol.33
, pp. 6298-6309
-
-
Liot, G.1
-
92
-
-
78650545423
-
Deficits in axonal transport precede ALS symptoms in vivo
-
Bilsland L.G., et al. Deficits in axonal transport precede ALS symptoms in vivo. Proc. Natl. Acad. Sci. U.S.A. 2010, 107:20523-20528.
-
(2010)
Proc. Natl. Acad. Sci. U.S.A.
, vol.107
, pp. 20523-20528
-
-
Bilsland, L.G.1
-
93
-
-
0026076826
-
Production of nerve growth factor in rat skeletal muscle
-
Amano T., et al. Production of nerve growth factor in rat skeletal muscle. Neurosci. Lett. 1991, 132:5-7.
-
(1991)
Neurosci. Lett.
, vol.132
, pp. 5-7
-
-
Amano, T.1
-
94
-
-
7244236359
-
NGF, BDNF, NT-3, and GDNF mRNA expression in rat skeletal muscle following denervation and sensory protection
-
Zhao C., et al. NGF, BDNF, NT-3, and GDNF mRNA expression in rat skeletal muscle following denervation and sensory protection. J. Neurotrauma 2004, 21:1468-1478.
-
(2004)
J. Neurotrauma
, vol.21
, pp. 1468-1478
-
-
Zhao, C.1
-
95
-
-
84865956863
-
Cerebrospinal fluid-based kinetic biomarkers of axonal transport in monitoring neurodegeneration
-
Fanara P., et al. Cerebrospinal fluid-based kinetic biomarkers of axonal transport in monitoring neurodegeneration. J. Clin. Invest. 2012, 122:3159-3169.
-
(2012)
J. Clin. Invest.
, vol.122
, pp. 3159-3169
-
-
Fanara, P.1
-
96
-
-
83655197838
-
Manganese enhanced MRI (MEMRI): neurophysiological applications
-
Inoue T., et al. Manganese enhanced MRI (MEMRI): neurophysiological applications. Rev. Neurosci. 2011, 22:675-694.
-
(2011)
Rev. Neurosci.
, vol.22
, pp. 675-694
-
-
Inoue, T.1
|