Pathogenic huntingtin inhibits fast axonal transport by activating JNK3 and phosphorylating kinesin

Nature Neuroscience

Volumn 12, Issue 7, 2009, Pages 864-871

  Morfini, Gerardo A ^a,b   You, Yi Mei ^a   Pollema, Sarah L ^a,b   Kaminska, Agnieszka ^a   Liu, Katherine ^b   Yoshioka, Katsuji ^c   Björkblom, Benny ^d   Coffey, Eleanor T ^d   Bagnato, Carolina ^e   Han, David ^e   Huang, Chun Fang ^f   Banker, Gary ^f   Pigino, Gustavo ^a,b   Brady, Scott T ^a,b  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^b MARINE BIOLOGICAL LABORATORY   (United States)

^c KANAZAWA UNIVERSITY   (Japan)

^d ÅBO AKADEMI UNIVERSITY   (Finland)

^e UNIVERSITY OF CONNECTICUT   (United States)

^f OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HUNTINGTIN; KINESIN 1; MITOGEN ACTIVATED PROTEIN KINASE 10; STRESS ACTIVATED PROTEIN KINASE 1; KINESIN; MITOGEN ACTIVATED PROTEIN KINASE 9; NERVE PROTEIN; PEPTIDE; POLYGLUTAMINE; SEROTONIN TRANSPORTER; SLC6A4 PROTEIN, HUMAN; SLC6A4 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME BINDING; ENZYME PHOSPHORYLATION; HUNTINGTON CHOREA; MASS SPECTROMETRY; MICROTUBULE; MOUSE; NERVE FIBER TRANSPORT; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; ANIMAL; CELL LINE; CEPHALOPOD; DISEASE MODEL; GENE TARGETING; GENETICS; HIPPOCAMPUS; HUMAN; METABOLISM; MUTATION; NERVE CELL; PHOSPHORYLATION; PHYSIOLOGY; TRANSGENIC MOUSE;

ANIMALS; AXONAL TRANSPORT; CELL LINE; DECAPODIFORMES; DISEASE MODELS, ANIMAL; GENE KNOCK-IN TECHNIQUES; HIPPOCAMPUS; HUMANS; KINESIN; MICE; MICE, TRANSGENIC; MICROTUBULES; MITOGEN-ACTIVATED PROTEIN KINASE 10; MITOGEN-ACTIVATED PROTEIN KINASE 8; MITOGEN-ACTIVATED PROTEIN KINASE 9; MUTATION; NERVE TISSUE PROTEINS; NEURONS; PEPTIDES; PHOSPHORYLATION; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS;

EID: 67649826155     PISSN: 10976256     EISSN: None     Source Type: Journal    
DOI: 10.1038/nn.2346     Document Type: Article

References (21)

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