Role of small GTPase protein Rac1 in cardiovascular diseases: Development of new selective pharmacological inhibitors

Journal of Cardiovascular Pharmacology

Volumn 62, Issue 5, 2013, Pages 425-435

  Ferri, Nicola ^a   Contini, Alessandro ^a   Bernini, Sergio Kevin ^a   Corsini, Alberto ^a  

^a UNIVERSITY OF MILAN   (Italy)

Author keywords

cardiomyocytes; cardiovascular disease; endothelial cells; Rac1 inhibitors; small GTPases; SMCs

Indexed keywords

4 AMINO 6 [2 [[4 (DIETHYLAMINO) 1 METHYLBUTYL]AMINO] 6 METHYL 4 PYRIMIDINYL] 2 METHYLQUINOLINE; 8 HYDROXYDEOXYGUANOSINE; CARDIOVASCULAR AGENT; EHOP 016; EHT 1864; GUANINE NUCLEOTIDE EXCHANGE FACTOR; GUANOSINE DIPHOSPHATE; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; GUANOSINE TRIPHOSPHATE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; ITX 3; PHOX I1; PROTEIN CDC42; RAC1 PROTEIN; RAC1 PROTEIN INHIBITOR; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; UNCLASSIFIED DRUG;

ATHEROSCLEROSIS; BLOOD VESSEL WALL; CARDIOVASCULAR DISEASE; CELL DIFFERENTIATION; CELL MIGRATION; CELL PROLIFERATION; DRUG MECHANISM; DRUG POTENCY; DRUG TARGETING; ENZYME INHIBITION; GENETIC ASSOCIATION; HEART FAILURE; HEART VENTRICLE HYPERTROPHY; HUMAN; IN VITRO STUDY; IN VIVO STUDY; ISCHEMIC HEART DISEASE; NONHUMAN; PRIORITY JOURNAL; REGULATORY MECHANISM; REVIEW; TRANSGENIC MOUSE; VASCULAR SMOOTH MUSCLE;

ANIMALS; CARDIOVASCULAR AGENTS; CARDIOVASCULAR DISEASES; DRUG DESIGN; GENOME-WIDE ASSOCIATION STUDY; HUMANS; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; MOLECULAR TARGETED THERAPY; RAC1 GTP-BINDING PROTEIN;

EID: 84888128682     PISSN: 01602446     EISSN: 15334023     Source Type: Journal    
DOI: 10.1097/FJC.0b013e3182a18bcc     Document Type: Review

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