Gene transfer of redox factor-1 inhibits neointimal formation: Involvement of platelet-derived growth factor-β receptor signaling via the inhibition of the reactive oxygen species-mediated syk pathway

Circulation Research

Volumn 104, Issue 2, 2009, Pages 219-227

  Lee, Hwan Myung ^a   Jeon, Byeong Hwa ^b   Won, Kyung Jong ^a   Lee, Chang Kwon ^a   Park, Tae Kyu ^a   Choi, Wahn Soo ^a   Bae, Young Min ^a   Kim, Hyo Shin ^b   Lee, Sang Ki ^b   Park, Seung Hwa ^a   Irani, Kaikobad ^c   Kim, Bokyung ^a  

^a Konkuk University School of Medicine   (South Korea)

^b Chungnam National University   (South Korea)

^c UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

Author keywords

Apurinic apyrimidinic endonuclease 1 redox factor 1 vascular smooth muscle cells migration reactive oxygen species spleen tyrosine kinase

Indexed keywords

ADENOVIRUS VECTOR; HEAT SHOCK PROTEIN 27; MITOGEN ACTIVATED PROTEIN KINASE; OXYGEN; PLATELET DERIVED GROWTH FACTOR BB; PLATELET DERIVED GROWTH FACTOR BETA RECEPTOR; PROTEIN KINASE SYK; PROTEIN KINASE SYK INHIBITOR; REACTIVE OXYGEN METABOLITE; REDOX EFFECTOR FACTOR 1; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SMALL INTERFERING RNA; APEX1 PROTEIN, HUMAN; DNA (APURINIC OR APYRIMIDINIC SITE) LYASE; ENZYME INHIBITOR; PLATELET DERIVED GROWTH FACTOR; PLATELET-DERIVED GROWTH FACTOR BB; PROTEIN TYROSINE KINASE; RAC1 PROTEIN; RAC1 PROTEIN, RAT; SIGNAL PEPTIDE; SUPEROXIDE;

AORTA MEDIA; ARTICLE; CELL MIGRATION; CONTROLLED STUDY; GENE TRANSFER; HUMAN; INTIMA; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER; ADENOVIRUS; ANGIOGENESIS; ANIMAL; AORTA; CAROTID ARTERY INJURY; CELL CULTURE; CELL MOTION; CELL PROLIFERATION; DISEASE MODEL; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; GENE SILENCING; GENE VECTOR; GENETIC TRANSDUCTION; GENETIC TRANSFECTION; GENETICS; HYPERPLASIA; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; PHOSPHORYLATION; SPRAGUE DAWLEY RAT; VASCULAR SMOOTH MUSCLE;

ADENOVIRIDAE; ANIMALS; AORTA; CAROTID ARTERY INJURIES; CELL MOVEMENT; CELL PROLIFERATION; CELLS, CULTURED; DISEASE MODELS, ANIMAL; DNA-(APURINIC OR APYRIMIDINIC SITE) LYASE; ENZYME INHIBITORS; GENE KNOCKDOWN TECHNIQUES; GENETIC VECTORS; HUMANS; HYPERPLASIA; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MUSCLE, SMOOTH, VASCULAR; NADPH OXIDASE; NEOVASCULARIZATION, PHYSIOLOGIC; PHOSPHORYLATION; PLATELET-DERIVED GROWTH FACTOR; PROTEIN-TYROSINE KINASES; RAC1 GTP-BINDING PROTEIN; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, PLATELET-DERIVED GROWTH FACTOR BETA; SIGNAL TRANSDUCTION; SUPEROXIDES; TRANSDUCTION, GENETIC; TRANSFECTION; TUNICA INTIMA;

EID: 59849121699     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.108.178699     Document Type: Article

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