Specificity and mechanism of action of EHT 1864, a novel small molecule inhibitor of Rac family small GTPases

Journal of Biological Chemistry

Volumn 282, Issue 49, 2007, Pages 35666-35678

  Shutes, Adam ^a   Onesto, Cercina ^a   Picard, Virginie ^b   Leblond, Bertrand ^b   Schweighoffer, Fabien ^b   Der, Channing J ^a  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b ExonHit Therapeutics   (France)

Author keywords

[No Author keywords available]

Indexed keywords

HUMAN CANCER CELLS; METASTATIC PROPERTIES; RAC PROTEINS;

BIOCHEMISTRY; CELL GROWTH; MOLECULAR DYNAMICS; NUCLEOTIDES;

ENZYME INHIBITION;

EHT 1864; GUANINE NUCLEOTIDE; GUANINE NUCLEOTIDE EXCHANGE FACTOR; GUANOSINE TRIPHOSPHATASE; ISOPROTEIN; NUCLEOTIDE; PLATELET DERIVED GROWTH FACTOR; PROTEIN KINASE INHIBITOR; RAC PROTEIN; RAC1 PROTEIN; RAC1B PROTEIN; RAC2 PROTEIN; RAC3 PROTEIN; RECOMBINANT PROTEIN; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; TIAM1 PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CANCER CELL; CELL INVASION; CELL PROLIFERATION; CHEMICAL ANALYSIS; CONTROLLED STUDY; ENZYME ACTIVATION; HUMAN; HUMAN CELL; LAMELLIPODIUM; METASTASIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN PROCESSING;

ANIMALS; CELL LINE, TUMOR; CELL PROLIFERATION; CELL TRANSFORMATION, NEOPLASTIC; ENZYME ACTIVATION; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HUMANS; MICE; NEOPLASM INVASIVENESS; NEOPLASM METASTASIS; NEOPLASMS; NIH 3T3 CELLS; PROTEIN PROCESSING, POST-TRANSLATIONAL; PSEUDOPODIA; PYRONES; QUINOLINES; RAC GTP-BINDING PROTEINS; SIGNAL TRANSDUCTION;

EID: 37249019970     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M703571200     Document Type: Article

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