Ajoene, a garlic compound, inhibits protein prenylation and arterial smooth muscle cell proliferation

British Journal of Pharmacology

Volumn 138, Issue 5, 2003, Pages 811-818

  Ferri, Nicola ^a   Yokoyama, Kohei ^b   Sadilek, Martin ^b   Paoletti, Rodolfo ^a   Apitz Castro, Rafael ^c   Gelb, Michael H ^b   Corsini, Alberto ^a  

^a UNIVERSITY OF MILAN   (Italy)

^b UNIVERSITY OF WASHINGTON   (United States)

^c INSTITUTO VENEZOLANO DE INVESTIGACIONES CIENTÍFICAS   (Venezuela)

Author keywords

Atherosclerosis; Farnesol; Farnesyl transferase; Geranylgeraniol; Geranylgeranyl transferase; Isoprenoids

Indexed keywords

AJOENE; CELL PROTEIN; CHOLESTEROL; CYSTEINE; FARNESOL; GARLIC EXTRACT; GERANYLGERANIOL; GERANYLGERANYLTRANSFERASE I; GERANYLTRANSFERASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; ISOPRENOID; MEVALONIC ACID; PROTEIN FARNESYLTRANSFERASE; SIMVASTATIN; TRITIUM; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTERY MUSCLE; ARTICLE; CELL COUNT; CELL CYCLE G1 PHASE; CELL LABELING; CELL PROLIFERATION; CHEMICAL MODIFICATION; CHOLESTEROL SYNTHESIS; CONCENTRATION RESPONSE; CONTROLLED STUDY; COVALENT BOND; DNA SYNTHESIS; DRUG EFFECT; DRUG MECHANISM; ENZYME ASSAY; ENZYME SUBSTRATE; GARLIC; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; MALE; MASS SPECTROMETRY; MITOSIS INHIBITION; NONHUMAN; PRECURSOR; PRENYLATION; PRIORITY JOURNAL; PROTEIN FUNCTION; RAT; REGULATORY MECHANISM; SMOOTH MUSCLE FIBER; THROMBOCYTE AGGREGATION INHIBITION;

ANIMALS; AORTA; CELL DIVISION; CELLS, CULTURED; DISULFIDES; DOSE-RESPONSE RELATIONSHIP, DRUG; GARLIC; GROWTH INHIBITORS; MALE; MUSCLE, SMOOTH, VASCULAR; PLANT EXTRACTS; PROTEIN ISOPRENYLATION; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0037349211     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0705126     Document Type: Article

References (37)

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