Endothelin-1 promotes myofibroblast induction through the ETA receptor via a rac/phosphoinositide 3-kinase/Akt-dependent pathway and is essential for the enhanced contractile phenotype of fibrotic fibroblasts

Molecular Biology of the Cell

Volumn 15, Issue 6, 2004, Pages 2707-2719

  Shi Wen, Xu ^a   Chen, Yunliang ^a   Denton, Christopher P ^a   Eastwood, Mark ^b   Renzoni, Elisabetta A ^c   Bou Gharios, George ^d   Pearson, Jeremy D ^e   Dashwood, Michael ^a   Du Bois, Roland M ^c   Black, Carol M ^a   Leask, Andrew ^a   Abraham, David J ^a  

^a ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

^b UNIVERSITY OF WESTMINSTER   (United Kingdom)

^c ROYAL BROMPTON HOSPITAL   (United Kingdom)

^d IMPERIAL COLLEGE LONDON   (United Kingdom)

^e KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; ALPHA ACTIN; COLLAGEN; ENDOTHELIN 1; ENDOTHELIN A RECEPTOR; ENDOTHELIN B RECEPTOR; EZRIN; MOESIN; PAXILLIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; WORTMANNIN;

ARTICLE; CONTROLLED STUDY; EXTRACELLULAR MATRIX; FIBROBLAST; HUMAN; HUMAN CELL; LUNG FIBROBLAST; LUNG FIBROSIS; MYOFIBROBLAST; NUCLEOTIDE SEQUENCE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; SCAR; SCLERODERMA; SMOOTH MUSCLE; SYSTEMIC SCLEROSIS; TISSUE REPAIR; VASOCONSTRICTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; CELL MEMBRANE; CELLS, CULTURED; COLLAGEN; CONTRACTILE PROTEINS; ENDOTHELIN-1; FIBROBLASTS; FIBROSIS; HUMANS; LUNG; PHENOTYPE; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RAC GTP-BINDING PROTEINS; RECEPTOR, ENDOTHELIN A; SCLERODERMA, SYSTEMIC; SIGNAL TRANSDUCTION;

SCLERODERMA;

EID: 2542485410     PISSN: 10591524     EISSN: None     Source Type: Journal    
DOI: 10.1091/mbc.E03-12-0902     Document Type: Article

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