Synthesis and biological evaluation of new epalrestat analogues as aldose reductase inhibitors (ARIs)

European Journal of Medicinal Chemistry

Volumn 71, Issue , 2014, Pages 53-66

  Reddy, Thatikonda Narendar ^a   Ravinder, Mettu ^a   Bagul, Pankaj ^a   Ravikanti, Keerthi ^a   Bagul, Chandrakant ^b   Nanubolu, Jagadeesh Babu ^a   Srinivas, Kolupula ^b   Banerjee, Sanjay K ^a   Rao, Vaidya Jayathirtha ^a,b  

^a INDIAN INSTITUTE OF CHEMICAL TECHNOLOGY   (India)

^b NATIONAL INSTITUTE OF PHARMACEUTICAL EDUCATION AND RESEARCH NIPER   (India)

Author keywords

Aldose reductase inhibitors; Baylis Hillman reaction; Crystal structure; Epalrestat analogues; Molecular docking; Rhodanine compounds

Indexed keywords

(Z) 2 [(Z) (4 OXO 2 THIOXOTHIAZOLIDIN 5 YLIDENE)METHYL] 3 (THIOPHEN 2 YL)ACRYLONITRILE; (Z) 2 [(Z) (4 OXO 2 THIOXOTHIAZOLIDIN 5 YLIDENE)METHYL] 3 P TOLYLACRYLONITRILE; 2 [(Z) 5 [(Z) 2 CYANO 3 (FURAN 2 YL)ALLYLIDENE] 4 OXO 2 THIOXOTHIAZOLIDIN 3 YL]; 4 [(Z) 5 [(Z) 2 CYANO 3 PHENYLALLYLIDENE] 4 OXO 2 THIOXOTHIAZOLIDIN 3 YL]BENZOIC ACID; 8' CHLORO 2',3' DIHYDROSPIRO[PYRROLIDINE 3,6'(5'H) PYRROLO[1,2,3 DE][1,4]BENZOXAZINE] 2,5,5' TRIONE; ALDEHYDE REDUCTASE; ALDOSE REDUCTASE INHIBITOR; EPALRESTAT; FIDARESTAT; LIDORESTAT; PONALRESTAT; QUERCETIN; RANIRESTAT; RESVERATROL; SORBINIL; TOLRESTAT; UNCLASSIFIED DRUG; ZENARESTAT; ZOPOLRESTAT;

ARTICLE; BAYLIS HILLMAN REACTION; CRYSTAL STRUCTURE; DRUG ACTIVITY; DRUG BINDING; DRUG INHIBITION; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; ENZYME INHIBITION; IN VITRO STUDY; MOLECULAR DOCKING; PHARMACOPHORE;

ALDOSE REDUCTASE INHIBITORS; BAYLIS-HILLMAN REACTION; CRYSTAL STRUCTURE; EPALRESTAT ANALOGUES; MOLECULAR DOCKING; RHODANINE COMPOUNDS;

ALDEHYDE REDUCTASE; CRYSTALLOGRAPHY, X-RAY; DIABETES COMPLICATIONS; ENZYME INHIBITORS; HUMANS; MOLECULAR DOCKING SIMULATION; RHODANINE; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLIDINES;

EID: 84888101590     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2013.10.043     Document Type: Article

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