Identification of 5-arylidene-4-thiazolidinone derivatives endowed with dual activity as aldose reductase inhibitors and antioxidant agents for the treatment of diabetic complications

European Journal of Medicinal Chemistry

Volumn 46, Issue 7, 2011, Pages 2797-2806

  Ottanà, Rosaria ^a   MacCari, Rosanna ^a   Giglio, Marco ^a   Del Corso, Antonella ^b   Cappiello, Mario ^b   Mura, Umberto ^b   Cosconati, Sandro ^c   Marinelli, Luciana ^c   Novellino, Ettore ^c   Sartini, Stefania ^b   La Motta, Concettina ^b   Da Settimo, Federico ^b  

^a UNIVERSITY OF MESSINA   (Italy)

^b UNIVERSITY OF PISA   (Italy)

^c UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

5 arylidene 4 thiazolidinones; Aldose reductase; Antioxidant agent; Diabetes mellitus; Molecular docking

Indexed keywords

4 THIAZOLIDINONE DERIVATIVE; 5 (3 PHENYL 2 PROPEN 1 YLIDENE) 2,4 THIAZOLIDINEDIONE; 5 [3 (4 METHOXYPHENYL) 2 PROPEN 1 YLIDENE] 2,4 THIAZOLIDINEDIONE; 5 [3 (4 METHYLPHENYL) 2 PROPEN 1 YLIDENE] 2,4 THIAZOLIDINEDIONE; 5 [3 (4 TRIFLUOROMETHYLPHENYL) 2 PROPEN 1 YLIDENE] 2,4 THIAZOLIDINEDIONE; 5 [[ 4 (2 PHENYLETHENYL)PHENYL]METHYLIDENE] 2,4 THIAZOLIDINEDIONE; 5 [[[4 [2 (4 METHOXYPHENYL)]ETHENYL]PHENYL]METHYLIDENE) 2,4 THIAZOLIDINEDIONE; 5 [[[4 [2 (4 METHYLPHENYL)]ETHENYL]PHENYL]METHYLIDENE] 2,4 THIAZOLIDINEDIONE; 5 [[[4 [2 (4 TRIFLUOROMETHYLPHENYL)]ETHENYL]PHENYL]METHYLIDENE] 2,4 THIAZOLIDINEDIONE; [2,4 DIOXO 5 (3 PHENYL 2 PROPEN 1 YLIDENE)THIAZOLIDIN 3 YL]ACETIC ACID; [2,4 DIOXO 5 [[4 (2 PHENYLETHENYL)PHENYL]METHYLIDENE]THIAZOLIDIN 3 YL]ACETIC ACID; [4 OXO 5 (4 PHENOXYPHENYLMETHYLIDENE) 2 PHENYLIMINOTHIAZOLIDIN 3 YL]ACETIC ACID; [5 (4 BENZYLOXYPHENYLMETHYLIDENE) 4 OXO 2 PHENYLIMINOTHIAZOLIDIN 3 YL]ACETIC ACID; [5 (NAPHTALEN 2 YLMETHYLIDENE) 4 OXO 2 PHENYLIMINOTHIAZOLIDIN 3 YL]ACETIC ACID; [5 [3 (4 METHOXYPHENYL) 2 PROPEN 1 YLIDENE] 2,4 DIOXOTHIAZOLIDIN 3 YL]ACETIC ACID; [5 [3 (4 TRIFLUOROMETHYLPHENYL) 2 PROPEN 1 YLIDENE] 2,4 DIOXOTHIAZOLIDIN 3 YL]ACETIC ACID; [5 [[4 [2 (4 METHOXYPHENYL)ETHENYL]PHENYL]METHYLIDENE] 2,4 DIOXOTHIAZOLIDIN 3 YL]ACETIC ACID; [5 [[4 [2 (4 METHYLPHENYL)ETHENYL]PHENYL]METHYLIDENE] 2,4 DIOXOTHIAZOLIDIN 3 YL]ACETIC ACID; [5 [[4 [2 (4 TRIFLUOROMETHYLPHENYL)ETHENYL]PHENYL]METHYLIDENE] 2,4 DIOXOTHIAZOLIDIN 3 YL]ACETIC ACID; ALDOSE REDUCTASE INHIBITOR; UNCLASSIFIED DRUG; 2,4 THIAZOLIDINEDIONE DERIVATIVE; ACETIC ACID DERIVATIVE; ALDEHYDE REDUCTASE; ANTIOXIDANT; ENZYME INHIBITOR;

ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; DIABETES MELLITUS; DRUG ACTIVITY; DRUG SYNTHESIS; ENZYME INHIBITION; IC 50; IN VITRO STUDY; MOLECULAR DOCKING; NONHUMAN; OXIDATIVE STRESS; STRUCTURE ACTIVITY RELATION; ANIMAL; ANTAGONISTS AND INHIBITORS; BOVINE; CHEMISTRY; DIABETES COMPLICATIONS; DRUG EFFECTS; HUMAN; SYNTHESIS;

ACETATES; ALDEHYDE REDUCTASE; ANIMALS; ANTIOXIDANTS; CATTLE; DIABETES COMPLICATIONS; ENZYME INHIBITORS; HUMANS; MOLECULAR DOCKING SIMULATION; OXIDATIVE STRESS; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLIDINEDIONES;

EID: 79957463623     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.03.068     Document Type: Article

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