Design and synthesis of potent and selective aldose reductase inhibitors based on pyridylthiadiazine scaffold

European Journal of Medicinal Chemistry

Volumn 46, Issue 5, 2011, Pages 1536-1544

  Chen, Xin ^a   Yang, Yanchun ^a   Ma, Bing ^a   Zhang, Shuzhen ^a   He, Minlan ^a   Gui, Dequan ^a   Hussain, Saghir ^a   Jing, Chaojun ^a   Zhu, Changjin ^a   Yu, Qun ^b   Liu, Yan ^c  

^a BEIJING INSTITUTE OF TECHNOLOGY   (China)

^b BEIJING INSTITUTE OF MICROBIOLOGY AND EPIDEMIOLOGY   (China)

^c XIAMEN UNIVERSITY   (China)

Author keywords

Acetic acid derivative; Aldose reductase; Inhibitor; Pyrido 2,3e 1,2,4 thiadiazine

Indexed keywords

[2 (2,4,5 TRIFLUOROBENZYL) 7 BROMO 3,4 DIHYDRO 2H PYRIDO[2,3 E][1,2,4]THIADIAZINE 1,1 DIOXIDE 4 YL]ACETIC ACID; [2 (2,4,5 TRIFLUOROBENZYL) 7 CHOLRO 3,4 DIHYDRO 2H PYRIDO[2,3 E][1,2,4]THIADIAZINE 1,1 DIOXIDE 4 YL]ACETIC ACID; [2 (2,4,5 TRIFLUOROBENZYL) 7 METHYL 3,4 DIHYDRO 2H PYRIDO[2,3 E][1,2,4]THIADIAZINE 1,1 DIOXIDE 4 YL]ACETIC ACID; [2 (3 NITROBENZYL) 7 BROMO 3,4 DIHYDRO 2H PYRIDO[2,3 E][1,2,4]THIADIAZINE 1,1 DIOXIDE 4 YL]ACETIC ACID; [2 (3 NITROBENZYL) 7 CHOLRO 3,4 DIHYDRO 2H PYRIDO[2,3 E][1,2,4]THIADIAZINE 1,1 DIOXIDE 4 YL]ACETIC ACID; [2 (3 NITROBENZYL) 7 METHYL 3,4 DIHYDRO 2H PYRIDO[2,3 E][1,2,4]THIADIAZINE 1,1 DIOXIDE 4 YL]ACETIC ACID; [2 (4 BROMO 2 FLUOROBENZYL) 7 BROMO 3,4 DIHYDRO 2H PYRIDO[2,3 E][1,2,4]THIADIAZINE 1,1 DIOXIDE 4 YL]ACETIC ACID; [2 (4 BROMO 2 FLUOROBENZYL) 7 CHOLRO 3,4 DIHYDRO 2H PYRIDO[2,3 E][1,2,4]THIADIAZINE 1,1 DIOXIDE 4 YL]ACETIC ACID; [2 (4 BROMO 2 FLUOROBENZYL) 7 METHYL 3,4 DIHYDRO 2H PYRIDO[2,3 E][1,2,4]THIADIAZINE 1,1 DIOXIDE 4 YL]ACETIC ACID; [2 (4 METHOXYBENZYL) 7 BROMO 3,4 DIHYDRO 2H PYRIDO[2,3 E][1,2,4]THIADIAZINE 1,1 DIOXIDE 4 YL]ACETIC ACID; [2 (4 METHOXYBENZYL) 7 CHOLRO 3,4 DIHYDRO 2H PYRIDO[2,3 E][1,2,4]THIADIAZINE 1,1 DIOXIDE 4 YL]ACETIC ACID; [2 (4 METHOXYBENZYL) 7 METHYL 3,4 DIHYDRO 2H PYRIDO[2,3 E][1,2,4]THIADIAZINE 1,1 DIOXIDE 4 YL]ACETIC ACID; [2 [4 (TRIFLUOROMETHYL)BENZYL] 7 BROMO 3,4 DIHYDRO 2H PYRIDO[2,3 E][1,2,4]THIADIAZINE 1,1 DIOXIDE 4 YL]ACETIC ACID; [2 [4 (TRIFLUOROMETHYL)BENZYL] 7 CHOLRO 3,4 DIHYDRO 2H PYRIDO[2,3 E][1,2,4]THIADIAZINE 1,1 DIOXIDE 4 YL]ACETIC ACID; [2 [4 (TRIFLUOROMETHYL)BENZYL] 7 METHYL 3,4 DIHYDRO 2H PYRIDO[2,3 E][1,2,4]THIADIAZINE 1,1 DIOXIDE 4 YL]ACETIC ACID; ALDOSE REDUCTASE INHIBITOR; THIADIAZINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; IC 50; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

ALDEHYDE REDUCTASE; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; ENZYME INHIBITORS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PYRIDINES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; THIADIAZINES;

EID: 79953226757     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.01.072     Document Type: Article

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