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Volumn 20, Issue 1, 2012, Pages 356-367
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Design, synthesis, and biological evaluation of novel (1-thioxo-1,2,3,4- tetrahydro-β-carbolin-9-yl)acetic acids as selective inhibitors for AKR1B1
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Author keywords
AKR1B1; Aldose reductase; Diabetes mellitus; Molecular docking; Selectivity index
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Indexed keywords
(1 THIOXO 1,2,3 TETRAHYDRO BETA CARBOLIN 9 YL)ACETIC ACID DERIVATIVE;
2 (4 BROMO 2 FLUOROBENZYL) 2,3,4,9 TETRAHYDRO BETA CARBOLIN 1 ONE;
2 (4 BROMO 2 FLUOROBENZYL) 6 FLUORO 2,3,4,9 TETRAHYDRO BETA CARBOLIN 1 ONE;
2 (4 BROMO 2 FLUOROBENZYL) 6 FLUORO 2,3,4,9 TETRAHYDRO BETA CARBOLINE 1 THIONE;
2 (4 BROMO 2 FLUOROMBENZYL) 2,3,4,9 TETRAHYDRO BETA CARBOLINE 1 THIONE;
2 (4 BROMOBENZYL) 2,3,4,9 TETRAHYDRO BETA CARBOLIN 1 ONE;
2 (4 BROMOBENZYL)2,3,4,9 TETRAHYDRO BETA CARBOLINE 1 THIONE;
2 (4 TRIFLUOROMETHYLBENZYL) 2,3,4,9 TETRAHYDRO BETA CARBOLIN 1 ONE;
2 (4 TRIFLUOROMETHYLBENZYL)2,3,4,9 TETRAHYDRO BETA CARBOLINE 1 THIONE;
2 BENZYL 2,3,4,9 TETRAHYDRO BETA CARBOLINE 1 THIONE;
2 BENZYL 5,7 DICHLORO 2,3,4,9 TETRAHYDRO BETA CARBOLIN 1 ONE;
2 BENZYL 5,7 DIFLUORO 2,3,4,9 TETRAHYDRO BETA CARBOLIN 1 ONE;
2 BENZYL 6 BROMO 2,3,4,9 TETRAHYDRO BETA CARBOLINE 1 THIONE;
2 BENZYL 6 CHLORO 2,3,4,9 TETRAHYDRO BETA CARBOLINE 1 THIONE;
2 BENZYL 6 FLUORO 2,3,4,9 TETRAHYDRO BETA CARBOLINE 1 THIONE;
2 BENZYL 6 IODO 2,3,4,9 TETRAHYDRO BETA CARBOLIN 1 ONE;
2 BENZYL 6 ISO PROPYL 2,3,4,9 TETRAHYDRO BETA CARBOLIN 1 ONE;
2 BENZYL 7 CHLORO 2,3,4,9 TETRAHYDRO BETA CARBOLINE 1 THIONE;
5,7 DICHLORO 4,9 DIHYDRO 3H PYRANO[3,4]INDOL 1 ONE;
5,7 DIFLUORO 2 PHENYLETHYL 2,3,4,9 TETRAHYDRO BETA CARBOLIN 1 ONE;
5,7 DIFLUORO 4,9 DIHYDRO 3H PYRANO[3,4]INDOL 1 ONE;
6 FLUORO 2 (4 TRIFLUOROMETHYLBENZYL) 2,3,4,9 TETRAHYDRO BETA CARBOLIN 1 ONE;
6 FLUORO 2 (4 TRIFLUOROMETHYLBENZYL) 2,3,4,9 TETRAHYDRO BETA CARBOLINE 1 THIONE;
6 IODO 4,9 DIHYDRO 3H PYRANO[3,4]INDOL 1 ONE;
6 ISOPOPYL 4,9 DIHYDRO 3H PYRANO[3,4]INDOL 1 ONE;
[6 FLUORO 2 (4 FLUOROBENZYL) 1 OXO 1,2,3,4,9 TETRAHYDRO BETA CARBOLIN 9 YL]ACETIC ACID METHYL ESTER;
ALDEHYDE REDUCTASE;
ENZYME INHIBITOR;
EPALRESTAT;
UNCLASSIFIED DRUG;
UNINDEXED DRUG;
ARTICLE;
BINDING AFFINITY;
CONCENTRATION RESPONSE;
CONTROLLED STUDY;
DRUG DESIGN;
DRUG SCREENING;
DRUG SELECTIVITY;
DRUG STRUCTURE;
DRUG SYNTHESIS;
ENZYME BINDING;
HYDROGEN BOND;
IC 50;
LIGAND BINDING;
STRUCTURE ACTIVITY RELATION;
ACETIC ACIDS;
ALDEHYDE REDUCTASE;
BINDING SITES;
CARBOLINES;
COMPUTER SIMULATION;
DRUG DESIGN;
ENZYME ACTIVATION;
ENZYME INHIBITORS;
EVODIA;
HUMANS;
HYDROGEN BONDING;
KINETICS;
PROTEIN STRUCTURE, TERTIARY;
STRUCTURE-ACTIVITY RELATIONSHIP;
EVODIA RUTAECARPA;
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EID: 84855195635
PISSN: 09680896
EISSN: 14643391
Source Type: Journal
DOI: 10.1016/j.bmc.2011.10.073 Document Type: Article |
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Times cited : (14)
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References (28)
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