Structure-activity relations on [1-(3,5-difluoro-4-hydroxyphenyl)-1H- pyrrol-3-yl]phenylmethanone. the effect of methoxy substitution on aldose reductase inhibitory activity and selectivity

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 4, 2011, Pages 1426-1433

  Chatzopoulou, Maria ^a   Mamadou, Eduard ^a   Juskova, Maria ^b   Koukoulitsa, Cathrine ^c   Nicolaou, Ioannis ^a   Stefek, Milan ^b   Demopoulos, Vassilis J ^a  

^a ARISTOTLE UNIVERSITY OF THESSALONIKI   (Greece)

^b INSTITUTE OF EXPERIMENTAL PHARMACOLOGY AND TOXICOLOGY   (Slovakia)

^c UNIVERSITY OF ATHENS   (Greece)

Author keywords

Aldose and aldehyde reductase; ARI; Docking; Long term diabetic complications; Sorbitol assay

Indexed keywords

1 (3,5 DIFLUORO 4 HYDROXYPHENYL) 1H PYRROL 2 YL] 3 METHOXYPHENYLMETHANONE; 1 (3,5 DIFLUORO 4 HYDROXYPHENYL) 1H PYRROL 2 YL] 4 METHOXYPHENYLMETHANONE; 1 (3,5 DIFLUORO 4 HYDROXYPHENYL) 1H PYRROL 2 YL]PHENYLMETHANONE; 1 (3,5 DIFLUORO 4 HYDROXYPHENYL) 1H PYRROL 3 YL] 3 METHOXYPHENYLMETHANONE; 1 (3,5 DIFLUORO 4 HYDROXYPHENYL) 1H PYRROL 3 YL] 4 METHOXYPHENYLMETHANONE; 1 (3,5 DIFLUORO 4 HYDROXYPHENYL) 1H PYRROL 3 YL]PHENYLMETHANONE; ALDEHYDE REDUCTASE; ALDOSE REDUCTASE INHIBITOR; SORBITOL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME INHIBITION; MALE; NONHUMAN; RAT; SIMULATION; STRUCTURE ACTIVITY RELATION;

ALDEHYDE REDUCTASE; ANIMALS; ENZYME INHIBITORS; MODELS, MOLECULAR; PHENOLS; PYRROLES; RATS; RATS, INBRED F344; STRUCTURE-ACTIVITY RELATIONSHIP;

RATTUS;

EID: 79951552668     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.01.009     Document Type: Article

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