Synthesis and evaluation of novel 2-pyridone derivatives as inhibitors of phosphodiesterase3 (PDE3): A target for heart failure and platelet aggregation

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 18, 2012, Pages 6010-6015

  Ravinder, Mettu ^a   Mahendar, Budde ^a   Mattapally, Saidulu ^a   Hamsini, Kommi Venkata ^a   Reddy, Thatikonda Narendar ^a   Rohit, Chilappa ^b   Srinivas, Kolupula ^b   Banerjee, Sanjay Kumar ^a   Rao, Vaidya Jayathirtha ^a,b  

^a INDIAN INSTITUTE OF CHEMICAL TECHNOLOGY   (India)

^b NATIONAL INSTITUTE OF PHARMACEUTICAL EDUCATION AND RESEARCH NIPER   (India)

Author keywords

2 Pyridone derivatives; Baylis Hillman acetates; Docking studies; Enamines; Leads; PDE3 inhibition

Indexed keywords

2 PYRIDONE DERIVATIVE; ACETIC ACID DERIVATIVE; AMRINONE; MILRINONE; NITRILE; PHOSPHODIESTERASE III; PYRIDONE DERIVATIVE;

ARTICLE; CONTROLLED STUDY; CYCLIZATION; DRUG BINDING; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; ENZYME INHIBITION; HEART FAILURE; THROMBOCYTE AGGREGATION;

CARDIOTONIC AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; HEART FAILURE; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PHOSPHODIESTERASE 3 INHIBITORS; PLATELET AGGREGATION; PYRIDONES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84865491180     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.05.019     Document Type: Article

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