The PPARδ agonist GW0742 inhibits neuroinflammation, but does not restore neurogenesis or prevent early delayed hippocampal-dependent cognitive impairment after whole-brain irradiation

Free Radical Biology and Medicine

Volumn 61, Issue , 2013, Pages 1-9

  Schnegg, Caroline I ^a   Greene Schloesser, Dana ^a   Kooshki, Mitra ^a   Payne, Valerie S ^a   Hsu, Fang Chi ^a   Robbins, Mike E ^a  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

Author keywords

C57Bl 6 wild type mice; Cognitive impairment; Free radicals; Neurogenesis; Neuroinflammation; PPAR agonists; PPAR KO mice; Whole brain irradiation

Indexed keywords

[4 [2 (3 FLUORO 4 TRIFLUOROMETHYLPHENYL) 4 METHYL 5 THIAZOLYLMETHYLTHIO] 2 METHYLPHENOXY]ACETIC ACID; INTERLEUKIN 1BETA; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ASTROCYTE; BARNES MAZE TASK; BRAIN INJURY; BRAIN RADIATION; CELL ACTIVATION; COGNITIVE DEFECT; CONTROLLED STUDY; DENTATE GYRUS; DENTATE HILUS; DISEASE MARKER; DRUG EFFICACY; DRUG INHIBITION; HIPPOCAMPUS; MAZE TEST; MEMORY DISORDER; MICROGLIA; MOUSE; NERVOUS SYSTEM DEVELOPMENT; NERVOUS SYSTEM INFLAMMATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SPATIAL MEMORY; TASK PERFORMANCE; WHOLE BRAIN IRRADIATION; WILD TYPE;

MUS;

EID: 84876003107     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2013.03.002     Document Type: Article

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