Proinflammatory cytokine and ligands modulate cardiac peroxisome proliferator-activated receptors

European Journal of Clinical Investigation

Volumn 39, Issue 1, 2009, Pages 23-30

  Lee, T I ^a,b,d   Kao, Y H ^a,d   Chen, Y C ^c   Chen, Y J ^a,b,d  

^a TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^b TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^c NATIONAL DEFENSE MEDICAL CENTER   (Taiwan)

^d TAIPEI MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Ascorbic acid; Coenzyme Q10; Peroxisome proliferator activated receptors; Tumour necrosis factor alpha

Indexed keywords

ASCORBIC ACID; FENOFIBRATE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIGAND; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PIOGLITAZONE; ROSIGLITAZONE; SN 50; TUMOR NECROSIS FACTOR ALPHA; UBIDECARENONE;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; HEART FUNCTION; INFLAMMATION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR UPREGULATION;

ASCORBIC ACID; CELLS, CULTURED; HUMANS; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TUMOR NECROSIS FACTOR-ALPHA; UBIQUINONE;

EID: 57649198440     PISSN: 00142972     EISSN: 13652362     Source Type: Journal    
DOI: 10.1111/j.1365-2362.2008.02062.x     Document Type: Article

References (33)

1. Issemann I, Green S. Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators. Nature 1990 347 : 645 50.
2. Plutzky J. Peroxisome proliferator-activated receptors as therapeutic targets in inflammation. J Am Coll Cardiol 2003 42 : 1764 6.
3. Staels B, Fruchart JC. Therapeutic roles of peroxisome proliferator-activated receptor agonists. Diabetes 2005 54 : 2460 70.
4. Smeets PJ, Planavila A, van der Vusse GJ, van Bilsen M. Peroxisome proliferator-activated receptors and inflammation: take it to heart. Acta Physiol (Oxf) 2007 191 : 171 88.
5. Moraes LA, Piqueras L, Bishop-Bailey D. Peroxisome proliferator-activated receptors and inflammation. Pharmacol Ther 2006 110 : 371 85.
6. Jiang C, Ting AT, Seed B. PPAR-γ agonists inhibit production of monocyte inflammatory cytokines. Nature 1998 391 : 82 6.
7. Ricote M, Li AC, Willson TM, Kelly CJ, Glass CK. The peroxisome proliferator-activated receptor-γ is a negative regulator of macrophage activation. Nature 1998 391 : 79 82.
8. Yuan Z, Liu Y, Zhang J, Kishimoto C, Wang Y, Ma A et al. Peroxisome proliferation-activated receptor-γ ligands ameliorate experimental autoimmune myocarditis. Cardiovasc Res 2003 59 : 685 94.
9. Matsumori A, Yamada T, Suzuki H, Matoba Y, Sasayama S. Increased circulating cytokines in patients with myocarditis and cardiomyopathy. Br Heart J 1994 72 : 561 6.
10. Neumann FJ, Ott I, Gawaz M, Richardt G, Holzapfel H, Jochum M et al. Cardiac release of cytokines and inflammatory responses in acute myocardial infarction. Circulation 1995 92 : 748 55.
11. Zhou M, Wu R, Dong W, Jacob A, Wang P. Endotoxin downregulates peroxisome proliferator-activated receptor-γ via the increase in TNF-α release. Am J Physiol Regul Integr Comp Physiol 2008 294 : R84 92.
12. Sung CK, She H, Xiong S, Tsukamoto H. Tumor necrosis factor-α inhibits peroxisome proliferator-activated receptor γ activity at a posttranslational level in hepatic stellate cells. Am J Physiol Gastrointest Liver Physiol 2004 286 : G722 9.
13. 2 and tumor necrosis factor-α induce differential binding of the redox-responsive transcription factors AP-1 and NF-κB to the interleukin-8 promoter in endothelial and epithelial cells. J Biol Chem 1998 273 : 32670 8.
14. Yue TL, Nerurkar SS, Bao W, Jucker BM, Sarov-Blat L, Steplewski K et al. In vivo activation of peroxisome proliferator-activated receptor-δ protects the heart from ischemia/reperfusion injury in Zucker fatty rats. J Pharmacol Exp Ther 2008 325 : 466 74.
15. Nissen SE, Wolski K. Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes. N Engl J Med 2007 356 : 2457 71.
16. Nissen SE, Wolski K, Topol EJ. Effect of muraglitazar on death and major adverse cardiovascular events in patients with type 2 diabetes mellitus. JAMA 2005 294 : 2581 6.
17. Claycomb WC, Lanson NA Jr., Stallworth BS, Egeland DB, Delcarpio JB, Bahinski A et al. HL-1 cells: a cardiac muscle cell line that contracts and retains phenotypic characteristics of the adult cardiomyocyte. Proc Natl Acad Sci USA 1998 95 : 2979 84.
18. 10 prevents high glucose-induced oxidative stress in human umbilical vein endothelial cells. Eur J Pharmacol 2007 566 : 1 10.
19. 2-induced damage and iron homeostasis in human cells. Free Radic Biol Med 2007 43 : 1165 75.
20. Gilde AJ, Van Bilsen M. Peroxisome proliferator-activated receptors (PPARS): regulators of gene expression in heart and skeletal muscle. Acta Physiol Scand 2003 178 : 425 34.
21. Yang Q, Li Y. Roles of PPARs on regulating myocardial energy and lipid homeostasis. J Mol Med 2007 85 : 697 706.
22. Finck BN, Han X, Courtois M, Aimond F, Nerbonne JM, Kovacs A et al. A critical role for PPARα-mediated lipotoxicity in the pathogenesis of diabetic cardiomyopathy: modulation by dietary fat content. Proc Natl Acad Sci USA 2003 100 : 1226 31.
23. Beier K, Völkl A, Fahimi HD. TNF-α downregulates the peroxisome proliferator activated receptor-α and the mRNAs encoding peroxisomal proteins in rat liver. FEBS Lett 1997 412 : 385 7.
24. Finck BN, Lehman JJ, Leone TC, Welch MJ, Bennett MJ, Kovacs A et al. The cardiac phenotype induced by PPARα overexpression mimics that caused by diabetes mellitus. J Clin Invest 2002 109 : 121 30.
25. Leone TC, Weinheimer CJ, Kelly DP. A critical role for the peroxisome proliferator-activated receptor α (PPARα) in the cellular fasting response: the PPARα-null mouse as a model of fatty acid oxidation disorders. Proc Natl Acad Sci USA 1999 96 : 7473 8.
26. Reddy RC, Narala VR, Keshamouni VG, Milam JE, Newstead MW, Standiford TJ. Sepsis-induced inhibition of neutrophil chemotaxis is mediated by activation of peroxisome proliferator-activated receptor-γ. Blood 2008 112 : 4250 8.
27. Zhang B, Berger J, Hu E, Szalkowski D, White-Carrington S, Spiegelman BM et al. Negative regulation of peroxisome proliferator-activated receptor-γ gene expression contributes to the antiadipogenic effects of tumor necrosis factor-α. Mol Endocrinol 1996 10 : 1457 66.
28. Sewter C, Blows F, Considine R, Vidal-Puig A, O′Rahilly S. Differential effects of adiposity on peroxisomal proliferator-activated receptor γ1 and γ2 messenger ribonucleic acid expression in human adipocytes. J Clin Endocrinol Metab 2002 87 : 4203 7.
29. Daniela F, Dirk W, Alexander R, Carola S, Eva B, Jens F et al. Up-regulation of PPAR-γ in myocardial infarction. Eur J Heart Fail 2008 10 : 30 8.
30. Li H, Lin X. Positive and negative signaling components involved in TNF α-induced NF-κB activation. Cytokine 2008 41 : 1 8.
31. Chen G, Goeddel DV. TNF-R1 signaling: a beautiful pathway. Science 2002 296 : 1634 5.
32. Carr A, Frei B. Does vitamin C act as a pro-oxidant under physiological conditions? FASEB J 1999 13 : 1007 24.
33. 10 on decreased oxidative stress resistance induced by simvastatin. J Clin Biochem Nutr 2007 40 : 194 202.