메뉴 건너뛰기




Volumn 149, Issue 3 PB, 2013, Pages 556-565

Roles of the protein tyrosine phosphatase PTPN22 in immunity and autoimmunity

Author keywords

Autoimmunity; Autoreactive cells; Genetic predisposition; Immune tolerance; PTPN22; T regulatory cells (Treg)

Indexed keywords

INTERFERON REGULATORY FACTOR 3; INTERFERON REGULATORY FACTOR 7; INTERLEUKIN 12; NON RECEPTOR PROTEIN TYROSINE PHOSPHATASE 22; PROTEIN KINASE SYK; PROTEIN KINASE ZAP 70; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 3;

EID: 84888022394     PISSN: 15216616     EISSN: 15217035     Source Type: Journal    
DOI: 10.1016/j.clim.2013.10.006     Document Type: Review
Times cited : (56)

References (66)
  • 2
    • 11144266638 scopus 로고    scopus 로고
    • Association of the single nucleotide polymorphism C1858T of the PTPN22 gene with type 1 diabetes
    • Ladner M.B., Bottini N., Valdes A.M., Noble J.A. Association of the single nucleotide polymorphism C1858T of the PTPN22 gene with type 1 diabetes. Hum. Immunol. 2005, 66:60-64.
    • (2005) Hum. Immunol. , vol.66 , pp. 60-64
    • Ladner, M.B.1    Bottini, N.2    Valdes, A.M.3    Noble, J.A.4
  • 4
    • 37449023760 scopus 로고    scopus 로고
    • PTPN22: its role in SLE and autoimmunity
    • Chung S.A., Criswell L.A. PTPN22: its role in SLE and autoimmunity. Autoimmunity 2007, 40:582-590.
    • (2007) Autoimmunity , vol.40 , pp. 582-590
    • Chung, S.A.1    Criswell, L.A.2
  • 8
    • 38449097457 scopus 로고    scopus 로고
    • Further evidence of a primary, causal association of the PTPN22 620W variant with type 1 diabetes
    • Zoledziewska M., Perra C., Orru V., Moi L., Frongia P., Congia M., Bottini N., Cucca F. Further evidence of a primary, causal association of the PTPN22 620W variant with type 1 diabetes. Diabetes 2008, 57:229-234.
    • (2008) Diabetes , vol.57 , pp. 229-234
    • Zoledziewska, M.1    Perra, C.2    Orru, V.3    Moi, L.4    Frongia, P.5    Congia, M.6    Bottini, N.7    Cucca, F.8
  • 9
    • 84880313934 scopus 로고    scopus 로고
    • Intersection between genetic polymorphisms and immune deviation in type 1 diabetes
    • Long A., Buckner J.H. Intersection between genetic polymorphisms and immune deviation in type 1 diabetes. Curr. Opin. Endocrinol. Diabetes Obes. 2013, 20:285-291.
    • (2013) Curr. Opin. Endocrinol. Diabetes Obes. , vol.20 , pp. 285-291
    • Long, A.1    Buckner, J.H.2
  • 11
    • 59649123838 scopus 로고    scopus 로고
    • The protein tyrosine phosphatase non-receptor type 22 C1858T polymorphism is a joint susceptibility locus for immunthyroiditis and autoimmune diabetes
    • Dultz G., Matheis N., Dittmar M., Rohrig B., Bender K., Kahaly G.J. The protein tyrosine phosphatase non-receptor type 22 C1858T polymorphism is a joint susceptibility locus for immunthyroiditis and autoimmune diabetes. Thyroid 2009, 19:143-148.
    • (2009) Thyroid , vol.19 , pp. 143-148
    • Dultz, G.1    Matheis, N.2    Dittmar, M.3    Rohrig, B.4    Bender, K.5    Kahaly, G.J.6
  • 15
    • 27844531635 scopus 로고    scopus 로고
    • A single-nucleotide polymorphism in the gene encoding lymphoid protein tyrosine phosphatase (PTPN22) confers susceptibility to generalised vitiligo
    • Canton I., Akhtar S., Gavalas N.G., Gawkrodger D.J., Blomhoff A., Watson P.F., Weetman A.P., Kemp E.H. A single-nucleotide polymorphism in the gene encoding lymphoid protein tyrosine phosphatase (PTPN22) confers susceptibility to generalised vitiligo. Genes Immun. 2005, 6:584-587.
    • (2005) Genes Immun. , vol.6 , pp. 584-587
    • Canton, I.1    Akhtar, S.2    Gavalas, N.G.3    Gawkrodger, D.J.4    Blomhoff, A.5    Watson, P.F.6    Weetman, A.P.7    Kemp, E.H.8
  • 17
    • 81755179431 scopus 로고    scopus 로고
    • Why is PTPN22 a good candidate susceptibility gene for autoimmune disease?
    • Burn G., Svensson L., Sanchez-Blanco C., Saini M., Cope A. Why is PTPN22 a good candidate susceptibility gene for autoimmune disease?. FEBS Lett. 2011, 585:3689-3698.
    • (2011) FEBS Lett. , vol.585 , pp. 3689-3698
    • Burn, G.1    Svensson, L.2    Sanchez-Blanco, C.3    Saini, M.4    Cope, A.5
  • 20
    • 33845653894 scopus 로고    scopus 로고
    • Is there a common genetic basis for autoimmune diseases?
    • Anaya J.M., Gomez L., Castiblanco J. Is there a common genetic basis for autoimmune diseases?. Clin. Dev. Immunol. 2006, 13:185-195.
    • (2006) Clin. Dev. Immunol. , vol.13 , pp. 185-195
    • Anaya, J.M.1    Gomez, L.2    Castiblanco, J.3
  • 21
    • 0033559313 scopus 로고    scopus 로고
    • Cloning and characterization of a lymphoid-specific, inducible human protein tyrosine phosphatase, Lyp
    • Cohen S., Dadi H., Shaoul E., Sharfe N., Roifman C.M. Cloning and characterization of a lymphoid-specific, inducible human protein tyrosine phosphatase, Lyp. Blood 1999, 93:2013-2024.
    • (1999) Blood , vol.93 , pp. 2013-2024
    • Cohen, S.1    Dadi, H.2    Shaoul, E.3    Sharfe, N.4    Roifman, C.M.5
  • 22
    • 0242712698 scopus 로고    scopus 로고
    • Characterization of TCR-induced receptor-proximal signaling events negatively regulated by the protein tyrosine phosphatase PEP
    • Gjorloff-Wingren A., Saxena M., Williams S., Hammi D., Mustelin T. Characterization of TCR-induced receptor-proximal signaling events negatively regulated by the protein tyrosine phosphatase PEP. Eur. J. Immunol. 1999, 29:3845-3854.
    • (1999) Eur. J. Immunol. , vol.29 , pp. 3845-3854
    • Gjorloff-Wingren, A.1    Saxena, M.2    Williams, S.3    Hammi, D.4    Mustelin, T.5
  • 23
    • 0942279640 scopus 로고    scopus 로고
    • PEST domain-enriched tyrosine phosphatase (PEP) regulation of effector/memory T cells
    • Hasegawa K. PEST domain-enriched tyrosine phosphatase (PEP) regulation of effector/memory T cells. Science 2004, 303.
    • (2004) Science , vol.303
    • Hasegawa, K.1
  • 24
    • 63749120634 scopus 로고    scopus 로고
    • Conjugation of antisense oligonucleotides to PEGylated carbon nanotubes enables efficient knockdown of PTPN22 in T lymphocytes
    • Delogu L.G., Magrini A., Bergamaschi A., Rosato N., Dawson M.I., Bottini N., Bottini M. Conjugation of antisense oligonucleotides to PEGylated carbon nanotubes enables efficient knockdown of PTPN22 in T lymphocytes. Bioconjug. Chem. 2009, 20:427-431.
    • (2009) Bioconjug. Chem. , vol.20 , pp. 427-431
    • Delogu, L.G.1    Magrini, A.2    Bergamaschi, A.3    Rosato, N.4    Dawson, M.I.5    Bottini, N.6    Bottini, M.7
  • 25
    • 84865362587 scopus 로고    scopus 로고
    • Regulatory NK cells in autoimmune disease
    • Tian Z., Gershwin M.E., Zhang C. Regulatory NK cells in autoimmune disease. J. Autoimmun. 2012, 39:206-215.
    • (2012) J. Autoimmun. , vol.39 , pp. 206-215
    • Tian, Z.1    Gershwin, M.E.2    Zhang, C.3
  • 26
    • 84870424721 scopus 로고    scopus 로고
    • Therapeutic manipulation of natural killer (NK) T cells in autoimmunity: are we close to reality?
    • Simoni Y., Diana J., Ghazarian L., Beaudoin L., Lehuen A. Therapeutic manipulation of natural killer (NK) T cells in autoimmunity: are we close to reality?. Clin. Exp. Immunol. 2013, 171:8-19.
    • (2013) Clin. Exp. Immunol. , vol.171 , pp. 8-19
    • Simoni, Y.1    Diana, J.2    Ghazarian, L.3    Beaudoin, L.4    Lehuen, A.5
  • 27
    • 77956305092 scopus 로고    scopus 로고
    • PTPN22 gene regulates natural killer cell proliferation during in vitro expansion
    • Douroudis K., Shcherbakova A., Everaus H., Aints A. PTPN22 gene regulates natural killer cell proliferation during in vitro expansion. Tissue Antigens 2010, 76:315-318.
    • (2010) Tissue Antigens , vol.76 , pp. 315-318
    • Douroudis, K.1    Shcherbakova, A.2    Everaus, H.3    Aints, A.4
  • 28
    • 33947590063 scopus 로고    scopus 로고
    • Whatever turns you on: accessory-cell-dependent activation of NK cells by pathogens
    • Newman K.C., Riley E.M. Whatever turns you on: accessory-cell-dependent activation of NK cells by pathogens. Nat. Rev. Immunol. 2007, 7:279-291.
    • (2007) Nat. Rev. Immunol. , vol.7 , pp. 279-291
    • Newman, K.C.1    Riley, E.M.2
  • 29
    • 84876463917 scopus 로고    scopus 로고
    • Loss of protein tyrosine phosphatase non-receptor type 22 regulates interferon-γ-induced signaling in human monocytes
    • Spalinger M., Lang S., Weber A., Frei P., Fried M., Rogler G., Scharl M. Loss of protein tyrosine phosphatase non-receptor type 22 regulates interferon-γ-induced signaling in human monocytes. Gastroenterology 2013, 144:978-988.
    • (2013) Gastroenterology , vol.144 , pp. 978-988
    • Spalinger, M.1    Lang, S.2    Weber, A.3    Frei, P.4    Fried, M.5    Rogler, G.6    Scharl, M.7
  • 30
    • 84883394259 scopus 로고    scopus 로고
    • Ptpn22 modulates macrophage polarization and susceptibility to dextran sulfate sodium-induced colitis
    • Chang H.H., Miaw S.C., Tseng W., Sun Y.W., Liu C.C., Tsao H.W., Ho I.C. ptpn22 modulates macrophage polarization and susceptibility to dextran sulfate sodium-induced colitis. J. Immunol. 2013, 191:2134-2143.
    • (2013) J. Immunol. , vol.191 , pp. 2134-2143
    • Chang, H.H.1    Miaw, S.C.2    Tseng, W.3    Sun, Y.W.4    Liu, C.C.5    Tsao, H.W.6    Ho, I.C.7
  • 32
    • 33748447541 scopus 로고    scopus 로고
    • Type I interferon in systemic lupus erythematosus and other autoimmune diseases
    • Banchereau J., Pascual V. Type I interferon in systemic lupus erythematosus and other autoimmune diseases. Immunity 2006, 25:383-392.
    • (2006) Immunity , vol.25 , pp. 383-392
    • Banchereau, J.1    Pascual, V.2
  • 33
    • 84861235405 scopus 로고    scopus 로고
    • Emerging therapies for systemic lupus erythematosus-focus on targeting interferon-alpha
    • Lichtman E.I., Helfgott S.M., Kriegel M.A. Emerging therapies for systemic lupus erythematosus-focus on targeting interferon-alpha. Clin. Immunol. 2012, 143:210-221.
    • (2012) Clin. Immunol. , vol.143 , pp. 210-221
    • Lichtman, E.I.1    Helfgott, S.M.2    Kriegel, M.A.3
  • 34
    • 66149086936 scopus 로고    scopus 로고
    • NOD-like receptors: role in innate immunity and inflammatory disease
    • Chen G., Shaw M.H., Kim Y.G., Nunez G. NOD-like receptors: role in innate immunity and inflammatory disease. Annu. Rev. Pathol. 2009, 4:365-398.
    • (2009) Annu. Rev. Pathol. , vol.4 , pp. 365-398
    • Chen, G.1    Shaw, M.H.2    Kim, Y.G.3    Nunez, G.4
  • 35
    • 84883082859 scopus 로고    scopus 로고
    • Protein tyrosine phosphatase non-receptor type 22 modulates NOD2-induced cytokine release and autophagy
    • Spalinger M.R., Lang S., Vavricka S.R., Fried M., Rogler G., Scharl M. Protein tyrosine phosphatase non-receptor type 22 modulates NOD2-induced cytokine release and autophagy. PLoS One 2013, 8:e72384.
    • (2013) PLoS One , vol.8
    • Spalinger, M.R.1    Lang, S.2    Vavricka, S.R.3    Fried, M.4    Rogler, G.5    Scharl, M.6
  • 39
    • 84870318487 scopus 로고    scopus 로고
    • Lack of the phosphatase PTPN22 increases adhesion of murine regulatory T cells to improve their immunosuppressive function
    • Brownlie R.J., Miosge L.A., Vassilakos D., Svensson L.M., Cope A., Zamoyska R. Lack of the phosphatase PTPN22 increases adhesion of murine regulatory T cells to improve their immunosuppressive function. Sci. Signal. 2012, 5.
    • (2012) Sci. Signal. , vol.5
    • Brownlie, R.J.1    Miosge, L.A.2    Vassilakos, D.3    Svensson, L.M.4    Cope, A.5    Zamoyska, R.6
  • 41
    • 84874424163 scopus 로고    scopus 로고
    • PTPN22 silencing in the NOD model indicates the type 1 diabetes-associated allele is not a loss-of-function variant
    • Zheng P., Kissler S. PTPN22 silencing in the NOD model indicates the type 1 diabetes-associated allele is not a loss-of-function variant. Diabetes 2013, 62:896-904.
    • (2013) Diabetes , vol.62 , pp. 896-904
    • Zheng, P.1    Kissler, S.2
  • 42
    • 84880111973 scopus 로고    scopus 로고
    • Different modulation of ptpn22 in effector and regulatory T cells leads to attenuation of autoimmune diabetes in transgenic nonobese diabetic mice
    • Yeh L.T., Miaw S.C., Lin M.H., Chou F.C., Shieh S.J., Chuang Y.P., Lin S.H., Chang D.M., Sytwu H.K. Different modulation of ptpn22 in effector and regulatory T cells leads to attenuation of autoimmune diabetes in transgenic nonobese diabetic mice. J. Immunol. 2013, 191:594-607.
    • (2013) J. Immunol. , vol.191 , pp. 594-607
    • Yeh, L.T.1    Miaw, S.C.2    Lin, M.H.3    Chou, F.C.4    Shieh, S.J.5    Chuang, Y.P.6    Lin, S.H.7    Chang, D.M.8    Sytwu, H.K.9
  • 44
    • 63049091860 scopus 로고    scopus 로고
    • The antigen-specific CD8+ T cell repertoire in unimmunized mice includes memory phenotype cells bearing markers of homeostatic expansion
    • Haluszczak C., Akue A.D., Hamilton S.E., Johnson L.D., Pujanauski L., Teodorovic L., Jameson S.C., Kedl R.M. The antigen-specific CD8+ T cell repertoire in unimmunized mice includes memory phenotype cells bearing markers of homeostatic expansion. J. Exp. Med. 2009, 206:435-448.
    • (2009) J. Exp. Med. , vol.206 , pp. 435-448
    • Haluszczak, C.1    Akue, A.D.2    Hamilton, S.E.3    Johnson, L.D.4    Pujanauski, L.5    Teodorovic, L.6    Jameson, S.C.7    Kedl, R.M.8
  • 45
    • 65549123867 scopus 로고    scopus 로고
    • Natural and adaptive foxp3+ regulatory T cells: more of the same or a division of labor?
    • Curotto de Lafaille M., Lafaille J. Natural and adaptive foxp3+ regulatory T cells: more of the same or a division of labor?. Immunity 2009, 30:626-635.
    • (2009) Immunity , vol.30 , pp. 626-635
    • Curotto de Lafaille, M.1    Lafaille, J.2
  • 46
    • 64249119896 scopus 로고    scopus 로고
    • PTPN22 deficiency cooperates with the CD45 E613R allele to break tolerance on a non-autoimmune background
    • Zikherman J., Hermiston M., Steiner D., Hasegawa K., Chan A., Weiss A. PTPN22 deficiency cooperates with the CD45 E613R allele to break tolerance on a non-autoimmune background. J. Immunol. 2009, 182.
    • (2009) J. Immunol. , vol.182
    • Zikherman, J.1    Hermiston, M.2    Steiner, D.3    Hasegawa, K.4    Chan, A.5    Weiss, A.6
  • 52
    • 0029164734 scopus 로고
    • TCR/CD3 complex-mediated signal transduction pathway in T cells and T cell lines from patients with systemic lupus erythematosus
    • Vassilopoulos D., Kovacs B., Tsokos G.C. TCR/CD3 complex-mediated signal transduction pathway in T cells and T cell lines from patients with systemic lupus erythematosus. J. Immunol. 1995, 155:2269-2281.
    • (1995) J. Immunol. , vol.155 , pp. 2269-2281
    • Vassilopoulos, D.1    Kovacs, B.2    Tsokos, G.C.3
  • 53
    • 0034744286 scopus 로고    scopus 로고
    • Fc epsilon receptor type I gamma chain replaces the deficient T cell receptor zeta chain in T cells of patients with systemic lupus erythematosus
    • Enyedy E.J., Nambiar M.P., Liossis S.N., Dennis G., Kammer G.M., Tsokos G.C. Fc epsilon receptor type I gamma chain replaces the deficient T cell receptor zeta chain in T cells of patients with systemic lupus erythematosus. Arthritis Rheum. 2001, 44:1114-1121.
    • (2001) Arthritis Rheum. , vol.44 , pp. 1114-1121
    • Enyedy, E.J.1    Nambiar, M.P.2    Liossis, S.N.3    Dennis, G.4    Kammer, G.M.5    Tsokos, G.C.6
  • 54
    • 0038062836 scopus 로고    scopus 로고
    • Rewiring the T-cell: signaling defects and novel prospects for the treatment of SLE
    • Tsokos G.C., Nambiar M.P., Tenbrock K., Juang Y.T. Rewiring the T-cell: signaling defects and novel prospects for the treatment of SLE. Trends Immunol. 2003, 24:259-263.
    • (2003) Trends Immunol. , vol.24 , pp. 259-263
    • Tsokos, G.C.1    Nambiar, M.P.2    Tenbrock, K.3    Juang, Y.T.4
  • 55
    • 0035869333 scopus 로고    scopus 로고
    • Molecular basis of deficient IL-2 production in T cells from patients with systemic lupus erythematosus
    • Solomou E.E., Juang Y.T., Gourley M.F., Kammer G.M., Tsokos G.C. Molecular basis of deficient IL-2 production in T cells from patients with systemic lupus erythematosus. J. Immunol. 2001, 166:4216-4222.
    • (2001) J. Immunol. , vol.166 , pp. 4216-4222
    • Solomou, E.E.1    Juang, Y.T.2    Gourley, M.F.3    Kammer, G.M.4    Tsokos, G.C.5
  • 56
    • 77955898582 scopus 로고    scopus 로고
    • T cells and follicular dendritic cells in germinal center B-cell formation and selection
    • Vinuesa C.G., Linterman M.A., Goodnow C.C., Randall K.L. T cells and follicular dendritic cells in germinal center B-cell formation and selection. Immunol. Rev. 2010, 237:72-89.
    • (2010) Immunol. Rev. , vol.237 , pp. 72-89
    • Vinuesa, C.G.1    Linterman, M.A.2    Goodnow, C.C.3    Randall, K.L.4
  • 57
    • 84859720726 scopus 로고    scopus 로고
    • T-follicular helper cell differentiation and the co-option of this pathway by non-helper cells
    • Linterman M.A., Liston A., Vinuesa C.G. T-follicular helper cell differentiation and the co-option of this pathway by non-helper cells. Immunol. Rev. 2012, 247:143-159.
    • (2012) Immunol. Rev. , vol.247 , pp. 143-159
    • Linterman, M.A.1    Liston, A.2    Vinuesa, C.G.3
  • 58
    • 84861694711 scopus 로고    scopus 로고
    • Follicular helper T cells in immunity and systemic autoimmunity
    • Craft J.E. Follicular helper T cells in immunity and systemic autoimmunity. Nat. Rev. Rheumatol. 2012, 8:337-347.
    • (2012) Nat. Rev. Rheumatol. , vol.8 , pp. 337-347
    • Craft, J.E.1
  • 59
    • 0029829026 scopus 로고    scopus 로고
    • B cells from patients with systemic lupus erythematosus display abnormal antigen receptor-mediated early signal transduction events
    • Liossis S.N., Kovacs B., Dennis G., Kammer G.M., Tsokos G.C. B cells from patients with systemic lupus erythematosus display abnormal antigen receptor-mediated early signal transduction events. J. Clin. Invest. 1996, 98:2549-2557.
    • (1996) J. Clin. Invest. , vol.98 , pp. 2549-2557
    • Liossis, S.N.1    Kovacs, B.2    Dennis, G.3    Kammer, G.M.4    Tsokos, G.C.5
  • 62
    • 65449176044 scopus 로고    scopus 로고
    • Cutting edge: the PTPN22 allelic variant associated with autoimmunity impairs B cell signaling
    • Arechiga A.F., Habib T., He Y., Zhang X., Zhang Z.Y., Funk A., Buckner J.H. Cutting edge: the PTPN22 allelic variant associated with autoimmunity impairs B cell signaling. J. Immunol. 2009, 182:3343-3347.
    • (2009) J. Immunol. , vol.182 , pp. 3343-3347
    • Arechiga, A.F.1    Habib, T.2    He, Y.3    Zhang, X.4    Zhang, Z.Y.5    Funk, A.6    Buckner, J.H.7
  • 63
    • 84855332531 scopus 로고    scopus 로고
    • The establishment of early B cell tolerance in humans: lessons from primary immunodeficiency diseases
    • Meffre E. The establishment of early B cell tolerance in humans: lessons from primary immunodeficiency diseases. Ann. N. Y. Acad. Sci. 2011, 1246:1-10.
    • (2011) Ann. N. Y. Acad. Sci. , vol.1246 , pp. 1-10
    • Meffre, E.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.