-
2
-
-
84864619362
-
Insights into type 1 diabetes provided by genetic analyses
-
Morahan G. Insights into type 1 diabetes provided by genetic analyses. Curr Opin Endocrinol Diabetes Obes 2012; 19:263-270.
-
(2012)
Curr Opin Endocrinol Diabetes Obes
, vol.19
, pp. 263-270
-
-
Morahan, G.1
-
3
-
-
77954288805
-
Genetics of type 1 diabetes. what's next?
-
Pociot F, Akolkar B, Concannon P, et al. Genetics of type 1 diabetes. what's next? Diabetes 2010; 59:1561-1571.
-
(2010)
Diabetes
, vol.59
, pp. 1561-1571
-
-
Pociot, F.1
Akolkar, B.2
Concannon, P.3
-
5
-
-
79951998354
-
The carriage of the type 1 diabetes-associated R262W variant of human LNK correlates with increased proliferation of peripheral blood monocytes in diabetic patients
-
Lavrikova EY, Nikitin AG, Kuraeva TL, et al. The carriage of the type 1 diabetes-associated R262W variant of human LNK correlates with increased proliferation of peripheral blood monocytes in diabetic patients. Pediatr Diabetes 2011; 12:127-132.
-
(2011)
Pediatr Diabetes
, vol.12
, pp. 127-132
-
-
Lavrikova, E.Y.1
Nikitin, A.G.2
Kuraeva, T.L.3
-
6
-
-
84055191068
-
T cell protein tyrosine phosphatase attenuates T cell signaling to maintain tolerance in mice
-
Wiede F, Shields BJ, Chew SH, et al. T cell protein tyrosine phosphatase attenuates T cell signaling to maintain tolerance in mice. J Clin Invest 2011; 121:4758-4774.
-
(2011)
J Clin Invest
, vol.121
, pp. 4758-4774
-
-
Wiede, F.1
Shields, B.J.2
Chew, S.H.3
-
7
-
-
84860818905
-
Type II membrane protein CD69 regulates the formation of resting T-helper memory
-
Shinoda K, Tokoyoda K, Hanazawa A, et al. Type II membrane protein CD69 regulates the formation of resting T-helper memory. Proc Natl Acad Sci USA 2012; 109:7409-7414.
-
(2012)
Proc Natl Acad Sci USA
, vol.109
, pp. 7409-7414
-
-
Shinoda, K.1
Tokoyoda, K.2
Hanazawa, A.3
-
8
-
-
67349199566
-
Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes
-
Barrett JC, Clayton DG, Concannon P, et al. Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes. Nat Genet 2009.
-
(2009)
Nat Genet
-
-
Barrett, J.C.1
Clayton, D.G.2
Concannon, P.3
-
9
-
-
69349102624
-
Cell-specific protein phenotypesforthe autoimmune locus IL2RA using a genotype-selectable human bioresource
-
Dendrou CA, Plagnol V, Fung E, et al. Cell-specific protein phenotypesforthe autoimmune locus IL2RA using a genotype-selectable human bioresource. Nat Genet 2009; 41:1011-1015.
-
(2009)
Nat Genet
, vol.41
, pp. 1011-1015
-
-
Dendrou, C.A.1
Plagnol, V.2
Fung, E.3
-
10
-
-
69349084545
-
Closing the gap between genotype and phenotype
-
Gregersen PK. Closing the gap between genotype and phenotype. Nat Genet 2009; 41:958-959.
-
(2009)
Nat Genet
, vol.41
, pp. 958-959
-
-
Gregersen, P.K.1
-
11
-
-
40349109578
-
Genetic variation in PTPN22 corresponds to altered function of T and B lymphocytes
-
Rieck M, Arechiga A, Onengut-Gumuscu S, et al. Genetic variation in PTPN22 corresponds to altered function of T and B lymphocytes. J Immunol 2007; 179:4704-4710.
-
(2007)
J Immunol
, vol.179
, pp. 4704-4710
-
-
Rieck, M.1
Arechiga, A.2
Onengut-Gumuscu, S.3
-
12
-
-
80053439315
-
A genome-wide meta-analysis of six type 1 diabetes cohorts identifies multiple associated loci
-
Bradfield JP, Qu HQ, Wang K, et al. A genome-wide meta-analysis of six type 1 diabetes cohorts identifies multiple associated loci. PLoS Genet 2011; 7:e1002293.
-
(2011)
PLoS Genet
, vol.7
-
-
Bradfield, J.P.1
Qu, H.Q.2
Wang, K.3
-
13
-
-
8744266374
-
The codon 620 tryptophan allele of the lymphoid tyrosine phosphatase (LYP) gene is a major determinant of Graves' disease
-
Velaga MR, Wilson V, Jennings CE, et al. The codon 620 tryptophan allele of the lymphoid tyrosine phosphatase (LYP) gene is a major determinant of Graves' disease. J Clin Endocrinol Metab 2004; 89:5862-5865.
-
(2004)
J Clin Endocrinol Metab
, vol.89
, pp. 5862-5865
-
-
Velaga, M.R.1
Wilson, V.2
Jennings, C.E.3
-
14
-
-
3242713277
-
A missense single-nucleotide polymorphism in a gene encoding a protein tyrosine phosphatase (PTPN22) is associated with rheumatoid arthritis
-
Begovich AB, Carlton VE, Honigberg LA, et al. A missense single-nucleotide polymorphism in a gene encoding a protein tyrosine phosphatase (PTPN22) is associated with rheumatoid arthritis. Am J Hum Genet 2004; 75:330-337.
-
(2004)
Am J Hum Genet
, vol.75
, pp. 330-337
-
-
Begovich, A.B.1
Carlton, V.E.2
Honigberg, L.A.3
-
15
-
-
4143105691
-
Genetic association of the R620W polymorphism of protein tyrosine phosphatase PTPN22 with human SLE
-
Kyogoku C, Langefeld CD, Ortmann WA, et al. Genetic association of the R620W polymorphism of protein tyrosine phosphatase PTPN22 with human SLE. Am J Hum Genet 2004; 75:504-507.
-
(2004)
Am J Hum Genet
, vol.75
, pp. 504-507
-
-
Kyogoku, C.1
Langefeld, C.D.2
Ortmann, W.A.3
-
16
-
-
27844531635
-
A single-nucleotide polymorphism in the gene encoding lymphoid protein tyrosine phosphatase (PTPN22) confers susceptibility to generalised vitiligo
-
Canton I, Akhtar S, Gavalas NG, et al. A single-nucleotide polymorphism in the gene encoding lymphoid protein tyrosine phosphatase (PTPN22) confers susceptibility to generalised vitiligo. Genes Immun 2005; 6:584-587.
-
(2005)
Genes Immun
, vol.6
, pp. 584-587
-
-
Canton, I.1
Akhtar, S.2
Gavalas, N.G.3
-
17
-
-
32044456473
-
Association of the PTPN22*R620W polymorphism with autoimmune myasthenia gravis
-
Vandiedonck C, Capdevielle C, Giraud M, et al. Association of the PTPN22*R620W polymorphism with autoimmune myasthenia gravis. Ann Neurol 2006; 59:404-407.
-
(2006)
Ann Neurol
, vol.59
, pp. 404-407
-
-
Vandiedonck, C.1
Capdevielle, C.2
Giraud, M.3
-
18
-
-
11144292728
-
The R620W polymorphism of the protein tyrosine phosphatase PTPN22 is not associated with multiple sclerosis
-
Begovich AB, Caillier SJ, Alexander HC, et al. The R620W polymorphism of the protein tyrosine phosphatase PTPN22 is not associated with multiple sclerosis. Am J Hum Genet 2005; 76:184-187.
-
(2005)
Am J Hum Genet
, vol.76
, pp. 184-187
-
-
Begovich, A.B.1
Caillier, S.J.2
Alexander, H.C.3
-
19
-
-
26044482775
-
The functional genetic variation in the PTPN22 gene has a negligible effect on the susceptibility to develop inflammatory bowel disease
-
Martin MC, Oliver J, Urcelay E, et al. The functional genetic variation in the PTPN22 gene has a negligible effect on the susceptibility to develop inflammatory bowel disease. Tissue Antigens 2005; 66:314-317.
-
(2005)
Tissue Antigens
, vol.66
, pp. 314-317
-
-
Martin, M.C.1
Oliver, J.2
Urcelay, E.3
-
20
-
-
33745168780
-
Lack of association between the protein tyrosine phosphatase nonreceptor 22 (PTPN22)*620W allele and systemic sclerosis in the French Caucasian population
-
Wipff J, Allanore Y, Kahan A, et al. Lack of association between the protein tyrosine phosphatase nonreceptor 22 (PTPN22)*620W allele and systemic sclerosis in the French Caucasian population. Ann Rheum Dis 2006; 65:1230-1232.
-
(2006)
Ann Rheum Dis
, vol.65
, pp. 1230-1232
-
-
Wipff, J.1
Allanore, Y.2
Kahan, A.3
-
21
-
-
84862776528
-
LYP inhibits T-cell activation when dissociated from CSK
-
Vang T, Liu WH, Delacroix L, et al. LYP inhibits T-cell activation when dissociated from CSK. Nat Chem Biol 2012; 8:437-446.
-
(2012)
Nat Chem Biol
, vol.8
, pp. 437-446
-
-
Vang, T.1
Liu, W.H.2
Delacroix, L.3
-
22
-
-
28444469783
-
Autoimmune-associated lymphoid tyrosine phosphatase is a gain-of-function variant
-
Vang T, Congia M, Macis MD, et al. Autoimmune-associated lymphoid tyrosine phosphatase is a gain-of-function variant. Nat Genet 2005; 37:1317-1319.
-
(2005)
Nat Genet
, vol.37
, pp. 1317-1319
-
-
Vang, T.1
Congia, M.2
MacIs, M.D.3
-
23
-
-
84877115482
-
The PTPN22 risk variant promotes systemic autoimmunity in murine models
-
Dai X, James R, Habib T, et al. The PTPN22 risk variant promotes systemic autoimmunity in murine models. J Clin Invest 2013; 123:2024-2036.
-
(2013)
J Clin Invest
, vol.123
, pp. 2024-2036
-
-
Dai, X.1
James, R.2
Habib, T.3
-
24
-
-
65449176044
-
The PTPN22 allelic variant associated with autoimmunity impairs B cell signaling
-
Arechiga A, Habib T, He Y, et al. The PTPN22 allelic variant associated with autoimmunity impairs B cell signaling. J Immunol 2009; 182:3343-3347.
-
(2009)
J Immunol
, vol.182
, pp. 3343-3347
-
-
Arechiga, A.1
Habib, T.2
He, Y.3
-
25
-
-
80052376347
-
The PTPN22 allele encoding an R620W variant interferes with the removal of developing autoreactive B cells in humans
-
Menard L, Saadoun D, Isnardi I, et al. The PTPN22 allele encoding an R620W variant interferes with the removal of developing autoreactive B cells in humans. J Clin Investig 2011; 121:3635-3644.
-
(2011)
J Clin Investig
, vol.121
, pp. 3635-3644
-
-
Menard, L.1
Saadoun, D.2
Isnardi, I.3
-
26
-
-
84855369247
-
Altered B cell homeostasis is associated with type i diabetes and carriers of the PTPN22 allelic variant
-
Habib T, Funk A, Rieck M, et al. Altered B cell homeostasis is associated with type I diabetes and carriers of the PTPN22 allelic variant. J Immunol 2012; 188:487-496.
-
(2012)
J Immunol
, vol.188
, pp. 487-496
-
-
Habib, T.1
Funk, A.2
Rieck, M.3
-
27
-
-
84872790689
-
Interleukin-2 at the crossroads of effector responses, tolerance, and immunotherapy
-
Liao W, Lin JX, Leonard WJ. Interleukin-2 at the crossroads of effector responses, tolerance, and immunotherapy. Immunity 2013; 38:13-25.
-
(2013)
Immunity
, vol.38
, pp. 13-25
-
-
Liao, W.1
Lin, J.X.2
Leonard, W.J.3
-
29
-
-
84969213492
-
Genome-wide association study of 14 000 cases of seven common diseases and 3000 shared, controls
-
Welcome Trust Case Control Consortium
-
Welcome Trust Case Control Consortium. Genome-wide association study of 14 000 cases of seven common diseases and 3000 shared, controls. Nature 2007; 447:661-678.
-
(2007)
Nature
, vol.447
, pp. 661-678
-
-
-
30
-
-
77954223152
-
Genome-wide association study in alopecia areata implicates both innate and adaptive immunity
-
Petukhova L, Duvic M, Hordinsky M, et al. Genome-wide association study in alopecia areata implicates both innate and adaptive immunity. Nature 2010; 466:113-117.
-
(2010)
Nature
, vol.466
, pp. 113-117
-
-
Petukhova, L.1
Duvic, M.2
Hordinsky, M.3
-
31
-
-
34347341846
-
Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes
-
Todd JA, Walker NM, Cooper JD, et al. Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes. Nat Genet 2007; 39:857-864.
-
(2007)
Nat Genet
, vol.39
, pp. 857-864
-
-
Todd, J.A.1
Walker, N.M.2
Cooper, J.D.3
-
32
-
-
34548299105
-
Risk alleles for multiple sclerosis identified by a genomewide study
-
International Multliple Sclerosis Genetics Consortuim
-
International Multliple Sclerosis Genetics Consortuim. Risk alleles for multiple sclerosis identified by a genomewide study. N Engl J Med 2007; 357:851-862.
-
(2007)
N Engl J Med
, vol.357
, pp. 851-862
-
-
-
33
-
-
33947274768
-
Association of the interleukin-2 receptor alpha (IL-2Ralpha)/CD25 gene region with Graves' disease using a multilocus test and tag SNPs
-
Brand OJ, Lowe CE, Heward JM, et al. Association of the interleukin-2 receptor alpha (IL-2Ralpha)/CD25 gene region with Graves' disease using a multilocus test and tag SNPs. Clin Endocrinol (Oxf) 2007; 66:508-512.
-
(2007)
Clin Endocrinol (Oxf)
, vol.66
, pp. 508-512
-
-
Brand, O.J.1
Lowe, C.E.2
Heward, J.M.3
-
34
-
-
77951780943
-
Variant of TYR and autoimmunity susceptibility loci in generalized vitiligo
-
Jin Y, Birlea SA, Fain PR, et al. Variant of TYR and autoimmunity susceptibility loci in generalized vitiligo. N Engl J Med 2010; 362:1686-1697.
-
(2010)
N Engl J Med
, vol.362
, pp. 1686-1697
-
-
Jin, Y.1
Birlea, S.A.2
Fain, P.R.3
-
35
-
-
58949100205
-
IL2RA genetic heterogeneity in multiple sclerosis and type 1 diabetes susceptibility and soluble interleukin-2 receptor production
-
Maier LM, Lowe CE, Cooper J, et al. IL2RA genetic heterogeneity in multiple sclerosis and type 1 diabetes susceptibility and soluble interleukin-2 receptor production. PLoS Genet 2009; 5:e1000322.
-
(2009)
PLoS Genet
, vol.5
-
-
Maier, L.M.1
Lowe, C.E.2
Cooper, J.3
-
36
-
-
34249030885
-
IL2RA/CD25 polymorphisms contribute to multiple sclerosis susceptibility
-
Matesanz F, Caro-Maldonado A, Fedetz M, et al. IL2RA/CD25 polymorphisms contribute to multiple sclerosis susceptibility. J Neurol 2007; 254:682-684.
-
(2007)
J Neurol
, vol.254
, pp. 682-684
-
-
Matesanz, F.1
Caro-Maldonado, A.2
Fedetz, M.3
-
37
-
-
44349173654
-
Replication of signals from recent studies of Crohn's disease identifies previously unknown disease loci for ulcerative colitis
-
Franke A, Balschun T, Karlsen TH, et al. Replication of signals from recent studies of Crohn's disease identifies previously unknown disease loci for ulcerative colitis. Nat Genet 2008; 40:713-715.
-
(2008)
Nat Genet
, vol.40
, pp. 713-715
-
-
Franke, A.1
Balschun, T.2
Karlsen, T.H.3
-
38
-
-
34347324029
-
A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21
-
van Heel DA, Franke L, Hunt KA, et al. A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21. Nat Geanet 2007; 39:827-829.
-
(2007)
Nat Geanet
, vol.39
, pp. 827-829
-
-
Van Heel, D.A.1
Franke, L.2
Hunt, K.A.3
-
39
-
-
84860317093
-
Type 1 diabetes-associated IL2RA variation lowers IL-2 signaling and contributes to diminished CD4\+CD25\+ regulatory T cell function
-
Garg G, Tyler JR, Yang JH, et al. Type 1 diabetes-associated IL2RA variation lowers IL-2 signaling and contributes to diminished CD4\+CD25\+ regulatory T cell function. J Immunol 2012; 188:4644-4653.
-
(2012)
J Immunol
, vol.188
, pp. 4644-4653
-
-
Garg, G.1
Tyler, J.R.2
Yang, J.H.3
-
40
-
-
77954134112
-
A cis-acting regulatory variant in the IL2RA locus
-
Qu HQ, Verlaan DJ, Ge B, et al. A cis-acting regulatory variant in the IL2RA locus. J Immunol 2009; 183:5158-5162.
-
(2009)
J Immunol
, vol.183
, pp. 5158-5162
-
-
Qu, H.Q.1
Verlaan, D.J.2
Ge, B.3
-
41
-
-
34548367511
-
Large-scale genetic fine mapping and genotype-phenotype associations implicate polymorphism in the IL2RA region in type 1 diabetes
-
Lowe CE, Cooper JD, Brusko T, et al. Large-scale genetic fine mapping and genotype-phenotype associations implicate polymorphism in the IL2RA region in type 1 diabetes. Nat Genet 2007; 9:1074-1082.
-
(2007)
Nat Genet
, vol.9
, pp. 1074-1082
-
-
Lowe, C.E.1
Cooper, J.D.2
Brusko, T.3
-
42
-
-
84866890450
-
Proteome-wide analysis of disease-associated SNPs that show allele-specific transcription factor binding
-
Butter F, Davison L, Viturawong T, et al. Proteome-wide analysis of disease-associated SNPs that show allele-specific transcription factor binding. PLoS Genet 2012; 8:e1002982.
-
(2012)
PLoS Genet
, vol.8
-
-
Butter, F.1
Davison, L.2
Viturawong, T.3
-
43
-
-
71049178714
-
Influence of membrane CD25 stability on T lymphocyte activity: Implications for immunoregulation
-
Brusko TM, Wasserfall CH, Hulme MA, et al. Influence of membrane CD25 stability on T lymphocyte activity: implications for immunoregulation. PLoS ONE 2009; 4:e7980.
-
(2009)
PLoS ONE
, vol.4
-
-
Brusko, T.M.1
Wasserfall, C.H.2
Hulme, M.A.3
-
44
-
-
84867515505
-
Soluble IL-2Ralpha (sCD25) exacerbates autoimmunity and enhances the developmentof Th17 responses in mice
-
Russell SE, Moore AC, Fallon PG, Walsh PT. Soluble IL-2Ralpha (sCD25) exacerbates autoimmunity and enhances the developmentof Th17 responses in mice. PLoS ONE 2012; 7:e47748.
-
(2012)
PLoS ONE
, vol.7
-
-
Russell, S.E.1
Moore, A.C.2
Fallon, P.G.3
Walsh, P.T.4
-
45
-
-
63149109244
-
Soluble IL-2RA levels in multiple sclerosis subjects and the effect of soluble IL-2RA on immune responses
-
Maier LM, Anderson DE, Severson CA, et al. Soluble IL-2RA levels in multiple sclerosis subjects and the effect of soluble IL-2RA on immune responses. J Immunol 2009; 182:1541-1547.
-
(2009)
J Immunol
, vol.182
, pp. 1541-1547
-
-
Maier, L.M.1
Anderson, D.E.2
Severson, C.A.3
-
46
-
-
79952280031
-
An autoimmune-associated variant in PTPN2 reveals an impairment of IL-2R signaling in CD4(\+) T cells
-
Long SA, Cerosaletti K, Wan JY, et al. An autoimmune-associated variant in PTPN2 reveals an impairment of IL-2R signaling in CD4(\+) T cells. Genes Immun 2011; 12:116-125.
-
(2011)
Genes Immun
, vol.12
, pp. 116-125
-
-
Long, S.A.1
Cerosaletti, K.2
Wan, J.Y.3
-
47
-
-
15044343929
-
Cytoplasmic protein tyrosine phospha-tases, regulation and function: The roles of PTP1B and TC-PTP
-
Bourdeau A, Dube N, Tremblay ML. Cytoplasmic protein tyrosine phospha-tases, regulation and function: the roles of PTP1B and TC-PTP. Curr Opin Cell Biol 2005; 17:203-209.
-
(2005)
Curr Opin Cell Biol
, vol.17
, pp. 203-209
-
-
Bourdeau, A.1
Dube, N.2
Tremblay, M.L.3
-
48
-
-
61849135255
-
T-cell proteintyrosine phosphataseis a key regulator in immune cell signaling: Lessons from the knockout mouse model and implicationsin human disease
-
Doody KM, Bourdeau A, Tremblay ML. T-cell proteintyrosine phosphataseis a key regulator in immune cell signaling: lessons from the knockout mouse model and implicationsin human disease. Immunol Rev 2009; 228:325-341.
-
(2009)
Immunol Rev
, vol.228
, pp. 325-341
-
-
Doody, K.M.1
Bourdeau, A.2
Tremblay, M.L.3
-
49
-
-
78649526238
-
Mechanisms of impaired regulation by CD4(\+)CD25 (\+)FOXP3(\+) regulatory T cells in human autoimmune diseases
-
Buckner JH. Mechanisms of impaired regulation by CD4(\+)CD25 (\+)FOXP3(\+) regulatory T cells in human autoimmune diseases. Nat Rev Immunol 2010; 10:849-859.
-
(2010)
Nat Rev Immunol
, vol.10
, pp. 849-859
-
-
Buckner, J.H.1
-
50
-
-
33847246293
-
Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity
-
Yamanouchi J, Rainbow D, Serra P, et al. Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity. Nat Genet 2007; 39:329-337.
-
(2007)
Nat Genet
, vol.39
, pp. 329-337
-
-
Yamanouchi, J.1
Rainbow, D.2
Serra, P.3
-
51
-
-
43049174722
-
Central role of defective interleukin-2 production in the triggering of islet autoimmune destruction
-
Tang Q, Adams JY, Penaranda C, et al. Central role of defective interleukin-2 production in the triggering of islet autoimmune destruction. Immunity 2008; 28:687-697.
-
(2008)
Immunity
, vol.28
, pp. 687-697
-
-
Tang, Q.1
Adams, J.Y.2
Penaranda, C.3
-
52
-
-
77449143100
-
Defects in IL-2R signaling contribute to diminished maintenance of FOXP3 expression in CD4\+CD25\+ regulatory T cells of type 1 diabetic subjects
-
Long SA, Cerosaletti K, Bollyky PL, et al. Defects in IL-2R signaling contribute to diminished maintenance of FOXP3 expression in CD4\+CD25\+ regulatory T cells of type 1 diabetic subjects. Diabetes 2010; 59:407-415.
-
(2010)
Diabetes
, vol.59
, pp. 407-415
-
-
Long, S.A.1
Cerosaletti, K.2
Bollyky, P.L.3
|