PTPN22 silencing in the NOD model indicates the type 1 diabetes-associated allele is not a loss-of-function variant

Diabetes

Volumn 62, Issue 3, 2013, Pages 896-904

  Zheng, Peilin ^a   Kissler, Stephan ^a,b  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NON RECEPTOR PROTEIN TYROSINE PHOSPHATASE 22; RNA;

ALLELE; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; B LYMPHOCYTE; CELL PROLIFERATION; GENE SILENCING; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; INSULIN DEPENDENT DIABETES MELLITUS; LOSS OF FUNCTION MUTATION; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REGULATORY T LYMPHOCYTE; RNA INTERFERENCE;

AMINO ACID SUBSTITUTION; ANIMALS; APOPTOSIS; B-LYMPHOCYTES; CELL DIFFERENTIATION; CELLS, CULTURED; DIABETES MELLITUS, TYPE 1; DISEASE MODELS, ANIMAL; ENZYME STABILITY; FEMALE; GENE SILENCING; GENETIC THERAPY; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED NOD; MICE, KNOCKOUT; MICE, TRANSGENIC; MUTANT PROTEINS; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 22; SPECIFIC PATHOGEN-FREE ORGANISMS; T-LYMPHOCYTES, REGULATORY;

EID: 84874424163     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db12-0929     Document Type: Article

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