Onjisaponin b derived from radix polygalae enhances autophagy and accelerates the degradation of mutant α-synuclein and huntingtin in PC-12 cells

International Journal of Molecular Sciences

Volumn 14, Issue 11, 2013, Pages 22618-22641

  Wu, An Guo ^a   Wong, Vincent Kam Wai ^a   Xu, Su Wei ^a   Chan, Wai Kit ^a   Ng, Choi In ^a   Liu, Liang ^a   Law, Betty Yuen Kwan ^a  

^a MACAU UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Macao)

Author keywords

AMPK; Autophagy; Huntingtin; mTOR; Onjisaponin B; PC 12; Radix Polygalae; synuclein

Indexed keywords

ALCOHOL; ALPHA SYNUCLEIN; GREEN FLUORESCENT PROTEIN; HERBACEOUS AGENT; HUNTINGTIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; MAMMALIAN TARGET OF RAPAMYCIN; NATURAL PRODUCT; ONJISAPONIN B; PLANT EXTRACT; POLYGALACIC ACID; POLYGALAE ROOT EXTRACT; SENEGENIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; AUTOPHAGY; CELL STRAIN; CELLULAR DISTRIBUTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG DETERMINATION; DRUG ISOLATION; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SCREENING; DRUG TARGETING; MOUSE; NEUROPROTECTION; NONHUMAN; PLANT ROOT; POLYGALACEAE; PROTEIN DEGRADATION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION;

POLYGALA TENUIFOLIA;

ALPHA-SYNUCLEIN; ANIMALS; AUTOPHAGY; CELL LINE; DRUGS, CHINESE HERBAL; HUMANS; HUNTINGTON DISEASE; MUTATION; NERVE TISSUE PROTEINS; NEURODEGENERATIVE DISEASES; PARKINSON DISEASE; PROTEOLYSIS; RATS; SAPONINS; SIGNAL TRANSDUCTION; TRITERPENES;

EID: 84887547769     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms141122618     Document Type: Article

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