Huperzine A, a potential therapeutic agent for dementia, reduces neuronal cell dearth caused by glutamate

NeuroReport

Volumn 8, Issue 4, 1997, Pages 963-968

  Ved, Haresh S ^a   Koenig, Michael L ^a   Dave, Jitendra R ^a   Doctor, Bhupendra P ^a  

^a WALTER REED ARMY INSTITUTE OF RESEARCH   (United States)

Author keywords

Acetylcholinesterase; Calcium mobilization; Cholinesterase inhibitors; Enriched primary neuronal cell culture; Glutamate toxicity; Hyperzine A; Neuronal survival

Indexed keywords

1,4 DIHYDRO 2,6 DIMETHYL 5 NITRO 4 [2 (TRIFLUOROMETHYL)PHENYL] 3 PYRIDINECARBOXYLIC ACID METHYL ESTER; GLUTAMIC ACID; HUPERZINE A; NEUROPROTECTIVE AGENT;

ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; CALCIUM TRANSPORT; CELL CULTURE; CELL SURVIVAL; CONTROLLED STUDY; CYTOTOXICITY; FETUS; FOREBRAIN; INTRACELLULAR RECORDING; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0030893633     PISSN: 09594965     EISSN: None     Source Type: Journal    
DOI: 10.1097/00001756-199703030-00029     Document Type: Article

References (23)

1. Di Chiara G and North RA. Trends Pharmacol Sci 13, 185-193 (1992).
2. Davis RE, Doyle PD, Carroll RT et al. Arzneimittel Forschung 45, 425-431 (1995).
3. Watkins PB, Zimmerman HJ, Knapp MJ et al. J Am Med Assoc 271, 992-998 (1994).
4. Arispe N, Rojas E and Pollard H. Proc Natl Acad Sci USA 90, 567-571 (1993).
5. Albin RL and Greenamyre JT. Neurology 42, 733-738 (1992).
6. Choi DW. Ann NY Acad Sci 747, 162-171 (1994).
7. Ashani Y, Grunwald J, Kroman C et al. Mol Pharmacol 45, 555-560 (1994).
8. Asani Y, Peggins JO and Doctor BP. Biochem Biophys Res Commun 184, 719-726 (1992).
9. Grunwald J, Raveh L and Doctor BP. Life Sci 54, 991-997 (1994).
10. Saxena A, Quin N, Kovach I et al. Protein Sci 3, 1770-1778 (1994).
11. Quinn DM. Chem Rev 87, 955-972 (1987).
12. McKinney M, Miller JH, Yamada F et al. Eur J Pharmacol 203, 303-305 (1991).
13. Ved HS, Gustow E and Pieringer RA. J Neurosci Res 30, 353-358 (1991).
14. Dave JR, Koenig ML, Pieringer RA et al. Mol Chem Pathol (in press) (1996).
15. Koenig ML, Rothbard PM, DeCoster MA et al. NeuroReport 5, 1063-1068 (1994).
16. Dodd P, Scott HI and Westphalen RI. Neurochem Int 25, 203-219 (1994)
17. Berridge MJ. Nature 361, 315-361 (1993).
18. Conley EC. N-Methyl-D-aspartate (NMDA)-selective glutamate receptor-channels. In: Conley EC, ed. The Ion Channel Facts Book. New York: Academic Press, 1996: 140-233.
19. Martinez A, Bogonez E and Vitorica J. In: Wray DW, Norman RI and Hess P, eds. Calcium Channels. Structure and Function, Vol. 560. New York: New York Academy of Sciences, 1989: 458-461.
20. Thomas G, Chung M and Cohen CJ. Circ Res 56, 87-96 (1985).
21. Hess P, Lansman JB and Tsien RW. Nature 311, 538-544 (1984).
22. McDonough JH and Shih TM. Neurosci Biobehev Rev 17, 203-215 (1993).
23. Lorenzi P, Bisso GM, Fortuna S et al. Neurochem Res 21, 323-329 (1996).