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Volumn 19, Issue , 2013, Pages 916-926

Genetic and molecular alterations in pancreatic cancer: Implications for personalized medicine

Author keywords

Biomarker; Genetics; Genomics; Molecular target; Pancreatic cancer; Personalized medicine

Indexed keywords

ATM PROTEIN; BRCA2 PROTEIN; CHLORAMBUCIL; CISPLATIN; CYCLIN DEPENDENT KINASE INHIBITOR 2A; CYCLIN G1; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; DJ 1 PROTEIN; EPIDERMAL GROWTH FACTOR RECEPTOR; FANCONI ANEMIA GROUP C PROTEIN; FANCONI ANEMIA GROUP G PROTEIN; FORETINIB; GELATINASE A; HEAT SHOCK PROTEIN 27; HEAT SHOCK PROTEIN 70; HIGH MOBILITY GROUP B1 PROTEIN; IPILIMUMAB; MELPHALAN; MICRORNA; MITOMYCIN; MIXED LINEAGE LEUKEMIA PROTEIN; PIMASERTIB; PROTEIN P53; RETINOBLASTOMA BINDING PROTEIN 2; SMAD4 PROTEIN; SORAFENIB; SUNITINIB; TRANSFORMING GROWTH FACTOR BETA2; UNINDEXED DRUG; VASCULOTROPIN;

EID: 84887350112     PISSN: 12341010     EISSN: 16433750     Source Type: Journal    
DOI: 10.12659/MSM.889636     Document Type: Review
Times cited : (42)

References (167)
  • 1
    • 34250330777 scopus 로고    scopus 로고
    • What is a gene, post-ENCODE? History and updated definition
    • Gerstein MB, Bruce C, Rozowsky JS et al: What is a gene, post-ENCODE? History and updated definition. Genome Res, 2007; 17: 669-81
    • (2007) Genome Res , vol.17 , pp. 669-681
    • Gerstein, M.B.1    Bruce, C.2    Rozowsky, J.S.3
  • 2
    • 0028371364 scopus 로고
    • A triple tribute to the experiment that transformed biology
    • Steinman RM, Moberg CL: A triple tribute to the experiment that transformed biology. J Exp Med, 1994; 179: 379-84
    • (1994) J Exp Med , vol.179 , pp. 379-384
    • Steinman, R.M.1    Moberg, C.L.2
  • 3
    • 84983711696 scopus 로고
    • Studies on the chemical nature of the substance inducing transformation of pneumococcal types: Induction of transformation by a desoxyribonucleic acid fraction isolated from pneumococcus type Iii
    • Avery O, MacLeod C, McCarty M: Studies on the chemical nature of the substance inducing transformation of pneumococcal types: Induction of transformation by a desoxyribonucleic acid fraction isolated from pneumococcus type Iii. J Exp Med, 1944; 79: 137-58
    • (1944) J Exp Med , vol.79 , pp. 137-158
    • Avery, O.1    McLeod, C.2    McCarty, M.3
  • 4
    • 33749048664 scopus 로고
    • A structure of deoxyribonucleic acid
    • Watson JD, Crick FHC: A structure of deoxyribonucleic acid. Nature, 1953; 171: 964-67
    • (1953) Nature , vol.171 , pp. 964-967
    • Watson, J.D.1    Crick, F.H.C.2
  • 5
    • 0015503810 scopus 로고
    • Nucleotide sequence of the gene coding for the bacteriophage MS2 coat protein
    • Min Jou W, Haegeman G, Ysebaert M, Fiers W: Nucleotide sequence of the gene coding for the bacteriophage MS2 coat protein. Nature, 1972; 237: 82-88
    • (1972) Nature , vol.237 , pp. 82-88
    • Min Jou, W.1    Haegeman, G.2    Ysebaert, M.3    Fiers, W.4
  • 6
    • 0015527778 scopus 로고
    • Studies on polynucleotides. 103. Total synthesis of the structural gene for an alanine transfer ribonucleic acid from yeast
    • Khorana HG, Agarwal KL, Buchi H et al: Studies on polynucleotides. 103. Total synthesis of the structural gene for an alanine transfer ribonucleic acid from yeast. J Mol Biol, 1972; 72: 209-17
    • (1972) J Mol Biol , vol.72 , pp. 209-217
    • Khorana, H.G.1    Agarwal, K.L.2    Buchi, H.3
  • 7
    • 0017697097 scopus 로고
    • Expression in Escherichia coli of a chemically synthesized gene for the hormone somatostatin
    • Itakura K, Hirose T, Crea R et al: Expression in Escherichia coli of a chemically synthesized gene for the hormone somatostatin. Science, 1977; 198: 1056-63
    • (1977) Science , vol.198 , pp. 1056-1063
    • Itakura, K.1    Hirose, T.2    Crea, R.3
  • 8
    • 0015412107 scopus 로고
    • Biochemical method for inserting new genetic information into DNA of Simian Virus 40: Circular SV40 DNA molecules containing lambda phage genes and the galactose operon of Escherichia coli
    • Jackson D, Symons R, Berg P: Biochemical method for inserting new genetic information into DNA of Simian Virus 40: Circular SV40 DNA molecules containing lambda phage genes and the galactose operon of Escherichia coli. Proc Natl Acad Sci USA, 1972; 69: 2904-9
    • (1972) Proc Natl Acad Sci USA , vol.69 , pp. 2904-2909
    • Jackson, D.1    Symons, R.2    Berg, P.3
  • 9
    • 0015863912 scopus 로고
    • Enzymatic end-to end joining of DNA molecules
    • Lobban P, Kaiser A: Enzymatic end-to end joining of DNA molecules. J Mol Biol, 1973; 78: 453-71
    • (1973) J Mol Biol , vol.78 , pp. 453-471
    • Lobban, P.1    Kaiser, A.2
  • 10
    • 2442728636 scopus 로고
    • Construction of biologically functional bacterial plasmids in vitro
    • Cohen S, Chang A, Boyer H, Helling R: Construction of biologically functional bacterial plasmids in vitro. Proc Natl Acad Sci USA, 1973; 70: 3240-44
    • (1973) Proc Natl Acad Sci USA , vol.70 , pp. 3240-3244
    • Cohen, S.1    Chang, A.2    Boyer, H.3    Helling, R.4
  • 13
    • 0018079391 scopus 로고
    • Mutagenesis at a specific position in a DNA sequence
    • Hutchison CA III, Phillips S, Edgell MH et al: Mutagenesis at a specific position in a DNA sequence. J Biol Chem, 1978; 253: 6551-60
    • (1978) J Biol Chem , vol.253 , pp. 6551-6560
    • Hutchison III, C.A.1    Phillips, S.2    Edgell, M.H.3
  • 14
    • 0015503810 scopus 로고
    • Nucleotide sequence of the gene coding for the bacteriophage MS2 coat protein
    • Min Jou W, Haegeman G, Ysebaert M, Fiers W: Nucleotide sequence of the gene coding for the bacteriophage MS2 coat protein. Nature, 1972; 237: 82-88
    • (1972) Nature , vol.237 , pp. 82-88
    • Min Jou, W.1    Haegeman, G.2    Ysebaert, M.3    Fiers, W.4
  • 15
    • 0017367852 scopus 로고
    • Nucleotide sequence of bacteriophage phi X174 DNA
    • Sanger F, Air GM, Barrell BG et al: Nucleotide sequence of bacteriophage phi X174 DNA. Nature, 1977; 265: 687-95
    • (1977) Nature , vol.265 , pp. 687-695
    • Sanger, F.1    Air, G.M.2    Barrell, B.G.3
  • 16
    • 0026727252 scopus 로고
    • Specific enzymatic amplification of DNA in vitro: The polymerase chain reaction. 1986
    • Mullis K, Faloona F, Scharf S et al: Specific enzymatic amplification of DNA in vitro: the polymerase chain reaction. 1986. Biotechnology, 1992; 24: 17-27
    • (1992) Biotechnology , vol.24 , pp. 17-27
    • Mullis, K.1    Faloona, F.2    Scharf, S.3
  • 17
    • 0029653518 scopus 로고
    • Whole-genome random sequencing and assembly of Haemophilus influenzae Rd
    • Fleischmann RD, Adams MD, White O et al: Whole-genome random sequencing and assembly of Haemophilus influenzae Rd. Science, 1995; 269: 496-512
    • (1995) Science , vol.269 , pp. 496-512
    • Fleischmann, R.D.1    Adams, M.D.2    White, O.3
  • 18
    • 2042437650 scopus 로고    scopus 로고
    • International Human Genome Sequencing Consortium. Initial sequencing and analysis of the human genome
    • International Human Genome Sequencing Consortium. Initial sequencing and analysis of the human genome. Nature, 2001;409(6822): 860-921
    • (2001) Nature , vol.409 , Issue.6822 , pp. 860-921
  • 19
    • 0035895505 scopus 로고    scopus 로고
    • The sequence of the human genome
    • Venter JC, Adams MD, Myers EW et al: The sequence of the human genome. Science, 2001; 291: 1304-51
    • (2001) Science , vol.291 , pp. 1304-1351
    • Venter, J.C.1    Adams, M.D.2    Myers, E.W.3
  • 20
    • 7244245762 scopus 로고    scopus 로고
    • International Human Genome Sequencing Consortium. Finishing the euchromatic sequence of the human genome
    • International Human Genome Sequencing Consortium: Finishing the euchromatic sequence of the human genome. Nature, 2004; 431: 931-45
    • (2004) Nature , vol.431 , pp. 931-945
  • 21
    • 0035080952 scopus 로고    scopus 로고
    • A bacterial artificial chromosome library for sequencing the complete human genome
    • Osoegawa K, Mammoser AG, Wu C et al: A bacterial artificial chromosome library for sequencing the complete human genome. Genome Res, 2001; 11: 483-96
    • (2001) Genome Res , vol.11 , pp. 483-496
    • Osoegawa, K.1    Mammoser, A.G.2    Wu, C.3
  • 22
    • 79959524146 scopus 로고    scopus 로고
    • A haplotype map of the human genome
    • International HapMap Consortium
    • International HapMap Consortium: A haplotype map of the human genome. Nature, 2005; 437: 1299-320
    • (2005) Nature , vol.437 , pp. 1299-1320
  • 23
    • 35348983887 scopus 로고    scopus 로고
    • A second generation human haplotype map of over 3.1 million SNPs
    • International HapMap Consortium
    • International HapMap Consortium: A second generation human haplotype map of over 3.1 million SNPs. Nature, 2007: 449: 851-61
    • (2007) Nature , vol.449 , pp. 851-861
  • 24
    • 77956331627 scopus 로고    scopus 로고
    • Integrating common and rare genetic variation in diverse human populations
    • International HapMap Consortium
    • International HapMap Consortium: Integrating common and rare genetic variation in diverse human populations. Nature, 2010; 467: 52-58
    • (2010) Nature , vol.467 , pp. 52-58
  • 25
    • 84975742565 scopus 로고    scopus 로고
    • A map of human genome variation from population-scale sequencing
    • Durbin RM, Altshuler DL, Durbin RM et al: A map of human genome variation from population-scale sequencing. Nature, 2010; 467: 1061-73
    • (2010) Nature , vol.467 , pp. 1061-1073
    • Durbin, R.M.1    Altshuler, D.L.2    Durbin, R.M.3
  • 26
    • 84975795680 scopus 로고    scopus 로고
    • An integrated map of genetic variation from 1,092 human genomes
    • McVean GA, Altshuler DM, Durbin RM et al: An integrated map of genetic variation from 1,092 human genomes. Nature, 2012; 491: 56-65
    • (2012) Nature , vol.491 , pp. 56-65
    • McVean, G.A.1    Altshuler, D.M.2    Durbin, R.M.3
  • 27
    • 33847355585 scopus 로고    scopus 로고
    • Genomics and personalized medicine act of 2006. Washington, DC: U.S. Congress
    • Obama B: Genomics and personalized medicine act of 2006. Washington, DC: U.S. Congress. Clin Adv Hematol Oncol, 2007; 5: 39-40
    • (2007) Clin Adv Hematol Oncol , vol.5 , pp. 39-40
    • Obama, B.1
  • 28
    • 77953315728 scopus 로고    scopus 로고
    • President's Council of Advisors on Science Technology. accessed on July 26, 2013
    • President's Council of Advisors on Science Technology: Priorities for Personalised Medicine, 2008. http://www.whitehouse.gov/files/documents/ ostp/PCAST/pcast_report_v2.pdf. accessed on July 26, 2013
    • (2008) Priorities for Personalised Medicine
  • 29
    • 62549133080 scopus 로고    scopus 로고
    • Overview of the molecular surgeon symposium on personalized genomic medicine and surgery
    • Brunicardi FC, Gibbs RA, Fisher W, Chen C: Overview of the molecular surgeon symposium on personalized genomic medicine and surgery. World J Surg, 2009; 33(4): 612-14
    • (2009) World J Surg , vol.33 , Issue.4 , pp. 612-614
    • Brunicardi, F.C.1    Gibbs, R.A.2    Fisher, W.3    Chen, C.4
  • 30
    • 80051557141 scopus 로고    scopus 로고
    • Overview of the development of personalized genomic medicine and surgery
    • Brunicardi FC, Gibbs RA, Wheeler DA et al: Overview of the development of personalized genomic medicine and surgery. World J Surg, 2011; 35: 1693-99
    • (2011) World J Surg , vol.35 , pp. 1693-1699
    • Brunicardi, F.C.1    Gibbs, R.A.2    Wheeler, D.A.3
  • 31
    • 84857924235 scopus 로고    scopus 로고
    • accessed June 13, 2013
    • Targeted Cancer Therapies. http://www.cancer.gov/cancertopics/factsheet/ Therapy/targeted. accessed June 13, 2013
    • Targeted Cancer Therapies
  • 32
    • 79952254324 scopus 로고    scopus 로고
    • accessed on June 13, 2013
    • Table of Pharmacogenomic Biomarkers in Drug Labels. http://www.fda. gov/drugs/scienceresearch/researchareas/pharmacogenetics/ucm083378. htm, accessed on June 13, 2013
    • Table of Pharmacogenomic Biomarkers in Drug Labels
  • 33
    • 0035824069 scopus 로고    scopus 로고
    • Efficacy of bilateral prophylactic mastectomy in BRCA1 and BRCA2 gene mutation carriers
    • Hartmann LC, Sellers TA, Schaid DJ et al: Efficacy of bilateral prophylactic mastectomy in BRCA1 and BRCA2 gene mutation carriers. J Natl Cancer Inst, 2001; 93: 1633-37
    • (2001) J Natl Cancer Inst , vol.93 , pp. 1633-1637
    • Hartmann, L.C.1    Sellers, T.A.2    Schaid, D.J.3
  • 34
    • 78751559414 scopus 로고    scopus 로고
    • Personalizing cancer treatment in the age of global genomic analyses: PALB2 gene mutations and the response to DNA damaging agents in pancreatic cancer
    • Villarroel MC, Rajeshkumar NV, Garrido-Laguna I et al: Personalizing cancer treatment in the age of global genomic analyses: PALB2 gene mutations and the response to DNA damaging agents in pancreatic cancer. Mol Cancer Ther, 2011; 10: 3-8
    • (2011) Mol Cancer Ther , vol.10 , pp. 3-8
    • Villarroel, M.C.1    Rajeshkumar, N.V.2    Garrido-Laguna, I.3
  • 36
    • 79955972755 scopus 로고    scopus 로고
    • NCI/NIH. accessed on June14, 2013
    • NCI/NIH. Pancreatic Cancer. http://www.cancer.gov/cancertopics/types/pancreatic. accessed on June14, 2013
    • Pancreatic Cancer.
  • 38
    • 68249130254 scopus 로고    scopus 로고
    • Survival after pancreaticoduodenectomy is not improved by extending resections to achieve negative margins
    • Hernandez J, Mullinax J, Clark W et al: Survival after pancreaticoduodenectomy is not improved by extending resections to achieve negative margins. Ann Surg, 2009; 250: 76-80
    • (2009) Ann Surg , vol.250 , pp. 76-80
    • Hernandez, J.1    Mullinax, J.2    Clark, W.3
  • 39
    • 9144266295 scopus 로고    scopus 로고
    • Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse
    • Hingorani SR, Petricoin EF, Maitra A et al: Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse. Cancer Cell, 2003; 4: 437-50
    • (2003) Cancer Cell , vol.4 , pp. 437-450
    • Hingorani, S.R.1    Petricoin, E.F.2    Maitra, A.3
  • 40
    • 19344362405 scopus 로고    scopus 로고
    • Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice
    • Hingorani SR, Wang L, Multani AS et al: Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice. Cancer Cell, 2005; 7: 469-83
    • (2005) Cancer Cell , vol.7 , pp. 469-483
    • Hingorani, S.R.1    Wang, L.2    Multani, A.S.3
  • 41
    • 52149123619 scopus 로고    scopus 로고
    • Core signaling pathways in human pancreatic cancers revealed by global genomic analyses
    • Jones S, Zhang X, Parsons DW et al: Core signaling pathways in human pancreatic cancers revealed by global genomic analyses. Science, 2008; 321: 1801-6
    • (2008) Science , vol.321 , pp. 1801-1806
    • Jones, S.1    Zhang, X.2    Parsons, D.W.3
  • 42
    • 4043181214 scopus 로고    scopus 로고
    • Cancer genes and the pathways they control
    • Vogelstein B, Kinzler KW: Cancer genes and the pathways they control. Nat Med, 2004; 10: 789-99
    • (2004) Nat Med , vol.10 , pp. 789-799
    • Vogelstein, B.1    Kinzler, K.W.2
  • 43
    • 84869091997 scopus 로고    scopus 로고
    • Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes
    • Biankin AV, Waddell N, Kassahn KS et al: Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes. Nature, 2012; 491: 399-405
    • (2012) Nature , vol.491 , pp. 399-405
    • Biankin, A.V.1    Waddell, N.2    Kassahn, K.S.3
  • 44
    • 0029125820 scopus 로고
    • K-ras mutation and pancreatic adenocarcinoma
    • 1995
    • Caldas C, Kern SE. 1995. K-ras mutation and pancreatic adenocarcinoma. Int J Pancreatol, 1995; 18: 1-6
    • (1995) Int J Pancreatol , vol.18 , pp. 1-6
    • Caldas, C.1    Kern, S.E.2
  • 45
    • 0030050945 scopus 로고    scopus 로고
    • Analysis of K-ras gene mutation in hyperplastic duct cells of the pancreas without pancreatic disease
    • Tada M, Ohashi M, Shiratori Y et al: Analysis of K-ras gene mutation in hyperplastic duct cells of the pancreas without pancreatic disease. Gastroenterology, 1996; 110: 227-31
    • (1996) Gastroenterology , vol.110 , pp. 227-231
    • Tada, M.1    Ohashi, M.2    Shiratori, Y.3
  • 46
    • 33745725763 scopus 로고    scopus 로고
    • PIK-3CA mutations in intraductal papillary mucinous neoplasm/carcinoma of the pancreas
    • Schonleben F, Qiu WL, Ciau NT: PIK-3CA mutations in intraductal papillary mucinous neoplasm/carcinoma of the pancreas. Clin Cancer Res, 2006; 12: 3851-55
    • (2006) Clin Cancer Res , vol.12 , pp. 3851-3855
    • Schonleben, F.1    Qiu, W.L.2    Ciau, N.T.3
  • 47
    • 0001457668 scopus 로고    scopus 로고
    • Amplification of AKT2 in human pancreatic cells and inhibition of AKT2 expression and tumorigenicity by antisense RNA
    • Cheng JQ, Ruggeri B, KleinWM et al: Amplification of AKT2 in human pancreatic cells and inhibition of AKT2 expression and tumorigenicity by antisense RNA. Proc Natl Acad Sci USA,1996; 93: 3636-41
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 3636-3641
    • Cheng, J.Q.1    Ruggeri, B.2    Klein, W.M.3
  • 48
    • 0348049845 scopus 로고    scopus 로고
    • Incidence, mechanism and prognostic value of activated AKT in pancreas cancer
    • Schlieman MG, Fahy BN, Ramsamooj R, et al: Incidence, mechanism and prognostic value of activated AKT in pancreas cancer. Br J Cancer, 2003; 89: 2110-15
    • (2003) Br J Cancer , vol.89 , pp. 2110-2115
    • Schlieman, M.G.1    Fahy, B.N.2    Ramsamooj, R.3
  • 49
    • 0141425732 scopus 로고    scopus 로고
    • 2003. BRAF and FBXW7 (CDC4, FBW7, AGO, SEL10) mutations in distinct subsets of pancreatic cancer: Potential therapeutic targets
    • Calhoun ES, Jones JB, Ashfaq R et al: 2003. BRAF and FBXW7 (CDC4, FBW7, AGO, SEL10) mutations in distinct subsets of pancreatic cancer: potential therapeutic targets. Am J Pathol, 2003; 163: 1255-60
    • (2003) Am J Pathol , vol.163 , pp. 1255-1260
    • Calhoun, E.S.1    Jones, J.B.2    Ashfaq, R.3
  • 50
    • 34547209343 scopus 로고    scopus 로고
    • Roles of the Raf/MEK/ ERK pathway in cell growth, malignant transformation and drug resistance
    • McCubrey JA, Steelman LS, Chappell WH et al: Roles of the Raf/MEK/ ERK pathway in cell growth, malignant transformation and drug resistance. Biochimica et Biophysica Acta, 2007; 1773: 1263-84
    • (2007) Biochimica et Biophysica Acta , vol.1773 , pp. 1263-1284
    • McCubrey, J.A.1    Steelman, L.S.2    Chappell, W.H.3
  • 51
    • 84861373535 scopus 로고    scopus 로고
    • A KrasG12D-driven genetic mouse model of pancreatic cancer requires glypican-1 for efficient proliferation and angiogenesis
    • Whipple CA, Young AL, Korc M: A KrasG12D-driven genetic mouse model of pancreatic cancer requires glypican-1 for efficient proliferation and angiogenesis. Oncogene, 2012; 31: 2535-44
    • (2012) Oncogene , vol.31 , pp. 2535-2544
    • Whipple, C.A.1    Young, A.L.2    Korc, M.3
  • 53
    • 10744223624 scopus 로고    scopus 로고
    • Notch mediates TGF alpha-induced changes in epithelial differentiation during pancreatic tumorigenesis
    • Miyamoto Y, Maitra A, Ghosh B et al: Notch mediates TGF alpha-induced changes in epithelial differentiation during pancreatic tumorigenesis. Cancer Cell, 2003; 3: 565-76
    • (2003) Cancer Cell , vol.3 , pp. 565-576
    • Miyamoto, Y.1    Maitra, A.2    Ghosh, B.3
  • 54
    • 84876969576 scopus 로고    scopus 로고
    • Significance of Notch1-signaling pathway in human pancreatic development and carcinogenesis
    • Hu H, Zhou L, Awadallah A, Xin W: Significance of Notch1-signaling pathway in human pancreatic development and carcinogenesis. Appl Immunohistochem Mol Morphol, 2013; 21: 242-47
    • (2013) Appl Immunohistochem Mol Morphol , vol.21 , pp. 242-247
    • Hu, H.1    Zhou, L.2    Awadallah, A.3    Xin, W.4
  • 55
    • 33947254016 scopus 로고    scopus 로고
    • Blockade of hedgehog signaling inhibits pancreatic cancer invasion and metastases: A new paradigm for combination therapy in solid cancers
    • Feldmann G, Dhara S, Fendrich V et al: Blockade of hedgehog signaling inhibits pancreatic cancer invasion and metastases: a new paradigm for combination therapy in solid cancers. Cancer Res, 2007; 67: 2187-96
    • (2007) Cancer Res , vol.67 , pp. 2187-2196
    • Feldmann, G.1    Dhara, S.2    Fendrich, V.3
  • 56
    • 79960383874 scopus 로고    scopus 로고
    • STAT3 plays a critical role in KRAS-induced pancreatic tumorigenesis
    • Corcoran RB, Contino G, Deshpande V et al: STAT3 plays a critical role in KRAS-induced pancreatic tumorigenesis. Cancer Res, 2011; 71: 5020-29
    • (2011) Cancer Res , vol.71 , pp. 5020-5029
    • Corcoran, R.B.1    Contino, G.2    Deshpande, V.3
  • 57
    • 79955823538 scopus 로고    scopus 로고
    • STAT3-targeting RNA interference inhibits pancreatic cancer angiogenesis in vitro and in vivo
    • Huang C, Jiang T, Zhu L, et al: STAT3-targeting RNA interference inhibits pancreatic cancer angiogenesis in vitro and in vivo. Int J Oncol, 2011; 38: 1637-44
    • (2011) Int J Oncol , vol.38 , pp. 1637-1644
    • Huang, C.1    Jiang, T.2    Zhu, L.3
  • 58
    • 0027359827 scopus 로고
    • WAF1, a potential mediator of p53 tumor suppression
    • el-Deiry WS, Tokino T, Velculescu VE et al: WAF1, a potential mediator of p53 tumor suppression. Cell, 1993; 75: 817-25
    • (1993) Cell , vol.75 , pp. 817-825
    • el-Deiry, W.S.1    Tokino, T.2    Velculescu, V.E.3
  • 59
    • 0027496935 scopus 로고
    • The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases
    • Harper JW, Adami GR, Wei N et al: The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell, 1993; 75: 805-16
    • (1993) Cell , vol.75 , pp. 805-816
    • Harper, J.W.1    Adami, G.R.2    Wei, N.3
  • 60
    • 0027717617 scopus 로고
    • p21 is a universal inhibitor of cyclin kinases
    • Xiong Y, Hannon GJ, Zhang H et al: p21 is a universal inhibitor of cyclin kinases. Nature, 1993; 366: 701-4
    • (1993) Nature , vol.366 , pp. 701-704
    • Xiong, Y.1    Hannon, G.J.2    Zhang, H.3
  • 61
    • 0028980494 scopus 로고
    • p53 controls both the G2/M and the G1 cell cycle checkpoints and mediates reversible growth arrest in human fibroblasts
    • Agarwal ML, Agarwal A, Taylor WR, Stark GR: p53 controls both the G2/M and the G1 cell cycle checkpoints and mediates reversible growth arrest in human fibroblasts. Proc Natl Acad Sci USA, 1995; 92: 8493-97
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 8493-8497
    • Agarwal, M.L.1    Agarwal, A.2    Taylor, W.R.3    Stark, G.R.4
  • 62
    • 0028946766 scopus 로고
    • Accumulation of wild-type p53 protein upon gamma-irradiation induces a G2 arrest-dependent immunoglobulin kappa light chain gene expression
    • Aloni-Grinstein R, Schwartz D, Rotter V: Accumulation of wild-type p53 protein upon gamma-irradiation induces a G2 arrest-dependent immunoglobulin kappa light chain gene expression. EMBO J, 1995; 14: 1392-401
    • (1995) EMBO J , vol.14 , pp. 1392-1401
    • Aloni-Grinstein, R.1    Schwartz, D.2    Rotter, V.3
  • 63
    • 15444355378 scopus 로고    scopus 로고
    • DNA damage-associated dysregulation of the cell cycle and apoptosis control in cells with germ-line p53 mutation
    • Goi K, Takagi M, Iwata S et al: DNA damage-associated dysregulation of the cell cycle and apoptosis control in cells with germ-line p53 mutation. Cancer Res, 1997; 57: 1895-902
    • (1997) Cancer Res , vol.57 , pp. 1895-1902
    • Goi, K.1    Takagi, M.2    Iwata, S.3
  • 64
    • 0035265686 scopus 로고    scopus 로고
    • PUMA, a novel proapoptotic gene, is induced by p53
    • Nakano K, Vousden KH: PUMA, a novel proapoptotic gene, is induced by p53. Mol Cell, 2001; 7: 683-94
    • (2001) Mol Cell , vol.7 , pp. 683-694
    • Nakano, K.1    Vousden, K.H.2
  • 65
    • 0027743438 scopus 로고
    • Pancreatic adenocarcinomas frequently show p53 gene mutations
    • Scarpa A, Capelli P, Mukai K et al: Pancreatic adenocarcinomas frequently show p53 gene mutations. Am J Pathol, 1993; 142: 1534-43
    • (1993) Am J Pathol , vol.142 , pp. 1534-1543
    • Scarpa, A.1    Capelli, P.2    Mukai, K.3
  • 66
    • 62249176551 scopus 로고    scopus 로고
    • DPC4 gene status of the primary carcinoma correlates with patterns of failure in patients with pancreatic cancer
    • Iacobuzio-Donahue CA, Fu B, Yachida S et al: DPC4 gene status of the primary carcinoma correlates with patterns of failure in patients with pancreatic cancer. J Clin Oncol, 2009; 27: 1806-13
    • (2009) J Clin Oncol , vol.27 , pp. 1806-1813
    • Iacobuzio-Donahue, C.A.1    Fu, B.2    Yachida, S.3
  • 67
    • 0030593038 scopus 로고    scopus 로고
    • DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1
    • Hahn SA, Schutte M, Hoque AT et al: DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1. Science, 1996; 271: 350-53
    • (1996) Science , vol.271 , pp. 350-353
    • Hahn, S.A.1    Schutte, M.2    Hoque, A.T.3
  • 68
    • 2442533068 scopus 로고    scopus 로고
    • The dissociated expression of protein and messenger RNA of DPC4 in human invasive ductal carcinoma of the pancreas and their implication for patient outcome
    • Toga T, Nio Y, Hashimoto K et al: The dissociated expression of protein and messenger RNA of DPC4 in human invasive ductal carcinoma of the pancreas and their implication for patient outcome. Anticancer Res, 2004; 24: 1173-78
    • (2004) Anticancer Res , vol.24 , pp. 1173-1178
    • Toga, T.1    Nio, Y.2    Hashimoto, K.3
  • 69
    • 67650898228 scopus 로고    scopus 로고
    • LKB1 and AMPK family signaling: The intimate link between cell polarity and energy metabolism
    • Jansen M, Ten Klooster JP, Offerhaus GJ et al: LKB1 and AMPK family signaling: the intimate link between cell polarity and energy metabolism. Physiol Rev, 2009; 89: 777-98
    • (2009) Physiol Rev , vol.89 , pp. 777-798
    • Jansen, M.1    Ten Klooster, J.P.2    Offerhaus, G.J.3
  • 70
    • 0023192463 scopus 로고
    • Increased risk of cancer in the Peutz-Jeghers syndrome
    • Giardiello FM, Welsh SB, Hamilton SR et al: Increased risk of cancer in the Peutz-Jeghers syndrome. N Engl J Med, 1987; 316: 1511-14
    • (1987) N Engl J Med , vol.316 , pp. 1511-1514
    • Giardiello, F.M.1    Welsh, S.B.2    Hamilton, S.R.3
  • 71
    • 33646577163 scopus 로고    scopus 로고
    • Genetics and biology of pancreatic ductal adenocarcinoma
    • Hezel AF, Kimmelman AC, Stanger BZ et al: Genetics and biology of pancreatic ductal adenocarcinoma. Genes Dev, 2006; 20: 1218-49
    • (2006) Genes Dev , vol.20 , pp. 1218-1249
    • Hezel, A.F.1    Kimmelman, A.C.2    Stanger, B.Z.3
  • 72
    • 79951691421 scopus 로고    scopus 로고
    • Genetic and epigenetic alterations in pancreatic carcinogenesis
    • Delpu Y, Hanoun N, Lulka, H et al: Genetic and epigenetic alterations in pancreatic carcinogenesis. Current Genomics, 2011; 12: 15-24
    • (2011) Current Genomics , vol.12 , pp. 15-24
    • Delpu, Y.1    Hanoun, N.2    Lulka, H.3
  • 73
    • 0032100617 scopus 로고    scopus 로고
    • Alterations in pancreatic, biliary, and breast carcinomas support MKK4 as a genetically targeted tumor suppressor gene
    • Su GH, Hilgers W, Shekher MC et al: Alterations in pancreatic, biliary, and breast carcinomas support MKK4 as a genetically targeted tumor suppressor gene. Cancer Res, 1998; 58: 2339-42
    • (1998) Cancer Res , vol.58 , pp. 2339-2342
    • Su, G.H.1    Hilgers, W.2    Shekher, M.C.3
  • 74
    • 84866738096 scopus 로고    scopus 로고
    • Identification of germline genomic copy number variation in familial pancreatic cancer
    • Al-Sukhni W, Joe S, Lionel AC et al: Identification of germline genomic copy number variation in familial pancreatic cancer. Hum Genet, 2012; 131: 1481-94
    • (2012) Hum Genet , vol.131 , pp. 1481-1494
    • Al-Sukhni, W.1    Joe, S.2    Lionel, A.C.3
  • 75
    • 84863957459 scopus 로고    scopus 로고
    • A replication study and genome-wide scan of single-nucleotide polymorphisms associated with pancreatic cancer risk and overall survival
    • Willis JA, Olson SH, Orlow I et al: A replication study and genome-wide scan of single-nucleotide polymorphisms associated with pancreatic cancer risk and overall survival. Clin Cancer Res, 2012; 18: 3942-51
    • (2012) Clin Cancer Res , vol.18 , pp. 3942-3951
    • Willis, J.A.1    Olson, S.H.2    Orlow, I.3
  • 76
    • 52149123619 scopus 로고    scopus 로고
    • Core signaling pathways in human pancreatic cancers revealed by global genomic analyses
    • Jones S, Zhang X, Parsons DW et al: Core signaling pathways in human pancreatic cancers revealed by global genomic analyses. Science, 2008; 321: 1801-6
    • (2008) Science , vol.321 , pp. 1801-1806
    • Jones, S.1    Zhang, X.2    Parsons, D.W.3
  • 77
    • 47549109327 scopus 로고    scopus 로고
    • Tumors of the pancreas
    • In: Hruban RH, Pitman MB, Klimstra DS (eds). Armed Forces Institute of Pathology, Washington DC
    • Hruban RH: Tumors of the pancreas. In: Hruban RH, Pitman MB, Klimstra DS (eds). Atlas of tumor pathology. Armed Forces Institute of Pathology, Washington DC. 2007
    • (2007) Atlas of tumor pathology.
    • Hruban, R.H.1
  • 78
    • 84863012865 scopus 로고    scopus 로고
    • Oncogenic Kras is required for both the initiation and maintenance of pancreatic cancer in mice
    • Collins MA, Bednar F, Zhang Y et al: Oncogenic Kras is required for both the initiation and maintenance of pancreatic cancer in mice. J Clin Invest, 2012; 122: 639-53
    • (2012) J Clin Invest , vol.122 , pp. 639-653
    • Collins, M.A.1    Bednar, F.2    Zhang, Y.3
  • 79
    • 77956060455 scopus 로고    scopus 로고
    • Intravenous administration of Reolysin, a live replication competent RNA virus is safe in patients with advanced solid tumors
    • Gollamudi R, Ghalib MH, Desai KK et al: Intravenous administration of Reolysin, a live replication competent RNA virus is safe in patients with advanced solid tumors. Invest New Drugs, 2010; 28: 641-49
    • (2010) Invest New Drugs , vol.28 , pp. 641-649
    • Gollamudi, R.1    Ghalib, M.H.2    Desai, K.K.3
  • 80
    • 78650511420 scopus 로고    scopus 로고
    • Evaluation of the mTOR inhibitor, everolimus, in combination with cytotoxic antitumor agents using human tumor models in vitro and in vivo
    • O'Reilly T, McSheehy PM, Wartmann M et al: Evaluation of the mTOR inhibitor, everolimus, in combination with cytotoxic antitumor agents using human tumor models in vitro and in vivo. Anticancer Drugs, 2011; 22: 58-78
    • (2011) Anticancer Drugs , vol.22 , pp. 58-78
    • O'Reilly, T.1    McSheehy, P.M.2    Wartmann, M.3
  • 81
    • 84860374357 scopus 로고    scopus 로고
    • Gamma secretase inhibition promotes hypoxic necrosis in mouse pancreatic ductal adenocarcinoma
    • Cook N, Frese KK, Bapiro TE et al: Gamma secretase inhibition promotes hypoxic necrosis in mouse pancreatic ductal adenocarcinoma. J Exp Med, 2012; 209: 437-44
    • (2012) J Exp Med , vol.209 , pp. 437-444
    • Cook, N.1    Frese, K.K.2    Bapiro, T.E.3
  • 82
    • 54049115162 scopus 로고    scopus 로고
    • An orally bioavailable small-molecule inhibitor of Hedgehog signaling inhibits tumor initiation and metastasis in pancreatic cancer
    • Feldmann G, Fendrich V, McGovern K et al: An orally bioavailable small-molecule inhibitor of Hedgehog signaling inhibits tumor initiation and metastasis in pancreatic cancer. Mol Cancer Ther, 2008; 7: 2725-35
    • (2008) Mol Cancer Ther , vol.7 , pp. 2725-2735
    • Feldmann, G.1    Fendrich, V.2    McGovern, K.3
  • 83
    • 27144532118 scopus 로고    scopus 로고
    • In vivo therapeutic responses contingent on Fanconi anemia/BRCA2 status of the tumor
    • van der Heijden MS, Brody JR et al: In vivo therapeutic responses contingent on Fanconi anemia/BRCA2 status of the tumor. Clin Cancer Res, 2005; 11: 7508-15
    • (2005) Clin Cancer Res , vol.11 , pp. 7508-7515
    • van der Heijden, M.S.1    Brody, J.R.2
  • 84
    • 76349096682 scopus 로고    scopus 로고
    • Advanced phase I/II studies of targeted gene delivery in vivo: Intravenous Rexin-G for gemcitabineresistant metastatic pancreatic cancer
    • Chawla SP, Chua VS, Fernandez L et al: Advanced phase I/II studies of targeted gene delivery in vivo: intravenous Rexin-G for gemcitabineresistant metastatic pancreatic cancer. Mol Ther, 2010; 18: 435-41
    • (2010) Mol Ther , vol.18 , pp. 435-441
    • Chawla, S.P.1    Chua, V.S.2    Fernandez, L.3
  • 85
    • 10644285602 scopus 로고    scopus 로고
    • Differential expression profiling of human pancreatic adenocarcinoma and healthy pancreatic tissue
    • Lu Z, Hu L, Evers S et al: Differential expression profiling of human pancreatic adenocarcinoma and healthy pancreatic tissue. Proteomics, 2004; 4: 3975-88
    • (2004) Proteomics , vol.4 , pp. 3975-3988
    • Lu, Z.1    Hu, L.2    Evers, S.3
  • 86
    • 38449115230 scopus 로고    scopus 로고
    • Comparative proteomic analysis for the detection of biomarkers in pancreatic ductal adenocarcinomas
    • Qi T, Han J, Cui Y, Zong M et al: Comparative proteomic analysis for the detection of biomarkers in pancreatic ductal adenocarcinomas. J Clin Pathol, 2008; 61: 49-58
    • (2008) J Clin Pathol , vol.61 , pp. 49-58
    • Qi, T.1    Han, J.2    Cui, Y.3    Zong, M.4
  • 87
    • 34247860855 scopus 로고    scopus 로고
    • Expression of glycolytic enzymes is increased in pancreatic cancerous tissues as evidenced by proteomic profiling by two-dimensional electrophoresis and liquid chromatography-mass spectrometry/mass spectrometry
    • Mikuriya K, Kuramitsu Y, Ryozawa S et al: Expression of glycolytic enzymes is increased in pancreatic cancerous tissues as evidenced by proteomic profiling by two-dimensional electrophoresis and liquid chromatography-mass spectrometry/mass spectrometry. Int J Oncol, 2007; 30: 849-55
    • (2007) Int J Oncol , vol.30 , pp. 849-855
    • Mikuriya, K.1    Kuramitsu, Y.2    Ryozawa, S.3
  • 88
    • 80054044048 scopus 로고    scopus 로고
    • Integrated proteomic profiling of cell line conditioned media and pancreatic juice for the identification of pancreatic cancer biomarkers
    • M111.008599
    • Makawita S, Smith C, Batruch I et al: Integrated proteomic profiling of cell line conditioned media and pancreatic juice for the identification of pancreatic cancer biomarkers. Mol Cell Proteomics, 2011; 10: M111.008599
    • (2011) Mol Cell Proteomics , vol.10
    • Makawita, S.1    Smith, C.2    Batruch, I.3
  • 89
    • 78049277867 scopus 로고    scopus 로고
    • Natural and amyloid self-assembly of S100 proteins: Structural basis of functional diversity
    • Fritz G, Botelho HM, Morozova-Roche LA, Gomes CM: Natural and amyloid self-assembly of S100 proteins: structural basis of functional diversity. FEBS J, 2010; 277: 4578-90
    • (2010) FEBS J , vol.277 , pp. 4578-4590
    • Fritz, G.1    Botelho, H.M.2    Morozova-Roche, L.A.3    Gomes, C.M.4
  • 90
    • 64949148135 scopus 로고    scopus 로고
    • Comparative proteomic analysis of differentially expressed proteins in human pancreatic cancer tissue
    • Chen JH, Ni RZ, Xiao MB et al: Comparative proteomic analysis of differentially expressed proteins in human pancreatic cancer tissue. Hepatobiliary Pancreat Dis Int, 2009; 8: 193-200
    • (2009) Hepatobiliary Pancreat Dis Int , vol.8 , pp. 193-200
    • Chen, J.H.1    Ni, R.Z.2    Xiao, M.B.3
  • 91
    • 70349659240 scopus 로고    scopus 로고
    • S100A6 binds to annexin 2 in pancreatic cancer cells and promotes pancreatic cancer cell motility
    • Nedjadi T, Kitteringham N, Campbell F et al: S100A6 binds to annexin 2 in pancreatic cancer cells and promotes pancreatic cancer cell motility. Br J Cancer, 2009; 101: 1145-54
    • (2009) Br J Cancer , vol.101 , pp. 1145-1154
    • Nedjadi, T.1    Kitteringham, N.2    Campbell, F.3
  • 92
    • 65249087370 scopus 로고    scopus 로고
    • Analysis of the pancreatic tumor progression by a quantitative proteomic approach and immunhistochemical validation
    • Sitek B, Sipos B, Alkatout I et al: Analysis of the pancreatic tumor progression by a quantitative proteomic approach and immunhistochemical validation. J Proteome Res, 2009; 8: 1647-56
    • (2009) J Proteome Res , vol.8 , pp. 1647-1656
    • Sitek, B.1    Sipos, B.2    Alkatout, I.3
  • 93
    • 84870721396 scopus 로고    scopus 로고
    • S100A4, frequently overexpressed in various human cancers, accelerates cell motility in pancreatic cancer cells
    • Sekine H, Chen N, Sato K et al: S100A4, frequently overexpressed in various human cancers, accelerates cell motility in pancreatic cancer cells. Biochem Biophys Res Commun, 2012; 429: 214-19
    • (2012) Biochem Biophys Res Commun , vol.429 , pp. 214-219
    • Sekine, H.1    Chen, N.2    Sato, K.3
  • 94
    • 78649894465 scopus 로고    scopus 로고
    • Discovery of putative pancreatic cancer biomarkers using subcellular proteomics
    • McKinney KQ, Lee YY, Choi HS et al: Discovery of putative pancreatic cancer biomarkers using subcellular proteomics. J Proteomics, 2011; 74: 79-88
    • (2011) J Proteomics , vol.74 , pp. 79-88
    • McKinney, K.Q.1    Lee, Y.Y.2    Choi, H.S.3
  • 95
    • 10844252383 scopus 로고    scopus 로고
    • Protein expression profiles in pancreatic adenocarcinoma compared with normal pancreatic tissue and tissue affected by pancreatitis as detected by two-dimensional gel electrophoresis and mass spectrometry
    • Shen J, Person MD, Zhu J et al: Protein expression profiles in pancreatic adenocarcinoma compared with normal pancreatic tissue and tissue affected by pancreatitis as detected by two-dimensional gel electrophoresis and mass spectrometry. Cancer Res, 2004; 64: 9018-26
    • (2004) Cancer Res , vol.64 , pp. 9018-9026
    • Shen, J.1    Person, M.D.2    Zhu, J.3
  • 96
    • 68849087652 scopus 로고    scopus 로고
    • Proteomic and tissue array profiling identifies elevated hypoxia-regulated proteins in pancreatic ductal adenocarcinoma
    • Cui Y, Zhang D, Jia Q, Li T et al: Proteomic and tissue array profiling identifies elevated hypoxia-regulated proteins in pancreatic ductal adenocarcinoma. Cancer Invest, 2009; 27: 747-55
    • (2009) Cancer Invest , vol.27 , pp. 747-755
    • Cui, Y.1    Zhang, D.2    Jia, Q.3    Li, T.4
  • 97
    • 55049125773 scopus 로고    scopus 로고
    • The ubiquitin-proteasome pathway mediates gelsolin protein downregulation in pancreatic cancer
    • Ni XG, Zhou L, Wang GQ et al: The ubiquitin-proteasome pathway mediates gelsolin protein downregulation in pancreatic cancer. Mol Med, 2008; 14: 582-89
    • (2008) Mol Med , vol.14 , pp. 582-589
    • Ni, X.G.1    Zhou, L.2    Wang, G.Q.3
  • 98
    • 61449224742 scopus 로고    scopus 로고
    • Proteomic profiling in pancreatic cancer with and without lymph node metastasis
    • Cui Y, Wu J, Zong M et al: Proteomic profiling in pancreatic cancer with and without lymph node metastasis. Int J Cancer, 2009; 124: 1614-21
    • (2009) Int J Cancer , vol.124 , pp. 1614-1621
    • Cui, Y.1    Wu, J.2    Zong, M.3
  • 99
    • 84877142888 scopus 로고    scopus 로고
    • Expression of NEDD9 in pancreatic ductal adenocarcinoma and its clinical significance
    • Xue YZ, Sheng YY, Liu ZL et al: Expression of NEDD9 in pancreatic ductal adenocarcinoma and its clinical significance. Tumour Biol, 2013; 34: 895-99
    • (2013) Tumour Biol , vol.34 , pp. 895-899
    • Xue, Y.Z.1    Sheng, Y.Y.2    Liu, Z.L.3
  • 100
    • 84877127360 scopus 로고    scopus 로고
    • High level of FOXC1 expression is associated with poor prognosis in pancreatic ductal adenocarcinoma
    • Wang L, Gu F, Liu CY et al: High level of FOXC1 expression is associated with poor prognosis in pancreatic ductal adenocarcinoma. Tumour Biol, 2013; 34: 853-58
    • (2013) Tumour Biol , vol.34 , pp. 853-858
    • Wang, L.1    Gu, F.2    Liu, C.Y.3
  • 101
    • 84872952806 scopus 로고    scopus 로고
    • Novel prognostic protein markers of resectable pancreatic cancer identified by coupled shotgun and targeted proteomics using formalin-fixed paraffin-embedded tissues
    • Takadate T, Onogawa T, Fukuda T et al: Novel prognostic protein markers of resectable pancreatic cancer identified by coupled shotgun and targeted proteomics using formalin-fixed paraffin-embedded tissues. Int J Cancer, 2013;132: 1368-82
    • (2013) Int J Cancer , vol.132 , pp. 1368-1382
    • Takadate, T.1    Onogawa, T.2    Fukuda, T.3
  • 102
    • 84886793850 scopus 로고    scopus 로고
    • Nm23/nucleoside diphosphate kinase-A as a potent prognostic marker in invasive pancreatic ductal carcinoma identified by proteomic analysis of laser micro-dissected formalinfixed paraffin-embedded tissue
    • Takadate T, Onogawa T, Fujii K, M et al: Nm23/nucleoside diphosphate kinase-A as a potent prognostic marker in invasive pancreatic ductal carcinoma identified by proteomic analysis of laser micro-dissected formalinfixed paraffin-embedded tissue. Clin Proteomics, 2012; 9: 8
    • (2012) Clin Proteomics , vol.9 , pp. 8
    • Takadate, T.1    Onogawa, T.2    Fujii, K.M.3
  • 103
    • 84871202034 scopus 로고    scopus 로고
    • Reduced expression of Raf kinase inhibitor protein correlates with poor prognosis in pancreatic cancer
    • Song SP, Zhang SB, Li ZH et al: Reduced expression of Raf kinase inhibitor protein correlates with poor prognosis in pancreatic cancer. Clin Transl Oncol, 2012; 14: 848-52
    • (2012) Clin Transl Oncol , vol.14 , pp. 848-852
    • Song, S.P.1    Zhang, S.B.2    Li, Z.H.3
  • 104
    • 84864090211 scopus 로고    scopus 로고
    • High expression of CX3CL1/CX3CR1 axis predicts a poor prognosis of pancreatic ductal adenocarcinoma
    • Xu X, Wang Y, Chen J et al: High expression of CX3CL1/CX3CR1 axis predicts a poor prognosis of pancreatic ductal adenocarcinoma. J Gastrointest Surg, 2012; 16: 1493-98
    • (2012) J Gastrointest Surg , vol.16 , pp. 1493-1498
    • Xu, X.1    Wang, Y.2    Chen, J.3
  • 105
    • 84859048356 scopus 로고    scopus 로고
    • Ack1 tyrosine kinase activation correlates with pancreatic cancer progression
    • Mahajan K, Coppola D, Chen YA et al: Ack1 tyrosine kinase activation correlates with pancreatic cancer progression. Am J Pathol, 2012; 180: 1386-93
    • (2012) Am J Pathol , vol.180 , pp. 1386-1393
    • Mahajan, K.1    Coppola, D.2    Chen, Y.A.3
  • 106
    • 84856296152 scopus 로고    scopus 로고
    • HMGA1 and HMGA2 protein expression correlates with advanced tumour grade and lymph node metastasis in pancreatic adenocarcinoma
    • Piscuoglio S, Zlobec I, Pallante P et al: HMGA1 and HMGA2 protein expression correlates with advanced tumour grade and lymph node metastasis in pancreatic adenocarcinoma. Histopathology, 2012; 60: 397-404
    • (2012) Histopathology , vol.60 , pp. 397-404
    • Piscuoglio, S.1    Zlobec, I.2    Pallante, P.3
  • 107
    • 84863156565 scopus 로고    scopus 로고
    • Dual combination therapy targeting DR5 and EMMPRIN in pancreatic adenocarcinoma
    • Kim H, Zhai G, Samuel SL et al: Dual combination therapy targeting DR5 and EMMPRIN in pancreatic adenocarcinoma. Mol Cancer Ther, 2012; 11: 405-15
    • (2012) Mol Cancer Ther , vol.11 , pp. 405-415
    • Kim, H.1    Zhai, G.2    Samuel, S.L.3
  • 108
    • 79954430750 scopus 로고    scopus 로고
    • Serum biomarkers for improved diagnostic of pancreatic cancer: A current overview
    • Bunger S, Laubert T, Roblick UJ, Habermann JK: Serum biomarkers for improved diagnostic of pancreatic cancer: a current overview. J Cancer Res Clin Oncol, 2011; 137: 375-89
    • (2011) J Cancer Res Clin Oncol , vol.137 , pp. 375-389
    • Bunger, S.1    Laubert, T.2    Roblick, U.J.3    Habermann, J.K.4
  • 109
    • 33645056682 scopus 로고    scopus 로고
    • Fibrinogen gamma overexpression in pancreatic cancer identified by large-scale proteomic analysis of serum samples
    • Bloomston M, Zhou JX, Rosemurgy AS et al: Fibrinogen gamma overexpression in pancreatic cancer identified by large-scale proteomic analysis of serum samples. Cancer Res, 2006; 66: 2592-99
    • (2006) Cancer Res , vol.66 , pp. 2592-2599
    • Bloomston, M.1    Zhou, J.X.2    Rosemurgy, A.S.3
  • 110
    • 33745827045 scopus 로고    scopus 로고
    • Comparative serum glycoproteomics using lectin selected sialic acid glycoproteins with mass spectrometric analysis: Application to pancreatic cancer serum
    • Zhao J, Simeone DM, Heidt D et al: Comparative serum glycoproteomics using lectin selected sialic acid glycoproteins with mass spectrometric analysis: application to pancreatic cancer serum. J Proteome Res, 2006: 5: 1792-802
    • (2006) J Proteome Res , vol.5 , pp. 1792-1802
    • Zhao, J.1    Simeone, D.M.2    Heidt, D.3
  • 111
    • 60849105679 scopus 로고    scopus 로고
    • Confounding effect of obstructive jaundice in the interpretation of proteomic plasma profiling data for pancreatic cancer
    • Yan L, Tonack S, Smith R et al: Confounding effect of obstructive jaundice in the interpretation of proteomic plasma profiling data for pancreatic cancer. J Proteome Res, 2009; 8: 142-48
    • (2009) J Proteome Res , vol.8 , pp. 142-148
    • Yan, L.1    Tonack, S.2    Smith, R.3
  • 112
    • 84857847927 scopus 로고    scopus 로고
    • Multiplex targeted proteomic assay for biomarker detection in plasma: A pancreatic cancer biomarker case study
    • Pan S, Chen R, Brand RE et al: Multiplex targeted proteomic assay for biomarker detection in plasma: a pancreatic cancer biomarker case study. J Proteome Res, 2012; 11: 1937-48
    • (2012) J Proteome Res , vol.11 , pp. 1937-1948
    • Pan, S.1    Chen, R.2    Brand, R.E.3
  • 113
    • 34147220062 scopus 로고    scopus 로고
    • Protein profiling of microdissected pancreas carcinoma and identification of HSP27 as a potential serum marker
    • Melle C, Ernst G, Escher N et al: Protein profiling of microdissected pancreas carcinoma and identification of HSP27 as a potential serum marker. Clin Chem, 2007; 53: 629-35
    • (2007) Clin Chem , vol.53 , pp. 629-635
    • Melle, C.1    Ernst, G.2    Escher, N.3
  • 114
    • 33645680173 scopus 로고    scopus 로고
    • Overexpression and elevated serum levels of phosphoglycerate kinase 1 in pancreatic ductal adenocarcinoma
    • Hwang TL, Liang Y, Chien KY, Yu JS: Overexpression and elevated serum levels of phosphoglycerate kinase 1 in pancreatic ductal adenocarcinoma. Proteomics, 2006; 6; 2259-72
    • (2006) Proteomics , vol.6 , pp. 2259-2272
    • Hwang, T.L.1    Liang, Y.2    Chien, K.Y.3    Yu, J.S.4
  • 115
    • 84865773782 scopus 로고    scopus 로고
    • Serum high mobility group box-1 is a powerful diagnostic and prognostic biomarker for pancreatic ductal adenocarcinoma
    • Chung HW, Lim JB, Jang S et al: Serum high mobility group box-1 is a powerful diagnostic and prognostic biomarker for pancreatic ductal adenocarcinoma Cancer Sci, 2012; 103: 1714-21
    • (2012) Cancer Sci , vol.103 , pp. 1714-1721
    • Chung, H.W.1    Lim, J.B.2    Jang, S.3
  • 116
    • 84859967986 scopus 로고    scopus 로고
    • Serum HSP70: A novel biomarker for early detection of pancreatic cancer
    • Dutta SK, Girotra M, Singla M et al: Serum HSP70: a novel biomarker for early detection of pancreatic cancer. Pancreas, 2012; 41: 530-34
    • (2012) Pancreas , vol.41 , pp. 530-534
    • Dutta, S.K.1    Girotra, M.2    Singla, M.3
  • 117
    • 81855183857 scopus 로고    scopus 로고
    • MicroRNA-150 directly targets MUC4 and suppresses growth and malignant behavior of pancreatic cancer cells
    • Srivastava SK, Bhardwaj A, Singh S et al: MicroRNA-150 directly targets MUC4 and suppresses growth and malignant behavior of pancreatic cancer cells. Carcinogenesis, 2011; 32: 1832-39
    • (2011) Carcinogenesis , vol.32 , pp. 1832-1839
    • Srivastava, S.K.1    Bhardwaj, A.2    Singh, S.3
  • 118
    • 66649092902 scopus 로고    scopus 로고
    • Serum peptidome profiling revealed platelet factor 4 as a potential discriminating Peptide associated with pancreatic cancer
    • Fiedler GM, Leichtle AB, Kase J et al: Serum peptidome profiling revealed platelet factor 4 as a potential discriminating Peptide associated with pancreatic cancer. Clin Cancer Res, 2009; 15: 3812-19
    • (2009) Clin Cancer Res , vol.15 , pp. 3812-3819
    • Fiedler, G.M.1    Leichtle, A.B.2    Kase, J.3
  • 119
    • 78651424414 scopus 로고    scopus 로고
    • Reduced plasma level of CXC chemokine ligand 7 in patients with pancreatic cancer
    • Matsubara J, Honda K, Ono M et al: Reduced plasma level of CXC chemokine ligand 7 in patients with pancreatic cancer. Cancer Epidemiol Biomarkers Prev, 2011;20: 160-71
    • (2011) Cancer Epidemiol Biomarkers Prev , vol.20 , pp. 160-171
    • Matsubara, J.1    Honda, K.2    Ono, M.3
  • 120
    • 34249813687 scopus 로고    scopus 로고
    • Serum proteomic-based analysis of pancreatic carcinoma for the identification of potential cancer biomarkers
    • Sun ZL, Zhu Y, Wang FQ et al: Serum proteomic-based analysis of pancreatic carcinoma for the identification of potential cancer biomarkers. Biochim Biophys Acta, 2007; 1774: 764-71
    • (2007) Biochim Biophys Acta , vol.1774 , pp. 764-771
    • Sun, Z.L.1    Zhu, Y.2    Wang, F.Q.3
  • 121
    • 77954656531 scopus 로고    scopus 로고
    • Increased circulating cell signalling phosphoproteins in sera are useful for the detection of pancreatic cancer
    • Takano S, Sogawa K, Yoshitomi H et al: Increased circulating cell signalling phosphoproteins in sera are useful for the detection of pancreatic cancer. Br J Cancer, 2010; 103: 223-31
    • (2010) Br J Cancer , vol.103 , pp. 223-231
    • Takano, S.1    Sogawa, K.2    Yoshitomi, H.3
  • 122
    • 33748323089 scopus 로고    scopus 로고
    • Proteins associated with disease and clinical course in pancreas cancer: A proteomic analysis of plasma in surgical patients
    • Lin Y, Goedegebuure PS, Tan MC et al: Proteins associated with disease and clinical course in pancreas cancer: a proteomic analysis of plasma in surgical patients. J Proteome Res, 2006; 5: 2169-76
    • (2006) J Proteome Res , vol.5 , pp. 2169-2176
    • Lin, Y.1    Goedegebuure, P.S.2    Tan, M.C.3
  • 123
    • 35649019358 scopus 로고    scopus 로고
    • Autoantibody signature in human ductal pancreatic adenocarcinoma
    • Tomaino B, Cappello P, Capello M et al: Autoantibody signature in human ductal pancreatic adenocarcinoma. J. Proteome Res, 2007; 6: 4025-31
    • (2007) J. Proteome Res , vol.6 , pp. 4025-4031
    • Tomaino, B.1    Cappello, P.2    Capello, M.3
  • 124
    • 33745993022 scopus 로고    scopus 로고
    • Quantitative proteomic profiling of pancreatic cancer juice
    • Chen R, Pan S, Yi EC et al: Quantitative proteomic profiling of pancreatic cancer juice. Proteomics, 2006; 6: 3871-79
    • (2006) Proteomics , vol.6 , pp. 3871-3879
    • Chen, R.1    Pan, S.2    Yi, E.C.3
  • 125
    • 51349092847 scopus 로고    scopus 로고
    • Proteomic analysis identifies MMP-9, DJ-1 and A1BG as overexpressed proteins in pancreatic juice from pancreatic ductal adenocarcinoma patients
    • Tian M, Cui YZ, Song GH et al: Proteomic analysis identifies MMP-9, DJ-1 and A1BG as overexpressed proteins in pancreatic juice from pancreatic ductal adenocarcinoma patients. BMC Cancer, 2008; 8: 241
    • (2008) BMC Cancer , vol.8 , pp. 241
    • Tian, M.1    Cui, Y.Z.2    Song, G.H.3
  • 126
    • 79961166826 scopus 로고    scopus 로고
    • Proteomic analysis of pancreatic juice for the identification of biomarkers of pancreatic cancer
    • Park JY, Kim SA, Chung JW et al: Proteomic analysis of pancreatic juice for the identification of biomarkers of pancreatic cancer. J Cancer Res Clin Oncol, 2011; 137: 1229-38
    • (2011) J Cancer Res Clin Oncol , vol.137 , pp. 1229-1238
    • Park, J.Y.1    Kim, S.A.2    Chung, J.W.3
  • 127
    • 7044237450 scopus 로고    scopus 로고
    • Comprehensive proteomic analysis of human pancreatic juice
    • Gronborg M, Bunkenborg J, Kristiansen TZ et al: Comprehensive proteomic analysis of human pancreatic juice. J Proteome Res, 2004; 3: 1042-55
    • (2004) J Proteome Res , vol.3 , pp. 1042-1055
    • Gronborg, M.1    Bunkenborg, J.2    Kristiansen, T.Z.3
  • 128
    • 34248182539 scopus 로고    scopus 로고
    • Comparative proteomic analysis of human pancreatic juice: Methodological study
    • Zhou L, Lu Z, Yang A et al: Comparative proteomic analysis of human pancreatic juice: methodological study. Proteomics, 2007; 7: 1345-55
    • (2007) Proteomics , vol.7 , pp. 1345-1355
    • Zhou, L.1    Lu, Z.2    Yang, A.3
  • 129
    • 80052963158 scopus 로고    scopus 로고
    • Cyst fluid carcinoembryonic antigen is an accurate diagnostic marker of pancreatic mucinous cysts
    • Cizginer S, Turner B, Bilge AR et al: Cyst fluid carcinoembryonic antigen is an accurate diagnostic marker of pancreatic mucinous cysts. Pancreas, 2011; 40: 1024-28
    • (2011) Pancreas , vol.40 , pp. 1024-1028
    • Cizginer, S.1    Turner, B.2    Bilge, A.R.3
  • 130
    • 79960607000 scopus 로고    scopus 로고
    • Accuracy of differential diagnosis for pancreatic cancer is improved in the combination of RCAS1 and CEA measurements and cytology in pancreatic juice
    • Naito Y, Okabe Y, Nagayama M et al: Accuracy of differential diagnosis for pancreatic cancer is improved in the combination of RCAS1 and CEA measurements and cytology in pancreatic juice. Med Mol Morphol, 2011; 44: 86-92
    • (2011) Med Mol Morphol , vol.44 , pp. 86-92
    • Naito, Y.1    Okabe, Y.2    Nagayama, M.3
  • 131
    • 0347444723 scopus 로고    scopus 로고
    • MicroRNAs: Genomics, biogenesis, mechanism, and function
    • Bartel DP: MicroRNAs: genomics, biogenesis, mechanism, and function. Cell, 2004; 116: 281-97
    • (2004) Cell , vol.116 , pp. 281-297
    • Bartel, D.P.1
  • 132
    • 9144225636 scopus 로고    scopus 로고
    • The microprocessor complex mediate the genesis of microRNAs
    • Gregory RI, Yan KP, Amuthan G et al: The microprocessor complex mediate the genesis of microRNAs. Nature, 2004; 432: 235-40
    • (2004) Nature , vol.432 , pp. 235-240
    • Gregory, R.I.1    Yan, K.P.2    Amuthan, G.3
  • 133
    • 0035905766 scopus 로고    scopus 로고
    • Role for a bidentate ribonuclease in the initiation step of RNA interference
    • Bernstein E, Caudy AA, Hammond SM, Hannon GJ: Role for a bidentate ribonuclease in the initiation step of RNA interference. Nature, 2001; 409: 363-66
    • (2001) Nature , vol.409 , pp. 363-366
    • Bernstein, E.1    Caudy, A.A.2    Hammond, S.M.3    Hannon, G.J.4
  • 134
    • 4644309196 scopus 로고    scopus 로고
    • The functions of animal microRNAs
    • Ambros V: The functions of animal microRNAs. Nature, 2004; 431: 350-55
    • (2004) Nature , vol.431 , pp. 350-355
    • Ambros, V.1
  • 135
    • 0027751663 scopus 로고
    • The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
    • Lee RC, Feinbaum RL, Ambros V: The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell, 1993; 75: 843-54
    • (1993) Cell , vol.75 , pp. 843-854
    • Lee, R.C.1    Feinbaum, R.L.2    Ambros, V.3
  • 136
    • 22844440427 scopus 로고    scopus 로고
    • Identification of hundreds of conserved and nonconserved human microRNAs
    • Bentwich I, Avniel A, Karov Y et al: Identification of hundreds of conserved and nonconserved human microRNAs. Nat Genet, 2005; 37: 766-70
    • (2005) Nat Genet , vol.37 , pp. 766-770
    • Bentwich, I.1    Avniel, A.2    Karov, Y.3
  • 137
    • 11844278458 scopus 로고    scopus 로고
    • Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets
    • Lewis BP, Burge CB, Bartel DP: Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell, 2005; 120: 15-20
    • (2005) Cell , vol.120 , pp. 15-20
    • Lewis, B.P.1    Burge, C.B.2    Bartel, D.P.3
  • 138
  • 139
    • 33645294070 scopus 로고    scopus 로고
    • Oncomirs microRNAs with a role in cancer
    • Esquela-Kerscher A, Slack FJ: Oncomirs microRNAs with a role in cancer. Nat Rev Cancer, 2006; 6: 259-69
    • (2006) Nat Rev Cancer , vol.6 , pp. 259-269
    • Esquela-Kerscher, A.1    Slack, F.J.2
  • 140
    • 62549098152 scopus 로고    scopus 로고
    • MicroRNAs: Control and loss of control in human physiology and disease
    • Li M, Marin-Muller C, Bharadwaj U et al: MicroRNAs: control and loss of control in human physiology and disease. World J Surg, 2009; 33: 667-84
    • (2009) World J Surg , vol.33 , pp. 667-684
    • Li, M.1    Marin-Muller, C.2    Bharadwaj, U.3
  • 141
    • 62549109089 scopus 로고    scopus 로고
    • Profiling of 95 microRNAs in pancreatic cancer cell lines and surgical specimens by real-time PCR analysis
    • Zhang Y, Li M, Wang H et al: Profiling of 95 microRNAs in pancreatic cancer cell lines and surgical specimens by real-time PCR analysis. World J Surg, 2009; 33: 698-709
    • (2009) World J Surg , vol.33 , pp. 698-709
    • Zhang, Y.1    Li, M.2    Wang, H.3
  • 142
    • 84872093873 scopus 로고    scopus 로고
    • Expression of microRNAs in patients with pancreatic cancer and its prognostic significance
    • Papaconstantinou IG, Manta A, Gazouli M et al: Expression of microRNAs in patients with pancreatic cancer and its prognostic significance. Pancreas, 2013; 42: 67-71
    • (2013) Pancreas , vol.42 , pp. 67-71
    • Papaconstantinou, I.G.1    Manta, A.2    Gazouli, M.3
  • 143
    • 34248200155 scopus 로고    scopus 로고
    • MicroRNA expression alterations are linked to tumorigenesis and non-neoplastic processes in pancreatic ductal adenocarcinoma
    • Szafranska AE, Davison TS, John J et al: MicroRNA expression alterations are linked to tumorigenesis and non-neoplastic processes in pancreatic ductal adenocarcinoma. Oncogene, 2007; 26: 4442-52
    • (2007) Oncogene , vol.26 , pp. 4442-4452
    • Szafranska, A.E.1    Davison, T.S.2    John, J.3
  • 144
    • 84870488427 scopus 로고    scopus 로고
    • MicroRNA expression profiles associated with pancreatic adenocarcinoma and ampullary adenocarcinoma
    • Schultz NA, Werner J, Willenbrock H et al: MicroRNA expression profiles associated with pancreatic adenocarcinoma and ampullary adenocarcinoma. Mod Pathol, 2012; 25: 1609-22
    • (2012) Mod Pathol , vol.25 , pp. 1609-1622
    • Schultz, N.A.1    Werner, J.2    Willenbrock, H.3
  • 145
    • 84859129420 scopus 로고    scopus 로고
    • MiRNA expression profiles identify drivers in colorectal and pancreatic cancers
    • Piepoli A, Tavano F, Copetti M, Mazza T et al: MiRNA expression profiles identify drivers in colorectal and pancreatic cancers. PLoS One, 2012; 7: e33663
    • (2012) PLoS One , vol.7
    • Piepoli, A.1    Tavano, F.2    Copetti, M.3    Mazza, T.4
  • 146
    • 84871535770 scopus 로고    scopus 로고
    • Towards a clinical use of miRNAs in pancreatic cancer biopsies
    • Frampton AE, Gall TM, Castellano L et al: Towards a clinical use of miRNAs in pancreatic cancer biopsies. Expert Rev Mol Diagn, 2013; 13: 31-34
    • (2013) Expert Rev Mol Diagn , vol.13 , pp. 31-34
    • Frampton, A.E.1    Gall, T.M.2    Castellano, L.3
  • 147
    • 84865119431 scopus 로고    scopus 로고
    • MicroRNA-10a is overexpressed in human pancreatic cancer and involved in its invasiveness partially via suppression of the HOXA1 gene
    • Ohuchida K, Mizumoto K, Lin C et al: MicroRNA-10a is overexpressed in human pancreatic cancer and involved in its invasiveness partially via suppression of the HOXA1 gene. Ann Surg Oncol, 2012; 19: 2394-402
    • (2012) Ann Surg Oncol , vol.19 , pp. 2394-2402
    • Ohuchida, K.1    Mizumoto, K.2    Lin, C.3
  • 148
    • 84865036176 scopus 로고    scopus 로고
    • miR-301a promotes pancreatic cancer cell proliferation by directly inhibiting Bim expression
    • Chen Z, Chen LY, Dai HY et al: miR-301a promotes pancreatic cancer cell proliferation by directly inhibiting Bim expression. J Cell Biochem, 2012; 113: 3229-35
    • (2012) J Cell Biochem , vol.113 , pp. 3229-3235
    • Chen, Z.1    Chen, L.Y.2    Dai, H.Y.3
  • 149
    • 84855992618 scopus 로고    scopus 로고
    • MiR-126 acts as a tumor suppressor in pancreatic cancer cells via the regulation of ADAM9
    • Hamada S, Satoh K, Fujibuchi W et al: MiR-126 acts as a tumor suppressor in pancreatic cancer cells via the regulation of ADAM9. Mol Cancer Res, 2012; 10: 3-10
    • (2012) Mol Cancer Res , vol.10 , pp. 3-10
    • Hamada, S.1    Satoh, K.2    Fujibuchi, W.3
  • 150
    • 69949087531 scopus 로고    scopus 로고
    • MicroRNA miR-34 inhibits human pancreatic cancer tumor-initiating cells
    • Ji Q, Hao X, Zhang M et al: MicroRNA miR-34 inhibits human pancreatic cancer tumor-initiating cells. PLoS One, 2009; 4: e6816
    • (2009) PLoS One , vol.4
    • Ji, Q.1    Hao, X.2    Zhang, M.3
  • 151
    • 84872586016 scopus 로고    scopus 로고
    • MiR-148b functions as a tumor suppressor in pancreatic cancer by targeting AMPKa1
    • Zhao G, Zhang J, Liu Y et al: MiR-148b functions as a tumor suppressor in pancreatic cancer by targeting AMPKa1. Mol Cancer Ther, 2013; 12: 83-93
    • (2013) Mol Cancer Ther , vol.12 , pp. 83-93
    • Zhao, G.1    Zhang, J.2    Liu, Y.3
  • 152
    • 84883184456 scopus 로고    scopus 로고
    • Let-7b and miR-495 stimulate differentiation and prevent metaplasia of pancreatic acinar cells by repressing HNF6
    • pii: S0016-5085(13)00748-8
    • Prevot PP, Augereau C, Simion A et al: Let-7b and miR-495 stimulate differentiation and prevent metaplasia of pancreatic acinar cells by repressing HNF6. Gastroenterology, 2013; pii: S0016-5085(13)00748-8
    • (2013) Gastroenterology
    • Prevot, P.P.1    Augereau, C.2    Simion, A.3
  • 153
    • 84864644681 scopus 로고    scopus 로고
    • Increased plasma microRNA and CD133/CK18-positive cancer cells in the pleural fluid of a pancreatic cancer patient with liver and pleural metastases and correlation with chemoresistance
    • Ren C, Chen H, Han C et al: Increased plasma microRNA and CD133/CK18-positive cancer cells in the pleural fluid of a pancreatic cancer patient with liver and pleural metastases and correlation with chemoresistance. Oncol Lett, 2012; 4: 691-94
    • (2012) Oncol Lett , vol.4 , pp. 691-694
    • Ren, C.1    Chen, H.2    Han, C.3
  • 154
    • 70449700281 scopus 로고    scopus 로고
    • MicroRNAs in plasma of pancreatic ductal adenocarcinoma patients as novel blood-based biomarkers of disease
    • Wang J, Chen J, Chang P, LeBlanc A et al: MicroRNAs in plasma of pancreatic ductal adenocarcinoma patients as novel blood-based biomarkers of disease. Cancer Prev Res, 2009; 2: 807-13
    • (2009) Cancer Prev Res , vol.2 , pp. 807-813
    • Wang, J.1    Chen, J.2    Chang, P.3    LeBlanc, A.4
  • 155
    • 84861578195 scopus 로고    scopus 로고
    • Combination of plasma microRNAs with serum CA19-9 for early detection of pancreatic cancer
    • Liu J, Gao J, Du Y et al: Combination of plasma microRNAs with serum CA19-9 for early detection of pancreatic cancer. Int J Cancer, 2012; 131: 683-91
    • (2012) Int J Cancer , vol.131 , pp. 683-691
    • Liu, J.1    Gao, J.2    Du, Y.3
  • 156
    • 84869112263 scopus 로고    scopus 로고
    • High-throughput microRNA (miRNAs) arrays unravel the prognostic role of miR-211 in pancreatic cancer
    • Giovannetti E, van der Velde A, Funel N et al: High-throughput microRNA (miRNAs) arrays unravel the prognostic role of miR-211 in pancreatic cancer. PLoS One, 2012; 7: e49145
    • (2012) PLoS One , vol.7
    • Giovannetti, E.1    van der Velde, A.2    Funel, N.3
  • 157
    • 82355164087 scopus 로고    scopus 로고
    • MicroRNAs as markers of survival and chemoresistance in pancreatic ductal adenocarcinoma
    • Frampton AE, Krell J, Jacob J et al: microRNAs as markers of survival and chemoresistance in pancreatic ductal adenocarcinoma. Expert Rev Anticancer Ther, 2011; 11: 1837-42
    • (2011) Expert Rev Anticancer Ther , vol.11 , pp. 1837-1842
    • Frampton, A.E.1    Krell, J.2    Jacob, J.3
  • 158
    • 79952382550 scopus 로고    scopus 로고
    • Anti-Tumor Activity of a Novel compound-CDF is mediated by regulating miR-21, miR-200, and PTEN in pancreatic cancer
    • Bao B, Ali S, Kong D, Sarkar SH, Wang Z et al: Anti-Tumor Activity of a Novel compound-CDF is mediated by regulating miR-21, miR-200, and PTEN in pancreatic cancer. PLoS ONE 2011; 6: e17850
    • (2011) PLoS ONE , vol.6
    • Bao, B.1    Ali, S.2    Kong, D.3    Sarkar, S.H.4    Wang, Z.5
  • 159
    • 70349904531 scopus 로고    scopus 로고
    • Antisense inhibition of microRNA-21 or-221 arrests cell cycle, induces apoptosis, and sensitizes the effects of gemcitabine in pancreatic adenocarcinoma
    • Park JK, Lee EJ, Esau C, Schmittgen TD: Antisense inhibition of microRNA-21 or-221 arrests cell cycle, induces apoptosis, and sensitizes the effects of gemcitabine in pancreatic adenocarcinoma. Pancreas, 2009; 38: e190-99
    • (2009) Pancreas , vol.38
    • Park, J.K.1    Lee, E.J.2    Esau, C.3    Schmittgen, T.D.4
  • 160
    • 84866007085 scopus 로고    scopus 로고
    • EGF receptor is required for KRASinduced pancreatic tumorigenesis
    • Ardito CM, Gruner BM, Takeuchi KK et al: EGF receptor is required for KRASinduced pancreatic tumorigenesis. Cancer Cell, 2012; 22: 304-17
    • (2012) Cancer Cell , vol.22 , pp. 304-317
    • Ardito, C.M.1    Gruner, B.M.2    Takeuchi, K.K.3
  • 161
    • 84873902406 scopus 로고    scopus 로고
    • Insights into erlotinib action in pancreatic cancer cells using a combined experimental and mathematical approach
    • Lange F, Rateitschak K, Kossow C, Wolkenhauer O, Jaster R: Insights into erlotinib action in pancreatic cancer cells using a combined experimental and mathematical approach. World J Gastroenterol, 2012; 18: 6226-34
    • (2012) World J Gastroenterol , vol.18 , pp. 6226-6234
    • Lange, F.1    Rateitschak, K.2    Kossow, C.3    Wolkenhauer, O.4    Jaster, R.5
  • 162
    • 84873742628 scopus 로고    scopus 로고
    • EGFR pathway biomarkers in erlotinib-treated patients with advanced pancreatic cancer: Translational results from the randomised, crossover phase 3 trial AIO-PK0104
    • Boeck S, Jung A, Laubender RP et al: EGFR pathway biomarkers in erlotinib-treated patients with advanced pancreatic cancer: translational results from the randomised, crossover phase 3 trial AIO-PK0104. Br J Cancer, 2013; 108: 469-76
    • (2013) Br J Cancer , vol.108 , pp. 469-476
    • Boeck, S.1    Jung, A.2    Laubender, R.P.3
  • 163
    • 84872083433 scopus 로고    scopus 로고
    • Clinical value of circulating lipocalins and insulin-like growth factor axis in pancreatic cancer diagnosis
    • El-Mesallamy HO, Hamdy NM, Zaghloul AS, Sallam AM: Clinical value of circulating lipocalins and insulin-like growth factor axis in pancreatic cancer diagnosis. Pancreas, 2013; 42: 149-54
    • (2013) Pancreas , vol.42 , pp. 149-154
    • El-Mesallamy, H.O.1    Hamdy, N.M.2    Zaghloul, A.S.3    Sallam, A.M.4
  • 164
    • 77951476693 scopus 로고    scopus 로고
    • Insulin-like growth factor-I receptor in proliferation and motility of pancreatic cancer
    • Tomizawa M, Shinozaki F, Sugiyama T et al: Insulin-like growth factor-I receptor in proliferation and motility of pancreatic cancer. World J Gastroenterol, 2010; 16: 1854-58
    • (2010) World J Gastroenterol , vol.16 , pp. 1854-1858
    • Tomizawa, M.1    Shinozaki, F.2    Sugiyama, T.3
  • 165
    • 84874458512 scopus 로고    scopus 로고
    • Role of a-gal epitope/anti-Gal antibody reaction in immunotherapy and its clinical application in pancreatic cancer
    • Tanemura M, Miyoshi E, Nagano H et al: Role of a-gal epitope/anti-Gal antibody reaction in immunotherapy and its clinical application in pancreatic cancer. Cancer Sci, 2013; 104: 282-90
    • (2013) Cancer Sci , vol.104 , pp. 282-290
    • Tanemura, M.1    Miyoshi, E.2    Nagano, H.3
  • 166
    • 84871991189 scopus 로고    scopus 로고
    • Addition of Algenpantucel-L immunotherapy to standard adjuvant therapy for pancreatic cancer: A phase 2 study
    • Hardacre JM, Mulcahy M, Small W et al: Addition of Algenpantucel-L immunotherapy to standard adjuvant therapy for pancreatic cancer: a phase 2 study. J Gastrointest Surg, 2013; 17: 94-100
    • (2013) J Gastrointest Surg , vol.17 , pp. 94-100
    • Hardacre, J.M.1    Mulcahy, M.2    Small, W.3
  • 167
    • 77958050577 scopus 로고    scopus 로고
    • Phase 2 trial of single agent Ipilimumab (anti-CTLA-4) for locally advanced or metastatic pancreatic adenocarcinoma
    • Royal RE, Levy C, Turner K et al: Phase 2 trial of single agent Ipilimumab (anti-CTLA-4) for locally advanced or metastatic pancreatic adenocarcinoma. J Immunother, 2010; 33: 828-33
    • (2010) J Immunother , vol.33 , pp. 828-833
    • Royal, R.E.1    Levy, C.2    Turner, K.3


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