메뉴 건너뛰기




Volumn 108, Issue 2, 2013, Pages 469-476

EGFR pathway biomarkers in erlotinib-treated patients with advanced pancreatic cancer: Translational results from the randomised, crossover phase 3 trial AIO-PK0104

(20)  Boeck, S a   Jung, A b   Laubender, R P b   Neumann, J b   Egg, R a,b   Goritschan, C a,b   Vehling Kaiser, U c   Winkelmann, C d   Fischer Von Weikersthal, L e   Clemens, M R f   Gauler, T C g   Marten A h   Klein, S i   Kojouharoff, G j   Barner, M k   Geissler, M l   Greten, T F m   Mansmann, U b   Kirchner, T b   Heinemann, V a  


Author keywords

Capecitabine; EGFR; Erlotinib; Gemcitabine; Pancreatic cancer

Indexed keywords

CAPECITABINE; EPIDERMAL GROWTH FACTOR RECEPTOR; ERLOTINIB; GEMCITABINE; K RAS PROTEIN; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE;

EID: 84873742628     PISSN: 00070920     EISSN: 15321827     Source Type: Journal    
DOI: 10.1038/bjc.2012.495     Document Type: Article
Times cited : (81)

References (31)
  • 2
    • 33846932358 scopus 로고    scopus 로고
    • Importance of performance status for treatment outcome in advanced pancreatic cancer
    • Boeck S, Hinke A, Wilkowski R, Heinemann V (2007) Importance of performance status for treatment outcome in advanced pancreatic cancer. World J Gastroenterol 13(2): 224-227. (Pubitemid 46231324)
    • (2007) World Journal of Gastroenterology , vol.13 , Issue.2 , pp. 224-227
    • Boeck, S.1    Hinke, A.2    Wilkowski, R.3    Helnemann, V.4
  • 5
    • 77953916705 scopus 로고    scopus 로고
    • K-ras mutational status predicts poor prognosis in unresectable pancreatic cancer
    • Chen H, TüH, Meng ZQ, Chen Z, Wang P, LiüLM (2010) K-ras mutational status predicts poor prognosis in unresectable pancreatic cancer. Eur J Surg Oncol 36(7): 657-662.
    • (2010) Eur J Surg Oncol , vol.36 , Issue.7 , pp. 657-662
    • Chen, H.1    Tü, H.2    Meng, Z.Q.3    Chen, Z.4    Wang, P.5    Liü, L.M.6
  • 6
    • 78650095716 scopus 로고    scopus 로고
    • Molecular predictors of outcome in a phase 3 study of gemcitabine and erlotinib therapy in patients with advanced pancreatic cancer: National cancer institute of canada clinical trials group study pa.3
    • Da Cunha Santos G, Dhani N, TüD, Chin K, Ludkovski O, Kamel-Reid S, Squire J, Parulekar W, Moore MJ, Tsao MS (2010) Molecular predictors of outcome in a phase 3 study of gemcitabine and erlotinib therapy in patients with advanced pancreatic cancer: National Cancer Institute of Canada Clinical Trials Group Study PA.3. Cancer 116(24): 5599-5607.
    • (2010) Cancer , vol.116 , Issue.24 , pp. 5599-5607
    • Da Cunha Santos, G.1    Dhani, N.2    Tü, D.3    Chin, K.4    Ludkovski, O.5    Kamel-Reid, S.6    Squire, J.7    Parulekar, W.8    Moore, M.J.9    Tsao, M.S.10
  • 9
    • 84862968354 scopus 로고    scopus 로고
    • High level of PTEN expression and its association with low-grade liver metastases and satisfactory patient survival in pancreatic cancer
    • Feng C, Yao R, Huang F, LiüX, Nie W (2011) High level of PTEN expression and its association with low-grade liver metastases and satisfactory patient survival in pancreatic cancer. Arch Med Res 42(7): 584-588.
    • (2011) Arch Med Res , vol.42 , Issue.7 , pp. 584-588
    • Feng, C.1    Yao, R.2    Huang, F.3    Liü, X.4    Nie, W.5
  • 11
    • 64049090889 scopus 로고    scopus 로고
    • Clinical relevance of EGFR- and KRAS-status in colorectal cancer patients treated with monoclonal antibodies directed against the EGFR
    • Heinemann V, Stintzing S, Kirchner T, Boeck S, Jung A (2009) Clinical relevance of EGFR- and KRAS-status in colorectal cancer patients treated with monoclonal antibodies directed against the EGFR. Cancer Treat Rev 35(3): 262-271.
    • (2009) Cancer Treat Rev , vol.35 , Issue.3 , pp. 262-271
    • Heinemann, V.1    Stintzing, S.2    Kirchner, T.3    Boeck, S.4    Jung, A.5
  • 14
    • 33744725273 scopus 로고    scopus 로고
    • Molecular analysis of the EGFR-RAS-RAF pathway in pancreatic ductal adenocarcinomas: Lack of mutations in the BRAF and EGFR genes
    • DOI 10.1007/s00428-006-0191-8
    • Immervoll H, Hoem D, Kugarajh K, Steine SJ, Molven A (2006) Molecular analysis of the EGFR-RAS-RAF pathway in pancreatic ductal adenocarcinomas: Lack of mutations in the BRAF and EGFR genes. Virchows Arch 448(6): 788-796. (Pubitemid 43824436)
    • (2006) Virchows Archiv , vol.448 , Issue.6 , pp. 788-796
    • Immervoll, H.1    Hoem, D.2    Kugarajh, K.3    Steine, S.J.4    Molven, A.5
  • 16
    • 74949098030 scopus 로고    scopus 로고
    • Association of epidermal growth factor receptor polymorphism, skin toxicity, and outcome in patients with squamous cell carcinoma of the head and neck receiving cetuximab-docetaxel treatment
    • Klinghammer K, Knödler M, Schmittel A, Budach V, Keilholz U, Tinhofer I (2010) Association of epidermal growth factor receptor polymorphism, skin toxicity, and outcome in patients with squamous cell carcinoma of the head and neck receiving cetuximab-docetaxel treatment. Clin Cancer Res 16(1): 304-310.
    • (2010) Clin Cancer Res , vol.16 , Issue.1 , pp. 304-310
    • Klinghammer, K.1    Knödler, M.2    Schmittel, A.3    Budach, V.4    Keilholz, U.5    Tinhofer, I.6
  • 17
    • 34247149803 scopus 로고    scopus 로고
    • Impact of Epidermal Growth Factor Receptor (EGFR) kinase mutations, EGFR gene amplifications, and KRAS mutations on survival of pancreatic adenocarcinoma
    • DOI 10.1002/cncr.22559
    • Lee J, Jang KT, Ki CS, Lim T, Park YS, Lim HY, Choi DW, Kang WK, Park K, Park JO (2007) Impact of epidermal growth factor receptor (EGFR) kinase mutations, EGFR gene amplifications, and KRAS mutations on survival of pancreatic adenocarcinoma. Cancer 109(8): 1561-1569. (Pubitemid 46595692)
    • (2007) Cancer , vol.109 , Issue.8 , pp. 1561-1569
    • Lee, J.1    Jang, K.-T.2    Ki, C.-S.3    Lim, T.4    Young, S.P.5    Ho, Y.L.6    Choi, D.-W.7    Won, K.K.8    Park, K.9    Joon, O.P.10
  • 20
    • 75549090214 scopus 로고    scopus 로고
    • Frequency and type of KRAS mutations in routine diagnostic analysis of metastatic colorectal cancer
    • Neumann J, Zeindl-Eberhart E, Kirchner T, Jung A (2009) Frequency and type of KRAS mutations in routine diagnostic analysis of metastatic colorectal cancer. Pathol Res Pract 205(12): 858-862.
    • (2009) Pathol Res Pract , vol.205 , Issue.12 , pp. 858-862
    • Neumann, J.1    Zeindl-Eberhart, E.2    Kirchner, T.3    Jung, A.4
  • 21
    • 0036690404 scopus 로고    scopus 로고
    • Effects of the epidermal growth factor receptor inhibitor OSI-774, Tarceva, on downstream signaling pathways and apoptosis in human pancreatic adenocarcinoma
    • Ng SS, Tsao MS, Nicklee T, Hedley DW (2002) Effects of the epidermal growth factor receptor inhibitor OSI-774, Tarceva, on downstream signaling pathways and apoptosis in human pancreatic adenocarcinoma. Mol Cancer Ther 1(10): 777-783.
    • (2002) Mol Cancer Ther , vol.1 , Issue.10 , pp. 777-783
    • Ng, S.S.1    Tsao, M.S.2    Nicklee, T.3    Hedley, D.W.4
  • 25
    • 77949264996 scopus 로고    scopus 로고
    • Advanced pancreatic carcinoma: Current treatment and future challenges
    • Stathis A, Moore MJ (2010) Advanced pancreatic carcinoma: Current treatment and future challenges. Nat Rev Clin Oncol 7(3): 163-172.
    • (2010) Nat Rev Clin Oncol , vol.7 , Issue.3 , pp. 163-172
    • Stathis, A.1    Moore, M.J.2
  • 26
    • 34250828460 scopus 로고    scopus 로고
    • Pancreatic cancer epidermal growth factor receptor (EGFR) intron 1 polymorphism influences postoperative patient survival and in vitro erlotinib response
    • DOI 10.1245/s10434-007-9409-5
    • Tzeng CW, Frolov A, Frolova N, Jhala NC, Howard JH, Vickers SM, Buchsbaum DJ, Heslin MJ, Arnoletti JP (2007a) Pancreatic cancer epidermal growth factor receptor (EGFR) intron 1 polymorphism influences postoperative patient survival and in vitro erlotinib response. Ann Surg Oncol 14(7): 2150-2158. (Pubitemid 46988271)
    • (2007) Annals of Surgical Oncology , vol.14 , Issue.7 , pp. 2150-2158
    • Tzeng, C.-W.D.1    Frolov, A.2    Frolova, N.3    Jhala, N.C.4    Howard, J.H.5    Vickers, S.M.6    Buchsbaum, D.J.7    Heslin, M.J.8    Arnoletti, J.P.9
  • 28
    • 6044241807 scopus 로고    scopus 로고
    • The correlation between cytoplasmic overexpression of epidermal growth factor receptor and tumor aggressiveness: Poor prognosis in patients with pancreatic ductal adenocarcinoma
    • Ueda S, Ogata S, Tsuda H, Kawarabayashi N, Kimura M, Sugiura Y, Tamai S, Matsubara O, Hatsuse K, Mochizuki H (2004) The correlation between cytoplasmic overexpression of epidermal growth factor receptor and tumor aggressiveness: Poor prognosis in patients with pancreatic ductal adenocarcinoma. Pancreas 29(1): E1-e8.
    • (2004) Pancreas , vol.29 , Issue.1
    • Ueda, S.1    Ogata, S.2    Tsuda, H.3    Kawarabayashi, N.4    Kimura, M.5    Sugiura, Y.6    Tamai, S.7    Matsubara, O.8    Hatsuse, K.9    Mochizuki, H.10
  • 30
    • 34250749285 scopus 로고    scopus 로고
    • Epidermal growth factor receptor R497K polymorphism is a favorable prognostic factor for patients with colorectal carcinoma
    • DOI 10.1158/1078-0432.CCR-06-2601
    • Wang WS, Chen PM, ChioüTJ, LiüJH, Lin JK, Lin TC, Wang HS, SüY (2007) Epidermal growth factor receptor R497K polymorphism is a favorable prognostic factor for patients with colorectal carcinoma. Clin Cancer Res 13(12): 3597-3604. (Pubitemid 46955121)
    • (2007) Clinical Cancer Research , vol.13 , Issue.12 , pp. 3597-3604
    • Wang, W.-S.1    Chen, P.-M.2    Chiou, T.-J.3    Liu, J.-H.4    Lin, J.-K.5    Lin, T.-C.6    Wang, H.-S.7    Su, Y.8
  • 31
    • 77956268839 scopus 로고    scopus 로고
    • Understanding resistance to EGFR inhibitors-impact on future treatment strategies
    • Wheeler DL, Dunn EF, Harari PM (2010) Understanding resistance to EGFR inhibitors-impact on future treatment strategies. Nat Rev Clin Oncol 7(9): 493-507.
    • (2010) Nat Rev Clin Oncol , vol.7 , Issue.9 , pp. 493-507
    • Wheeler, D.L.1    Dunn, E.F.2    Harari, P.M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.