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Volumn 32, Issue 12, 2011, Pages 1832-1839

MicroRNA-150 directly targets MUC4 and suppresses growth and malignant behavior of pancreatic cancer cells

Author keywords

[No Author keywords available]

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR 2; MICRORNA; MICRORNA 150; MUCIN 4; UNCLASSIFIED DRUG;

EID: 81855183857     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgr223     Document Type: Article
Times cited : (158)

References (39)
  • 1
    • 77955635233 scopus 로고    scopus 로고
    • Cancer statistics, 2010
    • Jemal,A. et al. (2010) Cancer statistics, 2010. CA Cancer J. Clin., 60, 277-300.
    • (2010) CA Cancer J. Clin. , vol.60 , pp. 277-300
    • Jemal, A.1
  • 2
    • 78650194206 scopus 로고    scopus 로고
    • CXCL12-CXCR4 signalling axis confers gemcita-bine resistance to pancreatic cancer cells: a novel target for therapy
    • Singh,S. et al. (2010) CXCL12-CXCR4 signalling axis confers gemcita-bine resistance to pancreatic cancer cells: a novel target for therapy. Br. J. Cancer, 103, 1671-1679.
    • (2010) Br. J. Cancer , vol.103 , pp. 1671-1679
    • Singh, S.1
  • 3
    • 1642588228 scopus 로고    scopus 로고
    • Pancreatic cancer
    • Li,D. et al. (2004) Pancreatic cancer. Lancet, 363, 1049-1057.
    • (2004) Lancet , vol.363 , pp. 1049-1057
    • Li, D.1
  • 4
    • 0036883940 scopus 로고    scopus 로고
    • Pancreatic cancer biology and genetics
    • Bardeesy,N. et al. (2002) Pancreatic cancer biology and genetics. Nat. Rev. Cancer, 2, 897-909.
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 897-909
    • Bardeesy, N.1
  • 5
    • 78649272579 scopus 로고    scopus 로고
    • Molecular biology of pancreatic ductal adenocar-cinoma progression: aberrant activation of developmental pathways
    • Rhim,A.D. et al. (2010) Molecular biology of pancreatic ductal adenocar-cinoma progression: aberrant activation of developmental pathways. Prog. Mol. Biol. Transl. Sci., 97, 41-78.
    • (2010) Prog. Mol. Biol. Transl. Sci. , vol.97 , pp. 41-78
    • Rhim, A.D.1
  • 6
    • 43449114782 scopus 로고    scopus 로고
    • Pancreatic carcinogenesis
    • Koorstra,J.B. et al. (2008) Pancreatic carcinogenesis. Pancreatology, 8, 110-125.
    • (2008) Pancreatology , vol.8 , pp. 110-125
    • Koorstra, J.B.1
  • 7
    • 27644549557 scopus 로고    scopus 로고
    • Recent advances on the molecular mechanisms involved in pancreatic cancer progression and therapies
    • Mimeault,M. et al. (2005) Recent advances on the molecular mechanisms involved in pancreatic cancer progression and therapies. Pancreas, 31, 301-316.
    • (2005) Pancreas , vol.31 , pp. 301-316
    • Mimeault, M.1
  • 8
    • 42049099903 scopus 로고    scopus 로고
    • Structure, evolution, and biology of the MUC4 mucin
    • Chaturvedi,P. et al. (2008) Structure, evolution, and biology of the MUC4 mucin. FASEB J., 22, 966-981.
    • (2008) FASEB J , vol.22 , pp. 966-981
    • Chaturvedi, P.1
  • 9
    • 0035678782 scopus 로고    scopus 로고
    • Mucin (MUC) gene expression in human pancreatic adenocarcinoma and chronic pancreatitis: a potential role of MUC4 as a tumor marker of diagnostic significance
    • Andrianifahanana,M. et al. (2001) Mucin (MUC) gene expression in human pancreatic adenocarcinoma and chronic pancreatitis: a potential role of MUC4 as a tumor marker of diagnostic significance. Clin. Cancer Res., 7, 4033-4040.
    • (2001) Clin. Cancer Res. , vol.7 , pp. 4033-4040
    • Andrianifahanana, M.1
  • 10
    • 0036233702 scopus 로고    scopus 로고
    • MUC4 expression increases progressively in pancreatic intraepithelial neoplasia
    • Swartz,M.J. et al. (2002) MUC4 expression increases progressively in pancreatic intraepithelial neoplasia. Am. J. Clin. Pathol., 117, 791-796.
    • (2002) Am. J. Clin. Pathol. , vol.117 , pp. 791-796
    • Swartz, M.J.1
  • 11
    • 34248218177 scopus 로고    scopus 로고
    • MUC4 mucin potentiates pancreatic tumor cell proliferation, survival, and invasive properties and interferes with its interaction to extracellular matrix proteins
    • Chaturvedi,P. et al. (2007) MUC4 mucin potentiates pancreatic tumor cell proliferation, survival, and invasive properties and interferes with its interaction to extracellular matrix proteins. Mol. Cancer Res., 5, 309-320.
    • (2007) Mol. Cancer Res. , vol.5 , pp. 309-320
    • Chaturvedi, P.1
  • 12
    • 1642475141 scopus 로고    scopus 로고
    • Inhibition of MUC4 expression suppresses pancreatic tumor cell growth and metastasis
    • Singh,A.P. et al. (2004) Inhibition of MUC4 expression suppresses pancreatic tumor cell growth and metastasis. Cancer Res., 64, 622-630.
    • (2004) Cancer Res. , vol.64 , pp. 622-630
    • Singh, A.P.1
  • 13
    • 33846658776 scopus 로고    scopus 로고
    • Emerging roles of MUC4 in cancer: a novel target for diagnosis and therapy
    • Singh,A.P. et al. (2007) Emerging roles of MUC4 in cancer: a novel target for diagnosis and therapy. Cancer Res., 67, 433-436.
    • (2007) Cancer Res. , vol.67 , pp. 433-436
    • Singh, A.P.1
  • 14
    • 75149137086 scopus 로고    scopus 로고
    • Muc4/MUC4 functions and regulation in cancer
    • Carraway,K.L. et al. (2009) Muc4/MUC4 functions and regulation in cancer. Future Oncol., 5, 1631-1640.
    • (2009) Future Oncol. , vol.5 , pp. 1631-1640
    • Carraway, K.L.1
  • 15
    • 78651517597 scopus 로고    scopus 로고
    • MicroRNA-based cancer therapeutics: big hope from small RNAs
    • Bhardwaj,A. et al. (2010) MicroRNA-based cancer therapeutics: big hope from small RNAs. Mol. Cell. Pharmacol., 2, 213-219.
    • (2010) Mol. Cell. Pharmacol. , vol.2 , pp. 213-219
    • Bhardwaj, A.1
  • 16
    • 67650711156 scopus 로고    scopus 로고
    • MicroRNAs in cancer
    • Garzon,R. et al. (2009) MicroRNAs in cancer. Annu. Rev. Med., 60, 167-179.
    • (2009) Annu. Rev. Med. , vol.60 , pp. 167-179
    • Garzon, R.1
  • 17
    • 73349125465 scopus 로고    scopus 로고
    • MicroRNAs in cancer: small molecules with a huge impact
    • Iorio,M.V. et al. (2009) MicroRNAs in cancer: small molecules with a huge impact. J. Clin. Oncol., 27, 5848-5856.
    • (2009) J. Clin. Oncol. , vol.27 , pp. 5848-5856
    • Iorio, M.V.1
  • 18
    • 42049105135 scopus 로고    scopus 로고
    • MUC4 mucin interacts with and stabilizes the HER2 oncoprotein in human pancreatic cancer cells
    • Chaturvedi,P. et al. (2008) MUC4 mucin interacts with and stabilizes the HER2 oncoprotein in human pancreatic cancer cells. Cancer Res., 68, 2065-2070.
    • (2008) Cancer Res. , vol.68 , pp. 2065-2070
    • Chaturvedi, P.1
  • 19
    • 29144470346 scopus 로고    scopus 로고
    • Real-time quantification of microRNAs by stem-loop RT-PCR
    • Chen,C. et al. (2005) Real-time quantification of microRNAs by stem-loop RT-PCR. Nucleic Acids Res., 33, e179.
    • (2005) Nucleic Acids Res. , vol.33
    • Chen, C.1
  • 20
    • 45849111603 scopus 로고    scopus 로고
    • Origin, evolution, and biological role of miRNA cluster in DLK-DIO3 genomic region in placental mammals
    • Glazov,E.A. et al. (2008) Origin, evolution, and biological role of miRNA cluster in DLK-DIO3 genomic region in placental mammals. Mol. Biol. Evol., 25, 939-948.
    • (2008) Mol. Biol. Evol. , vol.25 , pp. 939-948
    • Glazov, E.A.1
  • 21
    • 33846813656 scopus 로고    scopus 로고
    • Expression profiling identifies microRNA signature in pancreatic cancer
    • Lee,E.J. et al. (2007) Expression profiling identifies microRNA signature in pancreatic cancer. Int. J. Cancer, 120, 1046-1054.
    • (2007) Int. J. Cancer , vol.120 , pp. 1046-1054
    • Lee, E.J.1
  • 22
    • 34248200155 scopus 로고    scopus 로고
    • MicroRNA expression alterations are linked to tumorigenesis and non-neoplastic processes in pancreatic ductal adeno-carcinoma
    • Szafranska,A.E. et al. (2007) MicroRNA expression alterations are linked to tumorigenesis and non-neoplastic processes in pancreatic ductal adeno-carcinoma. Oncogene, 26, 4442-4452.
    • (2007) Oncogene , vol.26 , pp. 4442-4452
    • Szafranska, A.E.1
  • 23
    • 42949127525 scopus 로고    scopus 로고
    • miRNA analysis in B-cell chronic lymphocytic leukaemia: proliferation centres characterized by low miR-150 and high BIC/miR-155 expression
    • Wang,M. et al. (2008) miRNA analysis in B-cell chronic lymphocytic leukaemia: proliferation centres characterized by low miR-150 and high BIC/miR-155 expression. J. Pathol., 215, 13-20.
    • (2008) J. Pathol. , vol.215 , pp. 13-20
    • Wang, M.1
  • 24
    • 85027922313 scopus 로고    scopus 로고
    • The role of microRNA-150 as a tumor suppressor in malignant lymphoma
    • Watanabe,A. et al. (2011) The role of microRNA-150 as a tumor suppressor in malignant lymphoma. Leukemia, 25, 1324-1334.
    • (2011) Leukemia , vol.25 , pp. 1324-1334
    • Watanabe, A.1
  • 25
    • 79551613704 scopus 로고    scopus 로고
    • MicroRNA expression profiles in human colorectal cancers with liver metastases
    • Lin,M. et al. (2011) MicroRNA expression profiles in human colorectal cancers with liver metastases. Oncol. Rep., 25, 739-747.
    • (2011) Oncol. Rep. , vol.25 , pp. 739-747
    • Lin, M.1
  • 26
    • 76349110748 scopus 로고    scopus 로고
    • MiR-150 promotes gastric cancer proliferation by negatively regulating the pro-apoptotic gene EGR2
    • Wu,Q. et al. (2010) MiR-150 promotes gastric cancer proliferation by negatively regulating the pro-apoptotic gene EGR2. Biochem. Biophys. Res. Commun., 392, 340-345.
    • (2010) Biochem. Biophys. Res. Commun. , vol.392 , pp. 340-345
    • Wu, Q.1
  • 27
    • 34547941361 scopus 로고    scopus 로고
    • MiR-150 controls B cell differentiation by targeting the transcription factor c-Myb
    • Xiao,C. et al. (2007) MiR-150 controls B cell differentiation by targeting the transcription factor c-Myb. Cell, 131, 146-159.
    • (2007) Cell , vol.131 , pp. 146-159
    • Xiao, C.1
  • 28
    • 57649129015 scopus 로고    scopus 로고
    • MicroRNAs miR-186 and miR-150 down-regulate expression of the pro-apoptotic purinergic P2X7 receptor by activation of instability sites at the 3'-untranslated region of the gene that decrease steady-state levels of the transcript
    • Zhou,L. et al. (2008) MicroRNAs miR-186 and miR-150 down-regulate expression of the pro-apoptotic purinergic P2X7 receptor by activation of instability sites at the 3'-untranslated region of the gene that decrease steady-state levels of the transcript. J. Biol. Chem., 283, 28274-28286.
    • (2008) J. Biol. Chem. , vol.283 , pp. 28274-28286
    • Zhou, L.1
  • 29
    • 17544395847 scopus 로고    scopus 로고
    • Muc4/sialomucin complex, the intramembrane ErbB2 ligand, in cancer and epithelia: to protect and to survive
    • Carraway,K.L. et al. (2002) Muc4/sialomucin complex, the intramembrane ErbB2 ligand, in cancer and epithelia: to protect and to survive. Prog. Nucleic Acid Res. Mol. Biol., 71, 149-185.
    • (2002) Prog. Nucleic Acid Res. Mol. Biol. , vol.71 , pp. 149-185
    • Carraway, K.L.1
  • 30
    • 81855187244 scopus 로고    scopus 로고
    • MUC4 is a novel prognostic factor of oral squamous cell carcinoma
    • doi:10.1002/ijc.26187
    • Hamada,T. et al. (2011) MUC4 is a novel prognostic factor of oral squamous cell carcinoma. Int. J. Cancer. doi:10.1002/ijc.26187.
    • (2011) Int. J. Cancer.
    • Hamada, T.1
  • 31
    • 33644886605 scopus 로고    scopus 로고
    • MUC genes are differently expressed during onset and maintenance of inflammation in dextran sodium sulfate-treated mice
    • Hoebler,C. et al. (2006) MUC genes are differently expressed during onset and maintenance of inflammation in dextran sodium sulfate-treated mice. Dig. Dis. Sci., 51, 381-389.
    • (2006) Dig. Dis. Sci. , vol.51 , pp. 381-389
    • Hoebler, C.1
  • 32
    • 48349129798 scopus 로고    scopus 로고
    • MUC4 activates HER2 signalling and enhances the motility of human ovarian cancer cells
    • Ponnusamy,M.P. et al. (2008) MUC4 activates HER2 signalling and enhances the motility of human ovarian cancer cells. Br. J. Cancer, 99, 520-526.
    • (2008) Br. J. Cancer , vol.99 , pp. 520-526
    • Ponnusamy, M.P.1
  • 33
    • 33846056211 scopus 로고    scopus 로고
    • MUC4 expression is regulated by cystic fibrosis transmembrane conductance regulator in pancreatic adenocarcinoma cells via transcriptional and post-translational mechanisms
    • Singh,A.P. et al. (2007) MUC4 expression is regulated by cystic fibrosis transmembrane conductance regulator in pancreatic adenocarcinoma cells via transcriptional and post-translational mechanisms. Oncogene, 26, 30-41.
    • (2007) Oncogene , vol.26 , pp. 30-41
    • Singh, A.P.1
  • 34
    • 0347123435 scopus 로고    scopus 로고
    • Mucins in cancer: protection and control of the cell surface
    • Hollingsworth,M.A. et al. (2004) Mucins in cancer: protection and control of the cell surface. Nat. Rev. Cancer, 4, 45-60.
    • (2004) Nat. Rev. Cancer , vol.4 , pp. 45-60
    • Hollingsworth, M.A.1
  • 35
    • 27244432205 scopus 로고    scopus 로고
    • MicroRNAs as oncogenes and tumor suppressors
    • Chen,C.Z. (2005) MicroRNAs as oncogenes and tumor suppressors. N. Engl. J. Med., 353, 1768-1771.
    • (2005) N. Engl. J. Med. , vol.353 , pp. 1768-1771
    • Chen, C.Z.1
  • 36
    • 33750370444 scopus 로고    scopus 로고
    • MicroRNA signatures in human cancers
    • Calin,G.A. et al. (2006) MicroRNA signatures in human cancers. Nat. Rev. Cancer, 6, 857-866.
    • (2006) Nat. Rev. Cancer , vol.6 , pp. 857-866
    • Calin, G.A.1
  • 37
    • 75149124701 scopus 로고    scopus 로고
    • MicroRNA-145 suppresses cell invasion and metastasis by directly targeting mucin 1
    • Sachdeva,M. et al. (2010) MicroRNA-145 suppresses cell invasion and metastasis by directly targeting mucin 1. Cancer Res., 70, 378-387.
    • (2010) Cancer Res. , vol.70 , pp. 378-387
    • Sachdeva, M.1
  • 38
    • 79959703562 scopus 로고    scopus 로고
    • * inhibits androgen receptor expression in prostate carcinoma cells
    • * inhibits androgen receptor expression in prostate carcinoma cells. Int. J. Cancer, 129, 810-819.
    • (2011) Int. J. Cancer , vol.129 , pp. 810-819
    • Sikand, K.1
  • 39
    • 79959845414 scopus 로고    scopus 로고
    • MicroRNAs 103 and 107 regulate insulin sensitivity
    • Trajkovski,M. et al. (2011) MicroRNAs 103 and 107 regulate insulin sensitivity. Nature, 474, 649-653.
    • (2011) Nature , vol.474 , pp. 649-653
    • Trajkovski, M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.