Mismatch Repair Genes Mlh1 and Mlh3 Modify CAG Instability in Huntington's Disease Mice: Genome-Wide and Candidate Approaches

PLoS Genetics

Volumn 9, Issue 10, 2013, Pages

  Pinto, Ricardo Mouro ^a   Dragileva, Ella ^a   Kirby, Andrew ^a,b   Lloret, Alejandro ^a   Lopez, Edith ^a   St Claire, Jason ^a   Panigrahi, Gagan B ^c,d   Hou, Caixia ^e   Holloway, Kim ^f   Gillis, Tammy ^a   Guide, Jolene R ^a   Cohen, Paula E ^f   Li, Guo Min ^e   Pearson, Christopher E ^c,d   Daly, Mark J ^a,b   Wheeler, Vanessa C ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^c HOSPITAL FOR SICK CHILDREN   (Canada)

^d UNIVERSITY OF TORONTO   (Canada)

^e UNIVERSITY OF KENTUCKY   (United States)

^f Department of Obstetrics Gynecology   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HUNTINGTIN; CARRIER PROTEIN; MESSENGER RNA; MLH1 PROTEIN, MOUSE; MLH3 PROTEIN, MOUSE; NUCLEAR PROTEIN; SIGNAL TRANSDUCING ADAPTOR PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BASE MISPAIRING; CAG REPEAT; CHROMOSOME 9; DNA REPAIR; GENE; GENE DELETION; GENE FUNCTION; GENE LOCUS; GENE MAPPING; GENETIC LINKAGE; GENETIC VARIABILITY; GENOTYPE; HAPLOTYPE; HUNTINGTON CHOREA; LINKAGE ANALYSIS; MISMATCH REPAIR; MLH1 GENE; MLH3 GENE; MOUSE; NONHUMAN; PATHOGENESIS; QUANTITATIVE TRAIT LOCUS; SINGLE NUCLEOTIDE POLYMORPHISM; ANIMAL; DISEASE MODEL; GENETIC ASSOCIATION; GENETICS; GENOMIC INSTABILITY; HUMAN; PATHOLOGY; TRINUCLEOTIDE REPEAT;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; CARRIER PROTEINS; DISEASE MODELS, ANIMAL; GENETIC ASSOCIATION STUDIES; GENOME-WIDE ASSOCIATION STUDY; GENOMIC INSTABILITY; HUMANS; HUNTINGTON DISEASE; MICE; NUCLEAR PROTEINS; RNA, MESSENGER; TRINUCLEOTIDE REPEAT EXPANSION;

EID: 84887286407     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1003930     Document Type: Article

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