Phenotypic abnormalities in the YAC128 mouse model of Huntington disease are penetrant on multiple genetic backgrounds and modulated by strain

Neurobiology of Disease

Volumn 26, Issue 1, 2007, Pages 189-200

  Van Raamsdonk, Jeremy M ^a,b   Metzler, Martina ^a,b   Slow, Elizabeth ^a,b   Pearson, Jacqueline ^a,b   Schwab, Claudia ^a,b   Carroll, Jeffrey ^a,b   Graham, Rona K ^a,b   Leavitt, Blair R ^a,b   Hayden, Michael R ^a,b  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Genetic modifier; Huntington disease; Neurodegeneration; Polyglutamine disorder; Quantitative trait loci mapping; Trinucleotide repeat disorder; YAC128 mouse model

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACKCROSSING; COGNITIVE DEFECT; CONTROLLED STUDY; CORPUS STRIATUM; HUNTINGTON CHOREA; MOTOR DYSFUNCTION; MOUSE; MOUSE STRAIN; NEUROPATHOLOGY; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; TRANSGENIC MOUSE;

AGING; ANIMALS; BODY WEIGHT; CELL NUCLEUS; DISEASE MODELS, ANIMAL; HUMANS; HUNTINGTON DISEASE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MOTOR ACTIVITY; MUSCULOSKELETAL EQUILIBRIUM; NERVE TISSUE PROTEINS; NUCLEAR PROTEINS; ORGAN SIZE; PHENOTYPE; PSYCHOMOTOR PERFORMANCE; SPECIES SPECIFICITY; SURVIVAL ANALYSIS;

EID: 33947286031     PISSN: 09699961     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nbd.2006.12.010     Document Type: Article

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