Quantification of age-dependent somatic CAG repeat instability in Hdh CAG knock-in mice reveals different expansion dynamics in striatum and liver

PLoS ONE

Volumn 6, Issue 8, 2011, Pages

  Lee, Jong Min ^a   Pinto, Ricardo Mouro ^a   Gillis, Tammy ^a   St Claire, Jason C ^a   Wheeler, Vanessa C ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GENOMIC DNA; HDH PROTEIN, MOUSE; NERVE PROTEIN; NUCLEAR PROTEIN;

AGE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CAG REPEAT; CAG REPEAT INSTABILITY; CONTROLLED STUDY; CORPUS STRIATUM; GENE; GENE FUNCTION; HTT GENE; HUNTINGTON CHOREA; LIVER; LIVER CELL; MOUSE; NONHUMAN; POLYPLOIDY; SPLEEN; TAIL; AGING; ANIMAL; ANTIBODY SPECIFICITY; GENE TARGETING; GENETICS; GENOMIC INSTABILITY; HUMAN; METABOLISM; NEOSTRIATUM; TIME; TRINUCLEOTIDE REPEAT;

MUS;

AGING; ANIMALS; GENE KNOCK-IN TECHNIQUES; GENOMIC INSTABILITY; HUMANS; HUNTINGTON DISEASE; LIVER; MICE; NEOSTRIATUM; NERVE TISSUE PROTEINS; NUCLEAR PROTEINS; ORGAN SPECIFICITY; TIME FACTORS; TRINUCLEOTIDE REPEATS;

EID: 80052288666     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0023647     Document Type: Article

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