Msh2 Acts in Medium-Spiny Striatal Neurons as an Enhancer of CAG Instability and Mutant Huntingtin Phenotypes in Huntington's Disease Knock-In Mice

PLoS ONE

Volumn 7, Issue 9, 2012, Pages

  Kovalenko, Marina ^a   Dragileva, Ella ^a   St Claire, Jason ^a   Gillis, Tammy ^a   Guide, Jolene R ^a   New, Jaclyn ^a   Dong, Hualing ^a   Kucherlapati, Raju ^b   Kucherlapati, Melanie H ^b   Ehrlich, Michelle E ^c   Lee, Jong Min ^a   Wheeler, Vanessa C ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HUNTINGTIN; PROTEIN MSH2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN REGION; CAG REPEAT; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CORPUS STRIATUM; GENE DELETION; GENE FREQUENCY; GENE FUNCTION; GENE INACTIVATION; GENETIC SUSCEPTIBILITY; GENOMIC INSTABILITY; HUNTINGTON CHOREA; HUNTINGTON DISEASE GENE; INTRANUCLEAR SPACE; MEDIUM SPINY STRIATAL NEURON; MOUSE; MSH2 GENE; NERVE CELL; NEUROPATHOLOGY; NONHUMAN; PROTEIN LOCALIZATION; SOMATIC MUTATION; TISSUE SPECIFICITY;

ALLELES; ANIMALS; CELL NUCLEUS; DISEASE MODELS, ANIMAL; GENE DELETION; GENE KNOCK-IN TECHNIQUES; HUNTINGTON DISEASE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MUTANT PROTEINS; MUTS HOMOLOG 2 PROTEIN; NEOSTRIATUM; NERVE TISSUE PROTEINS; NEURONS; NUCLEAR PROTEINS; PHENOTYPE; TRINUCLEOTIDE REPEAT EXPANSION;

MUS; MUS MUSCULUS;

EID: 84866056680     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0044273     Document Type: Article

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