Intergenerational and striatal CAG repeat instability in Huntington's disease knock-in mice involve different DNA repair genes

Neurobiology of Disease

Volumn 33, Issue 1, 2009, Pages 37-47

  Dragileva, Ella ^a   Hendricks, Audrey ^b   Teed, Allison ^a   Gillis, Tammy ^a   Lopez, Edith T ^a   Friedberg, Errol C ^c   Kucherlapati, Raju ^d,e   Edelmann, Winfried ^f   Lunetta, Kathryn L ^b   MacDonald, Marcy E ^a   Wheeler, Vanessa C ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b BOSTON UNIVERSITY SCHOOL OF PUBLIC HEALTH   (United States)

^c UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^d LABORATORY FOR MOLECULAR MEDICINE   (United States)

^e HARVARD MEDICAL SCHOOL   (United States)

^f ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

Huntington's disease; Instability; Knock in; Mouse; Pathogenesis; Repair; Repeat; Striatum; Trinucleotide

Indexed keywords

TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR CAG REPEAT; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORPUS STRIATUM; DISEASE COURSE; DNA REPAIR; FEMALE; GENE; HUNTINGTON CHOREA; IMMUNOHISTOCHEMISTRY; MALE; MISMATCH REPAIR; MOUSE; MSH3 GENE; MSH6 GENE; NERVE CELL; NONHUMAN; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL;

ANIMALS; CORPUS STRIATUM; CROSSES, GENETIC; DISEASE MODELS, ANIMAL; DNA REPAIR; DNA-BINDING PROTEINS; FEMALE; GENOMIC INSTABILITY; HUNTINGTON DISEASE; IMMUNOHISTOCHEMISTRY; MALE; MICE; MICE, TRANSGENIC; MUTS HOMOLOG 2 PROTEIN; NERVE TISSUE PROTEINS; NEURONS; NUCLEAR PROTEINS; PHENOTYPE; PROTEINS; TRINUCLEOTIDE REPEAT EXPANSION;

EID: 57449091694     PISSN: 09699961     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nbd.2008.09.014     Document Type: Article

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