A universal mechanism ties genotype to phenotype in trinucleotide diseases

PLoS Computational Biology

Volumn 3, Issue 11, 2007, Pages 2291-2298

  Kaplan, Shai ^a   Itzkovitz, Shalev ^a   Shapiro, Ehud ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

NEURODEGENERATIVE DISEASES; NUCLEOTIDES;

CLINICAL DATA; CORE COMPONENTS; EXPANSION PROCESS; EXPONENTIALS; FRIEDREICH'S ATAXIAS; HUNTINGTON DISEASE; MATHEMATICAL ANALYSIS; SIMPLE++; TRINUCLEOTIDES; UNIVERSAL MECHANISMS;

GENES;

ARTICLE; DISEASE COURSE; FRIEDREICH ATAXIA; GENE MUTATION; GENETIC DISORDER; GENOTYPE PHENOTYPE CORRELATION; HETEROZYGOTE; HOMOZYGOTE; HUMAN; MATHEMATICAL ANALYSIS; TRINUCLEOTIDE DISEASE; ANIMAL; BIOLOGICAL MODEL; CHROMOSOME DISORDER; CHROMOSOME FRAGILE SITE; COMPUTER SIMULATION; GENETIC PREDISPOSITION; GENETICS; GENOTYPE; METHODOLOGY; NUCLEOTIDE SEQUENCE; PHENOTYPE; TRINUCLEOTIDE REPEAT;

DNA;

ANIMALS; CHROMOSOME DISORDERS; CHROMOSOME FRAGILE SITES; COMPUTER SIMULATION; DNA; DNA MUTATIONAL ANALYSIS; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; MODELS, GENETIC; PHENOTYPE; TRINUCLEOTIDE REPEAT EXPANSION;

EID: 36949031088     PISSN: 1553734X     EISSN: 15537358     Source Type: Journal    
DOI: 10.1371/journal.pcbi.0030235     Document Type: Article

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