Lipids: Absorption and Transport

Present Knowledge in Nutrition: Tenth Edition

Volumn , Issue , 2012, Pages 118-131

  Lichtenstein, Alice H ^a   Jones, Peter J H ^b  

^a TUFTS UNIVERSITY   (United States)

^b UNIVERSITY OF MANITOBA   (Canada)

Author keywords

Chylomicron delipidation as HDL source, and lipoprotein alteration; Chylomicron triacylglycerol, fatty acid composition; Chylomicrons, intestinally derived lipoproteins after fat ingestion; Dietary fats, and their breakdown in the gastrointestinal system; Fatty acid isomers with conjugated double bonds, reacting chemically; Hydrophobic nature of lipids, dietary fats handled differently; Lipid apolar nature, and multiple complex transport systems; Lipid cellular regulators, affecting fat synthesis and breakdown; Lipids, absorption and transport; The human body, and a fatty acid diet

Indexed keywords

EID: 84886963876     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9781119946045.ch9     Document Type: Chapter

References (94)

1. Abumweis, S.S., Barake, R., and Jones, P.J. (2008) Plant sterols/stanols as cholesterol lowering agents: a meta-analysis of randomized controlled trials. Food Nutr Res 52, 1811-1820.
2. Aloulou, A., Rodriguez, J.A., Fernandez, S., et al. (2006) Exploring the specific features of interfacial enzymology based on lipase studies. Biochim Biophys Acta 1761, 995-1013.
3. Altmann, S.W., Davis, H.R., Jr, Zhu, L.J., et al. (2004) Niemann-Pick C1 Like 1 protein is critical for intestinal cholesterol absorption. Science 303, 1201-1204.
4. Babin, P.J. and Gibbons, G.F. (2009) The evolution of plasma cholesterol: direct utility or a "spandrel" of hepatic lipid metabolism? Progr Lipid Res 48, 73-91.
5. Bajari, T.M., Strasser, V., Nimpf, J., et al. (2005) LDL receptor family: isolation, production, and ligand binding analysis. Methods 36, 109-116.
6. Belury, M.A. (2002) Inhibition of carcinogenesis by conjugated linoleic acid: potential mechanisms of action. J Nutr 132, 2995-2998.
7. Berry, S.E.E. (2009) Triacylglycerol structure and interesterification of palmitic and stearic acid-rich fats: an overview and implications for cardiovascular disease. Nutr Res Rev 22, 3-17.
8. Borggreve, S.E., De Vries, R., and Dullaart, R.P. (2003) Alterations in high-density lipoprotein metabolism and reverse cholesterol transport in insulin resistance and type 2 diabetes mellitus: role of lipolytic enzymes, lecithin:cholesterol acyltransferase and lipid transfer proteins. Eur J Clin Invest 33, 1051-1069.
9. Bretillon, L., Chardigny, J.M., Gregoire, S., et al. (1999) Effects of conjugated linoleic acid isomers on the hepatic microsomal desaturation activities in vitro. Lipids 34, 965-969.
10. Brown, W.V. (2007) High-density lipoprotein and transport of cholesterol and triglyceride in blood. J Clin Lipidol 1, 7-19.
11. Buhman, K.F., Accad, M., and Farese, R.V. (2000) Mammalian acyl-CoA:cholesterol acyltransferases. Biochim Biophys Acta 1529, 142-154.
12. Burris, T.P., Eacho, P.I., and Cao, G. (2002) Genetic disorders associated with ATP binding cassette cholesterol transporters. Mol Genet Metab 77, 13-20.
13. Canaan, S., Riviere, M., Verger, R., et al. (1999a) The cysteine residues of recombinant human gastric lipase. Biochem Biophys Research Commun 257, 851-854.
14. Canaan, S., Roussel, A., Verger, R., et al. (1999b) Gastric lipase: crystal structure and activity. Biochim Biophys Acta 1441, 197-204.
15. Capasso, R. and Izzo, A.A. (2008) Gastrointestinal regulation of food intake: general aspects and focus on anandamide and oleoylethanolamide. J Neuroendocrinol 20 Suppl 1, 39-46.
16. Chang, T.Y., Chang, C.C., and Cheng, D. (1997) Acyl-coenzyme A:cholesterol acyltransferase. Annu Rev Biochem 66, 613-638.
17. Chiang, J.Y. (2004) Regulation of bile acid synthesis: pathways, nuclear receptors, and mechanisms. J Hepatol 40, 539-551.
18. Choi, S.Y., Hirata, K., Ishida, T., et al. (2002) Endothelial lipase: a new lipase on the block. J Lipid Res 43, 1763-1769.
19. Cilingiroglu, M. and Ballantyne, C. (2004) Endothelial lipase and cholesterol metabolism. Curr Atheroscler Rep 6, 126-130.
20. Cooper, A.D. (1997) Hepatic uptake of chylomicron remnants. J Lipid Res 38, 2173-2192.
21. Damude, H.G. and Kinney, A.J. (2007) Engineering oilseed plants for a sustainable, land-based source of long chain polyunsaturated fatty acids. Lipids 42, 179-185.
22. Davis, H.R., Jr, Zhu, L.J., Hoos, L.M., et al. (2004) Niemann-Pick C1 Like 1 (NPC1L1) is the intestinal phytosterol and cholesterol transporter and a key modulator of whole-body cholesterol homeostasis. J Biol Chem 279, 33586-33592.
23. Davis, R.A., Miyake, J.H., Hui, T.Y., et al. (2002) Regulation of cholesterol-7alpha-hydroxylase: BAREly missing a SHP. J Lipid Res 43, 533-543.
24. Degirolamo, C., Shelness, G.S., and Rudel, L.L. (2009) LDL cholesteryl oleate as a predictor for atherosclerosis: evidence from human and animal studies on dietary fat. J Lipid Res 50 Suppl, S434-439.
25. Demonty, I., Ras, R.T., Van der Knaap, H.C.M., et al. (2009) Continuous dose-response relationship of the LDL-cholesterol-lowering effect of phytosterol intake. J Nutr 139, 271-284.
26. Dupont, J.L. (2005) Lipids: chemistry and classification. In B. Caballero, L. Allen, and A Prentice (eds), Encyclopedia of Human Nutrition. Academic Press, New York, pp. 126-132.
27. Field, F.J. and Mathur, S.N. (1983) Beta-sitosterol: esterification by intestinal acylcoenzyme A: cholesterol acyltransferase (ACAT) and its effect on cholesterol esterification. J Lipid Res 24, 409-417.
28. Frost, P.H. and Havel, R.J. (1998) Rationale for use of non-high-density lipoprotein cholesterol rather than low-density lipoprotein cholesterol as a tool for lipoprotein cholesterol screening and assessment of risk and therapy. Am J Cardiol 81, 26B-31B.
29. Ginsberg, H.N. (1994) Lipoprotein metabolism and its relationship to atherosclerosis. Med Clin North Am 78, 1-20.
30. Ginsberg, H.N. (1997) Role of lipid synthesis, chaperone proteins and proteasomes in the assembly and secretion of apoprotein B-containing lipoproteins from cultured liver cells. Clin Exp Pharmacol Physiol 24, A29-32.
31. Goldstein, J.L. and Brown, M.S. (2009) The LDL receptor. Arterioscler Thromb Vasc Biol 29, 431-438.
32. Gordon, D.A., Jamil, H., Sharp, D., et al. (1994) Secretion of apolipoprotein B-containing lipoproteins from HeLa cells is dependent on expression of the microsomal triglyceride transfer protein and is regulated by lipid availability. Proc Natl Acad Sci USA 91, 7628-7632.
33. Havel, R.J. (2000) Remnant lipoproteins as therapeutic targets. Curr Opin Lipidol 11, 615-620.
34. Hofmann, A. F. (2009) Bile acids: trying to understand their chemistry and biology with the hope of helping patients. Hepatology 49, 1403-1418.
35. Hussain, M.M. (2000) A proposed model for the assembly of chylomicrons. Atherosclerosis 148, 1-15.
36. Iqbal, J. and Hussain, M.M. (2009) Intestinal lipid absorption. Am J Physiol Endocrinol Metab 296, E1183-1194.
37. Jaureguiberry, M.S., Tricerri, M.A., Sanchez, S.A., et al. (2010) Membrane organization and regulaion of cellular cholesterol homeostasis. J Membr Biol 234, 183-194.
38. Ji, Y., Wang, N., Ramakrishnan, R., et al. (1999) Hepatic scavenger receptor BI promotes rapid clearance of high density lipoprotein free cholesterol and its transport into bile. J Biological Chem 274, 33398-33402.
39. Joyce, C., Skinner, K., Anderson, R A., et al. (1999) Acyl-coenzyme A:cholesteryl acyltransferase 2. Curr Opin Lipidol 10, 89-95.
40. Karpe, F. (1999) Postprandial lipoprotein metabolism and atherosclerosis. J Intern Med 246, 341-355.
41. Katan, M.B., Grundy, S.M., Jones, P., et al. (2003) Efficacy and safety of plant stanols and sterols in the management of blood cholesterol levels. Mayo Clin Proc 78, 965-978.
42. Kawai, T. and Fushiki, T. (2003) Importance of lipolysis in oral cavity for orosensory detection of fat. Am J Physiol Regul Integr Comp Physiol 285, R447-454.
43. Keating, N. and Keely, S.J. (2009) Bile acids in regulation of intestinal physiology. Curr Gastroenterol Rep 11, 375-382.
44. Kindel, T., Lee, D.M., and Tso, P. (2010) The mechanism of the formation and secretion of chylomicrons. Atheroscler Suppl 11, 11-16.
45. Knopp, R.H. (2000) Introduction: low-saturated fat, high-carbohydrate diets: effects on triglyceride and LDL synthesis, the LDL receptor, and cardiovascular disease risk. Proc Soc Exp Biol Med 225, 175-177.
46. Kolovou, G.D., Mikhailidis, D.P., Anagnostopoulou, K.K., et al. (2006) Tangier disease four decades of research: a reflection of the importance of HDL. Curr Med Chem 13, 771-782.
47. Leonard, A.E., Pereira, S.L., Sprecher, H., et al. (2004) Elongation of long-chain fatty acids. Progr Lipid Res 43, 36-54.
48. Lillis, A.P., Van Duyn, L.B., Murphy-Ullrich, J.E., et al. (2008) LDL receptor-related protein 1: unique tissue-specific functions revealed by selective gene knockout studies. Physiol Rev 88, 887-918.
49. Linton, M.F. and Fazio, S. (2001) Class A scavenger receptors, macrophages, and atherosclerosis. Curr Opin Lipidol 12, 489-495.
50. Lohse, P., Chahrokh-Zadeh, S., and Seidel, D. (1997) Human lysosomal acid lipase/cholesteryl ester hydrolase and human gastric lipase: site-directed mutagenesis of Cys227 and Cys236 results in substrate-dependent reduction of enzymatic activity. J Lipid Res 38, 1896-1905.
51. Marcil, M., O'Connell, B., Krimbou, L., et al. (2004) High-density lipoproteins: multifunctional vanguards of the cardiovascular system. Exp Rev Cardiovasc Ther 2, 417-430.
52. Masson, D., Jiang, X.-C., Lagrost, L., et al. (2009) The role of plasma lipid transfer proteins in lipoprotein metabolism and atherogenesis. J Lipid Res 50 Suppl, S201-206.
53. May, P., Woldt, E., Matz, R.L., et al. (2007) The LDL receptor-related protein (LRP) family: an old family of proteins with new physiological functions. Ann Med 39, 219-228.
54. Meagher, E.A. (2004) Addressing cardiovascular risk beyond low-density lipoprotein cholesterol: the high-density lipoprotein cholesterol story. Curr Cardiol Rep 6, 457-463.
55. Meijer, G.W., Bressers, M.A., De Groot, W.A., et al. (2003) Effect of structure and form on the ability of plant sterols to inhibit cholesterol absorption in hamsters. Lipids 38, 713-721.
56. Merkel, M., Eckel, R.H., and Goldberg, I.J. (2002) Lipoprotein lipase: genetics, lipid uptake, and regulation. J Lipid Res 43, 1997-2006.
57. Miller, M., Rhyne, J., Hamlette, S., et al. (2003) Genetics of HDL regulation in humans. Curr Opin Lipidol 14, 273-279.
58. Moestrup, S.K., Gliemann, J., and Pallesen, G. (1992) Distribution of the alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein in human tissues. Cell Tissue Res 269, 375-382.
59. Morgan, J., Carey, C., Lincoff, A., et al. (2004) High-density lipoprotein subfractions and risk of coronary artery disease. Curr Atheroscler Rep 6, 359-365.
60. Mu, H. and Hoy, C.E. (2004) The digestion of dietary triacylglycerols. Progr Lipid Res 43, 105-133.
61. Navab, M., Ananthramaiah, G.M., Reddy, S.T., et al. (2004) The oxidation hypothesis of atherogenesis: the role of oxidized phospholipids and HDL. J Lipid Res 45, 993-1007.
62. Navab, M., Yu, R., Gharavi, N., et al. (2007) High-density lipoprotein: antioxidant and anti-inflammatory properties. Curr Atheroscler Rep 9, 244-248.
63. Nordskog, B.K., Phan, C.T., Nutting, D.F., et al. (2001) An examination of the factors affecting intestinal lymphatic transport of dietary lipids. Adv Drug Deliv Rev 50, 21-44.
64. Olofsson, S.-O., Wiklund, O., and Boren, J. (2007) Apolipoproteins A-I and B: biosynthesis, role in the development of atherosclerosis and targets for intervention against cardiovascular disease. Vasc Health Risk Manag 3, 491-502.
65. Oram, J.F. (2002) ATP-binding cassette transporter A1 and cholesterol trafficking. Curr Opin Lipidol 13, 373-381.
66. Pafumi, Y., Lairon, D., De la Porte, P.L., et al. (2002) Mechanisms of inhibition of triacylglycerol hydrolysis by human gastric lipase. J Biol Chem 277, 28070-28079.
67. Plourde, M., Jew, S., Cunnane, S.C., et al. (2008) Conjugated linoleic acids: why the discrepancy between animal and human studies? Nutr Rev 66, 415-421.
68. Redgrave, T.G. (2004) Chylomicron metabolism. Biochem Soc Trans 32, 79-82.
69. Rudel, L.L., Lee, R.G., and Cockman, T.L. (2001) Acyl coenzyme A: cholesterol acyltransferase types 1 and 2: structure and function in atherosclerosis. Curr Opin Lipidol 12, 121-127.
70. Rudkowska, I. and Jones, P.J.H. (2008) Polymorphisms in ABCG5/G8 transporters linked to hypercholesterolemia and gallstone disease. Nutr Rev 66, 343-348.
71. Saito, H., Lund-Katz, S., and Phillips, M.C. (2004) Contributions of domain structure and lipid interaction to the functionality of exchangeable human apolipoproteins. Progr Lipid Res 43, 350-380.
72. Sehayek, E. (2003) Genetic regulation of cholesterol absorption and plasma plant sterol levels: commonalities and differences. J Lipid Res 44, 2030-2038.
73. Shachter, N.S. (2001) Apolipoproteins C-I and C-III as important modulators of lipoprotein metabolism. Curr Opin Lipidol 12, 297-304.
74. Spence, J.D. (2010) The role of lipoprotein(a) in the formation of arterial plaques, stenoses and occlusions. Can J Cardiol 26 Suppl A, 37A-40A.
75. Stein, Y. and Stein, O. (2003) Lipoprotein lipase and atherosclerosis. Atherosclerosis 170, 1-9.
76. Sudhop, T., Lutjohann, D., Agna, M., et al. (2003) Comparison of the effects of sitostanol, sitostanol acetate, and sitostanol oleate on the inhibition of cholesterol absorption in normolipemic healthy male volunteers. A placebo controlled randomized cross-over study. Arzneimittel-Forsch 53, 708-713.
77. Szapary, P.O. and Rader, D.J. (2004) The triglyceride-high-density lipoprotein axis: an important target of therapy? Am Heart J 148, 211-221.
78. Talati, R., Sobieraj, D.M., Makanji, S.S., et al. (2010) The comparative efficacy of plant sterols and stanols on serum lipids: a systematic review and meta-analysis. J Am Diet Assoc 110, 719-726.
79. Tall, A.R. (1998) An overview of reverse cholesterol transport. Eur Heart J 19 Suppl A, A31-35.
80. Taskinen, M.R. (2003) LDL-cholesterol, HDL-cholesterol or triglycerides-which is the culprit? Diabetes Res Clin Pract 61 Suppl 1, S19-26.
81. Tessari, P., Coracina, A., Cosma, A., et al. (2009) Hepatic lipid metabolism and non-alcoholic fatty liver disease. Nutr Metab Cardiovasc Dis 19, 291-302.
82. Tso, P. and Liu, M. (2004) Ingested fat and satiety. Physiol Behav 81, 275-287.
83. Tziomalos, K., Athyros, V.G., Wierzbicki, A.S., et al. (2009) Lipoprotein a: where are we now? Curr Opin Cardiol 24, 351-357.
84. Van Berkel, T.J., Van Eck, M., Herijgers, N., et al. (2000) Scavenger receptor classes A and B. Their roles in atherogenesis and the metabolism of modified LDL and HDL. Ann NY Acad Sci 902, 113-126 ; discussion 126-127.
85. Wang, J., Williams, C.M., and Hegele, R.A. (2004) Compound heterozygosity for two non-synonymous polymorphisms in NPC1L1 in a non-responder to ezetimibe. Clin Genet 67, 175-177.
86. Whitcomb, D.C. and Lowe, M.E. (2007) Human pancreatic digestive enzymes. Digestive Dis Sci 52, 1-17.
87. White, D.A., Bennett, A.J., Billett, M.A., et al. (1998) The assembly of triacylglycerol-rich lipoproteins: an essential role for the microsomal triacylglycerol transfer protein. Br J Nutr 80, 219-229.
88. White, D.A., Morris, A.J., Burgess, L., et al. (2004) Facilitators and barriers to improving the quality of referrals for potential oral cancer. Br Dental J 197, 537-540.
89. White, M.D., Papamandjaris, A.A., and Jones, P.J. (1999) Enhanced postprandial energy expenditure with medium-chain fatty acid feeding is attenuated after 14 d in premenopausal women. Am J Clin Nutr 69, 883-889.
90. Wijendran, V. and Hayes, K.C. (2004) Dietary n-6 and n-3 fatty acid balance and cardiovascular health. Annu Rev Nutr 24, 597-615.
91. Williams, C.M., Bateman, P.A., Jackson, K.G., et al. (2004) Dietary fatty acids and chylomicron synthesis and secretion. Biochem Soc Trans 32, 55-58.
92. Wilund, K.R., Yu, L., Xu, F., et al. (2004) High-level expression of ABCG5 and ABCG8 attenuates diet-induced hypercholesterolemia and atherosclerosis in Ldlr-/-mice. J Lipid Res 45, 1429-1436.
93. Wirtz, K.W.A. (2006) Phospholipid transfer proteins in perspective. FEBS Lett 580, 5436-5441.
94. Zambon, A., Bertocco, S., Vitturi, N., et al. (2003) Relevance of hepatic lipase to the metabolism of triacylglycerol-rich lipoproteins. Biochem Soc Trans 31, 1070-1074.