Conjugated linoleic acids: Why the discrepancy between animal and human studies?

Nutrition Reviews

Volumn 66, Issue 7, 2008, Pages 415-421

  Plourde, Mélanie ^a,d   Jew, Stephanie ^b   Cunnane, Stephen C ^a   Jones, Peter J H ^c  

^a UNIVERSITÉ DE SHERBROOKE   (Canada)

^b MCGILL UNIVERSITY   (Canada)

^c UNIVERSITY OF MANITOBA   (Canada)

^d Research Centre on Aging   (Canada)

Author keywords

Animal studies; Body weight; Conjugated linoleic acid; Fat loss; Human clinical trials; Metabolism

Indexed keywords

CONJUGATED LINOLEIC ACID; LINOLEIC ACID; RUMENIC ACID;

BODY FAT; CLINICAL TRIAL; DIET SUPPLEMENTATION; DRUG BLOOD LEVEL; DRUG EFFICACY; EXPERIMENTAL DESIGN; HUMAN; ISOMER; METHODOLOGY; NONHUMAN; OBESITY; REVIEW; TREATMENT OUTCOME; WEIGHT REDUCTION;

ADIPOSE TISSUE; AGE FACTORS; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENERGY METABOLISM; HUMANS; ISOMERISM; LINOLEIC ACIDS, CONJUGATED; OBESITY; SEX FACTORS; SPECIES SPECIFICITY;

ANIMALIA;

EID: 47349118803     PISSN: 00296643     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1753-4887.2008.00051.x     Document Type: Review

References (62)

1. Bauman DE, Lock AL, Corl BA, Ip C, Salter AM, Parodi PW. Milk fatty acids and human health: Potential role of conjugated linoleic acid and trans fatty acids. In : K. Sejrsen TH, M.O. Nielsen, ed. Ruminant Physiology: Digestion, Metabolism and Impact of Nutrition on Gene Expression, Immunology and Stress. Wageningen, The Netherlands. Academic Publishers, Wageningen 2006 : 529 561.
2. Kim MR, Park Y, Albright KJ, Pariza MW. Differential responses of hamsters and rats fed a high-fat or low-fat diet supplemented with conjugated linoleic acid. Nutr Res. 2002 22 : 715 722.
3. Koba K, Akahoshi A, Yamasaki M, et al. Dietary conjugated linolenic acid in relation to CLA differently modifies body fat mass and serum and liver lipid levels in rats. Lipids. 2002 37 : 343 350.
4. Ostrowska E, Muralitharan M, Cross RF, Bauman DE, Dunshea FR. Dietary conjugated linoleic acids increase lean tissue and decrease fat deposition in growing pigs. J Nutr. 1999 129 : 2037 2042.
5. Szymczyk B, Pisulewski PM, Szczurek W, Hanczakowski P. Effects of conjugated linoleic acid on growth performance, feed conversion efficiency, and subsequent carcass quality in broiler chickens. Br J Nutr. 2001 85 : 465 473.
6. Whigham LD, Watras AC, Schoeller DA. Efficacy of conjugated linoleic acid for reducing fat mass: a meta-analysis in humans. Am J Clin Nutr. 2007 85 : 1203 1211.
7. Laso N, Brugue E, Vidal J, et al. Effects of milk supplementation with conjugated linoleic acid (isomers cis-9, trans-11 and trans-10, cis-12) on body composition and metabolic syndrome components. Br J Nutr. 2007 98 : 860 867.
8. Gaullier JM, Halse J, Hoivik HO, et al. Six months supplementation with conjugated linoleic acid induces regional-specific fat mass decreases in overweight and obese. Br J Nutr. 2007 97 : 550 560.
9. Pinkoski C, Chilibeck PD, Candow DG, et al. The effects of conjugated linoleic acid supplementation during resistance training. Med Sci Sports Exerc. 2006 38 : 339 348.
10. Watras AC, Buchholz AC, Close RN, Zhang Z, Schoeller DA. The role of conjugated linoleic acid in reducing body fat and preventing holiday weight gain. Int J Obes (Lond). 2007 31 : 481 487.
11. Belury MA, Mahon A, Banni S. The conjugated linoleic acid (CLA) isomer, t10c12-CLA, is inversely associated with changes in body weight and serum leptin in subjects with type 2 diabetes mellitus. J Nutr. 2003 (Suppl 133 : S257 S260.
12. Benito P, Nelson GJ, Kelley DS, Bartolini G, Schmidt PC, Simon V. The effect of conjugated linoleic acid on plasma lipoproteins and tissue fatty acid composition in humans. Lipids. 2001 36 : 229 236.
13. Mougios V, Matsakas A, Petridou A, et al. Effect of supplementation with conjugated linoleic acid on human serum lipids and body fat. J Nutr Biochem. 2001 12 : 585 594.
14. Nazare JA, de la Perriere AB, Bonnet F, et al. Daily intake of conjugated linoleic acid-enriched yoghurts: effects on energy metabolism and adipose tissue gene expression in healthy subjects. Br J Nutr. 2007 97 : 273 280.
15. Smedman A, Vessby B. Conjugated linoleic acid supplementation in humans-metabolic effects. Lipids. 2001 36 : 773 781.
16. Thom E, Wadstein J, Gudmundsen O. Conjugated linoleic acid reduces body fat in healthy exercising humans. J Int Med Res. 2001 29 : 392 396.
17. Tricon S, Burdge GC, Jones EL, et al. Effects of dairy products naturally enriched with cis-9,trans-11 conjugated linoleic acid on the blood lipid profile in healthy middle-aged men. Am J Clin Nutr. 2006 83 : 744 753.
18. Tricon S, Burdge GC, Kew S, et al. Opposing effects of cis-9,trans-11 and trans-10,cis-12 conjugated linoleic acid on blood lipids in healthy humans. Am J Clin Nutr. 2004 80 : 614 620.
19. Zambell KL, Keim NL, Van Loan MD, et al. Conjugated linoleic acid supplementation in humans: effects on body composition and energy expenditure. Lipids. 2000 35 : 777 782.
20. Noone EJ, Roche HM, Nugent AP, Gibney MJ. The effect of dietary supplementation using isomeric blends of conjugated linoleic acid on lipid metabolism in healthy human subjects. Br J Nutr. 2002 88 : 243 251.
21. Petridou A, Mougios V, Sagredos A. Supplementation with CLA: isomer incorporation into serum lipids and effect on body fat of women. Lipids. 2003 38 : 805 811.
22. Colakoglu S, Colakoglu M, Taneli F, Cetinoz F, Turkmen M. Cumulative effects of conjugated linoleic acid and exercise on endurance development, body composition, serum leptin and insulin levels. J Sports Med Phys Fitness. 2006 46 : 570 577.
23. Lambert EV, Goedecke JH, Bluett K, et al. Conjugated linoleic acid versus high-oleic acid sunflower oil: effects on energy metabolism, glucose tolerance, blood lipids, appetite and body composition in regularly exercising individuals. Br J Nutr. 2007 97 : 1001 1011.
24. Gaullier JM, Halse J, Hoye K, et al. Conjugated linoleic acid supplementation for 1 y reduces body fat mass in healthy overweight humans. Am J Clin Nutr. 2004 79 : 1118 1125.
25. Gaullier JM, Halse J, Hoye K, et al. Supplementation with conjugated linoleic acid for 24 months is well tolerated by and reduces body fat mass in healthy, overweight humans. J Nutr. 2005 135 : 778 784.
26. Riserus U, Arner P, Brismar K, Vessby B. Treatment with dietary trans10,cis12 conjugated linoleic acid causes isomer-specific insulin resistance in obese men with the metabolic syndrome. Diabetes Care. 2002 25 : 1516 1521.
27. Riserus U, Vessby B, Arnlöv J, Basu S. Effect of cis-9, trans-11 conjugated linoleic acid supplementation on insulin sensitivity, lipid peroxidation, and proinflammatory markers in obese men. Am J Clin Nutr. 2004 80 : 279 283.
28. Park Y, Albright KJ, Liu W, Storkson JM, Cook ME, Pariza MW. Effect of conjugated linoleic acid on body composition in mice. Lipids. 1997 32 : 853 858.
29. Berven G, Bye A, Hals O, et al. Safety of conjugated linoleic acid (CLA) in overweight or obese human volunteers. Eur J Lipid Sci Technol. 2000 102 : 455 462.
30. Blankson H, Stakkestad JA, Fagertun H, Thom E, Wadstein J, Gudmundsen O. Conjugated linoleic acid reduces body fat mass in overweight and obese humans. J Nutr. 2000 130 : 2943 2948.
31. Wahle KW, Heys SD, Rotondo D. Conjugated linoleic acids: are they beneficial or detrimental to health? Prog Lipid Res. 2004 43 : 553 587.
32. Klingenberg M, Huang SG. Structure and function of the uncoupling protein from brown adipose tissue. Biochim Biophys Acta. 1999 1415 : 271 296.
33. Syvertsen C, Halse J, Hoivik HO, et al. The effect of 6 months supplementation with conjugated linoleic acid on insulin resistance in overweight and obese. Int J Obes (Lond). 2007 31 : 1148 1154.
34. Sisk MB, Hausman DB, Martin RJ, Azain MJ. Dietary conjugated linoleic acid reduces adiposity in lean but not obese Zucker rats. J Nutr. 2001 131 : 1668 1674.
35. Gaullier JM, Berven G, Blankson H, Gudmundsen O. Clinical trial results support a preference for using CLA preparations enriched with two isomers rather than four isomers in human studies. Lipids. 2002 37 : 1019 1025.
36. Choi Y, Kim YC, Han YB, Park Y, Pariza MW, Ntambi JM. The trans-10,cis-12 isomer of conjugated linoleic acid downregulates stearoyl-CoA desaturase 1 gene expression in 3T3-L1 adipocytes. J Nutr. 2000 130 : 1920 1924.
37. Kang K, Liu W, Albright KJ, Park Y, Pariza MW. trans-10,cis-12 CLA inhibits differentiation of 3T3-L1 adipocytes and decreases PPAR gamma expression. Biochem Biophys Res Commun. 2003 303 : 795 799.
38. Park Y, Storkson JM, Albright KJ, Liu W, Pariza MW. Evidence that the trans-10,cis-12 isomer of conjugated linoleic acid induces body composition changes in mice. Lipids. 1999 34 : 235 241.
39. Malpuech-Brugere C, Verboeket-van de Venne WP, Mensink RP, et al. Effects of two conjugated linoleic acid isomers on body fat mass in overweight humans. Obes Res. 2004 12 : 591 598.
40. Naumann E, Carpentier YA, Saebo A, et al. Cis-9, trans- 11 and trans-10, cis-12 conjugated linoleic acid (CLA) do not affect the plasma lipoprotein profile in moderately overweight subjects with LDL phenotype B. Atherosclerosis. 2006 188 : 167 174.
41. Desroches S, Chouinard PY, Galibois I, et al. Lack of effect of dietary conjugated linoleic acids naturally incorporated into butter on the lipid profile and body composition of overweight and obese men. Am J Clin Nutr. 2005 82 : 309 319.
42. Martin JC, Sébédio J-L, Caselli C, Pimont C, Martine L, Bernard A. Lymphatic delivery and in vivo pancreatic lipase hydrolysis of glycerol esters of conjugated linoleic acids in rats. J Nutr. 2000 130 : 1108 1114.
43. Plourde M, Sergiel JP, Chardigny JM, Gregoire S, Angers P, Sebedio JL. Absorption and metabolism of conjugated alpha-linolenic acids given as free fatty acids or triacylglycerols in rats. Nutr Metab. 2006 3 : 8.
44. Carta G, Angioni E, Murru E, Melis MP, Spada S, Banni S. Modulation of lipid metabolism and vitamin A by conjugated linoleic acid. Prost Leukot Essent Fatty Acids. 2002 67 : 187 191.
45. Fernie CE, Dupont IE, Scruel O, Carpentier YA, Sébédio JL, Scrimgeour CM. Relative absorption of conjugated linoleic acid as triacylglycerols, free fatty acid and ethyl ester in a functional food matrix. Eur J Lipid Sci. Technol. 2004 106 : 347 354.
46. Burdge GC, Lupoli B, Russell JJ, et al. Incorporation of cis-9,trans-11 or trans-10,cis-12 conjugated linoleic acid into plasma and cellular lipids in healthy men. J Lipid Res. 2004 45 : 736 741.
47. Burdge GC, Tricon S, Morgan R, et al. Incorporation of cis-9, trans-11 conjugated linoleic acid and vaccenic acid (trans-11 18 : 1) into plasma and leucocyte lipids in healthy men consuming dairy products naturally enriched in these fatty acids. Br J Nutr. 2005 94 : 237 243.
48. Chajes V, Lavillonniere F, Maillard V, et al. Conjugated linoleic acid content in breast adipose tissue of breast cancer patients and the risk of metastasis. Nutr Cancer. 2003 45 : 17 23.
49. Hasin A, Griinari JM, Williams JE, Shahin AM, McGuire MA, McGuire MK. Consumption of c9,t11-18:2 or t10,c12-18:2 enriched dietary supplements does not influence milk macronutrients in healthy, lactating women. Lipids. 2007 11.
50. Sergiel JP, Chardigny JM, Sebedio JL, et al. Beta-oxidation of conjugated linoleic acid isomers and linoleic acid in rats. Lipids. 2001 36 : 1327 1329.
51. Banni S, Carta G, Angioni E, et al. Distribution of conjugated linoleic acid and metabolites in different lipid fractions in the rat liver. J Lipid Res. 2001 42 : 1056 1061.
52. Sébédio J-L, Juaneda P, Grégoire S, Chardigny JM, Martin JC, Ginies C. Geometry of conjugated double bonds of cla isomers in a commercial mixture and in their hepatic 20:4 metabolites. Lipids. 1999 34 : 1319 1325.
53. Sebedio JL, Juaneda P, Dobson G, et al. Metabolites of conjugated isomers of linoleic acid (CLA) in the rat. Biochim Biophys Acta. 1997 1345 : 5 10.
54. Emken EA, Adlof RO, Duval S, Nelson G, Benito P. Effect of dietary conjugated linoleic acid (CLA) on metabolism of isotope-labeled oleic, linoleic, and CLA isomers in women. Lipids. 2002 37 : 741 750.
55. Plourde M, Cunnane SC. Extremely limited synthesis of long chain polyunsaturates in adults: implications for their dietary essentiality and use as supplements. Appl Physiol Nutr Metab. 2007 32 : 619 634.
56. Chawla A, Repa JJ, Evans RM, Mangelsdorf DJ. Nuclear receptors and lipid physiology: opening the X-files. Science. 2001 294 : 1866 1870.
57. Granlund L, Juvet LK, Pedersen JI, Nebb HI. Trans10, cis12-conjugated linoleic acid prevents triacylglycerol accumulation in adipocytes by acting as a PPARgamma modulator. J Lipid Res. 2003 44 : 1441 1452.
58. Moya-Camarena SY, Van den Heuvel JP, Belury MA. Conjugated linoleic acid activates peroxisome proliferator-activated receptor alpha and beta subtypes but does not induce hepatic peroxisome proliferation in Sprague-Dawley rats. Biochim Biophys Acta. 1999 1436 : 331 342.
59. Degrace P, Demizieux L, Gresti J, Chardigny JM, Sebedio JL, Clouet P. Hepatic steatosis is not due to impaired fatty acid oxidation capacities in C57BL/6J mice fed the conjugated trans-10,cis-12-isomer of linoleic acid. J Nutr. 2004 134 : 861 867.
60. Riserus U, Berglund L, Vessby B. Conjugated linoleic acid (CLA) reduced abdominal adipose tissue in obese middle-aged men with signs of the metabolic syndrome: a randomised controlled trial. Int J Obes Relat Metab Disord. 2001 25 : 1129 1135.
61. Taylor JS, Williams SR, Rhys R, James P, Frenneaux MP. Conjugated linoleic acid impairs endothelial function. Arterioscler Thromb Vasc Biol. 2006 26 : 307 312.
62. Steck SE, Chalecki AM, Miller P, et al. Conjugated linoleic acid supplementation for twelve weeks increases lean body mass in obese humans. J Nutr. 2007 137 : 1188 1193.