ATP-binding cassette transporter A1 and cholesterol trafficking

Current Opinion in Lipidology

Volumn 13, Issue 4, 2002, Pages 373-381

  Oram, John F ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

Author keywords

ABCA1; Cardiovascular disease; HDL; Reverse cholesterol transport; Tangier disease

Indexed keywords

ABC TRANSPORTER; APOLIPOPROTEIN; CELL MEMBRANE PROTEIN; CHOLESTEROL; HIGH DENSITY LIPOPROTEIN;

ARTERY WALL; ATHEROGENESIS; CARDIOVASCULAR DISEASE; CELL CULTURE; CELL MEMBRANE; CHOLESTEROL TRANSPORT; GENE MUTATION; HUMAN; LIPID METABOLISM; MACROPHAGE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW;

ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; BIOLOGICAL TRANSPORT; CHOLESTEROL; GENE EXPRESSION REGULATION; HUMANS; TANGIER DISEASE;

EID: 0036321948     PISSN: 09579672     EISSN: None     Source Type: Journal    
DOI: 10.1097/00041433-200208000-00004     Document Type: Review

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3. Defective removal of cellular cholesterol and phospholipids by apolipoprotein A-I in Tangier disease
4. Mutations in ABC1 in Tangier disease and familial high-density lipoprotein deficiency
5. The gene encoding ATP-binding cassette transporter 1 is mutated in Tangier disease
6. Tangier disease is caused by mutations in the gene encoding ATP-binding cassette transporter 1
7. The Tangier disease gene product ABC1 controls the cellular apolipoprotein-mediated lipid removal pathway
8. The human ATP-binding cassette (ABC) transporter superfamily
9. Membrane topology of the ATP binding cassette transporter ABCR and its relationship to ABC1 and related ABCA transporters: Identification of N-linked glycosylation sites
10. ATP-binding cassette transporter A1 contains an NH2-terminal signal anchor sequence that translocates the protein's first hydrophilic domain to the exoplasmic space
11. Human ABCA1 contains a large amino-terminal extracellular domain homologous to an epitope of Sjogren's syndrome
12. Cellular localization and trafficking of the human ABCA1 transporter
13. Apolipoprotein binding to protruding membrane domains during removal of excess cellular cholesterol
14. Characterization of the ATPase cycle of human ABCA1: Implications for its function as a regulator rather than an active transporter
15. Specific docking of apolipoprotein A-I at the cell surface requires a functional ABCA1 transporter
16. Preferential ATP-binding cassette transporter A1-mediated cholesterol efflux from late endosomes/lysosomes
17. ABCA1: The gatekeeper for eliminating excess tissue cholesterol
18. Cholesterol efflux to apolipoprotein A1 involves endocytosis and resecretion in a calcium-dependent pathway
19. Regulation and intracellular trafficking of the ABCA1 transporter
20. Unsaturated fatty acids inhibit cholesterol efflux from macrophages by increasing degradation of ATP-binding cassette transporter A1
21. Cellular cholesterol efflux is modulated by phospholipid-derived signaling molecules in familial HDL deficiency/Tangier disease fibroblasts
22. Specific binding of ApoA-I, enhanced cholesterol efflux, and altered plasma membrane morphology in cells expressing ABC1
23. Accumulation of RhoA, RhoB, RhoG, and Rac1 in fibroblasts from Tangier disease subjects suggests a regulatory role of Rho family proteins in cholesterol efflux
24. ATP-binding cassette transporter-1 induces rearrangement of actin cytoskeletons possibly through Cdc42/N-WASP
25. ATP-binding cassette transporter A1 (ABCA1) functions as a cholesterol efflux regulatory protein
26. A two-step mechanism for free cholesterol and phospholipid efflux from human vascular cells to apolipoprotein A-1
27. Involvement of caveolin-1 in cholesterol enrichment of high density lipoprotein during its assembly by apolipoprotein and THP-1 cells
28. Membrane lipid domains distinct from cholesterol/sphingomyelin-rich rafts are involved in the ABCA1-mediated lipid secretory pathway
29. ABC1 promotes engulfment of apoptotic cells and transbilayer redistribution of phosphatidylserine
30. Endocytosis is enhanced in Tangier fibroblasts: Possible role of ATP-binding cassette protein A1 in endosomal vesicular transport
31. Evaluation of the role of phosphatidylserine translocase activity in ABCA1 mediated lipid efflux
32. ATP-binding cassette transporter A1 mediates cellular secretion of alpha-tocopherol
33. ATP binding cassette transporter ABCA1 modulates the secretion of apolipoprotein E from human monocyte-derived macrophages
34. Interleukin-1beta secretion is impaired by inhibitors of the ATP binding cassette transporter, ABC1
35. The ATP binding cassette transporter A1 contributes to the secretion of interleukin 1beta from macrophages but not from monocytes
36. Structure of the multidrug resistance P-glycoprotein to 2.5 nm resolution determined by electron microscopy and image analysis
37. Sterol-dependent transactivation of the ABC1 promoter by the liver X receptor/retinoid X receptor
38. ABC1 gene expression and ApoA-I-mediated cholesterol efflux are regulated by LXR
39. Human ABCA1 BAC transgenic mice show increased high density lipoprotein cholesterol and ApoAI-dependent efflux stimulated by an internal promoter containing liver X receptor response elements in intron 1
40. PPAR-alpha and PPAR-gamma activators induce cholesterol removal from human macrophage foam cells through stimulation of the ABCA1 pathway
41. APPAR gamma-LXR-ABCA1 pathway in macrophages is involved in cholesterol efflux and atherogenesis
42. A selective peroxisome proliferator-activated receptor delta agonist promotes reverse cholesterol transport
43. Dual mechanisms of ABCA1 regulation by geranylgeranyl pyrophosphate
44. The correlation of ATP-binding cassette 1 mRNA levels with cholesterol efflux from various cell lines
45. ABCA1 is the cAMP-inducible apolipoprotein receptor that mediates cholesterol secretion from macrophages
46. The zinc finger protein 202 (ZNF202) is a transcriptional repressor of ATP binding cassette transporter A1 (ABCA1) and ABCG1 gene expression and a modulator of cellular lipid efflux
47. Identification of sterol-independent regulatory elements in the human ATP-binding cassette transporter A1 (ABCA1) promoter: Role of Sp1/3, E-Box binding factors and an oncostatin M responsive element
48. The E-box motif in the proximal ABCA1 promoter mediates transcriptional repression of the ABCA1 gene
49. TGF-beta increases cholesterol efflux and ABC-1 expression in macrophage-derived foam cells: Opposing the effects of IFN-gamma
50. Nuclear receptor regulation of cholesterol and bile acid metabolism
51. Autoregulation of the human liver X receptor alpha promoter
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53. Structural requirements of ligands for the oxysterol liver X receptors LXRalpha and LXRbeta
54. 27-Hydroxycholesterol is an endogenous ligand for liver X receptor in cholesterol-loaded cells
55. Unsaturated fatty acids inhibit transcription of the sterol regulatory element-binding protein-1c (SREBP-1c) gene by antagonizing ligand-dependent activation of the LXR
56. Cyclic AMP-specific phosphodiesterase 4 inhibitors promote ABCA1 expression and cholesterol efflux
57. Human and mouse ABCA1 comparative sequencing and transgenesis studies revealing novel regulatory sequences
58. Familial high density lipoprotein deficiency: Tangier disease
59. Transport of lipids from golgi to plasma membrane is defective in tangier disease patients and Abc1-deficient mice
60. High density lipoprotein deficiency and foam cell accumulation in mice with targeted disruption of ATP-binding cassette transporter-1
61. Pivotal role of ABCA1 in reverse cholesterol transport influencing HDL levels and susceptibility to atherosclerosis
62. Localization of human atp-binding cassette transporter 1 (abc1) in normal and atherosclerotic tissues
63. ABCA1 mRNA and protein distribution patterns predict multiple different roles and levels of regulation
64. Monocyte/macrophage expression of ABCA1 has minimal contribution to plasma HDL levels
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70. ABCA1 overexpression leads to hyperalphalipoproteinemia and increased biliary cholesterol excretion in transgenic mice
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72. Accumulation of dietary cholesterol in sitosterolemia caused by mutations in adjacent ABC transporters
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74. Hepatobiliary cholesterol transport is not impaired in Abca1-null mice lacking HDL
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76. Homozygous Tangier disease and cardiovascular disease
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78. Age and residual cholesterol efflux affect HDL cholesterol levels and coronary artery disease in ABCA1 heterozygotes
79. Association between increased arterial-wall thickness and impairment in ABCA1-driven cholesterol efflux: An observational study
80. The ATP binding cassette transporter A1 (ABCA1) modulates the development of aortic atherosclerosis in C57BL/6 and apoE-knockout mice