Comparison of the Effects of Sitostanol, Sitostanol Acetate, and Sitostanol Oleate on the Inhibition of Cholesterol Absorption in Normolipemic Healthy Male Volunteers: A placebo controlled randomized cross-over study

Arzneimittel-Forschung/Drug Research

Volumn 53, Issue 10, 2003, Pages 708-713

  Sudhop, Thomas ^a   Lütjohann, Dieter ^a   Agna, Mohamed ^a   Von Ameln, Claudia ^a   Prange, Wolfgang ^a   Von Bergmann, Klaus ^a,b  

^a UNIVERSITY OF BONN   (Germany)

^b UNIVERSITY HOSPITAL BONN   (Germany)

Author keywords

CAS 107615 79 2; CAS 19466 47 8; CAS 73052 08 1; Cholesterol, inhibition of absorption; Sitostanol; Sitostanol acetate; Sitostanol oleate

Indexed keywords

AVENASTEROL; CAMPESTANOL; CHOLESTANOL; CHOLESTEROL; LATHOSTEROL; LOW DENSITY LIPOPROTEIN; MARGARINE; PHYTOSTEROL; PLACEBO; SITOSTANOL; SITOSTANOL ACETATE; SITOSTANOL OLEATE; SITOSTEROL; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL METABOLISM; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; DRUG EFFECT; FOOD INTAKE; HUMAN; HYPERCHOLESTEROLEMIA; INHIBITION KINETICS; INTESTINE ABSORPTION; ISOTOPE LABELING; LIPID ABSORPTION; LIPID BLOOD LEVEL; MALE; RANDOMIZED CONTROLLED TRIAL; RECEPTOR AFFINITY;

EID: 0242351978     PISSN: 00044172     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0031-1299816     Document Type: Article

References (25)

1. Oster, P., Schlierf, G., Heuck, C. C. et al., Sitosterin bei familiärer Hyperlipoproteinämie Typ II. Eine randomisierte gekreuzte Doppelblindstudie. Dtsch. Med. Wochenschr. 101, 1308 (1976)
2. Pelletier, X., Belbraouet, S., Mirabel, D. et al., A diet moderately enriched in phytosterols lowers plasma cholesterol concentrations in normocholesterolemic humans. Ann. Nutr. Metab. 39, 291 (1995)
3. Schwartzkopff, W., Jantke, H. J., Dosiswirksamkeit von β-Sitosterin bei Hypercholesterinämie der Typen IIa und IIb. Münch. Med. Wochenschr. 120, 1575 (1978)
4. Grundy, S. M., Mok, H. Y. I., Effects of dose phytosterols on cholesterol absorption in man. In: H. Greten, (ed.), p. 112-118, Lipoprotein Metabolism. Springer, New York, (1976)
5. Becker, M., Staab, D., Von Bergman, K., Long-term treatment of severe familial hypercholesterolemia in children: effect of sitosterol and bezafibrate. Pediatrics 89, 138(1992)
6. Becker, M., Staab, D., Von Bergmann, K., Treatment of severe familial hypercholesterolemia in childhood with sitosterol and sitostanol. J. Pediatr. 122, 292 (1993)
7. Mattson, F. H., Grundy, S. M., Crouse, J. R., Optimizing the effect of plant sterols on cholesterol absorption in man. Am. J. Clin. Nutr. 35, 697 (1982)
8. Heinemann, T., Leiss, O., von Bergmann, K., Effect of low-dose sitostanol on serum cholesterol in patients with hypercholesterolemia. Atherosclerosis. 61, 219 (1986)
9. Heinemann, T., Pietruck, B., Kullak-Ublick, G. et al., Comparison of sitosterol and sitostanol on inhibition of intestinal cholesterol absorption. Agents Actions Suppl. 26, 117 (1988)
10. Heinemann, T., Axtmann, G., von Bergmann, K., Comparison of intestinal absorption of cholesterol with different plant sterols in man. Eur. J. Clin. Invest. 23, 827 (1993).
11. Czubayko, F., Beumers, B., Lammsfuss, S. et al., A simplified micro-method for quantification of fecal excretion of neutral and acidic sterols for outpatient studies in humans. J. Lipid Res. 32, 1861 (1991)
12. Lütjohann, D., Björkhem, I., Beil, U. F. et al., Sterol absorption and sterol balance in phytosterolemia evaluated by deuterium-labeled sterols: effect of sitostanol treatment. J. Lipid Res. 36, 1763 (1995)
13. Vanhanen, H. T., Kajander, J., Lehtovirta, H. et al., Serum levels, absorption efficiency, faecal elimination and synthesis of cholesterol during increasing doses of dietary sitostanol esters in hypercholesterolaemic subjects. Clin. Sci. (Lond.) 87, 61 (1994)
14. Gylling, H., Siimes, M. A., Miettinen, T. A., Sitostanol ester margarine in dietary treatment of children with familial hypercholesterolemia. J. Lipid Res. 36, 1807 (1995)
15. Miettinen, T. A., Puska, P., Gylling, H. et al., Reduction of serum cholesterol with sitostanol-ester margarine in a mildly hypercholesterolemic population. N. Engl. J. Med. 333, 1308 (1995)
16. Mok, H. Y., von Bergmann, K., Grundy, S. M., Effects of continuous and intermittent feeding on biliary lipid outputs in man: application for measurements of intestinal absorption of cholesterol and bile acids. J. Lipid Res. 20, 389 (1979)
17. Lütjohann, D., Meese, C. O., Crouse, J. R., 3rd et al., Evaluation of deuterated cholesterol and deuterated sitostanol for measurement of cholesterol absorption in humans. J. Lipid Res. 34, 1039 (1993)
18. Friedewald, W. T., Levy, R. I., Fredrickson, D. S., Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin. Chem. 18, 499 (1972)
19. Pollak, O., Reduction of blood cholesterol in man. Circulation. 7, 702 (1953)
20. Law, M., Plant sterol and stanol margarines and health. Br. Med. J. 320, 861 (2000)
21. Nguyen, T. T., Dale, L. C., von Bergmann, K. et al., Cholesterol- lowering effect of stanol ester in a US population of mildly hypercholesterolemic men and women: a randomized controlled trial. Mayo Clin. Proc. 74, 1198 (1999)
22. Nissinen, M., Gylling, H., Vuoristo, M., Miettinen, T. A., Micellar distribution of cholesterol and phytosterols after duodenal plant stanol ester infusion. Am. J. Physiol. Gastrointest. Liver Physiol. 282, G1009 (2002)
23. Miettinen, T. A., Vuoristo, M., Nissinen, M. et al., Serum, biliary, and fecal cholesterol and plant sterols in colectomized patients before and during consumption of stanol ester margarine. Am. J. Clin. Nutr. 71, 1095 (2000)
24. Ostlund, R. E., Jr., Spilburg, C. A., Stenson, W. F., Sitostanol administered in lecithin micelles potently reduces cholesterol absorption in humans. Am. J. Clin. Nutr. 70, 826 (1999)
25. Heinemann, T., Kullak-Ublick, G. A., Pietruck, B. et al., Mechanisms of action of plant sterols on inhibition of cholesterol absorption. Comparison of sitosterol and sitostanol. Eur. J. Clin. Pharmacol. 40, S59 (1991)